JP2017186372A5 - - Google Patents
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- Publication number
- JP2017186372A5 JP2017186372A5 JP2017136330A JP2017136330A JP2017186372A5 JP 2017186372 A5 JP2017186372 A5 JP 2017186372A5 JP 2017136330 A JP2017136330 A JP 2017136330A JP 2017136330 A JP2017136330 A JP 2017136330A JP 2017186372 A5 JP2017186372 A5 JP 2017186372A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- salt
- nonionic surfactant
- dorzolamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 10
- 239000002736 nonionic surfactant Substances 0.000 claims 8
- -1 fatty acid ester Chemical class 0.000 claims 7
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims 5
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 claims 5
- 229960003933 dorzolamide Drugs 0.000 claims 5
- 229960004605 timolol Drugs 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
- 239000004359 castor oil Substances 0.000 claims 3
- 235000019438 castor oil Nutrition 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010030043 Ocular hypertension Diseases 0.000 claims 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- WLRMANUAADYWEA-NWASOUNVSA-N (S)-timolol maleate Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 WLRMANUAADYWEA-NWASOUNVSA-N 0.000 claims 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 1
- OSRUSFPMRGDLAG-QMGYSKNISA-N dorzolamide hydrochloride Chemical compound [Cl-].CC[NH2+][C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 OSRUSFPMRGDLAG-QMGYSKNISA-N 0.000 claims 1
- 229960002506 dorzolamide hydrochloride Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960001484 edetic acid Drugs 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229920006150 hyperbranched polyester Polymers 0.000 claims 1
- 229920000587 hyperbranched polymer Polymers 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229960005221 timolol maleate Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016050092 | 2016-03-14 | ||
| JP2016050092 | 2016-03-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017027480A Division JP6178028B1 (ja) | 2016-03-14 | 2017-02-17 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017186372A JP2017186372A (ja) | 2017-10-12 |
| JP2017186372A5 true JP2017186372A5 (enExample) | 2020-03-26 |
| JP6886878B2 JP6886878B2 (ja) | 2021-06-16 |
Family
ID=59559197
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017027480A Active JP6178028B1 (ja) | 2016-03-14 | 2017-02-17 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
| JP2017136330A Active JP6886878B2 (ja) | 2016-03-14 | 2017-07-12 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017027480A Active JP6178028B1 (ja) | 2016-03-14 | 2017-02-17 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
Country Status (3)
| Country | Link |
|---|---|
| JP (2) | JP6178028B1 (enExample) |
| TW (1) | TW201733577A (enExample) |
| WO (1) | WO2017159586A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6178028B1 (ja) * | 2016-03-14 | 2017-08-09 | 参天製薬株式会社 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
| US20190134051A1 (en) * | 2017-11-06 | 2019-05-09 | Rheostasis, Llc | Composition for treating ocular disorders such as macular degeneration, retinopathy and glaucoma |
| WO2019112030A1 (ja) * | 2017-12-08 | 2019-06-13 | 千寿製薬株式会社 | 水溶性高分子を含む水性液剤 |
| WO2021237096A1 (en) * | 2020-05-21 | 2021-11-25 | Graybug Vision, Inc. | Durable implants and microparticles for long-term ocular therapy |
| JPWO2022173043A1 (enExample) * | 2021-02-15 | 2022-08-18 | ||
| WO2025004579A1 (ja) * | 2023-06-30 | 2025-01-02 | 株式会社ニデック | 眼科用組成物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8952051B2 (en) * | 2009-11-05 | 2015-02-10 | Allergan, Inc. | Ophthalmic formulations containing substituted gamma lactams and methods for use thereof |
| US8211450B2 (en) * | 2010-05-05 | 2012-07-03 | Senju Usa, Inc. | Ophthalmic composition |
| JP6185725B2 (ja) * | 2012-02-24 | 2017-08-23 | わかもと製薬株式会社 | 水性医薬組成物 |
| JP6304475B2 (ja) * | 2013-01-31 | 2018-04-04 | ロート製薬株式会社 | 点眼剤 |
| JP6178028B1 (ja) * | 2016-03-14 | 2017-08-09 | 参天製薬株式会社 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
-
2017
- 2017-02-17 JP JP2017027480A patent/JP6178028B1/ja active Active
- 2017-02-17 TW TW106105247A patent/TW201733577A/zh unknown
- 2017-03-13 WO PCT/JP2017/009876 patent/WO2017159586A1/ja not_active Ceased
- 2017-07-12 JP JP2017136330A patent/JP6886878B2/ja active Active
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