JP2017008109A5 - - Google Patents
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- JP2017008109A5 JP2017008109A5 JP2016199322A JP2016199322A JP2017008109A5 JP 2017008109 A5 JP2017008109 A5 JP 2017008109A5 JP 2016199322 A JP2016199322 A JP 2016199322A JP 2016199322 A JP2016199322 A JP 2016199322A JP 2017008109 A5 JP2017008109 A5 JP 2017008109A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- protein
- amino acid
- binding protein
- acid substitutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020001507 fusion proteins Proteins 0.000 claims 22
- 102000037865 fusion proteins Human genes 0.000 claims 22
- 102000023732 binding proteins Human genes 0.000 claims 19
- 108091008324 binding proteins Proteins 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 238000006467 substitution reaction Methods 0.000 claims 14
- 108010002350 Interleukin-2 Proteins 0.000 claims 13
- 102000000588 Interleukin-2 Human genes 0.000 claims 13
- 102220427331 c.274A>T Human genes 0.000 claims 8
- 102200142011 rs121909050 Human genes 0.000 claims 8
- 102200131576 rs121912452 Human genes 0.000 claims 8
- 102200158049 rs387906619 Human genes 0.000 claims 8
- 102200005671 rs1013940 Human genes 0.000 claims 5
- 102220606633 Zinc finger protein GLIS1_Q74N_mutation Human genes 0.000 claims 4
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims 3
- 102000008193 Interleukin-2 Receptor beta Subunit Human genes 0.000 claims 3
- 108010060632 Interleukin-2 Receptor beta Subunit Proteins 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102200004150 rs147750704 Human genes 0.000 claims 3
- 101100506090 Caenorhabditis elegans hil-2 gene Proteins 0.000 claims 2
- 108700004922 F42A Proteins 0.000 claims 2
- 102220495631 Putative uncharacterized protein LOC645739_F42A_mutation Human genes 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102220058213 rs730881465 Human genes 0.000 claims 2
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102220234588 rs1114167484 Human genes 0.000 claims 1
- 102200006514 rs121913236 Human genes 0.000 claims 1
- 102220082053 rs201520438 Human genes 0.000 claims 1
- 102200077167 rs2275591 Human genes 0.000 claims 1
- 102200032604 rs5030773 Human genes 0.000 claims 1
- 102220281620 rs551111938 Human genes 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426307P | 2010-12-22 | 2010-12-22 | |
| US61/426,307 | 2010-12-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546430A Division JP6093712B2 (ja) | 2010-12-22 | 2011-12-22 | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017008109A JP2017008109A (ja) | 2017-01-12 |
| JP2017008109A5 true JP2017008109A5 (https=) | 2017-07-20 |
| JP6441867B2 JP6441867B2 (ja) | 2018-12-19 |
Family
ID=46314487
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546430A Active JP6093712B2 (ja) | 2010-12-22 | 2011-12-22 | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
| JP2016199322A Active JP6441867B2 (ja) | 2010-12-22 | 2016-10-07 | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546430A Active JP6093712B2 (ja) | 2010-12-22 | 2011-12-22 | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US9428567B2 (https=) |
| EP (2) | EP3211001B1 (https=) |
| JP (2) | JP6093712B2 (https=) |
| CA (1) | CA2860170C (https=) |
| WO (1) | WO2012088446A1 (https=) |
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-
2011
- 2011-12-22 CA CA2860170A patent/CA2860170C/en active Active
- 2011-12-22 WO PCT/US2011/066911 patent/WO2012088446A1/en not_active Ceased
- 2011-12-22 EP EP16205861.4A patent/EP3211001B1/en active Active
- 2011-12-22 JP JP2013546430A patent/JP6093712B2/ja active Active
- 2011-12-22 US US13/997,503 patent/US9428567B2/en active Active
- 2011-12-22 EP EP11851134.4A patent/EP2655409A4/en not_active Withdrawn
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2016
- 2016-07-22 US US15/217,416 patent/US10183980B2/en active Active
- 2016-10-07 JP JP2016199322A patent/JP6441867B2/ja active Active
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2018
- 2018-12-13 US US16/219,786 patent/US11117943B2/en active Active
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2021
- 2021-09-09 US US17/470,246 patent/US12006347B2/en active Active
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