JP2017052786A5 - - Google Patents
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- JP2017052786A5 JP2017052786A5 JP2016221202A JP2016221202A JP2017052786A5 JP 2017052786 A5 JP2017052786 A5 JP 2017052786A5 JP 2016221202 A JP2016221202 A JP 2016221202A JP 2016221202 A JP2016221202 A JP 2016221202A JP 2017052786 A5 JP2017052786 A5 JP 2017052786A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- combination according
- combination
- cycloalkyl
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784089P | 2013-03-14 | 2013-03-14 | |
| US61/784,089 | 2013-03-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501035A Division JP6093903B2 (ja) | 2013-03-14 | 2014-03-10 | トリプトファン代謝によって媒介される免疫抑制の阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017052786A JP2017052786A (ja) | 2017-03-16 |
| JP2017052786A5 true JP2017052786A5 (https=) | 2017-09-07 |
| JP6352368B2 JP6352368B2 (ja) | 2018-07-04 |
Family
ID=50686105
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501035A Expired - Fee Related JP6093903B2 (ja) | 2013-03-14 | 2014-03-10 | トリプトファン代謝によって媒介される免疫抑制の阻害剤 |
| JP2016221202A Expired - Fee Related JP6352368B2 (ja) | 2013-03-14 | 2016-11-14 | トリプトファン代謝によって媒介される免疫抑制の阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501035A Expired - Fee Related JP6093903B2 (ja) | 2013-03-14 | 2014-03-10 | トリプトファン代謝によって媒介される免疫抑制の阻害剤 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9617272B2 (https=) |
| EP (2) | EP2976332B1 (https=) |
| JP (2) | JP6093903B2 (https=) |
| KR (1) | KR20150126623A (https=) |
| CN (1) | CN105189466A (https=) |
| AU (2) | AU2014241079C1 (https=) |
| BR (1) | BR112015022588A2 (https=) |
| CA (1) | CA2902174A1 (https=) |
| CL (2) | CL2015002649A1 (https=) |
| CR (1) | CR20150485A (https=) |
| IL (1) | IL241027A0 (https=) |
| MA (1) | MA38493B1 (https=) |
| MX (1) | MX361375B (https=) |
| PE (1) | PE20151593A1 (https=) |
| PH (1) | PH12015501866A1 (https=) |
| RU (1) | RU2667509C2 (https=) |
| SA (1) | SA515361127B1 (https=) |
| SG (2) | SG11201507255QA (https=) |
| UA (1) | UA118103C2 (https=) |
| WO (1) | WO2014159248A1 (https=) |
| ZA (1) | ZA201607948B (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2694640T3 (https=) | 2011-04-15 | 2018-03-17 | ||
| US9604982B2 (en) | 2013-03-14 | 2017-03-28 | Janssen Pharmaceutica Nv | P2X7 modulators |
| TWI644671B (zh) | 2013-03-14 | 2018-12-21 | 比利時商健生藥品公司 | Ｐ２ｘ７調節劑 |
| JO3509B1 (ar) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | معدلات p2x7 |
| US9040534B2 (en) | 2013-03-14 | 2015-05-26 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators |
| ES2845473T3 (es) | 2013-03-14 | 2021-07-26 | Boehringer Ingelheim Int | (Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C |
| CN103570727B (zh) | 2013-11-12 | 2015-08-19 | 复旦大学 | 一种n-苄基色胺酮衍生物及其制备方法和应用 |
| CA2956465A1 (en) | 2014-09-05 | 2016-03-10 | Merck Patent Gmbh | Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer |
| EP3511331A1 (en) | 2014-09-12 | 2019-07-17 | Boehringer Ingelheim International GmbH | Spirocyclic inhibitors of cathepsin c |
