MA38493A1 - Composés tricycliques utilisés en tant qu'inhibiteurs de l'immunosuppression dont la médiation est assurée par la métabolisation du tryptophane - Google Patents
Composés tricycliques utilisés en tant qu'inhibiteurs de l'immunosuppression dont la médiation est assurée par la métabolisation du tryptophaneInfo
- Publication number
- MA38493A1 MA38493A1 MA38493A MA38493A MA38493A1 MA 38493 A1 MA38493 A1 MA 38493A1 MA 38493 A MA38493 A MA 38493A MA 38493 A MA38493 A MA 38493A MA 38493 A1 MA38493 A1 MA 38493A1
- Authority
- MA
- Morocco
- Prior art keywords
- tryptophan
- treat
- immunosuppression
- inhibitors
- metabolism
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne des inhibiteurs d'ido et de tdo et des compositions pharmaceutiques les comprenant, qui peuvent être utilisés pour moduler une activité de l'indoleamine 2,3-dioxygénase et de la tryptophane 2,3 dioxygénase ; traiter l'immunosuppression ; traiter des états pathologiques qui sont améliorés par inhibition de la dégradation du tryptophane ; augmenter l'efficacité d'un traitement anticancéreux qui consiste à administrer un agent anticancéreux ; traiter l'immunosuppression spécifique d'une tumeur associée à un cancer ; et traiter l'immunosuppression associée à une maladie infectieuse.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361784089P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/022680 WO2014159248A1 (fr) | 2013-03-14 | 2014-03-10 | Composés tricycliques utilisés en tant qu'inhibiteurs de l'immunosuppression dont la médiation est assurée par la métabolisation du tryptophane |
Publications (2)
Publication Number | Publication Date |
---|---|
MA38493A1 true MA38493A1 (fr) | 2017-02-28 |
MA38493B1 MA38493B1 (fr) | 2017-10-31 |
Family
ID=50686105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38493A MA38493B1 (fr) | 2013-03-14 | 2014-03-10 | Composés tricycliques utilisés en tant qu'inhibiteurs de l'immunosuppression dont la médiation est assurée par la métabolisation du tryptophane |
Country Status (22)
Country | Link |
---|---|
US (2) | US9617272B2 (fr) |
EP (2) | EP2976332B1 (fr) |
JP (2) | JP6093903B2 (fr) |
KR (1) | KR20150126623A (fr) |
CN (1) | CN105189466A (fr) |
AU (2) | AU2014241079C1 (fr) |
BR (1) | BR112015022588A2 (fr) |
CA (1) | CA2902174A1 (fr) |
CL (2) | CL2015002649A1 (fr) |
CR (1) | CR20150485A (fr) |
HK (1) | HK1213259A1 (fr) |
IL (1) | IL241027A0 (fr) |
MA (1) | MA38493B1 (fr) |
MX (1) | MX361375B (fr) |
PE (1) | PE20151593A1 (fr) |
PH (1) | PH12015501866A1 (fr) |
RU (1) | RU2667509C2 (fr) |
SA (1) | SA515361127B1 (fr) |
SG (2) | SG10201707545XA (fr) |
UA (1) | UA118103C2 (fr) |
WO (1) | WO2014159248A1 (fr) |
ZA (1) | ZA201607948B (fr) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO2694640T3 (fr) | 2011-04-15 | 2018-03-17 | ||
TWI599567B (zh) | 2013-03-14 | 2017-09-21 | 健生藥品公司 | P2x7調節劑 |
JO3509B1 (ar) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | معدلات p2x7 |
US9604982B2 (en) | 2013-03-14 | 2017-03-28 | Janssen Pharmaceutica Nv | P2X7 modulators |
NZ710034A (en) | 2013-03-14 | 2020-06-26 | Boehringer Ingelheim Int | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
WO2014152537A1 (fr) | 2013-03-14 | 2014-09-25 | Janssen Pharmaceutica Nv | Modulateurs de p2x7 |
