JP2017060462A5 - - Google Patents

Download PDF

Info

Publication number
JP2017060462A5
JP2017060462A5 JP2016155028A JP2016155028A JP2017060462A5 JP 2017060462 A5 JP2017060462 A5 JP 2017060462A5 JP 2016155028 A JP2016155028 A JP 2016155028A JP 2016155028 A JP2016155028 A JP 2016155028A JP 2017060462 A5 JP2017060462 A5 JP 2017060462A5
Authority
JP
Japan
Prior art keywords
sirp
variant
cancer
construct according
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016155028A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017060462A (ja
JP6901834B2 (ja
Filing date
Publication date
Priority claimed from TW104125902A external-priority patent/TWI702228B/zh
Application filed filed Critical
Publication of JP2017060462A publication Critical patent/JP2017060462A/ja
Publication of JP2017060462A5 publication Critical patent/JP2017060462A5/ja
Priority to JP2021101516A priority Critical patent/JP2021166521A/ja
Application granted granted Critical
Publication of JP6901834B2 publication Critical patent/JP6901834B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016155028A 2015-08-07 2016-08-05 Sirp−アルファ変異体構築物及びその使用 Active JP6901834B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021101516A JP2021166521A (ja) 2015-08-07 2021-06-18 Sirp−アルファ変異体構築物及びその使用

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201562202775P 2015-08-07 2015-08-07
US201562202772P 2015-08-07 2015-08-07
US201562202779P 2015-08-07 2015-08-07
US62/202,772 2015-08-07
US62/202,775 2015-08-07
US62/202,779 2015-08-07
TW104125902 2015-08-10
TW104125902A TWI702228B (zh) 2014-08-08 2015-08-10 信號調節蛋白α(signal-regulatory protein α, SIRP-α)變體構築物及其用途
US14/971,931 2015-12-16
US14/971,931 US20160319256A9 (en) 2014-08-08 2015-12-16 Sirp-alpha variant constructs and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021101516A Division JP2021166521A (ja) 2015-08-07 2021-06-18 Sirp−アルファ変異体構築物及びその使用

Publications (3)

Publication Number Publication Date
JP2017060462A JP2017060462A (ja) 2017-03-30
JP2017060462A5 true JP2017060462A5 (enExample) 2019-09-12
JP6901834B2 JP6901834B2 (ja) 2021-07-14

Family

ID=57624246

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016155028A Active JP6901834B2 (ja) 2015-08-07 2016-08-05 Sirp−アルファ変異体構築物及びその使用
JP2021101516A Pending JP2021166521A (ja) 2015-08-07 2021-06-18 Sirp−アルファ変異体構築物及びその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021101516A Pending JP2021166521A (ja) 2015-08-07 2021-06-18 Sirp−アルファ変異体構築物及びその使用

Country Status (24)