| AU2015315693B2 (en) | 2014-09-12 | 2020-01-16 | Janssen Pharmaceutica Nv | P2X7 modulating n-acyl-triazolopyrazines |
| WO2016039977A1 (en) | 2014-09-12 | 2016-03-17 | Janssen Pharmaceutica Nv | P2x7 modulators |
| GB201417369D0 (en) * | 2014-10-01 | 2014-11-12 | Redx Pharma Ltd | Compounds |
| US20160145344A1 (en) * | 2014-10-20 | 2016-05-26 | University Of Southern California | Murine and human innate lymphoid cells and lung inflammation |
| WO2016071293A2 (en) | 2014-11-03 | 2016-05-12 | Iomet Pharma Ltd | Pharmaceutical compound |
| US10525035B2 (en) | 2014-12-18 | 2020-01-07 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of retinopathy and other ocular diseases |
| CN105884828A (zh) * | 2015-02-16 | 2016-08-24 | 上海迪诺医药科技有限公司 | 多环化合物、其药物组合物及应用 |
| TWI698435B (zh) | 2015-04-10 | 2020-07-11 | 英屬開曼群島商百濟神州有限公司 | 作為吲哚胺２,３-二加氧酶和/或色氨酸２,３-二加氧酶抑制劑之新穎之５或８-取代之咪唑並［１，５－ａ］吡啶 |
| CN108026098B (zh) | 2015-04-12 | 2019-09-03 | 杭州英创医药科技有限公司 | 作为ido和tdo抑制剂的杂环化合物 |
| CN107849024A (zh) * | 2015-05-15 | 2018-03-27 | 吉利德科学公司 | 具有作为吲哚胺2,3‑二加氧酶抑制剂活性的苯并咪唑和咪唑并吡啶亚氨代甲酰胺化合物 |
| GB2548542A (en) * | 2015-06-16 | 2017-09-27 | Redx Pharma Plc | Compounds |
| CN105037371A (zh) * | 2015-06-30 | 2015-11-11 | 西华大学 | 一种氘代的吲哚胺-2,3-双加氧酶抑制剂 |
| EP4659747A2 (en) | 2015-07-24 | 2025-12-10 | Lumos Pharma, Inc. | Salts and prodrugs of 1-methyl-d-tryptophan |
| CN110072864B (zh) | 2015-12-24 | 2022-05-27 | 基因泰克公司 | Tdo2抑制剂 |
| CN107056785B (zh) * | 2016-01-02 | 2021-06-22 | 杭州英创医药科技有限公司 | 作为ido和tdo抑制剂的杂环化合物 |
| US20190031665A1 (en) * | 2016-02-02 | 2019-01-31 | Emcure Pharmaceuticals Limited | Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancer |
| EP3418282A4 (en) * | 2016-02-19 | 2019-01-09 | Chai Tai Tianqing Pharmaceutical Group Co., Ltd. | TRICYCLIC CONNECTION AS IMMUNOMODULATOR |
| TW201736373A (zh) * | 2016-02-19 | 2017-10-16 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | 作為免疫調節劑的三並環化合物 |
| WO2017149469A1 (en) | 2016-03-03 | 2017-09-08 | Emcure Pharmaceuticals Limited | Heterocyclic compounds useful as ido and/or tdo modulators |
| JP6948345B2 (ja) * | 2016-04-29 | 2021-10-13 | イオメット ファーマ リミテッド | インドールアミン２，３−ジオキシゲナーゼ及び／又はトリプトファン−２，３−ジオキシゲナーゼの阻害薬としての新規置換イミダゾピリジン化合物 |
| CN107383012B (zh) * | 2016-05-16 | 2021-09-28 | 鲁南制药集团股份有限公司 | 含二环的咪唑醇衍生物 |
| WO2017198159A1 (zh) * | 2016-05-16 | 2017-11-23 | 鲁南制药集团股份有限公司 | 含桥环的咪唑衍生物 |
| CN107663159A (zh) * | 2016-07-29 | 2018-02-06 | 上海迪诺医药科技有限公司 | 多环化合物、其药物组合物及应用 |
| CA3037333A1 (en) | 2016-09-19 | 2018-03-22 | University Of South Florida | Method of targeting oncolytic viruses to tumors |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| US10882856B2 (en) | 2016-09-24 | 2021-01-05 | Beigene, Ltd. | 5 or 8-substituted imidazo [1,5-a] pyridines as selective inhibitors of indoleamine and/or tryptophane 2,3-dioxygenases |
| JP7623784B2 (ja) | 2016-10-13 | 2025-01-29 | ジュノー セラピューティクス インコーポレイテッド | トリプトファン代謝経路調節剤を含む免疫療法の方法および組成物 |
| TW201815793A (zh) * | 2016-10-21 | 2018-05-01 | 江蘇恆瑞醫藥股份有限公司 | 一種咪唑並異吲哚類衍生物的遊離鹼的結晶形式及其製備方法 |
