AU2014347004B2 - Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist and/or agonist of an immune checkpoint inhibitor - Google Patents

Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist and/or agonist of an immune checkpoint inhibitor Download PDF

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Publication number
AU2014347004B2
AU2014347004B2 AU2014347004A AU2014347004A AU2014347004B2 AU 2014347004 B2 AU2014347004 B2 AU 2014347004B2 AU 2014347004 A AU2014347004 A AU 2014347004A AU 2014347004 A AU2014347004 A AU 2014347004A AU 2014347004 B2 AU2014347004 B2 AU 2014347004B2
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cancer
antagonist
antigen
mva
lag
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AU2014347004A1 (en
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Alain Delcayre
Susan FOY
Stefanie Mandl
Ryan ROUNTREE
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Bavarian Nordic AS
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Bavarian Nordic AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/00117—Mucins, e.g. MUC-1
    • A—HUMAN NECESSITIES
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    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
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    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001194—Prostate specific antigen [PSA]
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C12N2710/24011—Poxviridae
    • C12N2710/24034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24171—Demonstrated in vivo effect
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AU2014347004A 2013-11-05 2014-10-31 Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist and/or agonist of an immune checkpoint inhibitor Active AU2014347004B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361900226P 2013-11-05 2013-11-05
US61/900,226 2013-11-05
PCT/US2014/063516 WO2015069571A1 (en) 2013-11-05 2014-10-31 Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist and/or agonist of an immune checkpoint inhibitor

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AU2014347004A1 AU2014347004A1 (en) 2016-05-12
AU2014347004B2 true AU2014347004B2 (en) 2019-08-08

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AU2014347004A Active AU2014347004B2 (en) 2013-11-05 2014-10-31 Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist and/or agonist of an immune checkpoint inhibitor

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US (2) US20160271239A1 (https=)
EP (1) EP3065770B1 (https=)
JP (1) JP6535337B2 (https=)
KR (2) KR102395820B1 (https=)
CN (1) CN105744950A (https=)
AU (1) AU2014347004B2 (https=)
CA (1) CA2928199C (https=)
DK (1) DK3065770T3 (https=)
IL (1) IL245219B (https=)
NZ (1) NZ719232A (https=)
RU (1) RU2714142C2 (https=)
WO (1) WO2015069571A1 (https=)

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