CN105899489A - 三氟甲基吡唑基胍f1f0-atp酶抑制剂及其治疗用途 - Google Patents

三氟甲基吡唑基胍f1f0-atp酶抑制剂及其治疗用途 Download PDF

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CN105899489A
CN105899489A CN201480072404.XA CN201480072404A CN105899489A CN 105899489 A CN105899489 A CN 105899489A CN 201480072404 A CN201480072404 A CN 201480072404A CN 105899489 A CN105899489 A CN 105899489A
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compound
crystalline compound
chloro
amino
disease
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Chinese (zh)
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A·R·赫德
C·B·泰勒
J·王
P·周
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Lycera Corp
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Lycera Corp
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
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    • A61K9/0012—Galenical forms characterised by the site of application
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  • Cardiology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Pain & Pain Management (AREA)
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  • Biomedical Technology (AREA)
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  • Obesity (AREA)
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  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480072404.XA 2013-12-10 2014-12-10 三氟甲基吡唑基胍f1f0-atp酶抑制剂及其治疗用途 Pending CN105899489A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361914085P 2013-12-10 2013-12-10
US61/914,085 2013-12-10
US201461979619P 2014-04-15 2014-04-15
US61/979,619 2014-04-15
PCT/US2014/069487 WO2015089149A1 (en) 2013-12-10 2014-12-10 Trifluoromethyl pyrazolyl guanidine f1fo-atpase inhibitors and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
CN105899489A true CN105899489A (zh) 2016-08-24

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CN201480072404.XA Pending CN105899489A (zh) 2013-12-10 2014-12-10 三氟甲基吡唑基胍f1f0-atp酶抑制剂及其治疗用途

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US (4) US9266839B2 (enExample)
EP (1) EP3080089B1 (enExample)
JP (1) JP6486364B2 (enExample)
CN (1) CN105899489A (enExample)
AU (1) AU2014363904B2 (enExample)
BR (1) BR112016013116A8 (enExample)
CA (1) CA2931851A1 (enExample)
IL (1) IL245930A0 (enExample)
MX (1) MX2016007445A (enExample)
WO (1) WO2015089149A1 (enExample)

Cited By (1)

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ES2639439T3 (es) 2010-12-08 2017-10-26 Lycera Corporation Inhibidores de F1F0-ATPasas de tipo pirazolilguanidina y sus usos terapéuticos de éstos
WO2012078869A1 (en) 2010-12-08 2012-06-14 Lycera Corporation Pyridonyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
US9221814B2 (en) 2012-06-08 2015-12-29 Lycera Corporation Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof
EP2861225A4 (en) 2012-06-08 2015-11-18 Lycera Corp Saturated acylguanidine for the inhibition of F1F0-ATPASE
US9920012B2 (en) 2012-06-08 2018-03-20 Lycera Corporation Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
WO2015089149A1 (en) 2013-12-10 2015-06-18 Lycera Corporation Trifluoromethyl pyrazolyl guanidine f1fo-atpase inhibitors and therapeutic uses thereof
AU2014363907B2 (en) 2013-12-10 2018-10-04 Lycera Corporation N-substituted pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
JP2016539983A (ja) 2013-12-10 2016-12-22 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ アルキルピラゾリルグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤及びその治療用途

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WO2012078869A1 (en) 2010-12-08 2012-06-14 Lycera Corporation Pyridonyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
EP2861225A4 (en) 2012-06-08 2015-11-18 Lycera Corp Saturated acylguanidine for the inhibition of F1F0-ATPASE
US9920012B2 (en) 2012-06-08 2018-03-20 Lycera Corporation Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
US9221814B2 (en) 2012-06-08 2015-12-29 Lycera Corporation Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof
WO2015089149A1 (en) 2013-12-10 2015-06-18 Lycera Corporation Trifluoromethyl pyrazolyl guanidine f1fo-atpase inhibitors and therapeutic uses thereof
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WO2012078867A2 (en) * 2010-12-08 2012-06-14 Lycera Corporation Cycloalkyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
WO2012078874A1 (en) * 2010-12-08 2012-06-14 Lycera Corporation Pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116570589A (zh) * 2023-05-30 2023-08-11 南阳理工学院 化合物Parimifasor在制备抗肿瘤药物中的应用
CN116570589B (zh) * 2023-05-30 2025-02-11 南阳理工学院 化合物Parimifasor在制备抗肿瘤药物中的应用

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EP3080089A1 (en) 2016-10-19
JP6486364B2 (ja) 2019-03-20
WO2015089149A1 (en) 2015-06-18
US20160287559A1 (en) 2016-10-06
MX2016007445A (es) 2016-09-09
JP2016539985A (ja) 2016-12-22
US20190175556A1 (en) 2019-06-13
US20170354643A1 (en) 2017-12-14
AU2014363904A1 (en) 2016-06-30
US20150183745A1 (en) 2015-07-02
US10085972B2 (en) 2018-10-02
IL245930A0 (en) 2016-08-02
EP3080089B1 (en) 2019-05-08
US9266839B2 (en) 2016-02-23
EP3080089A4 (en) 2017-08-23
BR112016013116A2 (pt) 2017-08-08
BR112016013116A8 (pt) 2020-05-12
CA2931851A1 (en) 2015-06-18
US9707211B2 (en) 2017-07-18

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