EA034582B1 - Конструкции варианта sirp-альфа и их применение - Google Patents

Конструкции варианта sirp-альфа и их применение Download PDF

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Publication number
EA034582B1
EA034582B1 EA201691384A EA201691384A EA034582B1 EA 034582 B1 EA034582 B1 EA 034582B1 EA 201691384 A EA201691384 A EA 201691384A EA 201691384 A EA201691384 A EA 201691384A EA 034582 B1 EA034582 B1 EA 034582B1
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EA
Eurasian Patent Office
Prior art keywords
sirp
variant
cancer
seq
binding
Prior art date
Application number
EA201691384A
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English (en)
Russian (ru)
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EA201691384A3 (ru
EA201691384A2 (ru
Inventor
Лаура Деминг
Кори Гудман
Хайме Понс
Бан Жанет Сим
Мария Врлйик
Original Assignee
АЭлЭкс ОНКОЛОДЖИ ИНК.
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Priority claimed from TW104125902A external-priority patent/TWI702228B/zh
Application filed by АЭлЭкс ОНКОЛОДЖИ ИНК. filed Critical АЭлЭкс ОНКОЛОДЖИ ИНК.
Publication of EA201691384A2 publication Critical patent/EA201691384A2/ru
Publication of EA201691384A3 publication Critical patent/EA201691384A3/ru
Publication of EA034582B1 publication Critical patent/EA034582B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3565828T3 (pl) 2017-01-05 2022-04-04 Kahr Medical Ltd. Białko fuzyjne SIRP1 ALFA-41BBL i sposoby jego zastosowania
KR102233993B1 (ko) * 2017-07-24 2021-03-31 한국과학기술원 면역 회피성 박테리오파지
AU2019235627B2 (en) * 2018-03-13 2026-01-15 Pfizer Inc. Improvements in CD47 blockade therapy by EGFR antibody
CA3104778A1 (en) 2018-07-11 2020-01-16 Kahr Medical Ltd. Pd1-4-1bbl variant fusion protein and methods of use thereof
KR102945860B1 (ko) 2018-07-11 2026-03-31 카 메디컬 리미티드 SIRPalpha-4-1BBL 변이체 융합 단백질 및 이의 사용 방법
WO2020047326A2 (en) * 2018-08-31 2020-03-05 ALX Oncology Inc. Decoy polypeptides
CN109535263B (zh) * 2018-12-04 2022-06-17 江苏东抗生物医药科技有限公司 SIRPα突变体及其融合蛋白
CN111763261B (zh) * 2019-04-02 2022-08-09 杭州尚健生物技术有限公司 一种融合蛋白及其用途
CN114845710A (zh) 2019-11-27 2022-08-02 Alx肿瘤生物技术公司 用于治疗癌症的组合疗法
JP2023518835A (ja) * 2020-03-26 2023-05-08 エショー バイオセラピー， インク． 制御性ｔ細胞の除去用の二重特異性融合タンパク質
CN114057888A (zh) * 2020-07-30 2022-02-18 三生国健药业（上海）股份有限公司 一种SIRPα-Fc融合蛋白
BR112023022774A2 (pt) 2021-05-13 2024-01-02 Alx Oncology Inc Terapias de combinação para tratamento de câncer
CN116178561B (zh) * 2021-11-26 2025-07-18 杭州尚健生物技术有限公司 包含SIRPα突变体的融合蛋白
CA3236718A1 (en) 2021-12-21 2023-06-29 Fbd Biologics Limited Engineered sirp.alpha. variants and methods of use thereof
CN119451994A (zh) 2023-05-31 2025-02-14 Fbd生物制品有限公司 靶向cd47/pd-l1的蛋白质复合物和其使用方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100239579A1 (en) * 2006-05-15 2010-09-23 Viral Logic Systems Technology Corp. CD47 Related Compositions and Methods for Treating Immunological Diseases and Disorders
EA201100947A1 (ru) * 2008-12-19 2012-02-28 Новартис Аг Растворимые полипептиды, предназначенные для применения при лечении аутоиммунных и воспалительных нарушений
WO2013109752A1 (en) * 2012-01-17 2013-07-25 The Board Of Trustees Of The Leland Stanford Junior University High affinity sirp-alpha reagents
US20140010810A1 (en) * 2012-06-22 2014-01-09 Cytomx Therapeutics, Inc. Anti-Jagged 1/Jagged 2 Cross-Reactive Antibodies, Activatable Anti-Jagged Antibodies And Methods Of Use Thereof
US20140113348A1 (en) * 2012-02-10 2014-04-24 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
US20140140926A1 (en) * 2011-02-07 2014-05-22 The Trustees Of The University Of Pennsylvania Novel Peptides and Methods Using Same