Country Link
EP (2) EP3913050A1 (enExample)
JP (2) JP6901834B2 (enExample)
KR (1) KR102675219B1 (enExample)
AU (2) AU2016210755B2 (enExample)
BR (1) BR102016018074A2 (enExample)
CO (1) CO2016000671A1 (enExample)
CY (1) CY1124272T1 (enExample)
DK (1) DK3128005T3 (enExample)
EA (1) EA034582B1 (enExample)
ES (1) ES2872528T3 (enExample)
HR (1) HRP20211079T1 (enExample)
HU (1) HUE055605T2 (enExample)
IL (2) IL247114B (enExample)
LT (1) LT3128005T (enExample)
MX (2) MX377080B (enExample)
NZ (1) NZ722947A (enExample)
PH (1) PH12016000277A1 (enExample)
PL (1) PL3128005T3 (enExample)
PT (1) PT3128005T (enExample)
RS (1) RS62150B1 (enExample)
SG (2) SG10201606520SA (enExample)
SI (1) SI3128005T1 (enExample)
SM (1) SMT202100400T1 (enExample)
ZA (2) ZA201605435B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20220230T1 (hr) 2017-01-05 2022-04-29 Kahr Medical Ltd. Sirp1 alfa-41bbl fuzijski protein i metoda njegove upotrebe
KR102233993B1 (ko) * 2017-07-24 2021-03-31 한국과학기술원 면역 회피성 박테리오파지
US20210040219A1 (en) * 2018-03-13 2021-02-11 Trillium Therapeutics Inc. Improvements in cd47 blockade therapy by egfr antibody
SG11202013170RA (en) 2018-07-11 2021-01-28 Kahr Medical Ltd Pd1-4-1bbl variant fusion protein and methods of use thereof
SG11202013167UA (en) 2018-07-11 2021-01-28 Kahr Medical Ltd SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF
MA53493A (fr) * 2018-08-31 2021-07-07 Alx Oncology Inc Polypeptides leurres
CN109535263B (zh) * 2018-12-04 2022-06-17 江苏东抗生物医药科技有限公司 SIRPα突变体及其融合蛋白
CN111763261B (zh) * 2019-04-02 2022-08-09 杭州尚健生物技术有限公司 一种融合蛋白及其用途
CN115551892A (zh) * 2020-03-26 2022-12-30 艾提欧生物疗法有限公司 用于耗竭调节性t细胞的双特异性融合蛋白
CN114057888A (zh) * 2020-07-30 2022-02-18 三生国健药业(上海)股份有限公司 一种SIRPα-Fc融合蛋白
JP2024520902A (ja) 2021-05-13 2024-05-27 エーエルエックス オンコロジー インコーポレイテッド がんを治療するための併用療法
CN116178561B (zh) * 2021-11-26 2025-07-18 杭州尚健生物技术有限公司 包含SIRPα突变体的融合蛋白
AU2022421675A1 (en) 2021-12-21 2024-05-02 Fbd Biologics Limited ENGINEERED SIRPα VARIANTS AND METHODS OF USE THEREOF

