JP2017507973A5 - - Google Patents
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- JP2017507973A5 JP2017507973A5 JP2016556969A JP2016556969A JP2017507973A5 JP 2017507973 A5 JP2017507973 A5 JP 2017507973A5 JP 2016556969 A JP2016556969 A JP 2016556969A JP 2016556969 A JP2016556969 A JP 2016556969A JP 2017507973 A5 JP2017507973 A5 JP 2017507973A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- weight
- composition according
- carbidopa
- levodopa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 35
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 24
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 20
- 229960004205 carbidopa Drugs 0.000 claims 18
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 18
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 17
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 17
- 229960004502 levodopa Drugs 0.000 claims 17
- 239000004475 Arginine Substances 0.000 claims 15
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- 235000010323 ascorbic acid Nutrition 0.000 claims 12
- 239000011668 ascorbic acid Substances 0.000 claims 12
- 229960005070 ascorbic acid Drugs 0.000 claims 12
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 10
- 235000013878 L-cysteine Nutrition 0.000 claims 10
- 239000004201 L-cysteine Substances 0.000 claims 10
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 10
- 229960004308 acetylcysteine Drugs 0.000 claims 10
- 229960002433 cysteine Drugs 0.000 claims 10
- 229960003194 meglumine Drugs 0.000 claims 10
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 8
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 8
- 229920000053 polysorbate 80 Polymers 0.000 claims 8
- 229940068968 polysorbate 80 Drugs 0.000 claims 8
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 7
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 6
- 235000010378 sodium ascorbate Nutrition 0.000 claims 6
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 6
- 229960005055 sodium ascorbate Drugs 0.000 claims 6
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 6
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 5
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 5
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 235000006708 antioxidants Nutrition 0.000 claims 3
- 229960001305 cysteine hydrochloride Drugs 0.000 claims 3
- 229960003638 dopamine Drugs 0.000 claims 3
- 210000005064 dopaminergic neuron Anatomy 0.000 claims 3
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- RGWPPSAULBHMAA-NXEZZACHSA-N (2r)-2-amino-2-[[[(2r)-2-amino-2-carboxy-3-oxobutyl]disulfanyl]methyl]-3-oxobutanoic acid Chemical compound CC(=O)[C@@](N)(C(O)=O)CSSC[C@@](N)(C(C)=O)C(O)=O RGWPPSAULBHMAA-NXEZZACHSA-N 0.000 claims 1
- LITUBCVUXPBCGA-WMZHIEFXSA-N Ascorbyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O LITUBCVUXPBCGA-WMZHIEFXSA-N 0.000 claims 1
- 239000004261 Ascorbyl stearate Substances 0.000 claims 1
- 208000033962 Fontaine progeroid syndrome Diseases 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000004260 Potassium ascorbate Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 235000019276 ascorbyl stearate Nutrition 0.000 claims 1
- 235000010376 calcium ascorbate Nutrition 0.000 claims 1
- 229940047036 calcium ascorbate Drugs 0.000 claims 1
- 239000011692 calcium ascorbate Substances 0.000 claims 1
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 239000007857 degradation product Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000010408 film Substances 0.000 claims 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 235000019275 potassium ascorbate Nutrition 0.000 claims 1
- 229940017794 potassium ascorbate Drugs 0.000 claims 1
- CONVKSGEGAVTMB-RXSVEWSESA-M potassium-L-ascorbate Chemical compound [K+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CONVKSGEGAVTMB-RXSVEWSESA-M 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952477P | 2014-03-13 | 2014-03-13 | |
| US61/952,477 | 2014-03-13 | ||
| US201461990967P | 2014-05-09 | 2014-05-09 | |
| US61/990,967 | 2014-05-09 | ||
| PCT/IL2015/050258 WO2015136538A1 (en) | 2014-03-13 | 2015-03-12 | Dopa decarboxylase inhibitor compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019170864A Division JP6770158B2 (ja) | 2014-03-13 | 2019-09-19 | ドーパデカルボキシラーゼ阻害剤組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507973A JP2017507973A (ja) | 2017-03-23 |
| JP2017507973A5 true JP2017507973A5 (enExample) | 2018-04-12 |
| JP6591995B2 JP6591995B2 (ja) | 2019-10-16 |
Family
ID=53488380
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556969A Active JP6591995B2 (ja) | 2014-03-13 | 2015-03-12 | ドーパデカルボキシラーゼ阻害剤組成物 |
| JP2019170864A Active JP6770158B2 (ja) | 2014-03-13 | 2019-09-19 | ドーパデカルボキシラーゼ阻害剤組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019170864A Active JP6770158B2 (ja) | 2014-03-13 | 2019-09-19 | ドーパデカルボキシラーゼ阻害剤組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US10022320B2 (enExample) |
| EP (3) | EP3777833B1 (enExample) |
| JP (2) | JP6591995B2 (enExample) |
| CN (1) | CN106413754B (enExample) |
| AU (1) | AU2015228369B2 (enExample) |
| BR (1) | BR112016021034A8 (enExample) |
| CA (1) | CA2942244C (enExample) |
| DK (2) | DK3777833T3 (enExample) |
| ES (2) | ES2836325T3 (enExample) |
| FI (1) | FI3777833T3 (enExample) |
| HR (2) | HRP20201948T1 (enExample) |
| HU (2) | HUE064818T2 (enExample) |
| IL (1) | IL247668B (enExample) |
| MX (1) | MX2016011837A (enExample) |
| PL (2) | PL3777833T3 (enExample) |
| PT (2) | PT3116475T (enExample) |
| RS (1) | RS65060B1 (enExample) |
| RU (1) | RU2684105C2 (enExample) |
| WO (1) | WO2015136538A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2432454T (pt) | 2009-05-19 | 2017-06-12 | Neuroderm Ltd | Composições para administração contínua de inibidores de dopa decarboxilase |
| SI2640358T1 (en) | 2010-11-15 | 2018-05-31 | Neuroderm Ltd. | Continuous administration of L-dopa, dopamine decarboxylase inhibitors, catechol-O-methyl transferase inhibitors, and compositions thereof |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| PL3777833T3 (pl) | 2014-03-13 | 2024-03-25 | Neuroderm Ltd. | Kompozycje inhibitorów dekarboksylazy dopa |
| CN107087397B (zh) | 2015-09-30 | 2020-12-18 | 杜克大学 | 用于磁共振成像的造影剂 |
| WO2018154447A1 (en) * | 2017-02-21 | 2018-08-30 | Neuroderm Ltd | Dopa decarboxylase inhibitor compositions |
| EP3880210A1 (en) | 2018-11-15 | 2021-09-22 | Abbvie Inc. | Pharmaceutical formulations for subcutaneous administration |
| WO2020178810A1 (en) * | 2019-03-04 | 2020-09-10 | Neuroderm, Ltd. | Pharmaceutical compositions comprising levodopa amide derivatives and uses thereof |
| CN111701024B (zh) * | 2020-05-26 | 2022-05-24 | 上海京新生物医药有限公司 | 一种左旋多巴制剂及其制备方法及其应用 |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| CN113396897B (zh) * | 2021-07-26 | 2022-06-07 | 苏州华测生物技术有限公司 | 一种稳定生物基质中卡比多巴/左旋多巴的方法 |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
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