JP2017060462A5 - - Google Patents
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- JP2017060462A5 JP2017060462A5 JP2016155028A JP2016155028A JP2017060462A5 JP 2017060462 A5 JP2017060462 A5 JP 2017060462A5 JP 2016155028 A JP2016155028 A JP 2016155028A JP 2016155028 A JP2016155028 A JP 2016155028A JP 2017060462 A5 JP2017060462 A5 JP 2017060462A5
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- sirp
- variant
- cancer
- construct according
- alpha
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Priority Applications (1)
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| JP2021101516A JP2021166521A (ja) | 2015-08-07 | 2021-06-18 | Sirp−アルファ変異体構築物及びその使用 |
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| US201562202775P | 2015-08-07 | 2015-08-07 | |
| US201562202772P | 2015-08-07 | 2015-08-07 | |
| US201562202779P | 2015-08-07 | 2015-08-07 | |
| US62/202,772 | 2015-08-07 | ||
| US62/202,775 | 2015-08-07 | ||
| US62/202,779 | 2015-08-07 | ||
| TW104125902 | 2015-08-10 | ||
| TW104125902A TWI702228B (zh) | 2014-08-08 | 2015-08-10 | 信號調節蛋白α(signal-regulatory protein α, SIRP-α)變體構築物及其用途 |
| US14/971,931 | 2015-12-16 | ||
| US14/971,931 US20160319256A9 (en) | 2014-08-08 | 2015-12-16 | Sirp-alpha variant constructs and uses thereof |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2021101516A Division JP2021166521A (ja) | 2015-08-07 | 2021-06-18 | Sirp−アルファ変異体構築物及びその使用 |
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| Publication Number | Publication Date |
|---|---|
| JP2017060462A JP2017060462A (ja) | 2017-03-30 |
| JP2017060462A5 true JP2017060462A5 (enExample) | 2019-09-12 |
| JP6901834B2 JP6901834B2 (ja) | 2021-07-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2021101516A Pending JP2021166521A (ja) | 2015-08-07 | 2021-06-18 | Sirp−アルファ変異体構築物及びその使用 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2021101516A Pending JP2021166521A (ja) | 2015-08-07 | 2021-06-18 | Sirp−アルファ変異体構築物及びその使用 |
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| CO (1) | CO2016000671A1 (enExample) |
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| LT (1) | LT3128005T (enExample) |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20220230T1 (hr) | 2017-01-05 | 2022-04-29 | Kahr Medical Ltd. | Sirp1 alfa-41bbl fuzijski protein i metoda njegove upotrebe |
| KR102233993B1 (ko) * | 2017-07-24 | 2021-03-31 | 한국과학기술원 | 면역 회피성 박테리오파지 |
| US20210040219A1 (en) * | 2018-03-13 | 2021-02-11 | Trillium Therapeutics Inc. | Improvements in cd47 blockade therapy by egfr antibody |
| SG11202013170RA (en) | 2018-07-11 | 2021-01-28 | Kahr Medical Ltd | Pd1-4-1bbl variant fusion protein and methods of use thereof |
| SG11202013167UA (en) | 2018-07-11 | 2021-01-28 | Kahr Medical Ltd | SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF |
| MA53493A (fr) * | 2018-08-31 | 2021-07-07 | Alx Oncology Inc | Polypeptides leurres |
| CN109535263B (zh) * | 2018-12-04 | 2022-06-17 | 江苏东抗生物医药科技有限公司 | SIRPα突变体及其融合蛋白 |
| CN111763261B (zh) * | 2019-04-02 | 2022-08-09 | 杭州尚健生物技术有限公司 | 一种融合蛋白及其用途 |
| CN115551892A (zh) * | 2020-03-26 | 2022-12-30 | 艾提欧生物疗法有限公司 | 用于耗竭调节性t细胞的双特异性融合蛋白 |
| CN114057888A (zh) * | 2020-07-30 | 2022-02-18 | 三生国健药业(上海)股份有限公司 | 一种SIRPα-Fc融合蛋白 |
| JP2024520902A (ja) | 2021-05-13 | 2024-05-27 | エーエルエックス オンコロジー インコーポレイテッド | がんを治療するための併用療法 |
| CN116178561B (zh) * | 2021-11-26 | 2025-07-18 | 杭州尚健生物技术有限公司 | 包含SIRPα突变体的融合蛋白 |
| AU2022421675A1 (en) | 2021-12-21 | 2024-05-02 | Fbd Biologics Limited | ENGINEERED SIRPα VARIANTS AND METHODS OF USE THEREOF |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
| FI101678B1 (fi) | 1990-12-31 | 1998-08-14 | Akzo Nv | Happolabiileja kytkentämolekyylejä |
| CA2110899C (en) | 1991-06-21 | 2006-08-08 | Jacob G. Michael | Orally administrable therapeutic proteins and method of making |
| US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
| IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
| WO1993006217A1 (en) | 1991-09-19 | 1993-04-01 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES |
| US5505931A (en) | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| JPH11510050A (ja) | 1995-07-25 | 1999-09-07 | イントロヘーネ ベスローテン フェンノートシャップ | 標的遺伝子送達のための方法および手段 |
| CA2246332C (en) | 1996-02-15 | 2009-04-14 | Biosense, Inc. | Catheter based surgery |
| EP0920339A2 (en) | 1996-07-09 | 1999-06-09 | The Johns Hopkins University | Gene delivery system |
| US6613026B1 (en) | 1999-12-08 | 2003-09-02 | Scimed Life Systems, Inc. | Lateral needle-less injection apparatus and method |
| US7662367B2 (en) | 2000-03-02 | 2010-02-16 | Xencor, Inc. | Pharmaceutical compositions for the treatment of TNF-α related disorders |
| TWI334439B (en) | 2001-08-01 | 2010-12-11 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
| EP3299393A1 (en) | 2002-11-08 | 2018-03-28 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| US7892558B2 (en) | 2004-02-27 | 2011-02-22 | Vaxconsulting | Isolated TNF-alpha peptide and pharmaceutical composition thereof |
| US8518869B2 (en) | 2004-03-29 | 2013-08-27 | Austria Wirtschaftsservice Gesellschaft M.B.H. | Pharmaceutical combined preparation containing a therapeutic protein |
| US8377448B2 (en) * | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
| PT2235064E (pt) | 2008-01-07 | 2016-03-01 | Amgen Inc | Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática |
| CA2747678A1 (en) * | 2008-12-19 | 2010-06-24 | Novartis Ag | Soluble polypeptides for use in treating autoimmune and inflammatory disorders |
| WO2010081173A2 (en) | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| AU2010215761B2 (en) | 2009-02-23 | 2017-04-06 | Cytomx Therapeutics, Inc | Proproteins and methods of use thereof |
| MX2012000895A (es) * | 2009-07-20 | 2012-06-01 | Univ Nat Cheng Kung | Polipeptidos selectivos para integrina alfavbeta3 conjugada con una variante de albumina de suero humana (hsa) y usos farmaceuticos de los mismos. |
| KR101632312B1 (ko) | 2009-11-03 | 2016-06-21 | 삼성전자주식회사 | 항체 불변 영역에 특이적으로 결합하는 융합 단백질, 그의 제조 방법 및 이를 이용한 항체 분리 방법 |
| AU2010334974A1 (en) * | 2009-12-22 | 2012-07-12 | Novartis Ag | Tetravalent CD47-antibody constant region fusion protein for use in therapy |
| EP2624868B1 (en) * | 2010-10-08 | 2018-09-26 | City of Hope | A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use |
| US8609621B2 (en) | 2010-11-15 | 2013-12-17 | E I Du Pont De Nemours And Company | Acid-cleavable linkers exhibiting altered rates of acid hydrolysis |
| US9566347B2 (en) * | 2011-02-07 | 2017-02-14 | The Trustees Of The University Of Pennsylvania | Peptides and methods using same |
| WO2012172521A1 (en) * | 2011-06-16 | 2012-12-20 | Novartis Ag | Soluble proteins for use as therapeutics |
| WO2013063076A1 (en) * | 2011-10-25 | 2013-05-02 | Indiana University Research & Technology Corporation | Compositions for and methods of modulating complications, risks and issues with xenotransplantation |
| EP3766511A1 (en) * | 2012-01-17 | 2021-01-20 | The Board of Trustees of the Leland Stanford Junior University | High affinity sirp-alpha reagents |
| US9428553B2 (en) * | 2012-02-10 | 2016-08-30 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| CA2876904C (en) * | 2012-06-22 | 2019-12-03 | Cytomx Therapeutics, Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
| JP6335189B2 (ja) * | 2012-12-17 | 2018-05-30 | トリリアム・セラピューティクス・インコーポレイテッドTrillium Therapeutics Inc. | SIRPアルファ−Fc融合体でのCD47+疾患細胞の治療 |
| US9873747B2 (en) * | 2013-01-31 | 2018-01-23 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
| CN106459153B (zh) * | 2014-01-31 | 2021-12-21 | 西托姆克斯治疗公司 | 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法 |
| CN113621075B (zh) * | 2014-08-08 | 2024-09-20 | Alx肿瘤生物技术公司 | SIRP-α变体构建体及其用途 |
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