JP2016537417A5 - - Google Patents
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- Publication number
- JP2016537417A5 JP2016537417A5 JP2016552257A JP2016552257A JP2016537417A5 JP 2016537417 A5 JP2016537417 A5 JP 2016537417A5 JP 2016552257 A JP2016552257 A JP 2016552257A JP 2016552257 A JP2016552257 A JP 2016552257A JP 2016537417 A5 JP2016537417 A5 JP 2016537417A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- cancer
- antagonist
- immunogenic combination
- tumor antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361900226P | 2013-11-05 | 2013-11-05 | |
| US61/900,226 | 2013-11-05 | ||
| PCT/US2014/063516 WO2015069571A1 (en) | 2013-11-05 | 2014-10-31 | Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist and/or agonist of an immune checkpoint inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016537417A JP2016537417A (ja) | 2016-12-01 |
| JP2016537417A5 true JP2016537417A5 (https=) | 2019-02-21 |
| JP6535337B2 JP6535337B2 (ja) | 2019-06-26 |
Family
ID=51987459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552257A Active JP6535337B2 (ja) | 2013-11-05 | 2014-10-31 | 腫瘍抗原を発現するポックスウイルスならびに免疫チェックポイント阻害剤のアンタゴニスト及び／またはアゴニストにより癌を治療するための組み合わせ療法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20160271239A1 (https=) |
| EP (1) | EP3065770B1 (https=) |
| JP (1) | JP6535337B2 (https=) |
| KR (2) | KR102395820B1 (https=) |
| CN (1) | CN105744950A (https=) |
| AU (1) | AU2014347004B2 (https=) |
| CA (1) | CA2928199C (https=) |
| DK (1) | DK3065770T3 (https=) |
| IL (1) | IL245219B (https=) |
| NZ (1) | NZ719232A (https=) |
| RU (1) | RU2714142C2 (https=) |
| WO (1) | WO2015069571A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201315321D0 (en) * | 2013-08-28 | 2013-10-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction Buffer |
| MY184154A (en) | 2013-12-12 | 2021-03-23 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| AU2015289081B2 (en) * | 2014-07-16 | 2020-02-06 | Transgene Sa | Combination of oncolytic virus with immune checkpoint modulators |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| ES3011733T3 (en) | 2015-02-13 | 2025-04-08 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| EP4122492A1 (en) | 2015-02-25 | 2023-01-25 | Memorial Sloan Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
| KR20180006916A (ko) * | 2015-04-17 | 2018-01-19 | 메모리얼 슬로안-케터링 캔서 센터 | 고형 종양에 대한 면역치료제로서 mva 또는 mva델타e3l의 용도 |
| CN114591433A (zh) | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
| FR3042121A1 (fr) * | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| KR20180086502A (ko) | 2015-12-16 | 2018-07-31 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항원-결합 단편 |
| US11612653B2 (en) * | 2016-01-08 | 2023-03-28 | Taiho Pharmaceutical Co., Ltd. | Anti-tumor agent containing immunomodulator, and antitumor effect potentiator |
| CN109152827B (zh) | 2016-02-25 | 2023-07-21 | 纪念斯隆凯特琳癌症中心 | 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途 |
| JP7025339B2 (ja) | 2016-02-25 | 2022-02-24 | メモリアル スローン ケタリング キャンサー センター | 癌免疫療法のための、チミジンキナーゼの欠失を伴い、ヒトｆｌｔ３ｌまたはｇｍ－ｃｓｆの発現を伴うかまたは伴わない、複製可能な弱毒化ワクシニアウイルス |
| US20210198689A1 (en) * | 2016-03-18 | 2021-07-01 | Nant Holdings Ip, Llc | Multimodal Vector for Dendritic Cell Infection |
| AU2017266298B2 (en) | 2016-05-18 | 2024-01-04 | Boehringer Ingelheim International Gmbh | Anti PD-1 and anti-LAG3 antibodies for cancer treatment |
| WO2018107011A1 (en) * | 2016-12-08 | 2018-06-14 | City Of Hope | P53-targeting vaccines and pd-1 pathway inhibitors and methods of use thereof |
| EP3621646A4 (en) | 2017-05-12 | 2021-06-02 | Memorial Sloan Kettering Cancer Center | VACCINIA VIRUS MUTANTS FOR CANCER IMMUNOTHERAPY |
| US12150978B2 (en) * | 2017-06-15 | 2024-11-26 | Cancer Advances Inc. | Compositions and methods for preventing tumors and cancer |
| WO2018232230A1 (en) * | 2017-06-15 | 2018-12-20 | Cancer Advances Inc. | Compositions and methods for inducing humoral and cellular immunities against tumors and cancer |
