JP2017501227A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017501227A5 JP2017501227A5 JP2016560871A JP2016560871A JP2017501227A5 JP 2017501227 A5 JP2017501227 A5 JP 2017501227A5 JP 2016560871 A JP2016560871 A JP 2016560871A JP 2016560871 A JP2016560871 A JP 2016560871A JP 2017501227 A5 JP2017501227 A5 JP 2017501227A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hours
- acid
- minutes
- alginic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000010443 alginic acid Nutrition 0.000 claims 8
- 239000000783 alginic acid Substances 0.000 claims 8
- 229920000615 alginic acid Polymers 0.000 claims 8
- 229960001126 alginic acid Drugs 0.000 claims 8
- 150000004781 alginic acids Chemical class 0.000 claims 7
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
- 239000000227 bioadhesive Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 230000001568 sexual effect Effects 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 239000005711 Benzoic acid Substances 0.000 claims 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 235000010233 benzoic acid Nutrition 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 235000010418 carrageenan Nutrition 0.000 claims 2
- 239000000679 carrageenan Substances 0.000 claims 2
- 229920001525 carrageenan Polymers 0.000 claims 2
- 229940113118 carrageenan Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229960001484 edetic acid Drugs 0.000 claims 2
- 229940097042 glucuronate Drugs 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- 229950005134 polycarbophil Drugs 0.000 claims 2
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004264 Petrolatum Substances 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- -1 alginic acid mannuronate Chemical class 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 229960004365 benzoic acid Drugs 0.000 claims 1
- 229940067596 butylparaben Drugs 0.000 claims 1
- 229960003260 chlorhexidine Drugs 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 235000011087 fumaric acid Nutrition 0.000 claims 1
- 235000010492 gellan gum Nutrition 0.000 claims 1
- 239000000216 gellan gum Substances 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 235000016337 monopotassium tartrate Nutrition 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- 229940066842 petrolatum Drugs 0.000 claims 1
- 235000019271 petrolatum Nutrition 0.000 claims 1
- PDTFCHSETJBPTR-UHFFFAOYSA-N phenylmercuric nitrate Chemical compound [O-][N+](=O)O[Hg]C1=CC=CC=C1 PDTFCHSETJBPTR-UHFFFAOYSA-N 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229940086065 potassium hydrogentartrate Drugs 0.000 claims 1
- 239000001472 potassium tartrate Substances 0.000 claims 1
- 229940111695 potassium tartrate Drugs 0.000 claims 1
- 235000011005 potassium tartrates Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 229960003415 propylparaben Drugs 0.000 claims 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
- 239000004299 sodium benzoate Substances 0.000 claims 1
- 235000010234 sodium benzoate Nutrition 0.000 claims 1
- 229960003885 sodium benzoate Drugs 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361918445P | 2013-12-19 | 2013-12-19 | |
| US61/918,445 | 2013-12-19 | ||
| PCT/US2014/071664 WO2015095793A1 (en) | 2013-12-19 | 2014-12-19 | Compositions and methods for inhibiting inflammation and diseases using an alginic acid-based antimicrobial compound |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020063444A Division JP2020125298A (ja) | 2013-12-19 | 2020-03-31 | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017501227A JP2017501227A (ja) | 2017-01-12 |
