KR20160100329A - 지질 합성의 헤테로사이클릭 조절물질 및 이들의 조합물 - Google Patents

지질 합성의 헤테로사이클릭 조절물질 및 이들의 조합물 Download PDF

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KR20160100329A
KR20160100329A KR1020167018773A KR20167018773A KR20160100329A KR 20160100329 A KR20160100329 A KR 20160100329A KR 1020167018773 A KR1020167018773 A KR 1020167018773A KR 20167018773 A KR20167018773 A KR 20167018773A KR 20160100329 A KR20160100329 A KR 20160100329A
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alkyl
compound
fatty acid
acid synthase
halogen
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Korean (ko)
Inventor
티모시 션 호이어
요한 디. 오슬롭
로버트 에스. 맥도웰
러셀 존슨
한비아오 양
마르크 에반치크
크리스티아나 에이. 자하리아
하잉 카이
릴리 더블유. 후
그레고리 듀크
야미니 오홀
마리 오패럴
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3-브이 바이오사이언시스, 인코포레이티드
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Publication of KR20160100329A publication Critical patent/KR20160100329A/ko
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1020167018773A 2013-12-20 2014-12-19 지질 합성의 헤테로사이클릭 조절물질 및 이들의 조합물 Ceased KR20160100329A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361919235P 2013-12-20 2013-12-20
US61/919,235 2013-12-20
PCT/US2014/071617 WO2015095767A1 (en) 2013-12-20 2014-12-19 Heterocyclic modulators of lipid synthesis and combinations thereof

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KR20160100329A true KR20160100329A (ko) 2016-08-23

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KR1020167018773A Ceased KR20160100329A (ko) 2013-12-20 2014-12-19 지질 합성의 헤테로사이클릭 조절물질 및 이들의 조합물

Country Status (9)

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US (1) US10226449B2 (https=)
EP (1) EP3083583B1 (https=)
JP (1) JP6820097B2 (https=)
KR (1) KR20160100329A (https=)
CN (1) CN106061963B (https=)
AU (1) AU2014368945C1 (https=)
CA (1) CA2934251C (https=)
ES (1) ES2841137T3 (https=)
WO (1) WO2015095767A1 (https=)

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JP6691909B2 (ja) 2014-08-15 2020-05-13 サギメット バイオサイエンシーズ インコーポレイテッド 薬物耐性癌の治療で用いるための脂肪酸シンターゼ阻害剤
WO2016149271A1 (en) * 2015-03-19 2016-09-22 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
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KR102644934B1 (ko) 2016-11-11 2024-03-08 새지메트 바이오사이언시스, 인코포레이티드 지질 합성의 헤테로사이클릭 조절인자
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
CN107163043A (zh) * 2017-06-16 2017-09-15 上海毕得医药科技有限公司 一种吡唑并[1,5‑a]吡啶‑3‑羧酸酯衍生物的合成方法
WO2019101511A1 (en) 2017-11-23 2019-05-31 Basf Se Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi
CN109956973B (zh) * 2017-12-25 2020-11-03 上海启甄环境科技有限公司 一种放射性同位素碳-14标记毒氟磷的合成方法
CN109503575B (zh) * 2018-12-20 2021-01-29 温州大学 无催化剂N-N偶联反应合成[1,2,3]三氮唑[1,5-a]吡啶类化合物的方法
CN111592495A (zh) * 2020-07-06 2020-08-28 上海启讯医药科技有限公司 一种2-正丁基-4-氯-5甲酰基咪唑的制备方法
GB202213166D0 (en) 2022-09-08 2022-10-26 Cambridge Entpr Ltd Novel compounds, compositions and therapeutic uses thereof
CN116482278B (zh) * 2023-05-06 2024-02-09 广州清瑞生物科技有限责任公司 一种用于检测阿昔洛韦的对照品的制备方法
CN119080742A (zh) * 2023-06-05 2024-12-06 甘莱制药有限公司 脂质合成的杂环调节剂的工业化制备
WO2025080818A1 (en) * 2023-10-10 2025-04-17 Sagimet Biosciences Inc. Combinations of fasn inhibitors and glp-1 agonists for liver diseases

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US20160338998A1 (en) 2016-11-24
US10226449B2 (en) 2019-03-12
EP3083583A1 (en) 2016-10-26
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JP6820097B2 (ja) 2021-01-27
AU2014368945C1 (en) 2019-05-16
AU2014368945B2 (en) 2019-01-24
AU2014368945A1 (en) 2016-06-16
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