JP6178028B1 - ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 - Google Patents

ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 Download PDF

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Publication number
JP6178028B1
JP6178028B1 JP2017027480A JP2017027480A JP6178028B1 JP 6178028 B1 JP6178028 B1 JP 6178028B1 JP 2017027480 A JP2017027480 A JP 2017027480A JP 2017027480 A JP2017027480 A JP 2017027480A JP 6178028 B1 JP6178028 B1 JP 6178028B1
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Prior art keywords
pharmaceutical composition
salt
composition according
timolol
dorzolamide
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JP2017027480A
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English (en)
Japanese (ja)
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JP2017165707A (ja
Inventor
隆司 森本
隆司 森本
松本　直樹
直樹 松本
貴司 坪井
貴司 坪井
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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Priority to PCT/JP2017/009876 priority Critical patent/WO2017159586A1/ja
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Publication of JP2017165707A publication Critical patent/JP2017165707A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017027480A 2016-03-14 2017-02-17 ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 Active JP6178028B1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2017/009876 WO2017159586A1 (ja) 2016-03-14 2017-03-13 ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016050092 2016-03-14
JP2016050092 2016-03-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017136330A Division JP6886878B2 (ja) 2016-03-14 2017-07-12 ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物

Publications (2)

Publication Number Publication Date
JP6178028B1 true JP6178028B1 (ja) 2017-08-09
JP2017165707A JP2017165707A (ja) 2017-09-21

Family

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Family Applications (2)

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JP2017027480A Active JP6178028B1 (ja) 2016-03-14 2017-02-17 ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物
JP2017136330A Active JP6886878B2 (ja) 2016-03-14 2017-07-12 ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物

Family Applications After (1)

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JP2017136330A Active JP6886878B2 (ja) 2016-03-14 2017-07-12 ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物

Country Status (3)

Country Link
JP (2) JP6178028B1 (enExample)
TW (1) TW201733577A (enExample)
WO (1) WO2017159586A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017186372A (ja) * 2016-03-14 2017-10-12 参天製薬株式会社 ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190134051A1 (en) * 2017-11-06 2019-05-09 Rheostasis, Llc Composition for treating ocular disorders such as macular degeneration, retinopathy and glaucoma
JP6603785B2 (ja) * 2017-12-08 2019-11-06 千寿製薬株式会社 水溶性高分子を含む水性液剤
TW202207943A (zh) * 2020-05-21 2022-03-01 美商灰色視覺公司 用於長期眼部治療之耐久植入物及微粒
CA3210908A1 (en) * 2021-02-15 2022-08-18 Santen Pharmaceutical Co., Ltd. Water-based pharmaceutical composition containing ursodeoxycholic acid or salt thereof
WO2025004579A1 (ja) * 2023-06-30 2025-01-02 株式会社ニデック 眼科用組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8952051B2 (en) * 2009-11-05 2015-02-10 Allergan, Inc. Ophthalmic formulations containing substituted gamma lactams and methods for use thereof
US8211450B2 (en) * 2010-05-05 2012-07-03 Senju Usa, Inc. Ophthalmic composition
JP6185725B2 (ja) * 2012-02-24 2017-08-23 わかもと製薬株式会社 水性医薬組成物
JP6304475B2 (ja) * 2013-01-31 2018-04-04 ロート製薬株式会社 点眼剤
TW201733577A (zh) * 2016-03-14 2017-10-01 Santen Pharmaceutical Co Ltd 含有多佐胺、噻嗎洛爾和界面活性劑之醫藥組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017186372A (ja) * 2016-03-14 2017-10-12 参天製薬株式会社 ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物

Also Published As

Publication number Publication date
JP2017165707A (ja) 2017-09-21
WO2017159586A1 (ja) 2017-09-21
JP6886878B2 (ja) 2021-06-16
TW201733577A (zh) 2017-10-01
JP2017186372A (ja) 2017-10-12

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