JP2017222654A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017222654A5 JP2017222654A5 JP2017115935A JP2017115935A JP2017222654A5 JP 2017222654 A5 JP2017222654 A5 JP 2017222654A5 JP 2017115935 A JP2017115935 A JP 2017115935A JP 2017115935 A JP2017115935 A JP 2017115935A JP 2017222654 A5 JP2017222654 A5 JP 2017222654A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- association
- arginine
- arginine amide
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011157654 | 2011-07-19 | ||
| JP2011157654 | 2011-07-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524738A Division JP6176849B2 (ja) | 2011-07-19 | 2012-07-19 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017222654A JP2017222654A (ja) | 2017-12-21 |
| JP2017222654A5 true JP2017222654A5 (enExample) | 2018-02-15 |
| JP6469765B2 JP6469765B2 (ja) | 2019-02-13 |
Family
ID=47558197
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524738A Active JP6176849B2 (ja) | 2011-07-19 | 2012-07-19 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
| JP2017115935A Active JP6469765B2 (ja) | 2011-07-19 | 2017-06-13 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524738A Active JP6176849B2 (ja) | 2011-07-19 | 2012-07-19 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9574005B2 (enExample) |
| EP (1) | EP2735315B1 (enExample) |
| JP (2) | JP6176849B2 (enExample) |
| WO (1) | WO2013012022A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6176849B2 (ja) | 2011-07-19 | 2017-08-09 | 中外製薬株式会社 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| EP3062814A1 (en) * | 2013-10-29 | 2016-09-07 | Albumedix A/S | Antibody composition |
| US10654933B2 (en) * | 2013-12-27 | 2020-05-19 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying antibody having low isoelectric point |
| TWI694836B (zh) * | 2014-05-16 | 2020-06-01 | 英商葛蘭素史克智慧財產管理有限公司 | 抗體調配物 |
| ES2964713T3 (es) | 2014-10-23 | 2024-04-09 | Amgen Inc | Reducción de la viscosidad de formulaciones farmacéuticas |
| AR104050A1 (es) * | 2015-03-26 | 2017-06-21 | Chugai Pharmaceutical Co Ltd | Proceso de producción con iones de cobre controlados |
| FI3284480T3 (fi) | 2015-04-14 | 2025-09-11 | Chugai Pharmaceutical Co Ltd | IL-31-antagonistia vaikuttavana ainesosana sisältävä farmaseuttinen koostumus atooppisen ihottuman ehkäisemiseksi ja/tai hoitamiseksi |
| TW201726111A (zh) * | 2015-09-30 | 2017-08-01 | 持田製藥股份有限公司 | 含高濃度抗體之液體製劑 |
| MA43734A (fr) | 2016-03-03 | 2018-11-28 | Regeneron Pharma | Procédés de traitement de patients atteints d'hyperlipidémie par administration d'un inhibiteur de pcsk9 en combinaison avec un inhibiteur d'angptl3 |
| JP7377596B2 (ja) | 2017-02-22 | 2023-11-10 | アムジエン・インコーポレーテツド | 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法 |
| PL3615066T3 (pl) | 2017-04-28 | 2024-04-29 | Amgen Inc. | Formulacje ludzkich przeciwciał anty-RANKL i sposoby ich zastosowania |
| CN110913906A (zh) | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| RS67656B1 (sr) | 2018-05-10 | 2026-02-27 | Regeneron Pharma | Formulacije koje sadrže visoke koncentracije fuzionog proteina vegf receptora |
| MX2021004356A (es) | 2018-10-18 | 2021-05-31 | Merck Sharp & Dohme Llc | Formulaciones de anticuerpos anti-rsv y metodos de uso de las mismas. |
| MA54089A (fr) | 2018-10-31 | 2022-02-09 | Merck Sharp & Dohme | Anticorps anti-pd-1 humain et procédés d'utilisation associés |
| JP7503056B6 (ja) | 2018-11-07 | 2024-07-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体および抗ｐｄ－１抗体の共－製剤 |
| US12559551B2 (en) | 2019-05-24 | 2026-02-24 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ANGPTL3 antibodies |
| EP3763356A1 (en) * | 2019-07-12 | 2021-01-13 | Ludwig-Maximilians-Universität München | Excipient for biotherapeutics |