| KR102754876B1 (ko) * | 2017-08-24 | 2025-01-13 | 버베리안 노딕 에이/에스 | 재조합 mva 및 항체의 정맥내 투여에 의한 암 치료를 위한 병용 요법 |
| WO2019090343A1 (en) * | 2017-11-06 | 2019-05-09 | Memorial Sloan Kettering Cancer Center | Heat-inactivated vaccinia virus as a vaccine immune adjuvant |
| RU2771384C2 (ru) * | 2017-12-22 | 2022-05-04 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Фармацевтическая композиция, содержащая антитело к lag-3, и ее применение |
| BR112021004692A2 (pt) | 2018-09-15 | 2021-06-08 | Memorial Sloan Kettering Cancer Center | poxvírus recombinantes para imunoterapia de câncer |
| US11638730B2 (en) * | 2018-09-26 | 2023-05-02 | Astellas Pharma Inc. | Cancer therapy by combination use of oncolytic vaccinia virus and immune checkpoint inhibitor, and pharmaceutical composition and combination medicine for use in the cancer therapy |
| JP7555334B2 (ja) * | 2018-10-05 | 2024-09-24 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組み換えｍｖａ、及び免疫チェックポイントアンタゴニストまたは免疫チェックポイントアゴニストの静脈内投与によって、がんを治療する併用療法 |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| JP7732977B2 (ja) | 2019-09-20 | 2025-09-02 | トランスジーン | Ｈｐｖポリペプチドおよびｉｌ－２をコードするポックスウイルスと抗ｐｄ－ｌ１抗体の組合せ |
| KR20220115569A (ko) | 2019-11-18 | 2022-08-17 | 얀센 바이오테크 인코포레이티드 | 돌연변이 calr 및 jak2에 기반한 백신 및 이의 용도 |
| TR202005738A1 (tr) * | 2020-04-10 | 2021-10-21 | Hacettepe Ueniversitesi Rektoerluek | Küçük hücreli̇ akci̇ğer kanseri̇nde cd44+ cd90+ kanser kök hücreleri̇ni̇n i̇ndükledi̇ği̇ tim-3 ve lag-3 reseptörünün hedeflenmesi̇ |
| US12295997B2 (en) | 2020-07-06 | 2025-05-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| CN115536749A (zh) * | 2021-06-29 | 2022-12-30 | 三生国健药业（上海）股份有限公司 | 三特异性抗体、其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2261989C (en) * | 1996-07-25 | 2008-09-30 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
| AU6845201A (en) * | 2000-06-15 | 2001-12-24 | Us Gov Health & Human Serv | A recombinant non-replicating virus expressing GM-CSF and uses thereof to enhance immune responses |
| EP1518932A1 (en) * | 2003-09-29 | 2005-03-30 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Modified vaccinia virus Ankara (MVA) mutant and use thereof |
| GB0706912D0 (en) * | 2007-04-10 | 2007-05-16 | Isis Innovation | Novel viral vaccines |
| KR101814408B1 (ko) * | 2008-09-26 | 2018-01-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-ｐｄ-１, ｐｄ-ｌ１, 및 ｐｄ-ｌ2 항체 및 그의 용도 |
| AU2008363648B9 (en) * | 2008-10-31 | 2013-08-22 | Tremrx, Inc. | Vaccination with poxvirus vectors via mechanical epidermal disruption |
| EP3375791A1 (en) * | 2009-09-30 | 2018-09-19 | Memorial Sloan Kettering Cancer Center | Combination immunotherapy for the treatment of cancer |
| AU2011281982B2 (en) * | 2010-07-20 | 2015-12-17 | Bavarian Nordic A/S | Method for harvesting expression products |
| CN113967253A (zh) * | 2012-05-15 | 2022-01-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
-
2014
- 2014-10-31 WO PCT/US2014/063516 patent/WO2015069571A1/en not_active Ceased
- 2014-10-31 CN CN201480060569.5A patent/CN105744950A/zh active Pending
- 2014-10-31 KR KR1020227010325A patent/KR102395820B1/ko active Active
- 2014-10-31 CA CA2928199A patent/CA2928199C/en active Active
- 2014-10-31 JP JP2016552257A patent/JP6535337B2/ja active Active
- 2014-10-31 KR KR1020167011924A patent/KR20160070095A/ko not_active Ceased
- 2014-10-31 AU AU2014347004A patent/AU2014347004B2/en active Active
- 2014-10-31 NZ NZ719232A patent/NZ719232A/en unknown
- 2014-10-31 EP EP14803277.4A patent/EP3065770B1/en active Active
- 2014-10-31 DK DK14803277.4T patent/DK3065770T3/da active
- 2014-10-31 RU RU2016122035A patent/RU2714142C2/ru active
- 2014-10-31 US US15/034,496 patent/US20160271239A1/en not_active Abandoned
-
2016
- 2016-04-20 IL IL245219A patent/IL245219B/en active IP Right Grant
-
2021
- 2021-03-18 US US17/205,634 patent/US20210205429A1/en not_active Abandoned
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