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
FI101678B1 (fi) 1990-12-31 1998-08-14 Akzo Nv Happolabiileja kytkentämolekyylejä
CA2110899C (en) 1991-06-21 2006-08-08 Jacob G. Michael Orally administrable therapeutic proteins and method of making
US6613332B1 (en) 1991-06-21 2003-09-02 The University Of Cincinnati Oral administration of therapeutic proteins
IL99120A0 (en) 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
WO1993006217A1 (en) 1991-09-19 1993-04-01 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
US5505931A (en) 1993-03-04 1996-04-09 The Dow Chemical Company Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
JPH11510050A (ja) 1995-07-25 1999-09-07 イントロヘーネ ベスローテン フェンノートシャップ 標的遺伝子送達のための方法および手段
CA2246332C (en) 1996-02-15 2009-04-14 Biosense, Inc. Catheter based surgery
EP0920339A2 (en) 1996-07-09 1999-06-09 The Johns Hopkins University Gene delivery system
US6613026B1 (en) 1999-12-08 2003-09-02 Scimed Life Systems, Inc. Lateral needle-less injection apparatus and method
US7662367B2 (en) 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
TWI334439B (en) 2001-08-01 2010-12-11 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
EP3299393A1 (en) 2002-11-08 2018-03-28 Ablynx N.V. Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
US7892558B2 (en) 2004-02-27 2011-02-22 Vaxconsulting Isolated TNF-alpha peptide and pharmaceutical composition thereof
US8518869B2 (en) 2004-03-29 2013-08-27 Austria Wirtschaftsservice Gesellschaft M.B.H. Pharmaceutical combined preparation containing a therapeutic protein
US8377448B2 (en) * 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
PT2235064E (pt) 2008-01-07 2016-03-01 Amgen Inc Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática
CA2747678A1 (en) * 2008-12-19 2010-06-24 Novartis Ag Soluble polypeptides for use in treating autoimmune and inflammatory disorders
WO2010081173A2 (en) 2009-01-12 2010-07-15 Cytomx Therapeutics, Llc Modified antibody compositions, methods of making and using thereof
AU2010215761B2 (en) 2009-02-23 2017-04-06 Cytomx Therapeutics, Inc Proproteins and methods of use thereof
MX2012000895A (es) * 2009-07-20 2012-06-01 Univ Nat Cheng Kung Polipeptidos selectivos para integrina alfavbeta3 conjugada con una variante de albumina de suero humana (hsa) y usos farmaceuticos de los mismos.
KR101632312B1 (ko) 2009-11-03 2016-06-21 삼성전자주식회사 항체 불변 영역에 특이적으로 결합하는 융합 단백질, 그의 제조 방법 및 이를 이용한 항체 분리 방법
AU2010334974A1 (en) * 2009-12-22 2012-07-12 Novartis Ag Tetravalent CD47-antibody constant region fusion protein for use in therapy
EP2624868B1 (en) * 2010-10-08 2018-09-26 City of Hope A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use
US8609621B2 (en) 2010-11-15 2013-12-17 E I Du Pont De Nemours And Company Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
US9566347B2 (en) * 2011-02-07 2017-02-14 The Trustees Of The University Of Pennsylvania Peptides and methods using same
WO2012172521A1 (en) * 2011-06-16 2012-12-20 Novartis Ag Soluble proteins for use as therapeutics
WO2013063076A1 (en) * 2011-10-25 2013-05-02 Indiana University Research & Technology Corporation Compositions for and methods of modulating complications, risks and issues with xenotransplantation
EP3766511A1 (en) * 2012-01-17 2021-01-20 The Board of Trustees of the Leland Stanford Junior University High affinity sirp-alpha reagents
US9428553B2 (en) * 2012-02-10 2016-08-30 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
CA2876904C (en) * 2012-06-22 2019-12-03 Cytomx Therapeutics, Inc. Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
JP6335189B2 (ja) * 2012-12-17 2018-05-30 トリリアム・セラピューティクス・インコーポレイテッドTrillium Therapeutics Inc. SIRPアルファ−Fc融合体でのCD47+疾患細胞の治療
US9873747B2 (en) * 2013-01-31 2018-01-23 Thomas Jefferson University Fusion proteins that facilitate cancer cell destruction
CN106459153B (zh) * 2014-01-31 2021-12-21 西托姆克斯治疗公司 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法
CN113621075B (zh) * 2014-08-08 2024-09-20 Alx肿瘤生物技术公司 SIRP-α变体构建体及其用途

Similar Documents

Publication Publication Date Title
JP2017060462A5 (enExample)
JP7457764B2 (ja) ヘテロ二量体多重特異性抗体フォーマット
AU2021215151B2 (en) SIRP-alpha variant constructs and uses thereof
US10047163B2 (en) Multispecific constructs
EP1605058B1 (en) Method of screening light chain of antibody light chains
TW201625674A (zh) 信號調節蛋白α(signal-regulatory protein α, SIRP-α)變體構築物及其用途
CN116888155A (zh) Ror1特异性变体抗原结合分子
AU2022206577A9 (en) Heterotandem bicyclic peptide complexes
Stone et al. The assembly of single domain antibodies into bispecific decavalent molecules
JP2019525897A (ja) リジン結合体化免疫グロブリン
CN117043184A (zh) 抗人血清白蛋白(hsa)的纳米抗体及其应用
CN113831411A (zh) 针对l1cam的单域抗体及其衍生蛋白和应用
Wang et al. Novel anti-LY6G6D/CD3 T-cell–dependent bispecific antibody for the treatment of colorectal cancer
WO2024193635A1 (en) Sirp variants and uses thereof
CN116063512B (zh) 多功能重组抗体及其制备方法和应用
AU2023332193A1 (en) Reciprocally masked antibody-cytokine fusion proteins and methods of use thereof
AU2023334288A1 (en) Biepitopic tetravalent antibody targeting egfr
KR20250126789A (ko) Alpp-특이적 변이 항원 결합 분자
CA3191859A1 (en) Nkp30 binders
RU2021112298A (ru) Полученные путем рационального дизайна новые белковые композиции