| WO2021100794A1 (ja) * | 2019-11-20 | 2021-05-27 | 中外製薬株式会社 | 抗体含有製剤 |
| JP2025078889A (ja) * | 2022-02-03 | 2025-05-21 | 天野エンザイム株式会社 | 酵素製剤 |
| TW202602486A (zh) | 2024-03-07 | 2026-01-16 | 瑞士商Ｃｓｌ貝林股份有限公司 | 免疫球蛋白組成物及產生氣溶膠之方法 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58201994A (ja) | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
| JPS6013718A (ja) | 1983-07-05 | 1985-01-24 | Chemo Sero Therapeut Res Inst | Ｂ型肝炎ワクチン |
| JPS60193925A (ja) | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
| US4597966A (en) * | 1985-01-09 | 1986-07-01 | Ortho Diagnostic Systems, Inc. | Histidine stabilized immunoglobulin and method of preparation |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| AU668349B2 (en) | 1991-04-25 | 1996-05-02 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin 6 receptor |
| JP3540315B2 (ja) | 1991-09-23 | 2004-07-07 | メディカル リサーチ カウンシル | キメラ抗体の製造−組合せアプローチ |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| JPH07503132A (ja) | 1991-12-17 | 1995-04-06 | ジェンファーム インターナショナル，インコーポレイティド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP2942412B2 (ja) * | 1991-12-26 | 1999-08-30 | 鐘紡株式会社 | 化粧料 |
| EP0656941B1 (en) | 1992-03-24 | 2005-06-01 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| CA2177367A1 (en) | 1993-12-03 | 1995-06-08 | Andrew David Griffiths | Recombinant binding proteins and peptides |
| ATE340590T1 (de) | 1994-07-13 | 2006-10-15 | Chugai Pharmaceutical Co Ltd | Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| CA2226575C (en) | 1995-07-27 | 2011-10-18 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
| CZ106299A3 (cs) | 1996-09-26 | 1999-08-11 | Chugai Seiyaku Kabushiki Kaisha | Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem |
| UA76934C2 (en) | 1996-10-04 | 2006-10-16 | Chugai Pharmaceutical Co Ltd | Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody |
| SK14812000A3 (sk) | 1998-04-03 | 2001-08-06 | Chugai Seiyaku Kabushiki Kaisha | Chimérny reťazec protilátky, chimérna protilátka, v oblasť, humanizovaný reťazec protilátky, humanizovaná protilátka, dna, expresný vektor, hostiteľ, spôsob prípravy a liečivo |
| TWI242043B (en) | 2000-03-10 | 2005-10-21 | Chugai Pharmaceutical Co Ltd | Polypeptide inducing apoptosis |
| US8632778B2 (en) | 2000-08-11 | 2014-01-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized anti-interleukin-6 antibody-containing preparations |
| AU1091702A (en) | 2000-10-20 | 2002-04-29 | Chugai Pharmaceutical Co Ltd | Degraded tpo agonist antibody |
| EP1391209A4 (en) | 2001-05-30 | 2009-12-16 | Chugai Pharmaceutical Co Ltd | PROTEIN PREPARATION |
| WO2003068260A1 (fr) | 2002-02-14 | 2003-08-21 | Chugai Seiyaku Kabushiki Kaisha | Produits pharmaceutiques en solution contenant des anticorps |
| JP4083634B2 (ja) | 2002-07-11 | 2008-04-30 | 旭化成ファーマ株式会社 | 光に安定なカルシトニン水溶液 |
| JP3976257B2 (ja) | 2002-09-17 | 2007-09-12 | 栄研化学株式会社 | 蛋白質の安定化方法 |
| US20050158303A1 (en) | 2003-04-04 | 2005-07-21 | Genentech, Inc. | Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations |
| EP2204190A1 (en) | 2003-07-15 | 2010-07-07 | Chugai Seiyaku Kabushiki Kaisha | IgM production by transformed cells and methods for quantifying said IgM production |
| CN101237890A (zh) * | 2005-06-10 | 2008-08-06 | 中外制药株式会社 | 含有葡甲胺的蛋白质制剂的稳定剂及其利用 |
| JP5405122B2 (ja) | 2005-12-21 | 2014-02-05 | ワイス・エルエルシー | 低粘度のタンパク質製剤およびその用途 |
| JP2009525986A (ja) * | 2006-02-03 | 2009-07-16 | メディミューン，エルエルシー | タンパク質製剤 |
| EP4793360A2 (en) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| JP2007332093A (ja) | 2006-06-16 | 2007-12-27 | Apro Life Science Institute Inc | タンパク質のリフォールディング添加剤及びそれを用いたタンパク質の再生方法 |
| JP5419709B2 (ja) * | 2007-01-09 | 2014-02-19 | ワイス・エルエルシー | 抗ｉｌ−１３抗体製剤およびその使用 |
