JP2016539985A5 - - Google Patents

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Publication number
JP2016539985A5
JP2016539985A5 JP2016537999A JP2016537999A JP2016539985A5 JP 2016539985 A5 JP2016539985 A5 JP 2016539985A5 JP 2016537999 A JP2016537999 A JP 2016537999A JP 2016537999 A JP2016537999 A JP 2016537999A JP 2016539985 A5 JP2016539985 A5 JP 2016539985A5
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JP
Japan
Prior art keywords
compound
disease
compound according
pharmaceutically acceptable
pharmaceutical composition
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JP2016537999A
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English (en)
Japanese (ja)
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JP2016539985A (ja
JP6486364B2 (ja
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Priority claimed from PCT/US2014/069487 external-priority patent/WO2015089149A1/en
Publication of JP2016539985A publication Critical patent/JP2016539985A/ja
Publication of JP2016539985A5 publication Critical patent/JP2016539985A5/ja
Application granted granted Critical
Publication of JP6486364B2 publication Critical patent/JP6486364B2/ja
Expired - Fee Related legal-status Critical Current
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JP2016537999A 2013-12-10 2014-12-10 トリフルオロメチルピラゾリルグアニジンf1f0−atpアーゼ阻害剤及びその治療用途 Expired - Fee Related JP6486364B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361914085P 2013-12-10 2013-12-10
US61/914,085 2013-12-10
US201461979619P 2014-04-15 2014-04-15
US61/979,619 2014-04-15
PCT/US2014/069487 WO2015089149A1 (en) 2013-12-10 2014-12-10 Trifluoromethyl pyrazolyl guanidine f1fo-atpase inhibitors and therapeutic uses thereof

Publications (3)

Publication Number Publication Date
JP2016539985A JP2016539985A (ja) 2016-12-22
JP2016539985A5 true JP2016539985A5 (enExample) 2018-01-25
JP6486364B2 JP6486364B2 (ja) 2019-03-20

Family

ID=53371791

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016537999A Expired - Fee Related JP6486364B2 (ja) 2013-12-10 2014-12-10 トリフルオロメチルピラゾリルグアニジンf1f0−atpアーゼ阻害剤及びその治療用途

Country Status (10)