| US10604529B2 (en) | 2016-12-20 | 2020-03-31 | Shenzhen Chipscreen Biosciences Co., Ltd. | Fused imidazole compound having indoleamine 2,3-dioxygenase inhibitory activity |
| CN114989205A (zh) | 2016-12-22 | 2022-09-02 | 卡里塞拉生物科学股份公司 | 用于抑制精氨酸酶活性的组合物和方法 |
| CA3047002A1 (en) | 2017-01-17 | 2018-07-26 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| EP3645537A1 (en) | 2017-06-28 | 2020-05-06 | Genentech, Inc. | Tdo2 and ido1 inhibitors |
| WO2019005559A1 (en) | 2017-06-28 | 2019-01-03 | Genentech, Inc. | INHIBITORS OF TDO2 AND IDO1 |
| CN109384791B (zh) * | 2017-08-09 | 2020-09-11 | 江苏恒瑞医药股份有限公司 | 一种咪唑并异吲哚类衍生物游离碱的晶型及其制备方法 |
| CN111051305A (zh) * | 2017-08-22 | 2020-04-21 | 吉利德科学公司 | 治疗性杂环化合物 |
| BR112020005100A2 (pt) * | 2017-09-15 | 2020-09-15 | Taiho Pharmaceutical Co., Ltd. | usos de um composto inibidor de hsp90 para produzir um agente profilático e/ou terapêutico para doenças que envolvem expressão de ido e para produzir uma composição farmacêutica para tratar tumores ido-positivos |
| JP7306634B2 (ja) * | 2017-10-19 | 2023-07-11 | 一般社団法人ファルマバレープロジェクト支援機構 | Ｉｄｏ／ｔｄｏ阻害剤 |
| CN111386114A (zh) | 2017-11-25 | 2020-07-07 | 百济神州有限公司 | 作为吲哚胺2,3-双加氧酶的选择性抑制剂的新颖苯并咪唑 |
| US11813280B2 (en) | 2018-01-05 | 2023-11-14 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin and IDO expression to potentiate immunotherapy |
| EP3768666A1 (en) | 2018-03-20 | 2021-01-27 | Plexxikon Inc. | Compounds and methods for ido and tdo modulation, and indications therefor |
| WO2020018670A1 (en) | 2018-07-17 | 2020-01-23 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| CN116574105B (zh) * | 2018-09-27 | 2025-10-10 | 深圳微芯生物科技股份有限公司 | 具有吲哚胺-2,3-双加氧酶抑制活性的喹啉衍生物 |
| MY205440A (en) | 2018-09-28 | 2024-10-21 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
| KR20210069079A (ko) | 2018-09-28 | 2021-06-10 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 조절제 |
| JP7697934B2 (ja) | 2019-09-30 | 2025-06-24 | ヤンセン ファーマシューティカ エヌ．ベー． | 放射線標識されたｍｇｌ ｐｅｔリガンド |
| BR112022019077A2 (pt) | 2020-03-26 | 2022-12-27 | Janssen Pharmaceutica Nv | Moduladores da monoacilglicerol lipase |
| US11839659B2 (en) | 2020-07-02 | 2023-12-12 | Northwestern University | Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein |
| MX2023010371A (es) | 2021-03-05 | 2024-02-12 | Univ Basel | Composiciones para el tratamiento de enfermedades o condiciones asociadas al veb. |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH516573A (de) * | 1967-08-15 | 1971-12-15 | Sandoz Ag | Verfahren zur Herstellung von 5-Hydroxy-5-phenyl-2,3-dihydro-5H-imidazo(2,1-a)isoindolen |
| US5807892A (en) | 1994-09-30 | 1998-09-15 | Alcon Laboratories, Inc. | Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension |
| US6451840B1 (en) | 1997-12-05 | 2002-09-17 | Medical College Of Georgia Research Institute, Inc. | Regulation of T cell-mediated immunity by tryptophan |
| CA2483451C (en) | 2002-04-12 | 2014-07-29 | Medical College Of Georgia Research Institute, Inc. | Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance |
| ES2323952T3 (es) * | 2002-05-15 | 2009-07-28 | Janssen Pharmaceutica Nv | 3-aminopirazol triciclicos sustituidos en n como inhibidores receptores de pdfg. |
| US7714139B2 (en) | 2003-03-27 | 2010-05-11 | Lankenau Institute For Medcial Research | IDO inhibitors and methods of use |
| DE102007020493A1 (de) | 2007-04-30 | 2008-11-06 | Grünenthal GmbH | Substituierte Amid-Derivate |
| US10047066B2 (en) | 2007-11-30 | 2018-08-14 | Newlink Genetics Corporation | IDO inhibitors |
| CA2722159C (en) | 2008-04-24 | 2016-04-05 | Newlink Genetics Corporation | Substituted phenylimidazole compounds and their use as ido inhibitors |
| WO2010056567A1 (en) * | 2008-11-13 | 2010-05-20 | Merck Sharp & Dohme Corp. | Imidazoisoindole neuropeptide s receptor antagonists |
| EP2493862B1 (en) | 2009-10-28 | 2016-10-05 | Newlink Genetics Corporation | Imidazole derivatives as ido inhibitors |
| JP2012037986A (ja) | 2010-08-04 | 2012-02-23 | Canon Inc | 画像形成装置及びその制御方法と画像形成システム |
| NO2694640T3 (https=) | 2011-04-15 | 2018-03-17 |
-
2014
- 2014-03-10 KR KR1020157025259A patent/KR20150126623A/ko not_active Withdrawn
- 2014-03-10 EP EP14722814.2A patent/EP2976332B1/en not_active Not-in-force
- 2014-03-10 PE PE2015001907A patent/PE20151593A1/es not_active Application Discontinuation
- 2014-03-10 CA CA2902174A patent/CA2902174A1/en not_active Abandoned
- 2014-03-10 SG SG11201507255QA patent/SG11201507255QA/en unknown
- 2014-03-10 MX MX2015011385A patent/MX361375B/es active IP Right Grant
- 2014-03-10 MA MA38493A patent/MA38493B1/fr unknown
- 2014-03-10 SG SG10201707545XA patent/SG10201707545XA/en unknown
- 2014-03-10 US US14/774,450 patent/US9617272B2/en not_active Expired - Fee Related
- 2014-03-10 CN CN201480015368.3A patent/CN105189466A/zh active Pending
- 2014-03-10 BR BR112015022588A patent/BR112015022588A2/pt not_active Application Discontinuation
- 2014-03-10 AU AU2014241079A patent/AU2014241079C1/en not_active Ceased
- 2014-03-10 JP JP2016501035A patent/JP6093903B2/ja not_active Expired - Fee Related
- 2014-03-10 EP EP18152869.6A patent/EP3366678A1/en not_active Withdrawn
- 2014-03-10 RU RU2015143990A patent/RU2667509C2/ru not_active IP Right Cessation
- 2014-03-10 WO PCT/US2014/022680 patent/WO2014159248A1/en not_active Ceased
- 2014-10-03 UA UAA201510014A patent/UA118103C2/uk unknown
-
2015
- 2015-08-25 PH PH12015501866A patent/PH12015501866A1/en unknown
- 2015-09-01 IL IL241027A patent/IL241027A0/en unknown
- 2015-09-11 CL CL2015002649A patent/CL2015002649A1/es unknown
- 2015-09-14 CR CR20150485A patent/CR20150485A/es unknown
- 2015-09-14 SA SA515361127A patent/SA515361127B1/ar unknown
-
2016
- 2016-08-01 CL CL2016001940A patent/CL2016001940A1/es unknown
- 2016-11-14 JP JP2016221202A patent/JP6352368B2/ja not_active Expired - Fee Related
- 2016-11-17 ZA ZA2016/07948A patent/ZA201607948B/en unknown
-
2017
- 2017-02-16 US US15/434,414 patent/US9981973B2/en not_active Expired - Fee Related
- 2017-03-13 AU AU2017201693A patent/AU2017201693A1/en not_active Abandoned
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