JP2017508759A5 - - Google Patents
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- JP2017508759A5 JP2017508759A5 JP2016556862A JP2016556862A JP2017508759A5 JP 2017508759 A5 JP2017508759 A5 JP 2017508759A5 JP 2016556862 A JP2016556862 A JP 2016556862A JP 2016556862 A JP2016556862 A JP 2016556862A JP 2017508759 A5 JP2017508759 A5 JP 2017508759A5
- Authority
- JP
- Japan
- Prior art keywords
- chromatography
- plasma
- column
- affinity
- fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 18
- 239000003446 ligand Substances 0.000 claims 13
- 238000001042 affinity chromatography Methods 0.000 claims 11
- 108060003951 Immunoglobulin Proteins 0.000 claims 9
- 102000018358 immunoglobulin Human genes 0.000 claims 9
- 108010088751 Albumins Proteins 0.000 claims 8
- 102000009027 Albumins Human genes 0.000 claims 8
- 238000000746 purification Methods 0.000 claims 8
- 102000008946 Fibrinogen Human genes 0.000 claims 7
- 108010049003 Fibrinogen Proteins 0.000 claims 7
- 229940012952 fibrinogen Drugs 0.000 claims 7
- 238000004440 column chromatography Methods 0.000 claims 6
- 239000006228 supernatant Substances 0.000 claims 6
- 102000004506 Blood Proteins Human genes 0.000 claims 5
- 108010017384 Blood Proteins Proteins 0.000 claims 5
- 238000004255 ion exchange chromatography Methods 0.000 claims 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 4
- 238000005571 anion exchange chromatography Methods 0.000 claims 3
- 239000012141 concentrate Substances 0.000 claims 3
- 238000012434 mixed-mode chromatography Methods 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 230000000717 retained effect Effects 0.000 claims 3
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 2
- 108010043958 Peptoids Proteins 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 229960002446 octanoic acid Drugs 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 239000012465 retentate Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- -1 Nanofichin Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 238000005349 anion exchange Methods 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 238000005277 cation exchange chromatography Methods 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 239000000535 fibrinogen concentrate Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims 1
- 230000015784 hyperosmotic salinity response Effects 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1451997A FR3018450B1 (fr) | 2014-03-11 | 2014-03-11 | Procede de preparation de proteines plasmatiques humaines |
| FR1451997 | 2014-03-11 | ||
| PCT/FR2015/050598 WO2015136217A1 (fr) | 2014-03-11 | 2015-03-10 | Procédé de préparation de protéines plasmatiques humaines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017508759A JP2017508759A (ja) | 2017-03-30 |
| JP2017508759A5 true JP2017508759A5 (enExample) | 2018-04-19 |
Family
ID=51210517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556862A Pending JP2017508759A (ja) | 2014-03-11 | 2015-03-10 | ヒト血漿タンパク質を調製するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170073396A1 (enExample) |
| EP (1) | EP3116527B1 (enExample) |
| JP (1) | JP2017508759A (enExample) |
| KR (1) | KR20160130495A (enExample) |
| CN (1) | CN106103473A (enExample) |
| AU (1) | AU2015228649A1 (enExample) |
| CA (1) | CA2942203A1 (enExample) |
| ES (1) | ES2759259T3 (enExample) |
| FR (1) | FR3018450B1 (enExample) |
| IL (1) | IL247508A0 (enExample) |
| MX (1) | MX2016011641A (enExample) |
| TW (1) | TW201620925A (enExample) |
