JP2017043614A - ［４−（１，３，３−トリメチル−２−オキソ−３，４−ジヒドロ−１ｈ−キノキサリン−７−イル）フェノキシ］エチルオキシ化合物またはその塩 - Google Patents

［４−（１，３，３−トリメチル−２−オキソ−３，４−ジヒドロ−１ｈ−キノキサリン−７−イル）フェノキシ］エチルオキシ化合物またはその塩 Download PDF

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Publication number
JP2017043614A
JP2017043614A JP2016164830A JP2016164830A JP2017043614A JP 2017043614 A JP2017043614 A JP 2017043614A JP 2016164830 A JP2016164830 A JP 2016164830A JP 2016164830 A JP2016164830 A JP 2016164830A JP 2017043614 A JP2017043614 A JP 2017043614A
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group
disease
compound
diseases
dihydro
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JP2017043614A5 (enExample
Inventor
健二 川島
Kenji Kawashima
健二 川島
裕輔 山崎
Hirosuke Yamazaki
裕輔 山崎
慎治 高岡
Shinji Takaoka
慎治 高岡
大介 椎
Daisuke Shii
大介 椎
知子 小田
Tomoko Oda
知子 小田
高央 松山
Takahisa Matsuyama
高央 松山
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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Publication of JP2017043614A publication Critical patent/JP2017043614A/ja
Publication of JP2017043614A5 publication Critical patent/JP2017043614A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016164830A 2015-08-25 2016-08-25 ［４−（１，３，３−トリメチル−２−オキソ−３，４−ジヒドロ−１ｈ−キノキサリン−７−イル）フェノキシ］エチルオキシ化合物またはその塩 Pending JP2017043614A (ja)

Applications Claiming Priority (2)

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JP2015166247 2015-08-25
JP2015166247 2015-08-25

Related Child Applications (1)

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JP2021089664A Division JP7037687B2 (ja) 2015-08-25 2021-05-28 ［４－（１，３，３－トリメチル－２－オキソ－３，４－ジヒドロ－１ｈ－キノキサリン－７－イル）フェノキシ］エチルオキシ化合物またはその塩

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JP2017043614A true JP2017043614A (ja) 2017-03-02
JP2017043614A5 JP2017043614A5 (enExample) 2019-10-03

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JP2016164830A Pending JP2017043614A (ja) 2015-08-25 2016-08-25 ［４−（１，３，３−トリメチル−２−オキソ−３，４−ジヒドロ−１ｈ−キノキサリン−７−イル）フェノキシ］エチルオキシ化合物またはその塩
JP2021089664A Expired - Fee Related JP7037687B2 (ja) 2015-08-25 2021-05-28 ［４－（１，３，３－トリメチル－２－オキソ－３，４－ジヒドロ－１ｈ－キノキサリン－７－イル）フェノキシ］エチルオキシ化合物またはその塩

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JP2021089664A Expired - Fee Related JP7037687B2 (ja) 2015-08-25 2021-05-28 ［４－（１，３，３－トリメチル－２－オキソ－３，４－ジヒドロ－１ｈ－キノキサリン－７－イル）フェノキシ］エチルオキシ化合物またはその塩

Country Status (9)