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
FI101678B1 (fi) 1990-12-31 1998-08-14 Akzo Nv Happolabiileja kytkentämolekyylejä
US6613332B1 (en) 1991-06-21 2003-09-02 The University Of Cincinnati Oral administration of therapeutic proteins
ES2109362T3 (es) 1991-06-21 1998-01-16 Univ Cincinnati Unas proteinas administrables oralmente y metodo para hacerlas.
IL99120A0 (en) 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
CA2116774C (en) 1991-09-19 2003-11-11 Paul J. Carter Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies
US5505931A (en) 1993-03-04 1996-04-09 The Dow Chemical Company Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
WO1997005266A1 (en) 1995-07-25 1997-02-13 Introgene B.V. Methods and means for targeted gene delivery
IL125756A (en) 1996-02-15 2003-05-29 Biosense Inc Catheter for use in surgery
AU3739697A (en) 1996-07-09 1998-02-02 Johns Hopkins University, The Gene delivery system
US6613026B1 (en) 1999-12-08 2003-09-02 Scimed Life Systems, Inc. Lateral needle-less injection apparatus and method
US7662367B2 (en) 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
TWI327597B (en) 2001-08-01 2010-07-21 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
EP2284192A3 (en) 2002-11-08 2011-07-20 Ablynx N.V. Camelidae antibodies for sublingual administration
MXPA06009805A (es) 2004-02-27 2007-04-02 Vaxconsulting Peptidos de interleucina 1 beta y factor de necrosis tumoral alfa y metodo de tratamiento utilizando los mismos.
US8518869B2 (en) 2004-03-29 2013-08-27 Austria Wirtschaftsservice Gesellschaft M.B.H. Pharmaceutical combined preparation containing a therapeutic protein
EP3663318A1 (en) 2008-01-07 2020-06-10 Amgen Inc. Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
WO2010081173A2 (en) 2009-01-12 2010-07-15 Cytomx Therapeutics, Llc Modified antibody compositions, methods of making and using thereof
US8399219B2 (en) 2009-02-23 2013-03-19 Cytomx Therapeutics, Inc. Protease activatable interferon alpha proprotein
NZ597580A (en) * 2009-07-20 2013-11-29 Univ Nat Taiwan Polypeptides selective for alpha.v.beta.3 integrin conjugated with a variant of human serum albumin (hsa) and pharmaceutical uses thereof
KR101632312B1 (ko) 2009-11-03 2016-06-21 삼성전자주식회사 항체 불변 영역에 특이적으로 결합하는 융합 단백질, 그의 제조 방법 및 이를 이용한 항체 분리 방법
JP2013514795A (ja) * 2009-12-22 2013-05-02 ノバルティス アーゲー 治療における使用のための四価ｃｄ４７抗体定常領域融合タンパク質
CN103501815B (zh) * 2010-10-08 2016-09-28 希望之城公司 针对中间位的单克隆抗体框架结合界面、中间位投递系统及其使用方法
US8609621B2 (en) 2010-11-15 2013-12-17 E I Du Pont De Nemours And Company Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
JP2014519338A (ja) * 2011-06-16 2014-08-14 ノバルティス アーゲー 治療薬として使用される可溶性タンパク質
WO2013063076A1 (en) * 2011-10-25 2013-05-02 Indiana University Research & Technology Corporation Compositions for and methods of modulating complications, risks and issues with xenotransplantation
HRP20192013T1 (hr) * 2012-12-17 2020-02-07 Trillium Therapeutics Inc. Liječenje cd47+ oboljelih stanica sa sirp alfa-fc fuzijama
WO2014121093A1 (en) * 2013-01-31 2014-08-07 Thomas Jefferson University Fusion proteins that facilitate cancer cell destruction
KR102466591B1 (ko) * 2014-01-31 2022-11-14 싸이톰스 테라퓨틱스, 인크. 마트립타제 및 ｕ-플라스미노겐 활성화인자 기질 및 다른 절단성 모이어티 및 이의 사용 방법
WO2016023040A1 (en) * 2014-08-08 2016-02-11 Alexo Therapeutics International Sirp-alpha variant constructs and uses thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100239579A1 (en) * 2006-05-15 2010-09-23 Viral Logic Systems Technology Corp. CD47 Related Compositions and Methods for Treating Immunological Diseases and Disorders
EA201100947A1 (ru) * 2008-12-19 2012-02-28 Новартис Аг Растворимые полипептиды, предназначенные для применения при лечении аутоиммунных и воспалительных нарушений
US20140140926A1 (en) * 2011-02-07 2014-05-22 The Trustees Of The University Of Pennsylvania Novel Peptides and Methods Using Same
WO2013109752A1 (en) * 2012-01-17 2013-07-25 The Board Of Trustees Of The Leland Stanford Junior University High affinity sirp-alpha reagents
US20140113348A1 (en) * 2012-02-10 2014-04-24 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
US20140010810A1 (en) * 2012-06-22 2014-01-09 Cytomx Therapeutics, Inc. Anti-Jagged 1/Jagged 2 Cross-Reactive Antibodies, Activatable Anti-Jagged Antibodies And Methods Of Use Thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIN Yan et al. Soluble extracellular domains of human SIRPα and CD47 expressed in Escherichia coli enhances the phagocytosis of leukemia cells by macrophages in vitro. Protein Expression and Purification, 2012, 85, p. 109-116 *

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