JP2017505777A - 標的化治療薬 - Google Patents

標的化治療薬 Download PDF

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Publication number
JP2017505777A
JP2017505777A JP2016549300A JP2016549300A JP2017505777A JP 2017505777 A JP2017505777 A JP 2017505777A JP 2016549300 A JP2016549300 A JP 2016549300A JP 2016549300 A JP2016549300 A JP 2016549300A JP 2017505777 A JP2017505777 A JP 2017505777A
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sdc
trap
moiety
effector
daltons
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JP2016549300A
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Japanese (ja)
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JP2017505777A5 (enExample
Inventor
チムマナマダ，ディネシュ，ユー．
イン，ウェイウェン
Original Assignee
シンタ ファーマスーティカルズ コーポレーション
シンタ ファーマスーティカルズ コーポレーション
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Publication of JP2017505777A publication Critical patent/JP2017505777A/ja
Publication of JP2017505777A5 publication Critical patent/JP2017505777A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016549300A 2014-01-29 2015-01-29 標的化治療薬 Pending JP2017505777A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461933224P 2014-01-29 2014-01-29
US61/933,224 2014-01-29
PCT/US2015/013440 WO2015116774A1 (en) 2014-01-29 2015-01-29 Targeted therapeutics

Publications (2)

Publication Number Publication Date
JP2017505777A true JP2017505777A (ja) 2017-02-23
JP2017505777A5 JP2017505777A5 (enExample) 2018-02-08

Family

ID=53757707

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016549300A Pending JP2017505777A (ja) 2014-01-29 2015-01-29 標的化治療薬

Country Status (4)

Country Link
US (1) US10117944B2 (enExample)
EP (1) EP3099332A4 (enExample)
JP (1) JP2017505777A (enExample)
WO (1) WO2015116774A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017507150A (ja) * 2014-03-03 2017-03-16 シンタ ファーマスーティカルズ コーポレイションＳｙｎｔａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐ． 標的治療薬
JP2020511536A (ja) * 2017-03-13 2020-04-16 アビデ セラピューティクス，インコーポレーテッド デュアルｍａｇｌ及びｆａａｈインヒビター
JP2021506797A (ja) * 2017-12-14 2021-02-22 ターベダ セラピューティクス インコーポレイテッドＴａｒｖｅｄａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｈｓｐ９０標的化コンジュゲート及びその製剤

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WO2015066053A2 (en) * 2013-10-28 2015-05-07 Synta Pharmaceuticals Corp. Targeted therapeutics
PT109941B (pt) 2017-03-02 2021-02-09 Hovione Farmaciência, S.A. Conjugados de boro multifuncionais com uma estrutura tripodal, composições farmacêuticas e processos de preparação dos mesmos
ES2993173T3 (en) * 2018-09-13 2024-12-23 Celgene Corp Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1-carboxylate, compositions and methods of use thereof
TWI705813B (zh) 2019-05-24 2020-10-01 國立交通大學 含有ganetespib的粒子與含有該粒子的藥學組成物及其在抗癌治療上的用途
KR102322956B1 (ko) * 2020-01-07 2021-11-09 이화여자대학교 산학협력단 신규 보르테조밉 전구약물 및 이의 용도
WO2022010539A1 (en) * 2020-07-08 2022-01-13 Octagon Therapeutics, Inc. Cancer cell modulators
WO2022184082A1 (en) 2021-03-03 2022-09-09 Sorrento Therapeutics, Inc. Antibody-drug conjugates comprising an anti-bcma antibody
JP2025509286A (ja) 2022-03-10 2025-04-11 ビバソル， インコーポレイテッド 抗体－薬物コンジュゲートおよびその使用
WO2024211234A1 (en) 2023-04-05 2024-10-10 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
CN121985963A (zh) 2023-04-05 2026-05-05 维硕公司 抗体偶联药物及其用途
WO2024211236A2 (en) 2023-04-05 2024-10-10 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof

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JP2010533180A (ja) * 2007-07-09 2010-10-21 グレン エス． クウォン， 治療剤
WO2013071163A2 (en) * 2011-11-11 2013-05-16 Millennium Pharamaceuticals, Inc. Biomarkers of response to proteasome inhibitors
WO2013158644A2 (en) * 2012-04-16 2013-10-24 Synta Pharmaceuticals Corp. Targeted therapeutics

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017507150A (ja) * 2014-03-03 2017-03-16 シンタ ファーマスーティカルズ コーポレイションＳｙｎｔａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐ． 標的治療薬
US10232049B2 (en) 2014-03-03 2019-03-19 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
US10675360B2 (en) 2014-03-03 2020-06-09 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
JP2020511536A (ja) * 2017-03-13 2020-04-16 アビデ セラピューティクス，インコーポレーテッド デュアルｍａｇｌ及びｆａａｈインヒビター
JP7178375B2 (ja) 2017-03-13 2022-11-25 ルンドベック ラ ホヤ リサーチ センター，インク． デュアルｍａｇｌ及びｆａａｈインヒビター
JP2021506797A (ja) * 2017-12-14 2021-02-22 ターベダ セラピューティクス インコーポレイテッドＴａｒｖｅｄａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｈｓｐ９０標的化コンジュゲート及びその製剤

Also Published As

Publication number Publication date
EP3099332A1 (en) 2016-12-07
US10117944B2 (en) 2018-11-06
US20170014519A1 (en) 2017-01-19
EP3099332A4 (en) 2017-06-21
WO2015116774A1 (en) 2015-08-06

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