JP2016537400A5 - - Google Patents

Download PDF

Info

Publication number
JP2016537400A5
JP2016537400A5 JP2016543268A JP2016543268A JP2016537400A5 JP 2016537400 A5 JP2016537400 A5 JP 2016537400A5 JP 2016543268 A JP2016543268 A JP 2016543268A JP 2016543268 A JP2016543268 A JP 2016543268A JP 2016537400 A5 JP2016537400 A5 JP 2016537400A5
Authority
JP
Japan
Prior art keywords
pkc
cancer
csc
cells
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016543268A
Other languages
English (en)
Japanese (ja)
Other versions
JP6998657B2 (ja
JP2016537400A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/AU2014/050237 external-priority patent/WO2015039187A1/en
Publication of JP2016537400A publication Critical patent/JP2016537400A/ja
Publication of JP2016537400A5 publication Critical patent/JP2016537400A5/ja
Application granted granted Critical
Publication of JP6998657B2 publication Critical patent/JP6998657B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016543268A 2013-09-18 2014-09-18 幹細胞調節ii Active JP6998657B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2013903589A AU2013903589A0 (en) 2013-09-18 Stem Cell Modulation II
AU2013903589 2013-09-18
PCT/AU2014/050237 WO2015039187A1 (en) 2013-09-18 2014-09-18 Stem cell modulation ii

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020143662A Division JP2021006530A (ja) 2013-09-18 2020-08-27 幹細胞調節ii

Publications (3)

Publication Number Publication Date
JP2016537400A JP2016537400A (ja) 2016-12-01
JP2016537400A5 true JP2016537400A5 (https=) 2019-05-30
JP6998657B2 JP6998657B2 (ja) 2022-02-04

Family

ID=52688010

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016543268A Active JP6998657B2 (ja) 2013-09-18 2014-09-18 幹細胞調節ii
JP2020143662A Pending JP2021006530A (ja) 2013-09-18 2020-08-27 幹細胞調節ii

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020143662A Pending JP2021006530A (ja) 2013-09-18 2020-08-27 幹細胞調節ii

Country Status (9)

Country Link
US (2) US10124001B2 (https=)
EP (1) EP3046560B1 (https=)
JP (2) JP6998657B2 (https=)
CN (1) CN105764513A (https=)
AU (1) AU2014324092B2 (https=)
CA (1) CA2923765C (https=)
ES (1) ES2851724T3 (https=)
SG (1) SG11201601408PA (https=)
WO (1) WO2015039187A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2958704A1 (en) * 2014-08-25 2016-03-03 University Of Canberra Compositions for modulating cancer stem cells and uses therefor
CA2984413A1 (en) * 2015-04-30 2016-11-03 Institute Of Immunology Co., Ltd. Transgenic non-human animal expressing human specific molecule and human fc.gamma. receptor family
JP7341451B2 (ja) * 2016-02-01 2023-09-11 エピアクシス セラピューティクス プロプライアタリー リミティド タンパク質性化合物とその利用
WO2018209312A1 (en) * 2017-05-12 2018-11-15 Tew Gregory N Ex vivo method of generating super regulatory t cells for the prevention of autoimmune disease
WO2019090390A1 (en) * 2017-11-08 2019-05-16 University Of Canberra Immunogenic compositions and uses therefor

