JP2017505291A5 - - Google Patents
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- JP2017505291A5 JP2017505291A5 JP2016541077A JP2016541077A JP2017505291A5 JP 2017505291 A5 JP2017505291 A5 JP 2017505291A5 JP 2016541077 A JP2016541077 A JP 2016541077A JP 2016541077 A JP2016541077 A JP 2016541077A JP 2017505291 A5 JP2017505291 A5 JP 2017505291A5
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- JP
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- Prior art keywords
- alkyl
- compound
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- composition according
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002367 halogens Chemical class 0.000 claims description 116
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 68
- 229940124597 therapeutic agent Drugs 0.000 claims description 65
- 239000003814 drug Substances 0.000 claims description 62
- 125000000623 heterocyclic group Chemical group 0.000 claims description 59
- WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims description 36
- 125000001424 substituent group Chemical group 0.000 claims description 27
- 125000005843 halogen group Chemical group 0.000 claims description 26
- -1 R 1 is H Chemical group 0.000 claims description 24
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- 239000001257 hydrogen Substances 0.000 claims description 18
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 16
- 229910052731 fluorine Inorganic materials 0.000 claims description 16
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
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| JP6691909B2 (ja) | 2014-08-15 | 2020-05-13 | サギメット バイオサイエンシーズ インコーポレイテッド | 薬物耐性癌の治療で用いるための脂肪酸シンターゼ阻害剤 |
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| CN107163043A (zh) * | 2017-06-16 | 2017-09-15 | 上海毕得医药科技有限公司 | 一种吡唑并[1,5‑a]吡啶‑3‑羧酸酯衍生物的合成方法 |
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| CN109956973B (zh) * | 2017-12-25 | 2020-11-03 | 上海启甄环境科技有限公司 | 一种放射性同位素碳-14标记毒氟磷的合成方法 |
| CN109503575B (zh) * | 2018-12-20 | 2021-01-29 | 温州大学 | 无催化剂N-N偶联反应合成[1,2,3]三氮唑[1,5-a]吡啶类化合物的方法 |
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| US8324250B2 (en) | 2009-03-19 | 2012-12-04 | Hoffmann-La Roche Inc. | Piperidine derivatives as NK3 receptor antagonists |
| US8748950B2 (en) | 2009-11-19 | 2014-06-10 | University of Pittsburgh—of the Commonwealth System of Higher Education | On-demand nanoelectronics platform |
| US8633183B2 (en) | 2010-01-26 | 2014-01-21 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyrimidines |
| US8871790B2 (en) * | 2011-03-08 | 2014-10-28 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
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