JP2016536332A5 - - Google Patents

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JP2016536332A5
JP2016536332A5 JP2016539564A JP2016539564A JP2016536332A5 JP 2016536332 A5 JP2016536332 A5 JP 2016536332A5 JP 2016539564 A JP2016539564 A JP 2016539564A JP 2016539564 A JP2016539564 A JP 2016539564A JP 2016536332 A5 JP2016536332 A5 JP 2016536332A5
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Japan
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seq
chain variable
variable region
antibody
free
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JP2016539564A
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JP6820743B2 (ja
JP2016536332A (ja
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Priority claimed from PCT/EP2014/069013 external-priority patent/WO2015032932A1/en
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JP2016539564A 2013-09-05 2014-09-05 炎症性疾患におけるｉｌ−１８結合タンパク質（ｉｌ−１８ｂｐ） Active JP6820743B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13183193 2013-09-05
EP13183193.5 2013-09-05
PCT/EP2014/069013 WO2015032932A1 (en) 2013-09-05 2014-09-05 Il-18 binding protein (il-18bp) in inflammatory diseases

Related Child Applications (1)

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JP2019210436A Division JP2020055821A (ja) 2013-09-05 2019-11-21 炎症性疾患におけるｉｌ−１８結合タンパク質（ｉｌ−１８ｂｐ）

Publications (3)

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JP2016536332A JP2016536332A (ja) 2016-11-24
JP2016536332A5 true JP2016536332A5 (cg-RX-API-DMAC7.html) 2017-08-10
JP6820743B2 JP6820743B2 (ja) 2021-01-27

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JP2016539564A Active JP6820743B2 (ja) 2013-09-05 2014-09-05 炎症性疾患におけるｉｌ−１８結合タンパク質（ｉｌ−１８ｂｐ）
JP2019210436A Pending JP2020055821A (ja) 2013-09-05 2019-11-21 炎症性疾患におけるｉｌ−１８結合タンパク質（ｉｌ−１８ｂｐ）

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JP2019210436A Pending JP2020055821A (ja) 2013-09-05 2019-11-21 炎症性疾患におけるｉｌ−１８結合タンパク質（ｉｌ−１８ｂｐ）

