JP2017503024A5 - - Google Patents
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- JP2017503024A5 JP2017503024A5 JP2016562455A JP2016562455A JP2017503024A5 JP 2017503024 A5 JP2017503024 A5 JP 2017503024A5 JP 2016562455 A JP2016562455 A JP 2016562455A JP 2016562455 A JP2016562455 A JP 2016562455A JP 2017503024 A5 JP2017503024 A5 JP 2017503024A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- member selected
- cyano
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C[C@](CCC1CC1)CCC=C(C1)[C@]1C(C1)C1[C@@](C1)[C@@]1(C)C1=CC[C@@](*)C1 Chemical compound C[C@](CCC1CC1)CCC=C(C1)[C@]1C(C1)C1[C@@](C1)[C@@]1(C)C1=CC[C@@](*)C1 0.000 description 9
- KYUDTBPIZLFHNU-UHFFFAOYSA-N CC(C)c(cc1)cnc1F Chemical compound CC(C)c(cc1)cnc1F KYUDTBPIZLFHNU-UHFFFAOYSA-N 0.000 description 1
- NWEJXSNMXOLSTN-UHFFFAOYSA-N CC1=CCC(C(F)(F)F)C(F)=C1 Chemical compound CC1=CCC(C(F)(F)F)C(F)=C1 NWEJXSNMXOLSTN-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461924119P | 2014-01-06 | 2014-01-06 | |
| US61/924,119 | 2014-01-06 | ||
| PCT/US2014/072291 WO2015103060A1 (en) | 2014-01-06 | 2014-12-23 | Trpa1 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503024A JP2017503024A (ja) | 2017-01-26 |
| JP2017503024A5 true JP2017503024A5 (https=) | 2018-02-08 |
| JP6626454B2 JP6626454B2 (ja) | 2019-12-25 |
Family
ID=53493929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562455A Active JP6626454B2 (ja) | 2014-01-06 | 2014-12-23 | Ｔｒｐａ１モジュレーター |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9951046B2 (https=) |
| EP (1) | EP3092228A4 (https=) |
| JP (1) | JP6626454B2 (https=) |
| CN (1) | CN106061969B (https=) |
| AU (1) | AU2014374043B2 (https=) |
| CA (1) | CA2936111C (https=) |
| IL (1) | IL246625B (https=) |
| SG (1) | SG11201605559VA (https=) |
| WO (1) | WO2015103060A1 (https=) |
| ZA (1) | ZA201605332B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015103060A1 (en) | 2014-01-06 | 2015-07-09 | Algomedix, Inc. | Trpa1 modulators |
| PL3381896T3 (pl) | 2015-11-27 | 2023-05-08 | Taiho Pharmaceutical Co., Ltd. | Związek bifenylowy lub jego sól |
| JP2019521189A (ja) * | 2016-07-06 | 2019-07-25 | アルゴメディックス，インク． | ドライアイ、眼痛および炎症の処置のためのｔｒｐａ１アンタゴニスト |
| CN106580984A (zh) * | 2016-12-12 | 2017-04-26 | 高群 | 一种治疗高血脂症的药物组合物 |
| WO2018162607A1 (en) * | 2017-03-07 | 2018-09-13 | F. Hoffmann-La Roche Ag | Oxadiazole transient receptor potential channel inhibitors |
| CN110740991B (zh) | 2017-05-26 | 2023-07-04 | 大鹏药品工业株式会社 | 新型联苯化合物或其盐 |
| JP6738962B2 (ja) * | 2017-05-26 | 2020-08-12 | 大鵬薬品工業株式会社 | 新規なビフェニル化合物を用いた抗腫瘍効果増強剤 |
| US12435128B2 (en) | 2017-05-31 | 2025-10-07 | Taiho Pharmaceutical Co., Ltd. | Method for predicting therapeutic effect of LSD1 inhibitor based on expression of INSM1 |
| CN109596818B (zh) * | 2018-12-13 | 2024-03-19 | 丁蓉 | 一种基于电生理学分析当归四逆汤预防奥沙利铂神经毒性机制的研究方法 |
| MX2022005812A (es) | 2019-11-13 | 2022-08-16 | Taiho Pharmaceutical Co Ltd | Metodos de tratamiento de enfermedades y trastornos relacionados con desmetilasa 1 especifica de lisina con inhibidores de desmetilasa 1 especifica de lisina. |
| JP7688339B2 (ja) * | 2020-01-22 | 2025-06-04 | 国立研究開発法人理化学研究所 | 新規化合物、およびその利用 |
| FR3114235A1 (fr) | 2020-09-18 | 2022-03-25 | Université Grenoble Alpes | Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer |
| CN112694436B (zh) * | 2020-12-30 | 2022-07-08 | 济南周行医药科技有限公司 | 一种槟榔碱的合成方法 |
| IT202100015098A1 (it) | 2021-06-09 | 2022-12-09 | Flonext S R L | Composto antagonista del canale trpa1 per uso in patologie degenerative della retina |