| WO (1) | WO2015136217A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3018450B1 (fr) | 2014-03-11 | 2016-04-15 | Lab Francais Du Fractionnement | Procede de preparation de proteines plasmatiques humaines |
| EP3362464B1 (en) * | 2015-10-15 | 2021-04-28 | Plasma Technologies LLC | Methods for extracting proteins from blood plasma |
| WO2017176735A1 (en) * | 2016-04-05 | 2017-10-12 | Haemonetics Corporation | Methods and devices for the enrichment of immunoglobulin from blood |
| CA3029075A1 (fr) | 2016-07-06 | 2018-01-11 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Fibrinogene liquide stable |
| FR3053592B1 (fr) * | 2016-07-06 | 2020-05-29 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Fibrinogene liquide stable |
| EP3275897A1 (en) * | 2016-07-27 | 2018-01-31 | Biotest AG | Process for preparing immunoglobulin compositions |
| WO2018019538A1 (en) | 2016-07-28 | 2018-02-01 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Anti- immunoglobulin g aptamers and uses thereof |
| JP6612472B2 (ja) * | 2016-12-22 | 2019-11-27 | Ｋｍバイオロジクス株式会社 | 血液凝固第ｖｉｉ因子の高収率回収のためのクロマトグラフィー法 |
| FR3061020B1 (fr) | 2016-12-22 | 2019-05-17 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Composition de fibrinogene humain |
| CA3058234A1 (en) * | 2017-03-16 | 2018-09-20 | Therapure Biopharma Inc. | Method for purification of albumin |
| CN107033237B (zh) * | 2017-05-11 | 2021-07-20 | 深圳市卫光生物制品股份有限公司 | 一种人血浆载脂蛋白a-i的分离纯化方法 |
| CN107216384A (zh) * | 2017-05-11 | 2017-09-29 | 深圳市卫光生物制品股份有限公司 | 一种人血浆转铁蛋白分离纯化的方法 |
| CN107827974B (zh) * | 2017-11-10 | 2021-01-01 | 中国科学院过程工程研究所 | 一种人纤维蛋白原的制备方法 |
| CN108101981B (zh) * | 2018-01-15 | 2019-06-04 | 四川远大蜀阳药业有限责任公司 | 一种静注免疫球蛋白的生产工艺 |
| FR3081328B1 (fr) * | 2018-05-24 | 2021-01-01 | Lab Francais Du Fractionnement | Composition d'immunoglobulines humaines concentrees |
| FR3090321B1 (fr) | 2018-12-21 | 2023-07-14 | Lab Francais Du Fractionnement | Procédé de filtration du fibrinogène |
| EP3962924A1 (en) * | 2019-05-03 | 2022-03-09 | Genentech, Inc. | Methods of reducing the enzymatic hydrolysis activity rate in a composition obtained from a purification platform |
| CN110314414B (zh) * | 2019-07-23 | 2021-10-19 | 宝锐生物科技泰州有限公司 | 凝血因子xiii的分离纯化方法及其应用 |
| EP3945095A1 (en) * | 2020-07-28 | 2022-02-02 | Bia Separations D.O.O. | A process for the purification of prothrombin complex concentrate (pcc) and fix from complete plasma or cryo-poor plasma |
| GB2621952A (en) * | 2021-06-11 | 2024-02-28 | Astaria Global Llc | System and method for isolating alpha 2M molecules |
| CN113754757B (zh) * | 2021-07-01 | 2024-06-14 | 华兰生物工程股份有限公司 | 一种人纤维蛋白原的制备方法 |
| WO2023007445A1 (en) * | 2021-07-29 | 2023-02-02 | Csl Behring Ag | Method of purifying immunoglobulin g and uses thereof |
| CN113563457B (zh) * | 2021-08-20 | 2023-02-24 | 华兰生物工程股份有限公司 | 一种同时制备人纤维蛋白原、凝血因子ⅷ和纤溶酶原的方法 |
| CN114835801B (zh) * | 2022-06-20 | 2023-09-22 | 华润博雅生物制药集团股份有限公司 | 一种c1酯酶抑制剂及其制备方法 |
| CN117069836B (zh) * | 2023-09-22 | 2024-08-27 | 武汉中生毓晋生物医药有限责任公司 | 一种抗人t细胞兔免疫球蛋白的制备方法 |
| CN121021671B (zh) * | 2025-10-29 | 2026-02-06 | 通化安睿特生物制药股份有限公司 | 一种重组人血清白蛋白的纯化方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1055825A (fr) | 1951-02-20 | 1954-02-22 | Perfectionnement aux montures de lunettes optiques, solaires et faces supplémentaires solaires | |
| BE517346A (enExample) | 1952-04-21 | |||
| CN1072419A (zh) * | 1991-11-20 | 1993-05-26 | 中国科学院大连化学物理研究所 | 径向色谱柱用离子交换介质的合成 |