Country Link
US (4) US9266839B2 (enExample)
EP (1) EP3080089B1 (enExample)
JP (1) JP6486364B2 (enExample)
CN (1) CN105899489A (enExample)
AU (1) AU2014363904B2 (enExample)
BR (1) BR112016013116A8 (enExample)
CA (1) CA2931851A1 (enExample)
IL (1) IL245930A0 (enExample)
MX (1) MX2016007445A (enExample)
WO (1) WO2015089149A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103458886B (zh) 2010-12-08 2016-06-08 莱斯拉公司 吡啶酮基胍f1f0-atp酶抑制剂及其治疗用途
DK2648511T3 (en) 2010-12-08 2017-09-18 Lycera Corp PYRAZOLYLGUANIDINE-F1F0 ATPASE INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF
US9221814B2 (en) 2012-06-08 2015-12-29 Lycera Corporation Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof
EP2866796A4 (en) 2012-06-08 2015-11-25 Lycera Corp PYRAZOLYL GUANIDINE F1FO ATPASE HEMMER AND THERAPEUTIC USES THEREOF
US9580391B2 (en) 2012-06-08 2017-02-28 Lycera Corporation Saturated acyl guanidine for inhibition of F1F0-ATPase
WO2015089152A1 (en) 2013-12-10 2015-06-18 Lycera Corporation N-substituted pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
WO2015089131A1 (en) 2013-12-10 2015-06-18 Lycera Corporation Alkylpyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
BR112016013116A8 (pt) 2013-12-10 2020-05-12 Lycera Corp inibidores de trifluorometil pirazolil guanidina f1f0-atpase, seus usos, e composições farmacêuticas
CN116570589B (zh) * 2023-05-30 2025-02-11 南阳理工学院 化合物Parimifasor在制备抗肿瘤药物中的应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977189A (en) * 1986-05-07 1990-12-11 American Cyanamid Company Substituted guanidinedicarbonyl derivatives
JPH07188197A (ja) 1993-11-17 1995-07-25 Fujisawa Pharmaceut Co Ltd オキサゾール誘導体
DE4344550A1 (de) 1993-12-24 1995-06-29 Hoechst Ag Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen
US7041702B1 (en) 1997-10-21 2006-05-09 Scion Pharmaceuticals, Inc. Pharmaceutically active compounds and methods of use
EP1156803A4 (en) 1999-02-09 2004-03-17 Bristol Myers Squibb Co FXA LACTAM INHIBITORS AND METHOD
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
CN1202095C (zh) 1999-07-15 2005-05-18 住友制药株式会社 杂芳环化合物
BR0111878A (pt) 2000-06-30 2005-05-24 Bristol Myers Squibb Co N-ureido-(heterociclo-alquil)-piperidinas como moduladores da atividade de receptores de quimiocinas
AU2002357137A1 (en) 2001-12-10 2003-06-23 Bristol-Myers Squibb Company (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase
GB0208224D0 (en) 2002-04-10 2002-05-22 Celltech R&D Ltd Chemical compounds
US20040009972A1 (en) 2002-06-17 2004-01-15 Ding Charles Z. Benzodiazepine inhibitors of mitochondial F1F0 ATP hydrolase and methods of inhibiting F1F0 ATP hydrolase
US7109224B2 (en) 2002-11-06 2006-09-19 Bristol-Myers Squibb Co. Acyl guanidine compounds and use thereof
CA2508914A1 (en) 2002-12-04 2004-06-17 Gene Logic Inc. Modulators of melanocortin receptor
DE102004008141A1 (de) 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
US20050272723A1 (en) 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US20090275099A1 (en) 2004-04-27 2009-11-05 Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
JP4990766B2 (ja) 2004-07-01 2012-08-01 シンタ ファーマシューティカルズ コーポレーション 二置換型ヘテロアリール化合物
EP2037741B1 (en) 2006-06-09 2013-11-27 The Regents Of The University Of Michigan Benzodiazepine derivatives for use in the treatment of immune, inflammatory and proliferative disorders
JP5416122B2 (ja) 2007-09-14 2014-02-12 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン F1F0−ATPaseインヒビターおよび関連の方法
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
KR100982661B1 (ko) 2008-04-22 2010-09-17 전남대학교산학협력단 플라스멥신 ⅱ 활성을 저해하는 화합물을 유효성분으로함유하는 말라리아 예방 및 치료를 위한 약학 조성물 및이를 이용한 말라리아 치료방법
JP5567573B2 (ja) 2008-09-11 2014-08-06 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アリールグアニジンf1f0−atpアーゼ阻害剤およびそれと関連する方法
DK2648511T3 (en) 2010-12-08 2017-09-18 Lycera Corp PYRAZOLYLGUANIDINE-F1F0 ATPASE INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF
CN103458886B (zh) 2010-12-08 2016-06-08 莱斯拉公司 吡啶酮基胍f1f0-atp酶抑制剂及其治疗用途
US9169199B2 (en) 2010-12-08 2015-10-27 Lycera Corporation Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
AU2011338302A1 (en) 2010-12-08 2013-07-11 Lycera Corporation Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
US9221814B2 (en) 2012-06-08 2015-12-29 Lycera Corporation Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof
EP2866796A4 (en) 2012-06-08 2015-11-25 Lycera Corp PYRAZOLYL GUANIDINE F1FO ATPASE HEMMER AND THERAPEUTIC USES THEREOF
US9580391B2 (en) 2012-06-08 2017-02-28 Lycera Corporation Saturated acyl guanidine for inhibition of F1F0-ATPase
WO2015089152A1 (en) 2013-12-10 2015-06-18 Lycera Corporation N-substituted pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
BR112016013116A8 (pt) 2013-12-10 2020-05-12 Lycera Corp inibidores de trifluorometil pirazolil guanidina f1f0-atpase, seus usos, e composições farmacêuticas
WO2015089131A1 (en) * 2013-12-10 2015-06-18 Lycera Corporation Alkylpyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof

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