JP2017081972A5 - - Google Patents

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Publication number
JP2017081972A5
JP2017081972A5 JP2017000107A JP2017000107A JP2017081972A5 JP 2017081972 A5 JP2017081972 A5 JP 2017081972A5 JP 2017000107 A JP2017000107 A JP 2017000107A JP 2017000107 A JP2017000107 A JP 2017000107A JP 2017081972 A5 JP2017081972 A5 JP 2017081972A5
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JP
Japan
Prior art keywords
composition
mesenchymal stem
stem cells
pharmaceutically acceptable
serum albumin
Prior art date
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Pending
Application number
JP2017000107A
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English (en)
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JP2017081972A (ja
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Publication of JP2017081972A publication Critical patent/JP2017081972A/ja
Publication of JP2017081972A5 publication Critical patent/JP2017081972A5/ja
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Claims (17)

  1. 精製済み間葉系幹細胞を含む薬学的に許容しうる組成物であって、一つまたはそれを超える間葉系幹細胞集合体を含み、そして該集合体のＤ９０が、約１５０μｍ未満である薬学的に許容しうる組成物。
  2. 前記集合体のＤ９０が、約１００μｍ未満である、請求項１に記載の薬学的に許容しうる組成物。
  3. 前記集合体のＤ９０が、約５０μｍ未満である、請求項２に記載の薬学的に許容しうる組成物。
  4. 精製済み間葉系幹細胞の生存能力が、約７０％より大である、請求項１に記載の薬学的に許容しうる組成物。
  5. 精製済み間葉系幹細胞の生存能力が、約８０％より大である、請求項４に記載の薬学的に許容しうる組成物。
  6. 精製済み間葉系幹細胞を含む薬学的に許容しうる組成物であって、約５５μｇ／ｍＬ未満の残留ウシ血清アルブミンを含み、そしてここにおいて、間葉系幹細胞が、約１８μｍ〜約３０μｍのＤ９０を示す薬学的に許容しうる組成物。
  7. 組成物が、約４２μｇ／ｍＬ未満の残留ウシ血清アルブミンを含む、請求項６に記載の組成物。
  8. 組成物が、約２５μｇ／ｍＬ未満の残留ウシ血清アルブミンを含む、請求項７に記載の組成物。
  9. 組成物が、約１３μｇ／ｍＬ未満の残留ウシ血清アルブミンを含む、請求項８に記載の組成物。
  10. 組成物が、約１０μｇ／ｍＬ未満の残留ウシ血清アルブミンを含む、請求項９に記載の組成物。
  11. 組成物が、約７μｇ／ｍＬ〜約１５μｇ／ｍＬの残留ウシ血清アルブミンを含む、請求項６に記載の組成物。
  12. 組成物が、約８μｇ／ｍＬ〜約１２μｇ／ｍＬの残留ウシ血清アルブミンを含む、請求項１１に記載の組成物。
  13. 間葉系幹細胞が、約１８μｍ〜約２５μｍのＤ９０を示す、請求項６に記載の組成物。
  14. 精製済み間葉系幹細胞の生存能力が、約７０％より大である、請求項６に記載の組成物。
  15. 精製済み間葉系幹細胞の生存能力が、約８０％より大である、請求項１４に記載の組成物。
  16. 免疫応答、肺塞栓症、血管収縮、または心臓性ショックの予防または治療に有用な医薬としての、請求項１〜１４のいずれか一項に記載の組成物。
  17. 該予防または治療が、免疫原性の増加およびレシピエントからの間葉系幹細胞のクリアランスまたは排泄の促進を防ぐ、請求項１６に記載の組成物。
JP2017000107A 2008-08-14 2017-01-04 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法 Pending JP2017081972A (ja)

Applications Claiming Priority (2)

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US8889808P 2008-08-14 2008-08-14
US61/088,898 2008-08-14

Related Parent Applications (1)

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JP2014224180A Division JP2015071610A (ja) 2008-08-14 2014-11-04 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法

Related Child Applications (1)

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JP2018036415A Division JP2018109052A (ja) 2008-08-14 2018-03-01 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法

Publications (2)

Publication Number Publication Date
JP2017081972A JP2017081972A (ja) 2017-05-18
JP2017081972A5 true JP2017081972A5 (ja) 2017-09-21

Family

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Family Applications (6)