| KR101540823B1 (ko) | 2007-03-30 | 2015-07-30 | 메디뮨 엘엘씨 | 항체 제제 |
| JP5119545B2 (ja) | 2007-06-19 | 2013-01-16 | 国立大学法人 筑波大学 | 蛋白質を含む液状組成物中における蛋白質の安定化方法 |
| ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| RU2505603C2 (ru) | 2007-09-26 | 2014-01-27 | Чугаи Сейяку Кабусики Кайся | Антитело против рецептора il-6 |
| TWI548418B (zh) | 2007-12-05 | 2016-09-11 | 中外製藥股份有限公司 | Anti-NR10 / IL-31RA antibody and its use |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| WO2009104369A1 (ja) | 2008-02-22 | 2009-08-27 | パナソニック株式会社 | 血漿に含まれる成分の検出方法ならびにそれに用いられる試薬および検出デバイス |
| AR080428A1 (es) * | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | Formulaciones liquidas estabilizadas contentivas de anticuerpos |
| BR112012027828A2 (pt) * | 2010-05-03 | 2016-08-09 | Genentech Inc | composição de matéria, artigo de fabricação e método de redução da viscosidade de uma formulação contendo proteína e de preparação de uma formulação aquosa contendo proteína |
| JP6176849B2 (ja) | 2011-07-19 | 2017-08-09 | 中外製薬株式会社 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
-
2012
- 2012-07-19 JP JP2013524738A patent/JP6176849B2/ja active Active
- 2012-07-19 US US14/232,922 patent/US9574005B2/en active Active
- 2012-07-19 WO PCT/JP2012/068276 patent/WO2013012022A1/ja not_active Ceased
- 2012-07-19 EP EP12814155.3A patent/EP2735315B1/en active Active
-
2017
- 2017-01-06 US US15/400,355 patent/US10898572B2/en active Active
- 2017-06-13 JP JP2017115935A patent/JP6469765B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201490815A1 (ru) | Составы этанерцепта, стабилизированные с помощью аминокислот | |
| CY1122181T1 (el) | Φαρμακοτεχνικη μορφη αντισωματος | |
| BR112017008660A2 (pt) | formulação de solução de proteína estável contendo alta concentração de um anticorpo anti-vegf | |
| CY1124592T1 (el) | Ζιζανιοκτονως δραστικα 3-φαινυλοïσοξαζολινο-5-καρβοξαμιδια αποτελουμενα απο τετραϋδρο- και διυδροφουρανοκαρβοξυλικα οξεα και εστερες | |
| CO2019011021A2 (es) | Formulacion estable de anticuerpos | |
| EP4233892A3 (en) | Stable anti-ifnar1 formulation | |
| MX387229B (es) | Composiciones antibióticas | |
| HRP20200434T1 (hr) | Stabilne vodene formulacije adalimumaba | |
| CO2020013552A2 (es) | Formulación de anticuerpos | |
| MX378502B (es) | Formulaciones de anticuerpos biespecificos anti-il-4/anti-il-13. | |
| AR107864A1 (es) | ÁCIDO 7a,11b-DIHIDROXI-6a-ETIL-5b-COLAN-24-OICO Y COMPOSICIONES FARMACÉUTICAS | |
| UA122478C2 (uk) | Водна фармацевтична композиція, яка містить моноклональне антитіло до pd-l1 | |
| PY1128718A (es) | Formulaciones estabilizadas que contienen anticuerpos anti- ngf | |
| PE20120342A1 (es) | Formulacion de anticuerpo | |
| EA202091398A1 (ru) | Составы вакцинных композиций от вируса денге | |
| SA521421715B1 (ar) | تركيبات سيماجلوتيد ثابتة واستخداماتها | |
| JP2019501920A5 (enExample) | ||
| AR100268A1 (es) | Formulación líquida que comprende compuesto neutralizante de gm-csf | |
| CR20210318A (es) | Formulación de solución de proteínas que contiene una alta concentración de un anticuerpo anti-vegf | |
| EA202091003A1 (ru) | Новые производные пиразолопирролопиримидиндиона в качестве ингибиторов p2x3 | |
| EA201991023A1 (ru) | Фармацевтическая композиция для парентерального введения, содержащая карглумовую кислоту | |
| EA202192568A1 (ru) | Стабилизированные составы, содержащие антитела к il-33 | |
| EA201892382A1 (ru) | Замещенные бициклические гетероциклические соединения | |
| BR112018068414A2 (pt) | derivados de ácido a-truxílico e composições farmacêuticas dos mesmos | |
| AR080127A1 (es) | Inhibidores de la amida hidrolasa de acidos grasos, composiciones farmaceuticas y sus usos |