JP2015522036A5 - - Google Patents
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- Publication number
- JP2015522036A5 JP2015522036A5 JP2015520627A JP2015520627A JP2015522036A5 JP 2015522036 A5 JP2015522036 A5 JP 2015522036A5 JP 2015520627 A JP2015520627 A JP 2015520627A JP 2015520627 A JP2015520627 A JP 2015520627A JP 2015522036 A5 JP2015522036 A5 JP 2015522036A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- cycloalkyl
- compound according
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261667894P | 2012-07-03 | 2012-07-03 | |
| US61/667,894 | 2012-07-03 | ||
| US201261698511P | 2012-09-07 | 2012-09-07 | |
| US61/698,511 | 2012-09-07 | ||
| US201261699819P | 2012-09-11 | 2012-09-11 | |
| US61/699,819 | 2012-09-11 | ||
| US201361785933P | 2013-03-14 | 2013-03-14 | |
| US61/785,933 | 2013-03-14 | ||
| PCT/US2013/048950 WO2014008197A1 (en) | 2012-07-03 | 2013-07-01 | Heterocyclic modulators of lipid synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522036A JP2015522036A (ja) | 2015-08-03 |
| JP2015522036A5 true JP2015522036A5 (https=) | 2016-08-18 |
| JP6109934B2 JP6109934B2 (ja) | 2017-04-05 |
Family
ID=48790663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520627A Active JP6109934B2 (ja) | 2012-07-03 | 2013-07-01 | 脂質合成の複素環モジュレーター |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9428502B2 (https=) |
| EP (1) | EP2870150B1 (https=) |
| JP (1) | JP6109934B2 (https=) |
| KR (1) | KR102071095B1 (https=) |
| CN (1) | CN104507928B (https=) |
| AU (2) | AU2013286894B2 (https=) |
| BR (1) | BR112015000106B1 (https=) |
| CA (1) | CA2877999C (https=) |
| ES (1) | ES2738823T3 (https=) |
| IL (1) | IL236407A (https=) |
| IN (1) | IN2015DN00137A (https=) |
| MX (1) | MX364815B (https=) |
| NZ (2) | NZ729443A (https=) |
| PL (1) | PL2870150T3 (https=) |
| SG (1) | SG11201500024YA (https=) |
| WO (1) | WO2014008197A1 (https=) |
| ZA (1) | ZA201409477B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170119786A1 (en) | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| TWI522348B (zh) * | 2011-03-08 | 2016-02-21 | ３ Ｖ生物科技公司 | 脂質合成之雜環調節劑 |
| US9624173B2 (en) * | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| BR112015000106B1 (pt) | 2012-07-03 | 2022-02-22 | Sagimet Biosciences Inc | Moduladores heterocíclicos de síntese de lipídio, composição farmacêutica e uso dos referidos moduladores |
| JP6820097B2 (ja) * | 2013-12-20 | 2021-01-27 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式モジュレータ及びその組み合わせ |
| EP3092232B1 (en) * | 2014-01-07 | 2022-03-09 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis for use against cancer and viral infections |
| KR102504168B1 (ko) * | 2014-08-15 | 2023-02-27 | 새지메트 바이오사이언시스, 인코포레이티드 | 약물 내성 암의 치료에서 사용하기 위한 지방산 신타제 억제제 |
| JP6633618B2 (ja) * | 2014-08-21 | 2020-01-22 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 強力なｒｏｃｋ阻害剤としてのタイドバックのベンズアミド誘導体 |
| EP3226915B1 (en) | 2014-12-03 | 2019-02-20 | Janssen Pharmaceutica NV | Radiolabelled mglur2 pet ligands |
| KR20170129151A (ko) | 2015-03-19 | 2017-11-24 | 3-브이 바이오사이언시스, 인코포레이티드 | 지질 합성의 복소환식 조절제 |
| JP2018083758A (ja) * | 2015-03-25 | 2018-05-31 | 旭硝子株式会社 | ピラゾール誘導体の製造方法 |
| WO2016205590A1 (en) | 2015-06-18 | 2016-12-22 | Cephalon, Inc. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| KR20180026459A (ko) | 2015-06-18 | 2018-03-12 | 세파론, 인코포레이티드 | 1,4-치환된 피페리딘 유도체 |
| RS60981B1 (sr) | 2015-12-18 | 2020-11-30 | Janssen Pharmaceutica Nv | Radiooznačeni mglur2/3 pet ligandi |
| JP6929285B2 (ja) | 2015-12-18 | 2021-09-01 | ヤンセン ファーマシューティカ エヌ．ベー． | 放射性標識ｍＧｌｕＲ２／３ＰＥＴリガンド |
| TWI726968B (zh) | 2016-01-07 | 2021-05-11 | 開曼群島商Ｃｓ醫藥技術公司 | Egfr酪胺酸激酶之臨床重要突變體之選擇性抑制劑 |
| WO2017119732A1 (en) | 2016-01-08 | 2017-07-13 | Samsung Electronics Co., Ltd. | Electronic device and operating method thereof |
| US11753626B2 (en) | 2016-03-09 | 2023-09-12 | Beijing Percans Oncology Co., Ltd. | Tumor cell suspension cultures and related methods |
| JP7668509B2 (ja) | 2016-11-11 | 2025-04-25 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式モジュレーター |
| US20220340556A1 (en) * | 2016-11-11 | 2022-10-27 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis |
| CN107954852A (zh) * | 2017-11-30 | 2018-04-24 | 贝利化学（张家港）有限公司 | 2，5-二卤代苯甲酸的制备方法 |
| WO2020135483A1 (en) | 2018-12-26 | 2020-07-02 | Janssen Pharmaceutica Nv | Thienopyridinone compounds |
| US20220400732A1 (en) * | 2019-03-21 | 2022-12-22 | Cornell University | Anti-fructose therapy for colorectal and small intestine cancers |
| CN111592495A (zh) * | 2020-07-06 | 2020-08-28 | 上海启讯医药科技有限公司 | 一种2-正丁基-4-氯-5甲酰基咪唑的制备方法 |
| CN114988975A (zh) * | 2022-06-28 | 2022-09-02 | 江苏科技大学 | 一种基于有机染料催化的β-三氟甲基烯胺化合物的制备方法 |
| CN116482278B (zh) * | 2023-05-06 | 2024-02-09 | 广州清瑞生物科技有限责任公司 | 一种用于检测阿昔洛韦的对照品的制备方法 |
| CN119080742A (zh) * | 2023-06-05 | 2024-12-06 | 甘莱制药有限公司 | 脂质合成的杂环调节剂的工业化制备 |
| WO2025086054A1 (zh) * | 2023-10-23 | 2025-05-01 | 歌礼生物科技（杭州）有限公司 | 一种包含苯甲腈衍生物的药物组合物 |
| WO2025120168A1 (en) | 2023-12-07 | 2025-06-12 | Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement (Inrae) | Sulfonamide derivatives and use thereof in the treatment of cryptosporidium infections |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1959951B1 (en) | 2005-12-01 | 2009-12-23 | F. Hoffmann-la Roche AG | Heteroaryl substituted piperidine derivatives as l-cpt1 inhibitors |
| CN101534836B (zh) | 2006-09-05 | 2011-09-28 | 彼帕科学公司 | Parp抑制剂在制备治疗肥胖症的药物中的用途 |
| WO2008059214A1 (en) * | 2006-11-13 | 2008-05-22 | Astrazeneca Ab | Bisamlde derivatives and use thereof as fatty acid synthase inhibitors |
| WO2008075077A1 (en) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Piperidine derivatives for the treatment of obesity |
| TW200833663A (en) * | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Therapeutic agents |
| TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
| EP3190108B1 (en) * | 2011-03-08 | 2021-05-19 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis |
| US9624173B2 (en) * | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| TWI522348B (zh) * | 2011-03-08 | 2016-02-21 | ３ Ｖ生物科技公司 | 脂質合成之雜環調節劑 |
| US20170119786A1 (en) * | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| BR112015000106B1 (pt) | 2012-07-03 | 2022-02-22 | Sagimet Biosciences Inc | Moduladores heterocíclicos de síntese de lipídio, composição farmacêutica e uso dos referidos moduladores |
| JP6820097B2 (ja) * | 2013-12-20 | 2021-01-27 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式モジュレータ及びその組み合わせ |
| EP3092232B1 (en) * | 2014-01-07 | 2022-03-09 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis for use against cancer and viral infections |
| KR102504168B1 (ko) * | 2014-08-15 | 2023-02-27 | 새지메트 바이오사이언시스, 인코포레이티드 | 약물 내성 암의 치료에서 사용하기 위한 지방산 신타제 억제제 |
| KR20170129151A (ko) * | 2015-03-19 | 2017-11-24 | 3-브이 바이오사이언시스, 인코포레이티드 | 지질 합성의 복소환식 조절제 |
-
2013
- 2013-07-01 BR BR112015000106-8A patent/BR112015000106B1/pt active IP Right Grant
- 2013-07-01 PL PL13737098T patent/PL2870150T3/pl unknown
- 2013-07-01 EP EP13737098.7A patent/EP2870150B1/en active Active
- 2013-07-01 CA CA2877999A patent/CA2877999C/en active Active
- 2013-07-01 ES ES13737098T patent/ES2738823T3/es active Active
- 2013-07-01 KR KR1020157002727A patent/KR102071095B1/ko active Active
- 2013-07-01 NZ NZ729443A patent/NZ729443A/en unknown
- 2013-07-01 JP JP2015520627A patent/JP6109934B2/ja active Active
- 2013-07-01 MX MX2015000151A patent/MX364815B/es active IP Right Grant
- 2013-07-01 IN IN137DEN2015 patent/IN2015DN00137A/en unknown
- 2013-07-01 AU AU2013286894A patent/AU2013286894B2/en active Active
- 2013-07-01 WO PCT/US2013/048950 patent/WO2014008197A1/en not_active Ceased
- 2013-07-01 CN CN201380035602.4A patent/CN104507928B/zh active Active
- 2013-07-01 NZ NZ703162A patent/NZ703162A/en active IP Right Revival
- 2013-07-01 SG SG11201500024YA patent/SG11201500024YA/en unknown
-
2014
- 2014-12-22 ZA ZA2014/09477A patent/ZA201409477B/en unknown
- 2014-12-23 IL IL236407A patent/IL236407A/en active IP Right Grant
- 2014-12-31 US US14/587,908 patent/US9428502B2/en active Active
-
2016
- 2016-07-05 US US15/201,824 patent/US10053450B2/en active Active
-
2017
- 2017-11-21 AU AU2017265027A patent/AU2017265027A1/en not_active Abandoned
-
2018
- 2018-03-30 US US15/941,387 patent/US10118913B2/en active Active
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