JP2011528897A5 - - Google Patents
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- Publication number
- JP2011528897A5 JP2011528897A5 JP2011519187A JP2011519187A JP2011528897A5 JP 2011528897 A5 JP2011528897 A5 JP 2011528897A5 JP 2011519187 A JP2011519187 A JP 2011519187A JP 2011519187 A JP2011519187 A JP 2011519187A JP 2011528897 A5 JP2011528897 A5 JP 2011528897A5
- Authority
- JP
- Japan
- Prior art keywords
- tuberculosis
- prevention
- treatment
- protein sequence
- rv1753c protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000008827 tuberculosis Diseases 0.000 claims 26
- 239000003814 drug Substances 0.000 claims 22
- 230000002265 prevention Effects 0.000 claims 22
- 101700026331 PPE24 Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 8
- 230000002163 immunogen Effects 0.000 claims 7
- 206010065048 Latent tuberculosis Diseases 0.000 claims 5
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 229920000023 polynucleotide Polymers 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 230000003111 delayed Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 230000002708 enhancing Effects 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (21)
- 以下のもの:
(i) Rv1753cタンパク質配列;
(ii) Rv1753cタンパク質配列の変異体; または
(iii) Rv1753cタンパク質配列の免疫原性断片
を含む単離されたポリペプチドを含む、結核の治療または予防のための医薬。 - 結核の治療または予防が、潜伏結核の治療である、請求項1に記載の医薬。
- 結核の治療または予防が、潜伏結核の予防である、請求項1に記載の医薬。
- 結核の治療または予防が、結核の再活性化の予防である、請求項1に記載の医薬。
- 結核の治療または予防が、結核の再活性化の遅延である、請求項1に記載の医薬。
- 結核の治療または予防が、結核の治療である、請求項1に記載の医薬。
- 結核の治療または予防が、結核の予防である、請求項1に記載の医薬。
- 以下のもの:
(i) Rv1753cタンパク質配列;
(ii) Rv1753cタンパク質配列の変異体; または
(iii) Rv1753cタンパク質配列の免疫原性断片
を含むポリペプチドをコードする核酸配列を含む単離されたポリヌクレオチドを含む、結核の治療または予防のための医薬。 - 結核の治療または予防が、潜伏結核の治療である、請求項8に記載の医薬。
- 結核の治療または予防が、潜伏結核の予防である、請求項8に記載の医薬。
- 結核の治療または予防が、結核の再活性化の予防である、請求項8に記載の医薬。
- 結核の治療または予防が、結核の再活性化の遅延である、請求項8に記載の医薬。
- 結核の治療または予防が、結核の治療である、請求項8に記載の医薬。
- 結核の治療または予防が、結核の予防である、請求項8に記載の医薬。
- 以下のもの:
(a) 以下のもの:
(i) Rv1753cタンパク質配列;
(ii) Rv1753cタンパク質配列の変異体; もしくは
(iii) Rv1753cタンパク質配列の免疫原性断片
を含むポリペプチド、または
(b) (a)のポリペプチドをコードする核酸配列を含むポリヌクレオチド; および
(c) 製薬的に許容される担体または賦形剤
を含む医薬組成物。 - 以下のもの:
(a) 以下のもの:
(i) Rv1753cタンパク質配列;
(ii) Rv1753cタンパク質配列の変異体; もしくは
(iii) Rv1753cタンパク質配列の免疫原性断片
を含むポリペプチド、または
(b) (a)のポリペプチドをコードする核酸配列を含むポリヌクレオチド; および
(c) 非特異的免疫応答エンハンサー
を含む免疫原性組成物。 - 医薬が、活動性結核を有する被験体用である、請求項1または8に記載の医薬。
- 医薬が、潜伏結核を有する被験体用である、請求項1または8に記載の医薬。
- 医薬が、結核を有さない被験体用である、請求項1または8に記載の医薬。
- 結核の治療または予防のための医薬の製造における、以下のもの:
(i) Rv1753cタンパク質配列;
(ii) Rv1753cタンパク質配列の変異体; または
(iii) Rv1753cタンパク質配列の免疫原性断片
を含むポリペプチドの、使用。 - 結核の治療または予防のための医薬の製造における、以下のもの:
(i) Rv1753cタンパク質配列;
(ii) Rv1753cタンパク質配列の変異体; または
(iii) Rv1753cタンパク質配列の免疫原性断片
を含むポリペプチドをコードする核酸配列を含むポリヌクレオチドの、使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8369208P | 2008-07-25 | 2008-07-25 | |
US61/083,692 | 2008-07-25 | ||
PCT/EP2009/059586 WO2010010180A1 (en) | 2008-07-25 | 2009-07-24 | Novel compositions and methods |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2011528897A JP2011528897A (ja) | 2011-12-01 |
JP2011528897A5 true JP2011528897A5 (ja) | 2012-09-06 |
JP5824360B2 JP5824360B2 (ja) | 2015-11-25 |
Family
ID=41172233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011519187A Active JP5824360B2 (ja) | 2008-07-25 | 2009-07-24 | 新規化合物および方法 |
Country Status (24)
Country | Link |
---|---|
US (2) | US9315556B2 (ja) |
EP (1) | EP2315597B1 (ja) |
JP (1) | JP5824360B2 (ja) |
KR (2) | KR20160013262A (ja) |
CN (2) | CN108059660A (ja) |
AU (1) | AU2009273133B2 (ja) |
BR (1) | BRPI0916705A2 (ja) |
