JP2017169559A5 - - Google Patents
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- Publication number
- JP2017169559A5 JP2017169559A5 JP2017037848A JP2017037848A JP2017169559A5 JP 2017169559 A5 JP2017169559 A5 JP 2017169559A5 JP 2017037848 A JP2017037848 A JP 2017037848A JP 2017037848 A JP2017037848 A JP 2017037848A JP 2017169559 A5 JP2017169559 A5 JP 2017169559A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- cell
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 101150074155 DHFR gene Proteins 0.000 claims 1
- 102100024746 Dihydrofolate reductase Human genes 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 108010022394 Threonine synthase Proteins 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 102000004419 dihydrofolate reductase Human genes 0.000 claims 1
- 108020001096 dihydrofolate reductase Proteins 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 108010068617 neonatal Fc receptor Proteins 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492617P | 2011-06-02 | 2011-06-02 | |
| US61/492,617 | 2011-06-02 | ||
| US201161498266P | 2011-06-17 | 2011-06-17 | |
| US61/498,266 | 2011-06-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513732A Division JP6104897B2 (ja) | 2011-06-02 | 2012-06-01 | Ｆｃレセプター結合タンパク質 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018085040A Division JP6638018B2 (ja) | 2011-06-02 | 2018-04-26 | Ｆｃレセプター結合タンパク質 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2017169559A JP2017169559A (ja) | 2017-09-28 |
| JP2017169559A5 true JP2017169559A5 (cg-RX-API-DMAC7.html) | 2017-12-07 |
| JP6334763B2 JP6334763B2 (ja) | 2018-05-30 |
| JP6334763B6 JP6334763B6 (ja) | 2018-07-11 |
Family
ID=47259886
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513732A Active JP6104897B2 (ja) | 2011-06-02 | 2012-06-01 | Ｆｃレセプター結合タンパク質 |
| JP2017037848A Active JP6334763B6 (ja) | 2011-06-02 | 2017-03-01 | Ｆｃレセプター結合タンパク質 |
| JP2018085040A Active JP6638018B2 (ja) | 2011-06-02 | 2018-04-26 | Ｆｃレセプター結合タンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513732A Active JP6104897B2 (ja) | 2011-06-02 | 2012-06-01 | Ｆｃレセプター結合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018085040A Active JP6638018B2 (ja) | 2011-06-02 | 2018-04-26 | Ｆｃレセプター結合タンパク質 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US9359438B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2714084B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6104897B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102014554B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN105622754B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2012262007B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013030352B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2837527C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2748583T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL229618B (cg-RX-API-DMAC7.html) |
| MX (1) | MX343659B (cg-RX-API-DMAC7.html) |
| PH (1) | PH12013502378A1 (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201604493TA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012167039A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI593423B (zh) * | 2008-04-25 | 2017-08-01 | 戴埃克斯有限公司 | Ｆｃ受體結合蛋白 |
| SG10201604493TA (en) | 2011-06-02 | 2016-07-28 | Dyax Corp | Fc RECEPTOR BINDING PROTEINS |
| GB201208370D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
| GB201320066D0 (en) | 2013-11-13 | 2013-12-25 | Ucb Pharma Sa | Biological products |
| JP6620094B2 (ja) | 2013-11-26 | 2019-12-11 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 免疫応答を調節するための組成物および方法 |
| EP4241852A3 (en) | 2014-04-30 | 2023-11-15 | Hanall Biopharma Co., Ltd. | Antibody binding to fcrn for treating autoimmune diseases |
| US10336825B2 (en) | 2014-04-30 | 2019-07-02 | Hanall Biopharma Co., Ltd. | Antibody binding to FcRn for treating autoimmune diseases |
| CN118667014A (zh) * | 2015-01-30 | 2024-09-20 | 动量制药公司 | Fcrn抗体及其使用方法 |
