JP2017505436A5 - - Google Patents

Info

Publication number

JP2017505436A5

JP2017505436A5 JP2016547569A JP2016547569A JP2017505436A5 JP 2017505436 A5 JP2017505436 A5 JP 2017505436A5 JP 2016547569 A JP2016547569 A JP 2016547569A JP 2016547569 A JP2016547569 A JP 2016547569A JP 2017505436 A5 JP2017505436 A5 JP 2017505436A5

Authority

JP

Japan

Prior art keywords

group

amino acid

acid selected

antibody

composition

Prior art date

2015-01-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001413 amino acids Chemical class 0.000 claims description 96
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 92
• 238000000034 method Methods 0.000 claims description 57
• 239000000203 mixture Substances 0.000 claims description 48
• 239000012634 fragment Substances 0.000 claims description 34
• 241000606646 Anaplasma Species 0.000 claims description 29
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 26
• 230000015572 biosynthetic process Effects 0.000 claims description 24
• 239000000427 antigen Substances 0.000 claims description 18
• 102000036639 antigens Human genes 0.000 claims description 18
• 108091007433 antigens Proteins 0.000 claims description 18
• 239000002184 metal Substances 0.000 claims description 16
• 229910052751 metal Inorganic materials 0.000 claims description 16
• 210000004027 cell Anatomy 0.000 claims description 12
• 241000894007 species Species 0.000 claims description 11
• 239000002052 molecular layer Substances 0.000 claims description 10
• 239000007787 solid Substances 0.000 claims description 10
• 102000004190 Enzymes Human genes 0.000 claims description 6
• 108090000790 Enzymes Proteins 0.000 claims description 6
• 238000003556 assay Methods 0.000 claims description 6
• 239000003153 chemical reaction reagent Substances 0.000 claims description 6
• 238000002372 labelling Methods 0.000 claims description 6
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
• 241000605281 Anaplasma phagocytophilum Species 0.000 claims description 4
• 239000011324 bead Substances 0.000 claims description 4
• 201000010099 disease Diseases 0.000 claims description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims description 4
• 239000004816 latex Substances 0.000 claims description 4
• 229920000126 latex Polymers 0.000 claims description 4
• 239000002082 metal nanoparticle Substances 0.000 claims description 4
• 239000002078 nanoshell Substances 0.000 claims description 4
• 239000002245 particle Substances 0.000 claims description 4
• 102000004169 proteins and genes Human genes 0.000 claims description 4
• 108090000623 proteins and genes Proteins 0.000 claims description 4
• 229910052757 nitrogen Inorganic materials 0.000 claims description 3
• 241000606665 Anaplasma marginale Species 0.000 claims description 2
• 108090001008 Avidin Proteins 0.000 claims description 2
• 241000589968 Borrelia Species 0.000 claims description 2
• 238000012286 ELISA Assay Methods 0.000 claims description 2
• 241000282326 Felis catus Species 0.000 claims description 2
• 102000007562 Serum Albumin Human genes 0.000 claims description 2
• 108010071390 Serum Albumin Proteins 0.000 claims description 2
• 108010090804 Streptavidin Proteins 0.000 claims description 2
• 101710120037 Toxin CcdB Proteins 0.000 claims description 2
• 238000007818 agglutination assay Methods 0.000 claims description 2
• 230000000890 antigenic effect Effects 0.000 claims description 2
• 229960002685 biotin Drugs 0.000 claims description 2
• 235000020958 biotin Nutrition 0.000 claims description 2
• 239000011616 biotin Substances 0.000 claims description 2
• 210000004369 blood Anatomy 0.000 claims description 2
• 239000008280 blood Substances 0.000 claims description 2
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 2
• 108020001507 fusion proteins Proteins 0.000 claims description 2
• 102000037865 fusion proteins Human genes 0.000 claims description 2
• 238000003018 immunoassay Methods 0.000 claims description 2
• 239000003446 ligand Substances 0.000 claims description 2
• 239000002086 nanomaterial Substances 0.000 claims description 2
• 108010087904 neutravidin Proteins 0.000 claims description 2
• 229910052698 phosphorus Inorganic materials 0.000 claims description 2
• 210000002381 plasma Anatomy 0.000 claims description 2
• 210000003296 saliva Anatomy 0.000 claims description 2
• 210000002966 serum Anatomy 0.000 claims description 2
• 210000001519 tissue Anatomy 0.000 claims description 2
• 210000002700 urine Anatomy 0.000 claims description 2
• 238000001262 western blot Methods 0.000 claims description 2
• 208000006730 anaplasmosis Diseases 0.000 claims 2
• 238000004458 analytical method Methods 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 208000016604 Lyme disease Diseases 0.000 description 1