CA (1) | CA2731549C (ja) |
CO (1) | CO6400198A2 (ja) |
CY (1) | CY1119737T1 (ja) |
EA (1) | EA022203B1 (ja) |
ES (1) | ES2647321T3 (ja) |
HR (1) | HRP20171694T1 (ja) |
HU (1) | HUE037121T2 (ja) |
IL (1) | IL210588A0 (ja) |
LT (1) | LT2315597T (ja) |
MX (1) | MX2011000981A (ja) |
NO (1) | NO2315597T3 (ja) |
PL (1) | PL2315597T3 (ja) |
PT (1) | PT2315597T (ja) |
SG (1) | SG10201505149WA (ja) |
SI (1) | SI2315597T1 (ja) |
UA (1) | UA107180C2 (ja) |
WO (1) | WO2010010180A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201100070A1 (ru) | 2008-07-25 | 2011-10-31 | Глаксо Груп Лимитед | Туберкулезный белок rv2386c, композиции и их применения |
GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
US20140349320A1 (en) * | 2011-12-15 | 2014-11-27 | The Trustees Of The University Of Pennsylvania | Using Adaptive Immunity to Detect Drug Resistance |
CN103467582A (zh) * | 2012-06-08 | 2013-12-25 | 同济大学 | 结核杆菌重要抗原的高通量筛选及其在结核病诊断中的应用 |
GB201405921D0 (en) * | 2014-04-02 | 2014-05-14 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
CN110035770B (zh) | 2016-12-07 | 2023-06-16 | 葛兰素史密丝克莱恩生物有限公司 | 新方法 |
GB201621686D0 (en) | 2016-12-20 | 2017-02-01 | Glaxosmithkline Biologicals Sa | Novel methods for inducing an immune response |
GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
IE87414B1 (en) | 2017-05-30 | 2023-07-19 | Glaxosmithkline Biologicals Sa | Novel methods for manufacturing an adjuvant |
EP3717001A1 (en) | 2017-12-01 | 2020-10-07 | GlaxoSmithKline Biologicals S.A. | Saponin purification |
US20220218811A1 (en) * | 2019-04-17 | 2022-07-14 | Codiak Biosciences, Inc. | Methods of treating tuberculosis |
CN114080393A (zh) | 2019-06-05 | 2022-02-22 | 葛兰素史克生物有限公司 | 皂苷纯化 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4016146A (en) * | 1974-12-10 | 1977-04-05 | Biological Developments, Inc. | Phenethylamine antigenic conjugates, their preparation, antibodies, and use |
PT761231E (pt) * | 1992-06-25 | 2000-06-30 | Smithkline Beecham Biolog | Composicao de vacina contendo adjuvantes |
US6592877B1 (en) | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
US6613881B1 (en) | 1997-05-20 | 2003-09-02 | Corixa Corporation | Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use |
AU753995B2 (en) | 1998-04-07 | 2002-10-31 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
US6291013B1 (en) * | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
AU7383500A (en) | 1999-09-17 | 2001-04-17 | United States Government, As Represented By The Department Of Veteran's Affairs | Virulence genes of m. marinum and m. tuberculosis |
WO2001024820A1 (en) | 1999-10-07 | 2001-04-12 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
WO2001062893A2 (en) | 2000-02-25 | 2001-08-30 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
ATE526994T1 (de) | 2000-06-20 | 2011-10-15 | Corixa Corp | Mtb32a antigen aus mycobakterium tuberculosis mit inaktivierter protease aktivität und fusionsproteine die das antigen enthalten |
CN1277843C (zh) | 2001-02-22 | 2006-10-04 | 巴斯德研究院 | 分枝杆菌比较基因组学作为鉴定分枝杆菌病的诊断、预防或治疗靶的工具 |
AU2003213118A1 (en) | 2002-02-15 | 2003-09-09 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
US20030236393A1 (en) | 2002-03-22 | 2003-12-25 | United States Of America Dept Of Vetrans Affairs | Virulence genes of M. marinum and M. tuberculosis |
US7424370B2 (en) * | 2004-02-06 | 2008-09-09 | Council Of Scientific And Industrial Research | Computational method for identifying adhesin and adhesin-like proteins of therapeutic potential |
