JP2017075173A5 - - Google Patents
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- Publication number
- JP2017075173A5 JP2017075173A5 JP2016249232A JP2016249232A JP2017075173A5 JP 2017075173 A5 JP2017075173 A5 JP 2017075173A5 JP 2016249232 A JP2016249232 A JP 2016249232A JP 2016249232 A JP2016249232 A JP 2016249232A JP 2017075173 A5 JP2017075173 A5 JP 2017075173A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- amyloidosis
- condition associated
- pathological condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010002022 amyloidosis Diseases 0.000 claims 5
- 230000001575 pathological effect Effects 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000007505 plaque formation Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 0 *C(C1*)[C@](*)C(*)C(*)[C@]1O Chemical compound *C(C1*)[C@](*)C(*)C(*)[C@]1O 0.000 description 14
- PXKXMLOHKWCCGD-XNIMQTFVSA-N O[C@@H](C(C(C(OCc1ccccc1)=C1OCc2ccccc2)OCc2ccccc2)OCc2ccccc2)C1O Chemical compound O[C@@H](C(C(C(OCc1ccccc1)=C1OCc2ccccc2)OCc2ccccc2)OCc2ccccc2)C1O PXKXMLOHKWCCGD-XNIMQTFVSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3857108P | 2008-03-21 | 2008-03-21 | |
| US61/038,571 | 2008-03-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014046341A Division JP6140090B2 (ja) | 2008-03-21 | 2014-03-10 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017075173A JP2017075173A (ja) | 2017-04-20 |
| JP2017075173A5 true JP2017075173A5 (OSRAM) | 2017-11-24 |
| JP6370361B2 JP6370361B2 (ja) | 2018-08-08 |
Family
ID=41091569
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501009A Expired - Fee Related JP5501339B2 (ja) | 2008-03-21 | 2009-03-23 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
| JP2014046341A Expired - Fee Related JP6140090B2 (ja) | 2008-03-21 | 2014-03-10 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
| JP2016249232A Expired - Fee Related JP6370361B2 (ja) | 2008-03-21 | 2016-12-22 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501009A Expired - Fee Related JP5501339B2 (ja) | 2008-03-21 | 2009-03-23 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
| JP2014046341A Expired - Fee Related JP6140090B2 (ja) | 2008-03-21 | 2014-03-10 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US8450466B2 (OSRAM) |
| EP (2) | EP3231804B1 (OSRAM) |
| JP (3) | JP5501339B2 (OSRAM) |
| CN (2) | CN104974024B (OSRAM) |
| AU (1) | AU2009225407B2 (OSRAM) |
| CA (2) | CA2978149C (OSRAM) |
| MX (2) | MX2010010314A (OSRAM) |
| WO (1) | WO2009117728A2 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| EP3231804B1 (en) * | 2008-03-21 | 2021-03-03 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| EP2605694B1 (en) * | 2010-08-16 | 2021-10-27 | Cognoptix, Inc. | Method for detecting amyloid proteins |
| WO2012099904A1 (en) * | 2011-01-18 | 2012-07-26 | General Atomics | Hydrolase enzyme substrates and uses thereof |
| CN109846862A (zh) | 2012-10-25 | 2019-06-07 | 通用医疗公司 | 治疗阿尔茨海默病及相关疾病的组合疗法 |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| EP3060205A4 (en) | 2013-10-22 | 2017-06-28 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| EP3119761B1 (en) | 2014-03-19 | 2023-06-07 | Amydis Diagnostics, Inc. | Amyloid targeting agents and methods of using the same |
| WO2018045217A1 (en) | 2016-08-31 | 2018-03-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| US10675365B2 (en) | 2016-09-29 | 2020-06-09 | Korea Atomic Energy Research Institute | Curcumin derivative, method for producing same, and photo-acoustic imaging agent comprising same for detecting beta-amyloid plaque |
| EP3654946A4 (en) | 2017-07-20 | 2021-04-21 | AZTherapies, Inc. | CROMOLYNE SODIUM AND IBUPROFEN POWDER FORMULATIONS |
| US12478693B2 (en) | 2018-05-31 | 2025-11-25 | Amydis, Inc. | Compositions and methods for detection of traumatic brain injury |
| CN113038944A (zh) | 2018-07-02 | 2021-06-25 | 通用医疗公司 | 色甘酸钠和α-乳糖的粉末化制剂 |
| JP2021534196A (ja) | 2018-08-23 | 2021-12-09 | シージェン インコーポレイテッド | 抗ｔｉｇｉｔ抗体 |
| MX2021006869A (es) | 2018-12-10 | 2021-07-02 | Massachusetts Gen Hospital | Esteres de cromolin y usos de los mismos. |
| WO2021207060A1 (en) | 2020-04-06 | 2021-10-14 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
| US20230364119A1 (en) * | 2020-09-17 | 2023-11-16 | Resonac Corporation | Autophagy activator |
| JP2025504589A (ja) * | 2022-02-07 | 2025-02-12 | モスコヴィッツ、マーティン・ジェイ | 凍結手術装置及びその材料、ならびにその使用方法 |
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| US3207780A (en) * | 1962-11-15 | 1965-09-21 | Upjohn Co | 1-deoxy-1-guanidino-3-o-carbamoyl-scyllo-inositol and acylates thereof |
| US4069262A (en) | 1977-03-07 | 1978-01-17 | E. I. Du Pont De Nemours And Company | Preparation of 2-fluoronitrobenzene |
| FR2498594A1 (fr) | 1981-01-23 | 1982-07-30 | Rhone Poulenc Ind | Procede de preparation de monoesters d'acides carboxyliques b,g-insatures |