| JP2017501227A5 true JP2017501227A5 (https=) | 2017-12-07 |
Family
ID=53403777
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016560871A Pending JP2017501227A (ja) | 2013-12-19 | 2014-12-19 | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
| JP2020063444A Pending JP2020125298A (ja) | 2013-12-19 | 2020-03-31 | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
| JP2022017393A Pending JP2022070924A (ja) | 2013-12-19 | 2022-02-07 | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020063444A Pending JP2020125298A (ja) | 2013-12-19 | 2020-03-31 | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
| JP2022017393A Pending JP2022070924A (ja) | 2013-12-19 | 2022-02-07 | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11337989B2 (https=) |
| EP (2) | EP3735966A1 (https=) |
| JP (3) | JP2017501227A (https=) |
| KR (1) | KR102407408B1 (https=) |
| CN (2) | CN106029078A (https=) |
| AU (2) | AU2014368971B2 (https=) |
| BR (1) | BR112016014506B1 (https=) |
| DK (1) | DK3082826T3 (https=) |
| ES (1) | ES2790703T3 (https=) |
| IL (1) | IL246146B2 (https=) |
| MX (2) | MX2016008023A (https=) |
| NZ (1) | NZ722215A (https=) |
| RU (1) | RU2691950C1 (https=) |
| WO (1) | WO2015095793A1 (https=) |
| ZA (1) | ZA201604862B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201590008A1 (ru) | 2012-06-13 | 2015-05-29 | Ивофем, Инк. | Композиции и способы повышения эффективности бактерицидных средств контрацепции |
| JP2017501227A (ja) | 2013-12-19 | 2017-01-12 | エヴォフェム，インク． | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
| DE102017110168A1 (de) | 2016-05-25 | 2017-11-30 | Samsung Electronics Co., Ltd. | Elektronische Vorrichtung mit NFC-Antenne |
| US20190209502A1 (en) * | 2016-09-12 | 2019-07-11 | Evofem, Inc. | Combination gel for sexually transmitted infections |
| US11419835B2 (en) * | 2016-10-04 | 2022-08-23 | Evofem, Inc. | Method of treatment and prevention of bacterial vaginosis |
| WO2023076968A1 (en) * | 2021-10-28 | 2023-05-04 | Evofem, Inc. | Rapidly dissolving vaginal film with contraceptive action and sexually transmitted infection prevention |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213323B (it) | 1986-08-07 | 1989-12-20 | Crinos Industria Farmaco | Composizione per uso locale ad atti vita' spermicida virulicida ,disinfettante e/o battericida |
| US4999342A (en) | 1988-08-16 | 1991-03-12 | Ortho Pharmaceutical Corporation | Long lasting contraceptive suppository composition and methods of use |
| JP3202365B2 (ja) * | 1992-12-04 | 2001-08-27 | 株式会社紀文フードケミファ | オリゴマンヌロン酸を重合度によって分離する方法 |
| US5592949A (en) | 1994-06-29 | 1997-01-14 | Moench; Thomas R. | Device for acidic buffering and method for inactivation of pathogens |
| US5667492A (en) | 1994-10-07 | 1997-09-16 | Columbia Laboratories, Inc. | Use and composition of an anti-sexually transmitted diseases formulation |
| FR2728464B1 (fr) | 1994-12-22 | 1997-04-30 | Innothera Lab Sa | Forme galenique unitaire, son procede d'obtention et ses utilisations |
| US6093394A (en) | 1997-04-11 | 2000-07-25 | Gynelogix, Inc. | Vaginal lactobacillus medicant |
| AU1661901A (en) | 1999-11-24 | 2001-06-04 | Cargill Dow Llc | Improved lactic acid processing; methods; arrangements; and, products |
| WO2001066084A2 (en) * | 2000-03-07 | 2001-09-13 | Rush-Presbyterian-St. Luke's Medical Center | Compositions and methods for trapping and inactivating pathogenic microbes and spermatozoa |