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US (3) US10858426B2 (cg-RX-API-DMAC7.html)
EP (2) EP3041864B1 (cg-RX-API-DMAC7.html)
JP (2) JP6820743B2 (cg-RX-API-DMAC7.html)
KR (2) KR102321172B1 (cg-RX-API-DMAC7.html)
CN (2) CN105722858A (cg-RX-API-DMAC7.html)
AU (1) AU2014317035B2 (cg-RX-API-DMAC7.html)
CL (1) CL2016000506A1 (cg-RX-API-DMAC7.html)
CY (1) CY1124698T1 (cg-RX-API-DMAC7.html)
DK (1) DK3041864T3 (cg-RX-API-DMAC7.html)
ES (1) ES2892923T3 (cg-RX-API-DMAC7.html)
HU (1) HUE055608T2 (cg-RX-API-DMAC7.html)
IL (1) IL244169B (cg-RX-API-DMAC7.html)
LT (1) LT3041864T (cg-RX-API-DMAC7.html)
MX (1) MX385868B (cg-RX-API-DMAC7.html)
NZ (1) NZ717671A (cg-RX-API-DMAC7.html)
PH (1) PH12016500425B1 (cg-RX-API-DMAC7.html)
PL (1) PL3041864T3 (cg-RX-API-DMAC7.html)
PT (1) PT3041864T (cg-RX-API-DMAC7.html)
RU (1) RU2731713C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201601717VA (cg-RX-API-DMAC7.html)
SI (1) SI3041864T1 (cg-RX-API-DMAC7.html)
UA (1) UA125204C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015032932A1 (cg-RX-API-DMAC7.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ717671A (en) 2013-09-05 2022-07-01 Ab2 Bio Sa Il-18 binding protein (il-18bp) in inflammatory diseases
MX2017010919A (es) * 2015-03-05 2017-12-07 Ab2 Bio Sa Proteina de union il-18 (il-18bp) y anticuerpos en enfermedades inflamatorias.
US20180362660A1 (en) * 2016-05-09 2018-12-20 Schickwann Tsai Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes
GB201614455D0 (en) 2016-08-24 2016-10-05 Univ Oxford Innovation Ltd Biomarkers
DE102016219607B4 (de) * 2016-10-10 2025-04-30 Siemens Healthineers Ag Erzeugung einer mit anatomischen Bilddaten korrelierten Ergebniskarte
US11629183B2 (en) 2017-12-29 2023-04-18 University Of Florida Research Foundation, Inc. Monoclonal antibodies targeting microtubule-binding domain of tau protein and methods of detecting tau protein in vivo
TWI679279B (zh) * 2018-05-09 2019-12-11 臺中榮民總醫院 檢測成人發作型史笛兒氏症之罹病風險及預後之方法
US12240909B2 (en) 2018-06-19 2025-03-04 Shanghaitech University Human antibodies to human interleukin 18 receptor alpha or beta
JP6892180B2 (ja) * 2018-12-03 2021-06-23 株式会社ｍＡｂＰｒｏｔｅｉｎ 活性型インターロイキン−１８タンパク質のネオエピトープを認識する抗体、及びその応用
CN110433289B (zh) * 2019-09-10 2024-12-17 中山大学附属口腔医院 用于治疗牙周致病菌感染引起的牙周膜细胞功能紊乱与牙槽骨丧失的药物
EP4054711A1 (en) * 2019-11-04 2022-09-14 MedImmune Limited Methods of using il-33 antagonists
WO2021224432A1 (en) 2020-05-06 2021-11-11 Ab2 Bio Sa Il-18 binding protein (il-18bp) in respiratory diseases
GB202007404D0 (en) * 2020-05-19 2020-07-01 Nasser Syed Muhammad Tahir Treatment for viral respiratory infections
EP4178614A4 (en) * 2020-07-08 2024-10-30 Georgia Tech Research Corporation COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF SARS-COV-2 VIRUS INFECTIONS
EP3943097A1 (en) 2020-07-24 2022-01-26 AB2 Bio SA Car-t cell therapy
KR20220044057A (ko) * 2020-09-29 2022-04-06 주식회사 에이프릴바이오 인터루킨-18 결합 단백질 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질, 및 이의 용도
TW202233237A (zh) 2020-11-18 2022-09-01 瑞士商諾華公司 用於在治療ｎｌｒｃ４－ｇｏｆ炎性體病變中使用的雙特異性抗體
JPWO2023286694A1 (cg-RX-API-DMAC7.html) 2021-07-13 2023-01-19
WO2023067348A1 (en) * 2021-10-21 2023-04-27 Biosirius Ltd Treatment for virally-induced pneumonia
CN114236139A (zh) * 2021-12-30 2022-03-25 苏州和锐生物科技有限公司 一种TNF-α生物制剂的抗体检测试剂盒、制备方法
JP2025507007A (ja) 2022-03-04 2025-03-13 エイビー２ バイオ ソシエテアノニム Ｖｅｘａｓの治療におけるｉｌ－１８結合タンパク質（ｉｌ－１８ｂｐ）
KR20250133728A (ko) 2023-01-06 2025-09-08 라센 테라퓨틱스, 인코포레이티드 항-il-18bp 항체
WO2024148232A2 (en) 2023-01-06 2024-07-11 Alector Llc Anti-il18 binding protein antibodies and methods of use thereof
TW202434634A (zh) * 2023-02-20 2024-09-01 大陸商瑞石生物醫藥有限公司 抗IL-18Rβ抗體、其抗原結合片段及其醫藥應用