| US4446123A (en) | 1982-10-13 | 1984-05-01 | Hahnemann University | Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations |
| BE900003A (fr) * | 1983-06-27 | 1984-12-27 | Sandoz Sa | Derives du spirosuccinimide utilisables comme medicaments. |
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| US5315043A (en) | 1992-02-05 | 1994-05-24 | E. I. Du Pont De Nemours And Company | Aromatic nucleophilic fluorination |
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| DE19624705A1 (de) * | 1996-06-20 | 1998-01-08 | Deutsches Krebsforsch | Dendrimere auf Saccharid-Basis |
| US5817877A (en) | 1996-09-23 | 1998-10-06 | Yale University | Metal-catalyzed amination of organic sulfonates to organic amines |
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| AU7723198A (en) | 1997-06-04 | 1998-12-21 | University Of Tennessee Research Corporation, The | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
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| JP4177472B2 (ja) * | 1997-10-02 | 2008-11-05 | 株式会社横浜国際バイオ研究所 | 窒素官能基を含有するアシル化剤及びその製造法 |
| US6660832B1 (en) | 1999-08-20 | 2003-12-09 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds and preparation methods thereof |
| CA2384879C (en) | 1999-09-13 | 2010-11-30 | Pola Chemical Industries, Inc. | Nitroimidazole derivative and diagnostic imaging agent containing the same |
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| UY27003A1 (es) | 2000-11-06 | 2002-07-31 | Schering Ag | Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer |
| JP4317955B2 (ja) | 2001-04-23 | 2009-08-19 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | アミロイド斑凝集阻害剤および診断用造影剤 |
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| US20080063599A1 (en) | 2002-11-18 | 2008-03-13 | Jorge Setoain Quinquer | Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils |
| CN101385722A (zh) * | 2003-02-27 | 2009-03-18 | 乔安妮·麦克劳林 | 预防、治疗和诊断蛋白聚集疾病的方法 |
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| EP1807119A2 (en) * | 2004-11-05 | 2007-07-18 | Wyeth a Corporation of the State of Delaware | Pet and magnetic resonance for screening alzheimer's disease therapeutics |
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| US20070197452A1 (en) * | 2006-02-17 | 2007-08-23 | Mclaurin Joanne | Treatment of amyloid-related diseases |
| EP2146753A2 (en) | 2007-03-01 | 2010-01-27 | Bayer Schering Pharma Aktiengesellschaft | 18f fluoro-benzoyl labelled biological active compounds as diagnostic imaging agents as well as benzotriazol-1-yloxy-benzoyl , 2,5-dioxo-pyrrolidin-1-yloxy)benzoyl and trimethylammonio-benzoyl precursers thereof |
| WO2009014203A1 (ja) * | 2007-07-26 | 2009-01-29 | Hokko Chemical Industry Co., Ltd. | （１，３，５／２，４，６）－１－フルオロ－２，３，４，５，６－シクロヘキサンペントールの製造方法 |
| EP3231804B1 (en) | 2008-03-21 | 2021-03-03 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders |
| KR20110106895A (ko) | 2008-12-22 | 2011-09-29 | 바이엘 파마 악티엔게젤샤프트 | 교환 수지를 사용하여 방사성핵종-표지된 화합물을 합성하는 방법 |
| GB201216017D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
| WO2014052454A1 (en) | 2012-09-25 | 2014-04-03 | The Regents Of The University Of Michigan | Imaging agents |
| WO2016070074A1 (en) | 2014-10-31 | 2016-05-06 | The General Hospital Corporation | F-18 labeled tracer and methods of manufacture |
-
2009
- 2009-03-23 EP EP17152886.2A patent/EP3231804B1/en active Active
- 2009-03-23 MX MX2010010314A patent/MX2010010314A/es active IP Right Grant
- 2009-03-23 CA CA2978149A patent/CA2978149C/en active Active
- 2009-03-23 MX MX2013012279A patent/MX375108B/es unknown
- 2009-03-23 AU AU2009225407A patent/AU2009225407B2/en not_active Ceased
- 2009-03-23 CN CN201510221345.4A patent/CN104974024B/zh not_active Expired - Fee Related
- 2009-03-23 JP JP2011501009A patent/JP5501339B2/ja not_active Expired - Fee Related
- 2009-03-23 WO PCT/US2009/037928 patent/WO2009117728A2/en not_active Ceased
- 2009-03-23 US US12/933,139 patent/US8450466B2/en not_active Expired - Fee Related
- 2009-03-23 CN CN200980119032.0A patent/CN102046638B/zh not_active Expired - Fee Related
- 2009-03-23 CA CA2718035A patent/CA2718035C/en active Active
- 2009-03-23 EP EP09723502.2A patent/EP2268647B1/en active Active
-
2013
- 2013-05-28 US US13/903,362 patent/US9005578B2/en active Active
-
2014
- 2014-03-10 JP JP2014046341A patent/JP6140090B2/ja not_active Expired - Fee Related
- 2014-12-15 US US14/569,855 patent/US20150098903A1/en not_active Abandoned
-
2016
- 2016-12-22 JP JP2016249232A patent/JP6370361B2/ja not_active Expired - Fee Related
-
2019
- 2019-08-29 US US16/555,290 patent/US10857247B2/en not_active Expired - Fee Related
-
2020
- 2020-12-08 US US17/115,344 patent/US20210338849A1/en not_active Abandoned
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