| JP2009102407A (ja) * | 2001-03-08 | 2009-05-14 | Rohto Pharmaceut Co Ltd | Ｇリッチなアルギン酸含有組成物 |
| US20020177624A1 (en) | 2001-03-16 | 2002-11-28 | Calvin Hanna | Acetate-lactate buffering vaginal gel and for method of making same and treating bacterial vaginosis |
| ITMI20010913A1 (it) | 2001-05-04 | 2002-11-04 | Univ Pavia | Composizioni a rilascio controllato di acido lattico a livello vaginale |
| CA2449247A1 (en) * | 2001-06-11 | 2002-12-19 | Merck & Co., Inc. | A method for treating inflammatory diseases by administering a ppar-delta agonist |
| US20130150810A1 (en) | 2002-04-30 | 2013-06-13 | The Population Council, Inc. | Intravaginal ring for the delivery of unique combinations of antimicrobial compositions |
| JP4712380B2 (ja) | 2002-07-26 | 2011-06-29 | 三笠製薬株式会社 | 外用剤 |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| ES2752773T3 (es) | 2003-06-13 | 2020-04-06 | Idh Holding Aps | Tratamiento de los síntomas asociados a la vaginosis bacteriana |
| US20050272700A1 (en) | 2004-05-10 | 2005-12-08 | Servet Buyuktimkin | Topical treatment and prevention of human papilloma virus (HPV) infection |
| RU2257197C1 (ru) * | 2004-05-12 | 2005-07-27 | Дулькис Мария Дмитриевна | Вагинальные суппозитории, обладающие контрацептивным действием |
| UA93354C2 (ru) | 2004-07-09 | 2011-02-10 | Гилиад Сайенсиз, Инк. | Местный противовирусный препарат |
| CN101534863A (zh) * | 2006-11-10 | 2009-09-16 | 日本乐敦制药株式会社 | 用于向皮肤或粘膜施用的组合物 |
| US7659259B2 (en) | 2006-12-21 | 2010-02-09 | Bausch & Lomb Incorporated | Method of treating inflammation of the eye |
| ES2482190T3 (es) | 2007-03-30 | 2014-08-01 | Laccure Ab | Uso de oligómeros de ácido láctico en el tratamiento de infecciones ginecológicas |
| JP2010528052A (ja) | 2007-05-24 | 2010-08-19 | ニューヨーク ブラッド センター， インコーポレイテッド | 生体接着性ジェルを提供する迅速に分散し得る膣錠剤 |
| TW200927141A (en) | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
| CA2721457A1 (en) | 2008-04-16 | 2009-10-22 | Cipla Limited | Topical combinations comprising an antimycotic agent and an antiviral agent |
| WO2009155118A1 (en) * | 2008-05-30 | 2009-12-23 | Reprotect, Inc. | Compositions and methods for inactivation of pathogens at genital tract surfaces |
| EP2130531A1 (en) | 2008-06-04 | 2009-12-09 | Rolf Kullgren AB | Vaginal suppository comprising lactic acid |
| EP2440560A1 (en) | 2009-06-10 | 2012-04-18 | Ultimorphix Technologies B.v. | The succinate of tenofovir disoproxil |
| WO2012151237A1 (en) * | 2011-05-02 | 2012-11-08 | Aptalis Pharmatech, Inc. | Rapid dissolve tablet compositions for vaginal administration |
| JP5986632B2 (ja) | 2011-06-28 | 2016-09-06 | メディシス ファーマシューティカル コーポレイション | 高用量粘膜接着性メトロニダゾール水系ゲル製剤および細菌性膣炎を治療するためのそれらの使用 |
| EA201590008A1 (ru) * | 2012-06-13 | 2015-05-29 | Ивофем, Инк. | Композиции и способы повышения эффективности бактерицидных средств контрацепции |
| WO2015027071A1 (en) | 2013-08-21 | 2015-02-26 | Georgia Regents Research Institute, Inc. | Gpr81 agonists and methods thereof for promoting production of secretory iga |
| JP2017501227A (ja) | 2013-12-19 | 2017-01-12 | エヴォフェム，インク． | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
| AU2015201042A1 (en) | 2014-02-28 | 2015-09-17 | Macfarlane Burnet Institute For Medical Research And Public Health Pty Ltd | Therapeutic Method |
-
2014
- 2014-12-19 JP JP2016560871A patent/JP2017501227A/ja active Pending
- 2014-12-19 IL IL246146A patent/IL246146B2/en unknown
- 2014-12-19 DK DK14871611.1T patent/DK3082826T3/da active