PL2426141T3 (pl) * | 2005-04-29 | 2015-02-27 | Glaxosmithkline Biologicals Sa | Sposób profilaktyki lub leczenia zakażenia m. tuberculosis |
WO2008007942A1 (en) | 2006-07-10 | 2008-01-17 | Het Nederlands Kanker Instituut | Means and methods for manipulating sequential phagolysomal-cytosolic translocation of mycobacteria, and uses thereof |
CL2008000611A1 (es) * | 2007-03-02 | 2008-09-05 | Glaxosmithkline Biolog Sa | Procedimiento para fomentar respuesta inmunitaria frente a un patogeno que comprende administrar i) uno o mas polipeptidos inmunogenicos derivados del patogeno, ii) uno o mas vectores adenoviricos que comprenden uno o mas polinucleotidos que codifica |
ES2602430T3 (es) | 2008-07-25 | 2017-02-21 | Glaxosmithkline Biologicals S.A. | Polipéptidos, polinucleótidos y composiciones para uso en el tratamiento de tuberculosis latente |
EA201100070A1 (ru) * | 2008-07-25 | 2011-10-31 | Глаксо Груп Лимитед | Туберкулезный белок rv2386c, композиции и их применения |
WO2010010178A1 (en) | 2008-07-25 | 2010-01-28 | Glaxosmithkline Biologicals S.A | The tuberculosis rv2707c protein, compositions and uses thereof |
MX370744B (es) | 2009-04-24 | 2019-12-20 | Una vacuna antituberculosis tb para evitar la reactivación. | |
US8367055B2 (en) | 2009-05-14 | 2013-02-05 | Wisconsin Alumni Research Foundation | Immunogenic compositions against tuberculosis |
SI2528621T1 (sl) | 2010-01-27 | 2017-01-31 | Glaxosmithkline Biologicals S.A., | Modificirani tuberkolozni antigeni |
-
2009
- 2009-07-24 AU AU2009273133A patent/AU2009273133B2/en not_active Ceased
- 2009-07-24 EP EP09781058.4A patent/EP2315597B1/en active Active
- 2009-07-24 KR KR1020167001375A patent/KR20160013262A/ko not_active Application Discontinuation
- 2009-07-24 JP JP2011519187A patent/JP5824360B2/ja active Active
- 2009-07-24 CN CN201711306994.XA patent/CN108059660A/zh active Pending
- 2009-07-24 UA UAA201100362A patent/UA107180C2/uk unknown
- 2009-07-24 KR KR1020117004475A patent/KR20110060891A/ko not_active Application Discontinuation
- 2009-07-24 WO PCT/EP2009/059586 patent/WO2010010180A1/en active Application Filing
- 2009-07-24 NO NO09781058A patent/NO2315597T3/no unknown
- 2009-07-24 BR BRPI0916705A patent/BRPI0916705A2/pt not_active Application Discontinuation
- 2009-07-24 CN CN200980138416.7A patent/CN102164612B/zh active Active
- 2009-07-24 ES ES09781058.4T patent/ES2647321T3/es active Active
- 2009-07-24 LT LTEP09781058.4T patent/LT2315597T/lt unknown
- 2009-07-24 PL PL09781058T patent/PL2315597T3/pl unknown
- 2009-07-24 EA EA201100071A patent/EA022203B1/ru not_active IP Right Cessation
- 2009-07-24 SG SG10201505149WA patent/SG10201505149WA/en unknown
- 2009-07-24 PT PT97810584T patent/PT2315597T/pt unknown
- 2009-07-24 MX MX2011000981A patent/MX2011000981A/es active IP Right Grant
- 2009-07-24 HU HUE09781058A patent/HUE037121T2/hu unknown
- 2009-07-24 SI SI200931748T patent/SI2315597T1/sl unknown
- 2009-07-24 CA CA2731549A patent/CA2731549C/en active Active
- 2009-07-24 US US13/055,775 patent/US9315556B2/en active Active
-
2011
- 2011-01-12 IL IL210588A patent/IL210588A0/en unknown
- 2011-01-27 CO CO11009236A patent/CO6400198A2/es not_active Application Discontinuation
-
2016
- 2016-03-11 US US15/067,469 patent/US9750794B2/en active Active
-
2017
- 2017-11-06 HR HRP20171694TT patent/HRP20171694T1/hr unknown
- 2017-11-13 CY CY20171101185T patent/CY1119737T1/el unknown
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