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JP2011523195A Active JP6025329B2 (ja) 2008-08-14 2009-08-14 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法
JP2014224180A Pending JP2015071610A (ja) 2008-08-14 2014-11-04 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法
JP2017000107A Pending JP2017081972A (ja) 2008-08-14 2017-01-04 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法
JP2018036415A Pending JP2018109052A (ja) 2008-08-14 2018-03-01 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法
JP2020072934A Pending JP2020120671A (ja) 2008-08-14 2020-04-15 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法
JP2023000381A Pending JP2023052211A (ja) 2008-08-14 2023-01-05 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法

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JP2011523195A Active JP6025329B2 (ja) 2008-08-14 2009-08-14 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法
JP2014224180A Pending JP2015071610A (ja) 2008-08-14 2014-11-04 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法

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JP2018036415A Pending JP2018109052A (ja) 2008-08-14 2018-03-01 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法
JP2020072934A Pending JP2020120671A (ja) 2008-08-14 2020-04-15 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法
JP2023000381A Pending JP2023052211A (ja) 2008-08-14 2023-01-05 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法

Country Status (14)

Country Link
US (5) US8637004B2 (ja)
EP (2) EP2318519B1 (ja)
JP (6) JP6025329B2 (ja)
AR (2) AR073069A1 (ja)
AU (1) AU2009281809B2 (ja)
BR (1) BRPI0917993B8 (ja)
CA (1) CA2733985C (ja)
DK (1) DK2318519T3 (ja)
ES (1) ES2608974T3 (ja)
IL (1) IL211214A0 (ja)
MX (2) MX362512B (ja)
NZ (2) NZ591146A (ja)
WO (1) WO2010019886A1 (ja)
ZA (1) ZA201101858B (ja)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530543A (ja) 2004-03-22 2007-11-01 オシリス セラピューティクス，インコーポレイテッド 間葉幹細胞及びその使用法
ES2415855T3 (es) 2006-01-13 2013-07-29 Osiris Therapeutics, Inc. Células troncales mesenquimatosas que expresan el receptor de TNF
ES2608974T3 (es) 2008-08-14 2017-04-17 Mesoblast International Sàrl Composiciones de células madre mesenquimales purificadas
CA2734236C (en) 2008-08-20 2020-08-25 Anthrogenesis Corporation Improved cell composition and methods of making the same
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US20140286911A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
EP3679939A1 (en) 2010-10-08 2020-07-15 Mesoblast International Sàrl Enhanced msc preparations
ITGE20120034A1 (it) * 2012-03-28 2013-09-29 Carlo Tremolada Preparato e metodo per la produzione di un preparato comprendente cellule staminali mesenchimali
JP2013252126A (ja) * 2012-05-08 2013-12-19 Otsuka Pharmaceut Factory Inc デキストラン含有肺塞栓形成予防用哺乳動物細胞懸濁液
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3613841B1 (en) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passive replacement of media
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3238759B1 (en) 2016-04-29 2019-07-17 Fenwal, Inc. System and method for processing, incubating and/or selecting biological cells
US10449283B2 (en) 2016-04-29 2019-10-22 Fenwal, Inc. System and method for selecting and culturing cells
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US10274495B2 (en) 2016-12-21 2019-04-30 Fenwal, Inc. System and method for separating cells incorporating magnetic separation
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
US20210395693A1 (en) * 2018-10-26 2021-12-23 Guy MARTI Method and apparatus for mesenchymal stem cells isolation and purification
JP2022533949A (ja) * 2019-05-15 2022-07-27 ステムサイト インコーポレーテッド 高濃度細胞のパッケージングおよび輸送
WO2021144995A1 (ja) * 2020-01-16 2021-07-22 ＰｕＲＥＣ株式会社 高純度間葉系幹細胞