| FR2706466B1 (fr) | 1993-06-14 | 1995-08-25 | Aetsrn | Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré. |
| ES2170788T3 (es) * | 1995-09-22 | 2002-08-16 | Zlb Bioplasma Ag | Procedimiento para la obtencion de inmunoglobulinas a partir de fracciones que resultan de plasma sanguineo humano. |
| ES2229784T3 (es) * | 1998-06-09 | 2005-04-16 | Statens Serum Institut | Proceso de produccion de inmunoglobulinas para administracion intravenosa y otros productos de inmunoglobulina. |
| DK2272870T3 (da) * | 1998-06-09 | 2013-08-05 | Csl Behring Ag | Fremgangsmåde til fremstilling af immunoglobuliner med henblik på intravenøs indgivelse og andre immunoglobulin-lignende produkter. |
| DE19858892A1 (de) * | 1998-12-19 | 2000-06-21 | Merck Patent Gmbh | Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße |
| SE0001128D0 (sv) * | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
| FR2824568B1 (fr) * | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
| JP4970260B2 (ja) * | 2004-08-20 | 2012-07-04 | プロメティック バイオサイエンシズ，リミテッド | 親和性クロマトグラフィーによるタンパク質の逐次的単離および精製スキーム |
| EP1775001A1 (en) * | 2005-10-13 | 2007-04-18 | Xendo Holding B.V. | Device for chromatographic separations |
| FR2895263B1 (fr) * | 2005-12-26 | 2008-05-30 | Lab Francais Du Fractionnement | Concentre d'immunoglobines g (lg) appauvri en anticorps anti-a et anti-b, et en igg polyreactives |
| WO2007144476A1 (fr) * | 2006-06-16 | 2007-12-21 | Groupe Novasep | Procede de separation sequence multicolonnes |
| US7901581B2 (en) * | 2007-06-15 | 2011-03-08 | Ge Healthcare Bio-Sciences Ab | Chromatography method |
| FR2929533B1 (fr) * | 2008-04-03 | 2010-04-30 | Novasep | Procede de separation multicolonnes a gradient. |
| FR2939667B1 (fr) * | 2008-12-17 | 2012-01-27 | Fractionnement Et Des Biotechonologies Lab Franc | Composition d'immunoglobine g comme medicament pour le traitement de l'ictere neonatal par incompatibilite foetomaternelle dans le systeme abo |
| FR2942233B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine du plasma sanguin, et procedes pour sa mise en oeuvre |
| FR2970003B1 (fr) | 2010-12-30 | 2013-01-25 | Lfb Biotechnologies | Procede d'immobilisation d'acides nucleiques |
| FR2977893B1 (fr) | 2011-07-11 | 2015-02-20 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre d'immunoglobulines polyvalentes |
| EP2656892A1 (en) | 2012-04-23 | 2013-10-30 | Merck Patent GmbH | Chromatography method |
| FR3018450B1 (fr) | 2014-03-11 | 2016-04-15 | Lab Francais Du Fractionnement | Procede de preparation de proteines plasmatiques humaines |
-
2014
- 2014-03-11 FR FR1451997A patent/FR3018450B1/fr active Active
-
2015
- 2015-03-10 MX MX2016011641A patent/MX2016011641A/es unknown
- 2015-03-10 CA CA2942203A patent/CA2942203A1/fr not_active Abandoned
- 2015-03-10 US US15/125,483 patent/US20170073396A1/en not_active Abandoned
- 2015-03-10 AU AU2015228649A patent/AU2015228649A1/en not_active Abandoned
- 2015-03-10 JP JP2016556862A patent/JP2017508759A/ja active Pending
- 2015-03-10 KR KR1020167028103A patent/KR20160130495A/ko not_active Withdrawn
- 2015-03-10 ES ES15717016T patent/ES2759259T3/es active Active
- 2015-03-10 WO PCT/FR2015/050598 patent/WO2015136217A1/fr not_active Ceased
- 2015-03-10 EP EP15717016.8A patent/EP3116527B1/fr not_active Revoked
- 2015-03-10 CN CN201580012945.8A patent/CN106103473A/zh active Pending
- 2015-03-11 TW TW104107803A patent/TW201620925A/zh unknown
-
2016
- 2016-08-28 IL IL247508A patent/IL247508A0/en unknown
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