| US10822417B2 (en) * | 2016-04-25 | 2020-11-03 | Syntimmune, Inc. | Humanized affinity matured anti-FcRn antibodies |
| EP4282487A3 (en) * | 2016-07-29 | 2024-02-14 | Momenta Pharmaceuticals, Inc. | Fcrn antibodies and methods of use thereof |
| KR20190089941A (ko) | 2016-12-01 | 2019-07-31 | 사빅 글로벌 테크놀러지스 비.브이. | 하이브리드 복합 뒷문 |
| RU2020100880A (ru) * | 2017-06-15 | 2021-07-15 | Юсб Биофарма Срл | Способ лечения иммунной тромбоцитопении |
| AU2018380979B2 (en) | 2017-12-08 | 2023-07-20 | argenx BV | Use of FcRn antagonists for treatment of generalized myasthenia gravis |
| SG11202005021PA (en) | 2017-12-13 | 2020-07-29 | Momenta Pharmaceuticals Inc | Fcrn antibodies and methods of use thereof |
| BR112020025001A2 (pt) | 2018-06-08 | 2021-03-23 | Argenx Bvba | composições e métodos para o tratamento da trombocitopenia imune |
| MX2021000788A (es) * | 2018-07-20 | 2021-07-21 | Momenta Pharmaceuticals Inc | Composiciones de anticuerpos del receptor de fc (fcrn). |
| US20230287107A1 (en) * | 2019-07-23 | 2023-09-14 | Shanghaitech University | Asic1 channel antagonist antibody |
| TW202140552A (zh) | 2020-01-08 | 2021-11-01 | 比利時商阿根思公司 | 用於治療天皰瘡病症的方法 |
| CA3183153A1 (en) | 2020-06-17 | 2021-12-23 | Christian HINDERER | Compositions and methods for treatment of gene therapy patients |
| KR20250018382A (ko) | 2022-05-30 | 2025-02-05 | 한올바이오파마주식회사 | 안정성이 향상된 항-FcRn 항체 또는 이의 항원 결합 단편 |
| AU2023291783A1 (en) | 2022-06-15 | 2024-12-12 | argenx BV | Fcrn binding molecules and methods of use |
| WO2025099576A1 (en) | 2023-11-06 | 2025-05-15 | Momenta Pharmaceuticals, Inc. | Compositions and methods for treating rheumatoid arthritis |
| WO2025163617A1 (en) | 2024-02-04 | 2025-08-07 | Momenta Pharmaceuticals, Inc. | Compositions and methods for treating sjögren's disease |
| CN119490588A (zh) * | 2024-10-17 | 2025-02-21 | 广州康盛生物科技股份有限公司 | 一种抗人FcRn的VHH抗体及其应用 |
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| AU2018281045A1 (en) | 2017-06-05 | 2019-12-12 | Janssen Biotech, Inc. | Engineered multispecific antibodies and other multimeric proteins with asymmetrical CH2-CH3 region mutations |
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-
2012
- 2012-06-01 SG SG10201604493TA patent/SG10201604493TA/en unknown
- 2012-06-01 WO PCT/US2012/040409 patent/WO2012167039A1/en not_active Ceased
- 2012-06-01 MX MX2013013832A patent/MX343659B/es active IP Right Grant
- 2012-06-01 CN CN201510926183.4A patent/CN105622754B/zh active Active
- 2012-06-01 EP EP12793948.6A patent/EP2714084B1/en active Active
- 2012-06-01 ES ES12793948T patent/ES2748583T3/es active Active
- 2012-06-01 EP EP15167896.8A patent/EP2966089B1/en active Active
- 2012-06-01 SG SG2013085204A patent/SG195025A1/en unknown
- 2012-06-01 PH PH1/2013/502378A patent/PH12013502378A1/en unknown
- 2012-06-01 CA CA2837527A patent/CA2837527C/en active Active
- 2012-06-01 KR KR1020137034618A patent/KR102014554B1/ko active Active
- 2012-06-01 AU AU2012262007A patent/AU2012262007B2/en active Active
- 2012-06-01 JP JP2014513732A patent/JP6104897B2/ja active Active
- 2012-06-01 CN CN201280031902.0A patent/CN103619353B/zh active Active
- 2012-06-01 BR BR112013030352-2A patent/BR112013030352B1/pt active IP Right Grant
- 2012-06-01 US US14/122,880 patent/US9359438B2/en active Active
-
2013
- 2013-11-25 IL IL229618A patent/IL229618B/en active IP Right Grant
-
2016
- 2016-04-27 US US15/139,784 patent/US9862768B2/en active Active
-
2017
- 2017-03-01 JP JP2017037848A patent/JP6334763B6/ja active Active
- 2017-09-21 AU AU2017232160A patent/AU2017232160B2/en active Active
- 2017-12-04 US US15/830,998 patent/US10479834B2/en active Active
-
2018
- 2018-04-26 JP JP2018085040A patent/JP6638018B2/ja active Active
-
2019
- 2019-10-07 US US16/594,218 patent/US11014988B2/en active Active
-
2021
- 2021-03-17 US US17/203,816 patent/US11739152B2/en active Active
-
2023
- 2023-07-06 US US18/347,626 patent/US12454575B2/en active Active
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