JP2017508759A - ヒト血漿タンパク質を調製するための方法 - Google Patents

ヒト血漿タンパク質を調製するための方法 Download PDF

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Publication number
JP2017508759A
JP2017508759A JP2016556862A JP2016556862A JP2017508759A JP 2017508759 A JP2017508759 A JP 2017508759A JP 2016556862 A JP2016556862 A JP 2016556862A JP 2016556862 A JP2016556862 A JP 2016556862A JP 2017508759 A JP2017508759 A JP 2017508759A
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Prior art keywords
plasma
chromatography
column
immunoglobulin
affinity
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Japanese (ja)
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JP2017508759A5 (enExample
Inventor
ダミアン・バタイユ
アブデサタール・シュトゥル
パトリック・サンタンビヤン
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LFB SA
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LFB SA
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Publication of JP2017508759A publication Critical patent/JP2017508759A/ja
Publication of JP2017508759A5 publication Critical patent/JP2017508759A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016556862A 2014-03-11 2015-03-10 ヒト血漿タンパク質を調製するための方法 Pending JP2017508759A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1451997 2014-03-11
FR1451997A FR3018450B1 (fr) 2014-03-11 2014-03-11 Procede de preparation de proteines plasmatiques humaines
PCT/FR2015/050598 WO2015136217A1 (fr) 2014-03-11 2015-03-10 Procédé de préparation de protéines plasmatiques humaines

Publications (2)

Publication Number Publication Date
JP2017508759A true JP2017508759A (ja) 2017-03-30
JP2017508759A5 JP2017508759A5 (enExample) 2018-04-19

Family

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JP2016556862A Pending JP2017508759A (ja) 2014-03-11 2015-03-10 ヒト血漿タンパク質を調製するための方法

Country Status (13)

Country Link
US (1) US20170073396A1 (enExample)
EP (1) EP3116527B1 (enExample)
JP (1) JP2017508759A (enExample)
KR (1) KR20160130495A (enExample)
CN (1) CN106103473A (enExample)
AU (1) AU2015228649A1 (enExample)
CA (1) CA2942203A1 (enExample)
ES (1) ES2759259T3 (enExample)
FR (1) FR3018450B1 (enExample)
IL (1) IL247508A0 (enExample)
MX (1) MX2016011641A (enExample)
TW (1) TW201620925A (enExample)
WO (1) WO2015136217A1 (enExample)

Cited By (1)

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JP2022531317A (ja) * 2019-05-03 2022-07-06 ジェネンテック， インコーポレイテッド 精製プラットフォームから得られた組成物中の酵素加水分解活性速度を低下させる方法

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FR3018450B1 (fr) 2014-03-11 2016-04-15 Lab Francais Du Fractionnement Procede de preparation de proteines plasmatiques humaines
WO2017066683A1 (en) * 2015-10-15 2017-04-20 Plasma Technologies, Llc Methods for extracting proteins from blood plasma
WO2017176735A1 (en) * 2016-04-05 2017-10-12 Haemonetics Corporation Methods and devices for the enrichment of immunoglobulin from blood
FR3053592B1 (fr) * 2016-07-06 2020-05-29 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Fibrinogene liquide stable
WO2018007767A1 (fr) 2016-07-06 2018-01-11 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Fibrinogène liquide stable
EP3275897A1 (en) 2016-07-27 2018-01-31 Biotest AG Process for preparing immunoglobulin compositions
EP3491136A1 (en) 2016-07-28 2019-06-05 Laboratoire Francais du Fractionnement et des Biotechnologies Societe Anonyme Anti- immunoglobulin g aptamers and uses thereof
WO2018117143A1 (ja) * 2016-12-22 2018-06-28 一般財団法人化学及血清療法研究所 血液凝固第ｖｉｉ因子の高収率回収のためのクロマトグラフィー法
FR3061020B1 (fr) 2016-12-22 2019-05-17 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Composition de fibrinogene humain
WO2018165766A1 (en) * 2017-03-16 2018-09-20 Therapure Biopharma Inc. Method for purification of albumin
CN107033237B (zh) * 2017-05-11 2021-07-20 深圳市卫光生物制品股份有限公司 一种人血浆载脂蛋白a-i的分离纯化方法
CN107216384A (zh) * 2017-05-11 2017-09-29 深圳市卫光生物制品股份有限公司 一种人血浆转铁蛋白分离纯化的方法
CN107827974B (zh) * 2017-11-10 2021-01-01 中国科学院过程工程研究所 一种人纤维蛋白原的制备方法
CN108101981B (zh) * 2018-01-15 2019-06-04 四川远大蜀阳药业有限责任公司 一种静注免疫球蛋白的生产工艺
FR3081328B1 (fr) * 2018-05-24 2021-01-01 Lab Francais Du Fractionnement Composition d'immunoglobulines humaines concentrees
FR3090321B1 (fr) * 2018-12-21 2023-07-14 Lab Francais Du Fractionnement Procédé de filtration du fibrinogène
CN110314414B (zh) * 2019-07-23 2021-10-19 宝锐生物科技泰州有限公司 凝血因子xiii的分离纯化方法及其应用
US11833279B2 (en) * 2021-06-11 2023-12-05 Astaria Global, LLC System and method for isolating alpha 2M molecules
CN113754757B (zh) * 2021-07-01 2024-06-14 华兰生物工程股份有限公司 一种人纤维蛋白原的制备方法
EP4377361A1 (en) * 2021-07-29 2024-06-05 CSL Behring AG Method of purifying immunoglobulin g and uses thereof
CN113563457B (zh) * 2021-08-20 2023-02-24 华兰生物工程股份有限公司 一种同时制备人纤维蛋白原、凝血因子ⅷ和纤溶酶原的方法
CN114835801B (zh) * 2022-06-20 2023-09-22 华润博雅生物制药集团股份有限公司 一种c1酯酶抑制剂及其制备方法
CN117069836B (zh) * 2023-09-22 2024-08-27 武汉中生毓晋生物医药有限责任公司 一种抗人t细胞兔免疫球蛋白的制备方法

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JP2002532730A (ja) * 1998-12-19 2002-10-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 分子サイズによる物質の連続分離方法
JP2009511900A (ja) * 2005-10-13 2009-03-19 イクスエンド、ホールディング、ベスローテン、フェンノートシャップ クロマトグラフ分離のための装置
JP2010530068A (ja) * 2007-06-15 2010-09-02 ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー クロマトグラフィー法
JP2012518033A (ja) * 2009-02-19 2012-08-09 エルエフベー ビオテクノロジーズ 血漿タンパクの精製手段と、それを実施する方法

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022531317A (ja) * 2019-05-03 2022-07-06 ジェネンテック， インコーポレイテッド 精製プラットフォームから得られた組成物中の酵素加水分解活性速度を低下させる方法

Also Published As

Publication number Publication date
IL247508A0 (en) 2016-11-30
KR20160130495A (ko) 2016-11-11
AU2015228649A1 (en) 2016-09-15
MX2016011641A (es) 2016-10-31
FR3018450B1 (fr) 2016-04-15
EP3116527B1 (fr) 2019-09-04
CN106103473A (zh) 2016-11-09
ES2759259T3 (es) 2020-05-08
FR3018450A1 (fr) 2015-09-18
TW201620925A (zh) 2016-06-16
US20170073396A1 (en) 2017-03-16
WO2015136217A1 (fr) 2015-09-17
CA2942203A1 (fr) 2015-09-17
EP3116527A1 (fr) 2017-01-18

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