| KR20250091305A (ko) * | 2022-11-10 | 2025-06-20 | 프라임 진 테라퓨틱스 컴퍼니 리미티드 | 질소 함유 스피로 고리 화합물, 약학 조성물 및 이의 용도 |
| CN121735881A (zh) * | 2026-02-27 | 2026-03-27 | 泰励生物科技（上海）有限公司 | 砜类化合物的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8429128D0 (en) * | 1984-11-17 | 1984-12-27 | Fisons Plc | Heterocyclic compounds |
| DE3575130D1 (de) * | 1984-05-12 | 1990-02-08 | Fisons Plc | Antiinflammatorische 1,n-diarylpyrazol-3-amine, deren zusammensetzungen und verfahren zu deren herstellung. |
| AU7726898A (en) * | 1997-05-22 | 1998-12-11 | G.D. Searle & Co. | Pyrazole derivatives as p38 kinase inhibitors |
| WO1999058523A1 (en) * | 1998-05-14 | 1999-11-18 | G.D. Searle & Co. | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
| AU2004200420A1 (en) * | 2003-03-11 | 2004-09-30 | Astellas Pharma Inc. | Inhibitor of cyclooxygenase |
| EP1620095A4 (en) * | 2003-04-24 | 2009-04-01 | Merck & Co Inc | HEMMER OF ACT ACTIVITY |
| KR100798161B1 (ko) | 2003-10-23 | 2008-01-28 | 에프. 호프만-라 로슈 아게 | 신경병적 또는 신경정신병적 장애의 치료에서 ｇｌｙｔ-1저해제로서 사용하기 위한 트라이아자-스피로피페리딘유도체 |
| TW200526641A (en) * | 2003-12-26 | 2005-08-16 | Daiichi Seiyaku Co | Amidopyrazole derivatives |
| ZA200605252B (en) * | 2003-12-26 | 2007-11-28 | Daiichi Seiyaku Co | Amidopyrazole derivative |
| GB0417910D0 (en) * | 2004-08-11 | 2004-09-15 | Novartis Ag | Organic compounds |
| US8703805B2 (en) | 2005-06-27 | 2014-04-22 | Exelixis Patent Company Llc | Modulators of LXR |
| JP5858557B2 (ja) | 2005-12-22 | 2016-02-10 | ハイドラ バイオサイエンシズ インコーポレイテッドＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． | 疼痛を処置するためのｔｒｐａ１阻害剤 |
| US7977358B2 (en) | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
| MX2010007391A (es) | 2008-01-04 | 2010-10-05 | Abbott Lab | Antagonistas de trpa1. |
| EP2300440B1 (en) | 2008-06-02 | 2013-02-27 | Janssen Pharmaceutica, N.V. | 3,4-dihydropyrimidine trpa1 antagonists |
| WO2010125469A1 (en) * | 2009-04-29 | 2010-11-04 | Glenmark Pharmaceuticals, S.A. | Pyrimidinedione-fused heterocyclic compounds as trpa1 modulators |
| WO2011043954A1 (en) | 2009-10-07 | 2011-04-14 | Merck Sharp & Dohme Corp. | Novel trpa1 antagonists |
| US9133128B2 (en) | 2011-06-17 | 2015-09-15 | Research Triangle Institute | Pyrazole derivatives as cannabinoid receptor 1 antagonists |
| DE102011055815A1 (de) | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
| PL2903965T3 (pl) | 2012-10-01 | 2017-08-31 | Orion Corporation | Pochodne n-prop-2-ynylokarboksamidu i ich zastosowanie jako antagonistów trpa1 |
| WO2015103060A1 (en) | 2014-01-06 | 2015-07-09 | Algomedix, Inc. | Trpa1 modulators |
| JP2019521189A (ja) | 2016-07-06 | 2019-07-25 | アルゴメディックス，インク． | ドライアイ、眼痛および炎症の処置のためのｔｒｐａ１アンタゴニスト |
-
2014
- 2014-12-23 WO PCT/US2014/072291 patent/WO2015103060A1/en not_active Ceased
- 2014-12-23 EP EP14876732.0A patent/EP3092228A4/en not_active Withdrawn
- 2014-12-23 JP JP2016562455A patent/JP6626454B2/ja active Active
- 2014-12-23 CA CA2936111A patent/CA2936111C/en active Active
- 2014-12-23 AU AU2014374043A patent/AU2014374043B2/en not_active Ceased
- 2014-12-23 CN CN201480076547.8A patent/CN106061969B/zh not_active Expired - Fee Related
- 2014-12-23 SG SG11201605559VA patent/SG11201605559VA/en unknown
-
2016
- 2016-07-06 US US15/203,774 patent/US9951046B2/en not_active Expired - Fee Related
- 2016-07-06 IL IL246625A patent/IL246625B/en active IP Right Grant
- 2016-08-02 ZA ZA2016/05332A patent/ZA201605332B/en unknown
-
2018
- 2018-03-01 US US15/909,652 patent/US10428049B2/en not_active Expired - Fee Related
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