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US (3) US10189796B2 (enExample)
EP (1) EP3342768A4 (enExample)
JP (2) JP2017043614A (enExample)
KR (1) KR20180043329A (enExample)
CN (1) CN107922356A (enExample)
CA (1) CA2996278A1 (enExample)
EA (1) EA201890570A1 (enExample)
HK (1) HK1252159A1 (enExample)
WO (1) WO2017034006A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018230713A1 (ja) 2017-06-16 2018-12-20 学校法人同志社 カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用
JP2021532103A (ja) * 2018-07-20 2021-11-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換トリアゾロキノキサリン誘導体
US11433090B2 (en) 2017-06-16 2022-09-06 The Doshisha mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1252159A1 (zh) * 2015-08-25 2019-05-17 参天制药株式会社 [4-(1，3，3-三甲基-2-氧代-3，4-二氢-1h-喹喔啉-7-基)苯氧基]乙基氧基化合物或其盐
EA202091429A1 (ru) 2017-12-18 2020-10-27 Грюненталь Гмбх Замещенные амиды i пирролидина
TW201927769A (zh) 2017-12-18 2019-07-16 德商歌林達有限公司 經取代之吡咯啶醯胺ｉｉ
TWI811400B (zh) 2018-07-20 2023-08-11 德商歌林達有限公司 經進一步取代之三唑并喹噁啉衍生物
WO2020144375A1 (en) 2019-01-11 2020-07-16 Grünenthal GmbH Substituted pyrrolidine amides iii
EP3986885B1 (en) 2019-06-19 2023-05-03 Grünenthal GmbH Substituted pyrrolidine amides iv
EP3986886A2 (en) 2019-06-19 2022-04-27 Grünenthal GmbH Substituted pyrrolidine amides v
WO2021144439A1 (en) 2020-01-17 2021-07-22 Grünenthal GmbH Quinoxaline derivatives
WO2021144440A1 (en) 2020-01-17 2021-07-22 Grünenthal GmbH Quinoxaline derivatives as modulators of the glucocorticoid receptor
EP4178954B1 (en) 2020-07-09 2025-11-19 Grünenthal GmbH Substituted pyrrolidine amines and amides as mediator of the glucocortoid receptor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008074829A (ja) * 2006-03-14 2008-04-03 Santen Pharmaceut Co Ltd グルココルチコイド受容体結合活性を有する新規１，２，３，４−テトラヒドロキノキサリン誘導体
JP2009084273A (ja) * 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd １，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体からなるグルココルチコイド受容体アゴニスト
JP2009084274A (ja) * 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd 新規１，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体
JP2009298775A (ja) * 2008-05-12 2009-12-24 Santen Pharmaceut Co Ltd 置換オキシ基を有する２，２，４−トリメチル−６−フェニル−１，２−ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60113032T2 (de) 2000-10-30 2006-07-06 Pfizer Products Inc., Groton Glukokortikoidrezeptor-Modulatoren
MX2008011779A (es) * 2006-03-14 2008-09-25 Santen Pharma Co Ltd Derivado novedoso de 1,2,3,4-tetrahidroquinoxalina con actividad de union de receptor glucocorticoide.
PL2151436T3 (pl) * 2007-05-29 2013-09-30 Santen Pharmaceutical Co Ltd Nowe pochodne 1,2,3,4-tetrahydrochinoksaliny, które jako podstawnik zawierają grupę fenylową z wprowadzoną strukturą estru kwasu sulfonowego lub amidu kwasu sulfonowego i które mają aktywność wiążącą wobec receptora glukokortykoidowego
GEP20135804B (en) * 2008-09-12 2013-04-10 Santen Pharmaceutical Co Ltd Glucocorticoid receptor agonist comprising novel 1,2,3,4-tetrahydroquinoxaline derivative containing phenyl group having sulfonic acid ester introduced therein as substituent
HK1252159A1 (zh) * 2015-08-25 2019-05-17 参天制药株式会社 [4-(1，3，3-三甲基-2-氧代-3，4-二氢-1h-喹喔啉-7-基)苯氧基]乙基氧基化合物或其盐

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008074829A (ja) * 2006-03-14 2008-04-03 Santen Pharmaceut Co Ltd グルココルチコイド受容体結合活性を有する新規１，２，３，４−テトラヒドロキノキサリン誘導体
JP2009084273A (ja) * 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd １，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体からなるグルココルチコイド受容体アゴニスト
JP2009084274A (ja) * 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd 新規１，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体
JP2009298775A (ja) * 2008-05-12 2009-12-24 Santen Pharmaceut Co Ltd 置換オキシ基を有する２，２，４−トリメチル−６−フェニル−１，２−ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018230713A1 (ja) 2017-06-16 2018-12-20 学校法人同志社 カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用
US11433090B2 (en) 2017-06-16 2022-09-06 The Doshisha mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof
US12343356B2 (en) 2017-06-16 2025-07-01 The Doshisha mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof
JP2021532103A (ja) * 2018-07-20 2021-11-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換トリアゾロキノキサリン誘導体
JP7336506B2 (ja) 2018-07-20 2023-08-31 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換トリアゾロキノキサリン誘導体

Also Published As

Publication number Publication date
CA2996278A1 (en) 2017-03-02
EA201890570A1 (ru) 2018-08-31
US20180244633A1 (en) 2018-08-30
CN107922356A (zh) 2018-04-17
JP7037687B2 (ja) 2022-03-16
EP3342768A4 (en) 2019-01-23
US20190359577A1 (en) 2019-11-28
EP3342768A1 (en) 2018-07-04
HK1252159A1 (zh) 2019-05-17
US10435379B2 (en) 2019-10-08
US10189796B2 (en) 2019-01-29
JP2021138728A (ja) 2021-09-16
WO2017034006A1 (ja) 2017-03-02
KR20180043329A (ko) 2018-04-27
US20190106393A1 (en) 2019-04-11

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