- 2014-12-19 CN CN201480075975.9A patent/CN106029078A/zh active Pending
- 2014-12-19 WO PCT/US2014/071664 patent/WO2015095793A1/en not_active Ceased
- 2014-12-19 BR BR112016014506-2A patent/BR112016014506B1/pt active IP Right Grant
- 2014-12-19 EP EP20161479.9A patent/EP3735966A1/en not_active Withdrawn
- 2014-12-19 EP EP14871611.1A patent/EP3082826B1/en active Active
- 2014-12-19 MX MX2016008023A patent/MX2016008023A/es unknown
- 2014-12-19 CN CN202210078304.4A patent/CN114452298A/zh active Pending
- 2014-12-19 US US15/106,755 patent/US11337989B2/en active Active
- 2014-12-19 KR KR1020167019494A patent/KR102407408B1/ko active Active
- 2014-12-19 RU RU2016129069A patent/RU2691950C1/ru active
- 2014-12-19 NZ NZ722215A patent/NZ722215A/en unknown
- 2014-12-19 AU AU2014368971A patent/AU2014368971B2/en active Active
- 2014-12-19 ES ES14871611T patent/ES2790703T3/es active Active
-
2016
- 2016-06-17 MX MX2021001742A patent/MX2021001742A/es unknown
- 2016-07-14 ZA ZA2016/04862A patent/ZA201604862B/en unknown
-
2020
- 2020-03-31 JP JP2020063444A patent/JP2020125298A/ja active Pending
- 2020-04-29 AU AU2020202835A patent/AU2020202835B2/en active Active
-
2022
- 2022-02-07 JP JP2022017393A patent/JP2022070924A/ja active Pending
- 2022-04-19 US US17/724,378 patent/US20220241301A1/en not_active Abandoned
-
2024
- 2024-01-08 US US18/407,371 patent/US20240299426A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017501227A5 (https=) | ||
| JP2016532722A5 (https=) | ||
| WO2012079092A3 (en) | Testosterone undecanoate compositions | |
| JP2017514850A5 (https=) | ||
| UA105766C2 (uk) | Фармацевтична композиція, яка містить сіль стронцію, вітамін d і циклодекстрин | |
| JP2016534153A5 (https=) | ||
| NZ612686A (en) | Sublingual films | |
| JP2017214429A5 (https=) | ||
| JP2014505733A5 (https=) | ||
| MX2016000727A (es) | Composicion farmaceutica acuosa liquida que contiene derivados de ciclodextrina eterificada con conservante. | |
| RU2013134257A (ru) | Водная композиция для ухода за полостью рта, включающая ксантановую камедь, целлюлозную камедь и карбомер | |
| PH12013500923A1 (en) | Compositions of rotigotine, derivatives thereof, or pharmaceutically acceptable salts of rotigotine or its derivative | |
| RU2016129069A (ru) | Композиции и способы ингибирования воспаления и заболеваний с применением антимикробного соединения на основе альгиновой кислоты | |
| RU2013113222A (ru) | Способы лечения или профилактики тромбообразования или эмболии | |
| PH12015501312A1 (en) | Solid dispersion with improved solubility comprising tetrazole derivative as an active ingredient | |
| WO2013022243A3 (ko) | 신규한 바이페닐 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 염증성 질환 또는 자가면역질환의 예방 또는 치료용 약학적 조성물 | |
| RU2014119858A (ru) | Применение мелатонина для лечения и/или предотвращения мукозита | |
| WO2018234871A3 (en) | COMPOSITIONS FOR DRUG DELIVERY AND METHODS OF USE | |
| RU2012134065A (ru) | Альфа-2 адренергический агонист, обладающий эффектом длительного снижения внутриглазного давления | |
| JP2014510156A5 (https=) | ||
| MX2013004117A (es) | Formulacion farmaceutica para inhibidores de histona desacetilasa. | |
| AR085273A1 (es) | Formulacion liquida libre de propelente que comprende una droga antimuscarinica | |
| JP2015519398A5 (https=) | ||
| JP2019529572A5 (https=) | ||
| RU2013147613A (ru) | Местное дезинфицирующее средство, содержащее йод, обладающее низким содержанием поверхностно-активного вещества |