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034135A (en) * 1982-12-13 1991-07-23 William F. McLaughlin Blood fractionation system and method
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
WO1988001193A1 (en) * 1986-08-11 1988-02-25 Hemascience Laboratories, Inc. Blood cell washing systems and methods
US5536475A (en) 1988-10-11 1996-07-16 Baxter International Inc. Apparatus for magnetic cell separation
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5837539A (en) * 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5234608A (en) * 1990-12-11 1993-08-10 Baxter International Inc. Systems and methods for processing cellular rich suspensions
CA2192103C (en) * 1994-06-06 2002-02-05 Arnold I. Caplan Biomatrix for tissue regeneration
US5707996A (en) * 1995-11-06 1998-01-13 Macleod Pharmaceuticals, Inc. Pharmaceutical solution and methods for preparation thereof
EP0906415B1 (en) * 1996-04-19 2009-08-19 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
US5827740A (en) * 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
DK1007631T4 (da) * 1997-07-14 2009-04-27 Osiris Therapeutics Inc Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller
US6251295B1 (en) * 1998-01-08 2001-06-26 Nexell Therapeutics Inc. Method for recirculation washing of blood cells
US6328960B1 (en) 1998-03-18 2001-12-11 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
FR2787463B1 (fr) 1998-12-21 2001-03-30 Neurotech Preparation de cellules de mammifere eventuellement transfectees avec un gene codant pour une substance active et les compositions les contenant
JP2002325572A (ja) * 2000-12-25 2002-11-12 Univ Osaka 外来物質の導入方法
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
US8105580B2 (en) * 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US20050008626A1 (en) 2001-12-07 2005-01-13 Fraser John K. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US20050095228A1 (en) * 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
EP2305276A3 (en) * 2001-12-07 2011-09-21 Cytori Therapeutics, Inc. Processed lipoaspirate cells for use in therapy
US20050048036A1 (en) * 2001-12-07 2005-03-03 Hedrick Marc H. Methods of using regenerative cells in the treatment of inherited and acquired disorders of the bone, bone marrow, liver, and other tissues
US9597395B2 (en) * 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7585670B2 (en) * 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US7514075B2 (en) * 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
US8404229B2 (en) * 2001-12-07 2013-03-26 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to treat acute tubular necrosis
ZA200404101B (en) 2003-05-26 2005-03-07 Reliance Life Sciences Pvt Ltd In vitro culture of Mesenchymal Stem Cells (MSC) and a process for the preparation thereof for therapeutic use.
JP2007524396A (ja) 2003-06-25 2007-08-30 サイトリ セラピューティクス インコーポレイテッド 組織から再生細胞を分離して濃縮するためのシステム及び方法
JP2007530543A (ja) * 2004-03-22 2007-11-01 オシリス セラピューティクス，インコーポレイテッド 間葉幹細胞及びその使用法
JP3828905B2 (ja) * 2004-08-05 2006-10-04 株式会社Ｒ＆Ｄセルサイエンス・オプショナルメディコ 局所麻酔薬を含有する細胞凝集抑制剤
US8512724B2 (en) * 2005-06-10 2013-08-20 The Board Of Regents Of The University Of Texas System Antiseptic compositions
WO2008020815A1 (en) 2006-08-15 2008-02-21 Agency For Science, Technology And Research Mesenchymal stem cell conditioned medium
US20070128174A1 (en) 2005-09-21 2007-06-07 Kleinsek Donald A Methods and compositions for organ and tissue functionality
US7888119B2 (en) * 2005-10-14 2011-02-15 University Of Central Florida Research Foundation, Inc. Tissue substitutes comprising stem cells and reduced ceria
US20070253931A1 (en) * 2006-01-12 2007-11-01 Osiris Therapeutics, Inc. Use of mesenchymal stem cells for treating genetic diseases and disorders
WO2007089798A2 (en) * 2006-01-30 2007-08-09 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
US8679809B2 (en) 2006-05-19 2014-03-25 The University Of Hong Kong Cell-matrix microspheres, methods for preparation and applications
DE602007012290D1 (de) * 2006-11-03 2011-03-10 Aastrom Biosciences Inc Mischzell-populationen für die gewebereparatur und trenntechnik für die zellaufbereitung
JP2008139106A (ja) * 2006-11-30 2008-06-19 Sysmex Corp 骨髄穿刺液収容具及び骨髄穿刺液濾過方法
KR20090086260A (ko) 2006-12-07 2009-08-11 테바 파마슈티컬 인더스트리즈 리미티드 미손상 골수 또는 미손상 제대 조직으로부터 조직 전구체 세포 및 성숙 조직 세포를 형성 및 증식시키는 방법
US20110262402A1 (en) 2007-09-07 2011-10-27 Masahiko Kuroda Therapeutic and prophylactic agents for arthritis
US8465733B2 (en) 2007-11-02 2013-06-18 Jcr Pharmaceuticals Co., Ltd. Pharmaceutical composition containing human mesenchymal stem cell
ES2608974T3 (es) 2008-08-14 2017-04-17 Mesoblast International Sàrl Composiciones de células madre mesenquimales purificadas
US8217128B2 (en) 2008-09-04 2012-07-10 Amyris, Inc. Farnesene interpolymers

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