WO2024196976A2 (en) * 2023-03-21 2024-09-26 The Methodist Hospital Biomarkers of amyotrophic lateral sclerosis and uses thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9014932D0 (en) 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
WO1992013095A1 (en) 1991-01-18 1992-08-06 Synergen, Inc. Methods for treating tumor necrosis factor mediated diseases
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
JPH05244982A (ja) 1991-12-06 1993-09-24 Sumitomo Chem Co Ltd 擬人化ｂ−ｂ１０
US5635599A (en) 1994-04-08 1997-06-03 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins comprising circularly permuted ligands
BR9509421A (pt) 1994-10-21 1997-09-30 Innogenetics Nv Novas sequências de genotipos de vírus de hepatite C e uso como agentes profiláticos terapêuticos e diagnósticos
US5756662A (en) 1995-03-14 1998-05-26 Corixa Corporation Compounds and methods for the detection of T. cruzi infection
US7220717B2 (en) 1997-08-14 2007-05-22 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
EP1257585A2 (en) 2000-02-10 2002-11-20 Basf Aktiengesellschaft Antibodies that bind human interleukin-18 and methods of making and using
TR200502508T2 (tr) * 2000-02-21 2007-04-24 Applied Research Systems Ar� Holding N.V. IL-18 İnhibitörlerinin kullanımı.
MXPA02010895A (es) 2000-05-05 2003-03-27 Applied Research Systems Uso de inhibidores de interleucina 18 para el tratamiento y/o prevencion de aterosclerosis.
US20040198706A1 (en) 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
EP1311530A4 (en) 2000-08-03 2004-10-06 Wim-Van Schooten PRODUCTION OF HUMANIZED ANTIBODIES IN TRANSGENIC ANIMALS
WO2002032374A2 (en) 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders
KR100857376B1 (ko) * 2001-01-29 2008-09-05 라보라토리스 세로노 에스.에이. 심장 질환의 치료 및/또는 예방에 사용되는 ｉｌ-18저해물질
UA85531C2 (uk) * 2001-05-16 2009-02-10 Йеда Рисерч Энд Дивелопмент Ко. Лтд. Застосування il-18 інгібіторів для лікування або попередження пов'язаної з сепсисом дисфункції серця
HRP20030842B1 (hr) * 2001-05-25 2017-06-02 Ares Trading S.A. UPOTREBA IL-18 INHIBITORA ZA LIJEČENJE I PREVENCIJU OZLJEDA CNS-a
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
ATE549353T1 (de) * 2003-05-13 2012-03-15 Merck Serono Sa Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen
AU2011224023C1 (en) 2003-11-12 2013-08-29 Abbvie Inc. IL-18 binding proteins
US20050100965A1 (en) * 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
EP1736168A4 (en) 2004-03-11 2008-07-09 Redox Bioscience Inc INHIBITOR OF PROSTHESIS AND PREVENTIVES OR REMEDIES FOR DISEASES.
US7862829B2 (en) 2004-07-09 2011-01-04 University Of North Carolina At Chapel Hill Viral adjuvants
EP2161032B1 (en) 2004-08-20 2011-09-28 GlaxoSmithKline LLC Healing of wounds by administering human IL-18
EP1885753B1 (en) 2005-06-03 2011-07-27 Ares Trading S.A. Production of recombinant Il-18 binding protein
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
ATE503846T1 (de) 2005-09-15 2011-04-15 Val Chum S E C Verfahren zur diagnose eines ovarialkarzinoms
EP2112923A1 (en) 2007-01-22 2009-11-04 Targacept Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
AU2008260572A1 (en) 2007-05-29 2008-12-11 Yale University IL- 18 and protein kinase R inhibition for the treatment of COPD
WO2012085015A1 (en) * 2010-12-20 2012-06-28 Medimmune Limited Anti-il-18 antibodies and their uses
JOP20200308A1 (ar) * 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
NZ717671A (en) 2013-09-05 2022-07-01 Ab2 Bio Sa Il-18 binding protein (il-18bp) in inflammatory diseases
MX2017010919A (es) 2015-03-05 2017-12-07 Ab2 Bio Sa Proteina de union il-18 (il-18bp) y anticuerpos en enfermedades inflamatorias.

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