CN103570727B (zh) | 2013-11-12 | 2015-08-19 | 复旦大学 | 一种n-苄基色胺酮衍生物及其制备方法和应用 |
EP3189054B1 (fr) * | 2014-09-05 | 2019-07-24 | Merck Patent GmbH | Composés tricycliques diaza et triaza substitués par (1-fluoro-cyclohéx-1-yl)-éthyl en tant qu'antagonistes de l'indole-amine-2,3-dioxygenase (ido) pour le traitement du cancer |
EA034015B1 (ru) | 2014-09-12 | 2019-12-19 | Янссен Фармацевтика Нв | Модуляторы р2х7 |
DK3191487T3 (da) | 2014-09-12 | 2019-10-28 | Boehringer Ingelheim Int | Spirocykliske cathepsin-c-inhibitorer |
GB201417369D0 (en) * | 2014-10-01 | 2014-11-12 | Redx Pharma Ltd | Compounds |
US20160145344A1 (en) * | 2014-10-20 | 2016-05-26 | University Of Southern California | Murine and human innate lymphoid cells and lung inflammation |
AU2015341913B2 (en) | 2014-11-03 | 2020-07-16 | Iomet Pharma Ltd | Pharmaceutical compound |
US10525035B2 (en) | 2014-12-18 | 2020-01-07 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of retinopathy and other ocular diseases |
CN105884828A (zh) * | 2015-02-16 | 2016-08-24 | 上海迪诺医药科技有限公司 | 多环化合物、其药物组合物及应用 |
KR20170137165A (ko) * | 2015-04-10 | 2017-12-12 | 베이진 엘티디 | 인돌아민 및/또는 트립토판 2,3-디옥시게나아제로서 신규한 5 또는 8-치환된 이미다조[1,5-a]피리딘 |
US10358451B2 (en) | 2015-04-12 | 2019-07-23 | Hangzhou Innogate Pharma Co., Ltd. | Heterocycles useful as IDO and TDO inhibitors |
ES2761824T3 (es) * | 2015-05-15 | 2020-05-21 | Gilead Sciences Inc | Compuestos de carboximidamida de benzimidazol y imidazopiridina que tienen actividad como inhibidores de indoleamina 2,3-dioxigenasa |
GB2548542A (en) * | 2015-06-16 | 2017-09-27 | Redx Pharma Plc | Compounds |
CN105037371A (zh) * | 2015-06-30 | 2015-11-11 | 西华大学 | 一种氘代的吲哚胺-2,3-双加氧酶抑制剂 |
NZ736978A (en) | 2015-07-24 | 2019-06-28 | Newlink Genetics Corp | Salts and prodrugs of 1-methyl-d-tryptophan |
CN110072864B (zh) | 2015-12-24 | 2022-05-27 | 基因泰克公司 | Tdo2抑制剂 |
CN107056785B (zh) * | 2016-01-02 | 2021-06-22 | 杭州英创医药科技有限公司 | 作为ido和tdo抑制剂的杂环化合物 |
WO2017134555A1 (fr) | 2016-02-02 | 2017-08-10 | Emcure Pharmaceuticals Limited | Dérivés de pyrroloimidazole ou analogues de ceux-ci utiles, entre autres, dans le traitement du cancer |
CN108884104B (zh) * | 2016-02-19 | 2021-01-15 | 正大天晴药业集团股份有限公司 | 作为免疫调节剂的三并环化合物 |
EP3418282A4 (fr) * | 2016-02-19 | 2019-01-09 | Chai Tai Tianqing Pharmaceutical Group Co., Ltd. | Composé tricyclique servant d'immunomodulateur |
WO2017149469A1 (fr) | 2016-03-03 | 2017-09-08 | Emcure Pharmaceuticals Limited | Composés hétérocycliques utiles en tant que modulateurs de l'ido et/ou de la tdo |
CA3021589A1 (fr) * | 2016-04-29 | 2017-11-02 | Merck Sharp & Dohme Corp. | Composes d'imidazopyridine substitues en tant qu'inhibiteurs d'indoleamine 2,3-dioxygenase et/ou de tryptophane-2,3-dioxygenase |
CN107383012B (zh) * | 2016-05-16 | 2021-09-28 | 鲁南制药集团股份有限公司 | 含二环的咪唑醇衍生物 |
WO2017198159A1 (fr) * | 2016-05-16 | 2017-11-23 | 鲁南制药集团股份有限公司 | Dérivé d'imidazole contenant un cycle de liaison |
CN107663159A (zh) * | 2016-07-29 | 2018-02-06 | 上海迪诺医药科技有限公司 | 多环化合物、其药物组合物及应用 |
EP3515462B1 (fr) | 2016-09-19 | 2023-06-14 | University of South Florida | Procédé de ciblage de virus oncolytiques aux tumeurs |
TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ido及tdo調節之化合物及方法以及其適應症 |