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5804604A (en) 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
EP0786469B1 (en) 1990-06-11 2006-03-01 Gilead Sciences, Inc. Methods of use of nucleic acid ligands
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5151360A (en) 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
JP3534749B2 (ja) 1991-08-20 2004-06-07 アメリカ合衆国 アデノウイルスが介在する胃腸管への遺伝子の輸送
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
AU680459B2 (en) 1992-12-03 1997-07-31 Genzyme Corporation Gene therapy for cystic fibrosis
ES2249761T3 (es) 1993-06-24 2006-04-01 Advec Inc. Vectores de adenovirus para terapia genica.
EP1637608B1 (en) 1993-10-25 2009-07-22 CANJI, Inc. Recombinant adenoviral vector and methods of use
US5783405A (en) 1994-02-01 1998-07-21 Terrapin Technologies, Inc. Rapid screening method for effectors of signal transduction
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
US6291455B1 (en) 1996-03-05 2001-09-18 Zeneca Limited 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
US20030073640A1 (en) 1997-07-23 2003-04-17 Ribozyme Pharmaceuticals, Inc. Novel compositions for the delivery of negatively charged molecules
AU3751299A (en) 1998-04-20 1999-11-08 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
TW440494B (en) * 1999-05-13 2001-06-16 Sumitomo Spec Metals Machining method of rare earth alloy and manufacture of rare earth magnet using it
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US20050020525A1 (en) 2002-02-20 2005-01-27 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
PT1309726E (pt) 2000-03-30 2010-03-08 Whitehead Biomedical Inst Mediadores de interferência por rna específicos de sequência de rna
NZ522074A (en) 2000-05-31 2004-06-25 Astrazeneca Ab Indole derivatives with vascular damaging activity
IL153484A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
CN1255392C (zh) 2000-07-07 2006-05-10 安吉奥金尼药品有限公司 作为血管生成抑制剂的秋水仙醇衍生物
US20020150936A1 (en) 2000-09-01 2002-10-17 Leonid Beigelman Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
DE60144479D1 (https=) 2000-09-01 2011-06-01 Ribozyme Pharm Inc
US20040259247A1 (en) 2000-12-01 2004-12-23 Thomas Tuschl Rna interference mediating small rna molecules
WO2002090595A1 (en) * 2001-05-03 2002-11-14 President And Fellows Of Harvard College Methods for modulating an immune response by modulating krc activity
US20050239731A1 (en) 2001-05-18 2005-10-27 Sirna Therapeutics, Inc. RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA)
US20050282188A1 (en) 2001-05-18 2005-12-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
AU2003234185C1 (en) 2002-04-22 2009-11-19 The Board Of Trustees Of The Leland Stanford Junior University Peptide inhibitors of protein kinase C
AU2003236720A1 (en) * 2002-06-14 2003-12-31 Altana Pharma Ag Substituted diaminopyrimidines
US7482337B2 (en) 2002-11-08 2009-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
ATE440087T1 (de) 2003-01-30 2009-09-15 Boehringer Ingelheim Pharma 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
US20070142401A1 (en) 2003-10-27 2007-06-21 Novartis Ag Indolyl-pyrroledione derivatives for the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation
JP2007513974A (ja) 2003-12-11 2007-05-31 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー プロテインキナーゼcのアイソザイム特異的アンタゴニスト
TW200533357A (en) 2004-01-08 2005-10-16 Millennium Pharm Inc 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
US7582631B2 (en) 2004-01-14 2009-09-01 Amgen Inc. Substituted heterocyclic compounds and methods of use
WO2006105023A1 (en) 2005-03-28 2006-10-05 Boehringer Ingelheim International Gmbh Pyridine derivatives useful as inhibitors of pkc-theta
CA2633992A1 (en) 2005-12-21 2007-07-05 Boehringer Ingelheim International Gmbh Pyrimidine derivatives useful as inhibitors of pkc-theta
DE102006029447A1 (de) 2006-06-21 2007-12-27 Bayer Schering Pharma Ag Oxo-substituierte Imidazo[1,2b]pyridazine, deren Herstellung und Verwendung als Arzneimittel
US9180118B2 (en) 2006-07-18 2015-11-10 University Of Rochester Thiadiazolidinone derivatives
WO2009062059A2 (en) * 2007-11-08 2009-05-14 Pharmacopeia, Inc. Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
US8569337B2 (en) * 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
AU2009274023A1 (en) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
MX2011001319A (es) 2008-08-06 2011-04-05 Vertex Pharma Inhibidores de aminopiridina cinasa.
WO2010033655A1 (en) 2008-09-19 2010-03-25 Complegen, Inc. Compounds and methods for pkc theta inhibition
ES2555982T3 (es) 2009-01-15 2016-01-12 Rigel Pharmaceuticals, Inc. Inhibidores de la proteína quinasa C y usos de los mismos
EP3825833B1 (en) 2009-06-10 2022-08-03 Hexagon Technology Center GmbH Ontological filtering using spatial boundary of 3d objects
EP2528917B1 (en) * 2010-01-27 2016-10-19 Vertex Pharmaceuticals Incorporated Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
JP2013518112A (ja) 2010-01-27 2013-05-20 バーテックス ファーマシューティカルズ インコーポレイテッド ピラゾロピリジンキナーゼ阻害剤
WO2011094288A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol

Similar Documents

Publication Publication Date Title
JP2022050493A (ja) 癌を治療する方法における使用のための毛細血管拡張性運動失調症の変異したRad3関連タンパク質キナーゼ(ATR)の阻害剤
JP2023108628A (ja) 抗腫瘍免疫応答に対する耐性と関連する細胞内キナーゼ、及びその使用
KR101540838B1 (ko) 방사선치료 효능을 강화시키는 met 억제제
US20220323478A1 (en) Agents for the treatment of diseases associated with undesired cell proliferation
JP2016537400A5 (https=)
US10736892B2 (en) Stem cell modulation II
JP2023123748A (ja) 転移性癌の診断及び治療の方法
US11920135B2 (en) Methods of treating VEGF/VEGFR resistant prostate, renal, or colorectal cancers using combination therapies
JP2022532303A (ja) Fmrp及び癌治療
JP2024511354A (ja) 増殖性疾患の治療および予防のためのp2x4受容体の阻害剤を含む併用療法
US20170298128A1 (en) Methods and compositions for treating age-related disorders
WO2020032160A1 (ja) 炎症性腸疾患治療薬およびそのスクリーニング方法
Yang et al. TRIM38-mediated ubiquitination of IκBα promotes glioma development by activating the NF-κB signaling pathway
KR20240139138A (ko) 항-egfr 치료에 대한 반응성 예측용 조성물
US20110044991A1 (en) Methods and compositions for treating lymphoma and myeloma
CN104491880A (zh) MicroRNA-141作为抑制剂的用途
KR20180095694A (ko) 핵산 올리고머 및 이의 용도