MA38493B1 - Composés tricycliques utilisés en tant qu'inhibiteurs de l'immunosuppression dont la médiation est assurée par la métabolisation du tryptophane - Google Patents

Composés tricycliques utilisés en tant qu'inhibiteurs de l'immunosuppression dont la médiation est assurée par la métabolisation du tryptophane

Info

Publication number
MA38493B1
MA38493B1 MA38493A MA38493A MA38493B1 MA 38493 B1 MA38493 B1 MA 38493B1 MA 38493 A MA38493 A MA 38493A MA 38493 A MA38493 A MA 38493A MA 38493 B1 MA38493 B1 MA 38493B1
Authority
MA
Morocco
Prior art keywords
tryptophan
treat
immunosuppression
inhibitors
metabolism
Prior art date
Application number
MA38493A
Other languages
English (en)
Other versions
MA38493A1 (fr
Inventor
Sanjeev Kumar
Jesse Waldo
Firoz Jaipuri
Mario Mautino
Original Assignee
Newlink Genetics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50686105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA38493(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Newlink Genetics Corp filed Critical Newlink Genetics Corp
Publication of MA38493A1 publication Critical patent/MA38493A1/fr
Publication of MA38493B1 publication Critical patent/MA38493B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des inhibiteurs d'ido et de tdo et des compositions pharmaceutiques les comprenant, qui peuvent être utilisés pour moduler une activité de l'indoleamine 2,3-dioxygénase et de la tryptophane 2,3 dioxygénase ; traiter l'immunosuppression ; traiter des états pathologiques qui sont améliorés par inhibition de la dégradation du tryptophane ; augmenter l'efficacité d'un traitement anticancéreux qui consiste à administrer un agent anticancéreux ; traiter l'immunosuppression spécifique d'une tumeur associée à un cancer ; et traiter l'immunosuppression associée à une maladie infectieuse.
MA38493A 2013-03-14 2014-03-10 Composés tricycliques utilisés en tant qu'inhibiteurs de l'immunosuppression dont la médiation est assurée par la métabolisation du tryptophane MA38493B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361784089P 2013-03-14 2013-03-14
PCT/US2014/022680 WO2014159248A1 (fr) 2013-03-14 2014-03-10 Composés tricycliques utilisés en tant qu'inhibiteurs de l'immunosuppression dont la médiation est assurée par la métabolisation du tryptophane

Publications (2)

Publication Number Publication Date
MA38493A1 MA38493A1 (fr) 2017-02-28
MA38493B1 true MA38493B1 (fr) 2017-10-31

Family

ID=50686105

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38493A MA38493B1 (fr) 2013-03-14 2014-03-10 Composés tricycliques utilisés en tant qu'inhibiteurs de l'immunosuppression dont la médiation est assurée par la métabolisation du tryptophane

Country Status (22)

Country Link
US (2) US9617272B2 (fr)
EP (2) EP2976332B1 (fr)
JP (2) JP6093903B2 (fr)
KR (1) KR20150126623A (fr)
CN (1) CN105189466A (fr)
AU (2) AU2014241079C1 (fr)
BR (1) BR112015022588A2 (fr)
CA (1) CA2902174A1 (fr)
CL (2) CL2015002649A1 (fr)
CR (1) CR20150485A (fr)
HK (1) HK1213259A1 (fr)
IL (1) IL241027A0 (fr)
MA (1) MA38493B1 (fr)
MX (1) MX361375B (fr)
PE (1) PE20151593A1 (fr)
PH (1) PH12015501866A1 (fr)
RU (1) RU2667509C2 (fr)
SA (1) SA515361127B1 (fr)
SG (2) SG10201707545XA (fr)
UA (1) UA118103C2 (fr)
WO (1) WO2014159248A1 (fr)
ZA (1) ZA201607948B (fr)

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Also Published As

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SG10201707545XA (en) 2017-10-30
AU2014241079B2 (en) 2016-12-15
PE20151593A1 (es) 2015-11-05
PH12015501866A1 (en) 2015-12-07
AU2017201693A1 (en) 2017-03-30
AU2014241079A1 (en) 2015-09-03
WO2014159248A1 (fr) 2014-10-02
JP2017052786A (ja) 2017-03-16
EP2976332B1 (fr) 2018-01-31
US20160060266A1 (en) 2016-03-03
JP6352368B2 (ja) 2018-07-04
MA38493A1 (fr) 2017-02-28
MX2015011385A (es) 2016-02-03
US9981973B2 (en) 2018-05-29
CL2015002649A1 (es) 2016-07-29
HK1213259A1 (zh) 2016-06-30
JP2016519056A (ja) 2016-06-30
MX361375B (es) 2018-12-05
SG11201507255QA (en) 2015-10-29
RU2667509C2 (ru) 2018-09-21
SA515361127B1 (ar) 2017-10-19
IL241027A0 (en) 2015-11-30
EP3366678A1 (fr) 2018-08-29
UA118103C2 (uk) 2018-11-26
BR112015022588A2 (pt) 2017-07-18
EP2976332A1 (fr) 2016-01-27
CN105189466A (zh) 2015-12-23
ZA201607948B (en) 2018-05-30
JP6093903B2 (ja) 2017-03-08
AU2014241079B9 (en) 2017-04-06
AU2014241079C1 (en) 2017-07-06
CA2902174A1 (fr) 2014-10-02
RU2015143990A (ru) 2017-04-19
US20170260188A1 (en) 2017-09-14
CL2016001940A1 (es) 2017-03-10
US9617272B2 (en) 2017-04-11
CR20150485A (es) 2015-11-26
KR20150126623A (ko) 2015-11-12

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