EP3515914A4 (fr) | 2016-09-24 | 2020-04-15 | BeiGene, Ltd. | Nouvelles imidazo[1,5-a]pyridines substituées en position 5 ou 8 en tant qu'indoleamine et/ou tryptophane 2,3-dioxygénases |
EP4190335A1 (fr) | 2016-10-13 | 2023-06-07 | Juno Therapeutics, Inc. | Procédés et compositions d'immunothérapie impliquant des modulateurs de la voie métabolique du tryptophane |
TW201815793A (zh) * | 2016-10-21 | 2018-05-01 | 江蘇恆瑞醫藥股份有限公司 | 一種咪唑並異吲哚類衍生物的遊離鹼的結晶形式及其製備方法 |
CN108203438B (zh) | 2016-12-20 | 2021-09-28 | 深圳微芯生物科技股份有限公司 | 具有吲哚胺2,3-双加氧酶抑制活性的稠合咪唑化合物 |
KR102579849B1 (ko) | 2016-12-22 | 2023-09-18 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 아르기나제 활성을 억제시키기 위한 조성물 및 방법 |
JP2020506895A (ja) | 2017-01-17 | 2020-03-05 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | インドールアミン2,3−ジオキシゲナーゼおよび/またはトリプトファンジオキシゲナーゼの阻害剤として有用な化合物 |
WO2019006047A1 (fr) | 2017-06-28 | 2019-01-03 | Genentech, Inc. | Inhibiteurs de tdo2 et ido1 |
WO2019005559A1 (fr) | 2017-06-28 | 2019-01-03 | Genentech, Inc. | Inhibiteurs de tdo2 et ido1 |
CN109384791B (zh) * | 2017-08-09 | 2020-09-11 | 江苏恒瑞医药股份有限公司 | 一种咪唑并异吲哚类衍生物游离碱的晶型及其制备方法 |
TWI733055B (zh) * | 2017-09-15 | 2021-07-11 | 日商大鵬藥品工業股份有限公司 | 與ido之表現有關之疾病之預防及/或治療劑 |
WO2019078246A1 (fr) * | 2017-10-19 | 2019-04-25 | 一般社団法人ファルマバレープロジェクト支援機構 | Inhibiteur de ido/tdo |
US11472788B2 (en) | 2017-11-25 | 2022-10-18 | Beigene, Ltd. | Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases |
KR20200106513A (ko) | 2018-01-05 | 2020-09-14 | 다이서나 파마수이티컬, 인크. | 면역요법을 강화시키기 위하여 베타-카테닌 및 ido 발현의 감소 |
CN112119072A (zh) | 2018-03-20 | 2020-12-22 | 普莱希科公司 | 用于ido和tdo调节的化合物和方法,以及其适应症 |
US11046649B2 (en) | 2018-07-17 | 2021-06-29 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
SG11202102281VA (en) | 2018-09-28 | 2021-04-29 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
WO2020065614A1 (fr) | 2018-09-28 | 2020-04-02 | Janssen Pharmaceutica Nv | Modulateurs de la monoacylglycérol lipase |
US11839663B2 (en) | 2019-09-30 | 2023-12-12 | Janssen Pharmaceutica Nv | Radiolabelled MGL pet ligands |
MX2022011902A (es) | 2020-03-26 | 2023-01-04 | Janssen Pharmaceutica Nv | Moduladores de la monoacilglicerol lipasa. |
US11839659B2 (en) | 2020-07-02 | 2023-12-12 | Northwestern University | Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein |
EP4052705A1 (fr) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions pour le traitement des maladies ou des pathologies associées à l'ebv |
WO2022184930A2 (fr) | 2021-03-05 | 2022-09-09 | Universität Basel | Compositions pour le traitement de maladies ou d'états associés à ebv |
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CH516573A (de) * | 1967-08-15 | 1971-12-15 | Sandoz Ag | Verfahren zur Herstellung von 5-Hydroxy-5-phenyl-2,3-dihydro-5H-imidazo(2,1-a)isoindolen |
US5807892A (en) | 1994-09-30 | 1998-09-15 | Alcon Laboratories, Inc. | Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension |
US6451840B1 (en) | 1997-12-05 | 2002-09-17 | Medical College Of Georgia Research Institute, Inc. | Regulation of T cell-mediated immunity by tryptophan |
AU2002307243B2 (en) | 2002-04-12 | 2008-01-03 | Medical College Of Georgia Research Institute, Inc. | Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance |
CN100396670C (zh) * | 2002-05-15 | 2008-06-25 | 詹森药业有限公司 | 作为pdfg受体抑制剂的n-取代的3-氨基苯并环戊二烯并吡唑及药用组合物和用途 |
WO2004094409A1 (fr) | 2003-03-27 | 2004-11-04 | Lankenau Institute For Medical Research | Inhibiteurs de ido et procedes d'utilisation de ceux-ci |
DE102007020493A1 (de) | 2007-04-30 | 2008-11-06 | Grünenthal GmbH | Substituierte Amid-Derivate |
JP5583592B2 (ja) | 2007-11-30 | 2014-09-03 | ニューリンク ジェネティクス コーポレイション | Ido阻害剤 |
US8748469B2 (en) | 2008-04-24 | 2014-06-10 | Newlink Genetics Corporation | IDO inhibitors |
US8541595B2 (en) * | 2008-11-13 | 2013-09-24 | Merch Sharp & Dohme Corp. | Imidazoisoindole neuropeptide S receptor antagonists |
ES2601226T3 (es) | 2009-10-28 | 2017-02-14 | Newlink Genetics Corporation | Derivados de imidazol como inhibidores de IDO |
JP2012037986A (ja) | 2010-08-04 | 2012-02-23 | Canon Inc | 画像形成装置及びその制御方法と画像形成システム |
NO2694640T3 (fr) * | 2011-04-15 | 2018-03-17 |
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2014
- 2014-03-10 RU RU2015143990A patent/RU2667509C2/ru not_active IP Right Cessation
- 2014-03-10 SG SG10201707545XA patent/SG10201707545XA/en unknown
- 2014-03-10 PE PE2015001907A patent/PE20151593A1/es not_active Application Discontinuation
- 2014-03-10 JP JP2016501035A patent/JP6093903B2/ja not_active Expired - Fee Related
- 2014-03-10 KR KR1020157025259A patent/KR20150126623A/ko not_active Application Discontinuation
- 2014-03-10 EP EP14722814.2A patent/EP2976332B1/fr not_active Not-in-force
- 2014-03-10 EP EP18152869.6A patent/EP3366678A1/fr not_active Withdrawn
- 2014-03-10 US US14/774,450 patent/US9617272B2/en not_active Expired - Fee Related
- 2014-03-10 BR BR112015022588A patent/BR112015022588A2/pt not_active Application Discontinuation
- 2014-03-10 SG SG11201507255QA patent/SG11201507255QA/en unknown
- 2014-03-10 MA MA38493A patent/MA38493B1/fr unknown
- 2014-03-10 CA CA2902174A patent/CA2902174A1/fr not_active Abandoned
- 2014-03-10 WO PCT/US2014/022680 patent/WO2014159248A1/fr active Application Filing
- 2014-03-10 CN CN201480015368.3A patent/CN105189466A/zh active Pending
- 2014-03-10 MX MX2015011385A patent/MX361375B/es active IP Right Grant
- 2014-03-10 AU AU2014241079A patent/AU2014241079C1/en not_active Ceased
- 2014-10-03 UA UAA201510014A patent/UA118103C2/uk unknown
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2015
- 2015-08-25 PH PH12015501866A patent/PH12015501866A1/en unknown
- 2015-09-01 IL IL241027A patent/IL241027A0/en unknown
- 2015-09-11 CL CL2015002649A patent/CL2015002649A1/es unknown
- 2015-09-14 CR CR20150485A patent/CR20150485A/es unknown
- 2015-09-14 SA SA515361127A patent/SA515361127B1/ar unknown
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2016
- 2016-02-04 HK HK16101323.8A patent/HK1213259A1/zh not_active IP Right Cessation
- 2016-08-01 CL CL2016001940A patent/CL2016001940A1/es unknown
- 2016-11-14 JP JP2016221202A patent/JP6352368B2/ja not_active Expired - Fee Related
- 2016-11-17 ZA ZA2016/07948A patent/ZA201607948B/en unknown
-
2017
- 2017-02-16 US US15/434,414 patent/US9981973B2/en not_active Expired - Fee Related
- 2017-03-13 AU AU2017201693A patent/AU2017201693A1/en not_active Abandoned
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