JP2016535795A5 - - Google Patents
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- Publication number
- JP2016535795A5 JP2016535795A5 JP2016553270A JP2016553270A JP2016535795A5 JP 2016535795 A5 JP2016535795 A5 JP 2016535795A5 JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016535795 A5 JP2016535795 A5 JP 2016535795A5
- Authority
- JP
- Japan
- Prior art keywords
- chlorophenyl
- pharmaceutical composition
- oxopiperidin
- methylbutan
- isopropylsulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 8
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 6
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 6
- 201000001441 melanoma Diseases 0.000 claims 6
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 5
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 5
- -1 3-methyl-2-oxopiperidin-3-yl Chemical group 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 3
- 125000003542 3-methylbutan-2-yl group Chemical group [H]C([H])([H])C([H])(*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 229960002465 dabrafenib Drugs 0.000 claims 2
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims 2
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims 2
- 229960004066 trametinib Drugs 0.000 claims 2
- DRLCSJFKKILATL-YWCVFVGNSA-N 2-[(3r,5r,6s)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2s)-3-methyl-1-propan-2-ylsulfonylbutan-2-yl]-2-oxopiperidin-3-yl]acetic acid Chemical compound C1([C@@H]2[C@H](N(C([C@@](C)(CC(O)=O)C2)=O)[C@H](CS(=O)(=O)C(C)C)C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 DRLCSJFKKILATL-YWCVFVGNSA-N 0.000 claims 1
- 102200055464 rs113488022 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902717P | 2013-11-11 | 2013-11-11 | |
| US61/902,717 | 2013-11-11 | ||
| PCT/US2014/065034 WO2015070224A2 (en) | 2013-11-11 | 2014-11-11 | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078325A Division JP2019142916A (ja) | 2013-11-11 | 2019-04-17 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016535795A JP2016535795A (ja) | 2016-11-17 |
| JP2016535795A5 true JP2016535795A5 (cg-RX-API-DMAC7.html) | 2017-12-21 |
Family
ID=52001089
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553270A Ceased JP2016535795A (ja) | 2013-11-11 | 2014-11-11 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2019078325A Pending JP2019142916A (ja) | 2013-11-11 | 2019-04-17 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2020172367A Expired - Fee Related JP6972274B2 (ja) | 2013-11-11 | 2020-10-13 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2021178554A Pending JP2022009805A (ja) | 2013-11-11 | 2021-11-01 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2023003579A Pending JP2023033414A (ja) | 2013-11-11 | 2023-01-13 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078325A Pending JP2019142916A (ja) | 2013-11-11 | 2019-04-17 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2020172367A Expired - Fee Related JP6972274B2 (ja) | 2013-11-11 | 2020-10-13 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2021178554A Pending JP2022009805A (ja) | 2013-11-11 | 2021-11-01 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2023003579A Pending JP2023033414A (ja) | 2013-11-11 | 2023-01-13 | Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Country Status (33)
Families Citing this family (33)
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| CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
| WO2012021875A1 (en) | 2010-08-13 | 2012-02-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with triazole linkers |
| WO2013049250A1 (en) | 2011-09-27 | 2013-04-04 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
| CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| CN104812384B (zh) | 2012-11-01 | 2020-09-18 | 爱勒让治疗公司 | 二取代的氨基酸及其制备和使用方法 |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| JP6377123B2 (ja) | 2013-03-14 | 2018-08-22 | アムジエン・インコーポレーテツド | 癌の治療のためのｍｄｍ２阻害剤としてのヘテロアリール酸モルホリノン化合物 |
| DK3068393T5 (da) * | 2013-11-11 | 2022-08-22 | Amgen Inc | Kombinationsterapi som inkluderer en mdm2-inhibitor og et eller flere yderligere farmaceutisk aktive midler til behandlingen af kræftformer |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10905739B2 (en) | 2014-09-24 | 2021-02-02 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| KR102595395B1 (ko) | 2015-02-20 | 2023-10-27 | 다이이찌 산쿄 가부시키가이샤 | 암의 병용 치료법 |
| SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| WO2017037586A1 (en) * | 2015-08-28 | 2017-03-09 | Novartis Ag | Combination therapy using pi3k inhbitor and mdm2 inhibitor |
| AU2016314082B2 (en) * | 2015-08-28 | 2019-07-25 | Novartis Ag | Mdm2 inhibitors and combinations thereof |
| WO2017200826A1 (en) * | 2016-05-16 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Assays and compounds for treatment of cancer |
| JP2019522633A (ja) | 2016-05-20 | 2019-08-15 | ジェネンテック， インコーポレイテッド | Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法 |
| WO2018074387A1 (ja) * | 2016-10-17 | 2018-04-26 | 第一三共株式会社 | Ｍｄｍ２阻害剤とｄｎａメチルトランスフェラーゼ阻害剤との併用治療法 |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| IL308399B2 (en) * | 2018-04-30 | 2025-08-01 | Kartos Therapeutics Inc | Methods of treating cancer |
| EP3801476A4 (en) * | 2018-05-25 | 2022-07-06 | Kartos Therapeutics, Inc. | METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS |
| US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN110963958B (zh) * | 2018-09-30 | 2025-10-10 | 上海长森药业有限公司 | 一种mdm2抑制剂，及其制备方法、药物组合物和应用 |
| TW202034918A (zh) * | 2018-12-11 | 2020-10-01 | 美商卡托斯醫療公司 | 治療眼睛病況之方法及組合物 |
| CN111434353A (zh) * | 2019-02-02 | 2020-07-21 | 中国科学院上海营养与健康研究所 | Ras抑制剂筛选及疗效标志物 |
| WO2021018032A1 (en) * | 2019-07-26 | 2021-02-04 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition of mdm2 inhibitor and use thereof for preventing and/or treating disease |
| TW202128156A (zh) * | 2019-11-14 | 2021-08-01 | 美商夸格智財控股有限公司 | 用於癌症治療之btk抑制劑及mdm2抑制劑之組合 |
| CN113801120B (zh) * | 2020-06-15 | 2024-03-22 | 苏州亚盛药业有限公司 | Mdm2抑制剂的微悬浮液以及治疗应用 |
| AR123227A1 (es) * | 2020-08-12 | 2022-11-09 | Servier Pharmaceuticals Llc | Terapias combinadas para su uso en el tratamiento del cáncer |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| CN115089585A (zh) * | 2022-08-05 | 2022-09-23 | 中国科学院大学宁波华美医院 | Mdm2抑制剂rg7112联合依托泊苷在治疗肺癌中的应用 |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
| WO2024254156A1 (en) * | 2023-06-05 | 2024-12-12 | Kartos Therapeutics, Inc. | Treatment of endometrial cancer with mdm2 inhibitors |
| WO2025098488A1 (zh) * | 2023-11-09 | 2025-05-15 | 深圳艾欣达伟医药科技有限公司 | 上调p53蛋白表达或激活p53功能的药物与DNA烷化剂联用治疗癌症 |
Family Cites Families (37)
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| YU2503A (sh) | 2000-07-19 | 2006-05-25 | Warner-Lambert Company | Oksigenovani estri 4-jodo fenilamino benzhidroksamskih kiselina |
| CN101389335A (zh) | 2004-10-18 | 2009-03-18 | 安姆根有限公司 | 噻二唑化合物和使用方法 |
| CN101421265A (zh) | 2006-01-18 | 2009-04-29 | 安姆根有限公司 | 作为蛋白激酶b(pkb)抑制剂的噻唑化合物 |
| AU2008231384B2 (en) | 2007-03-23 | 2011-09-15 | Amgen Inc. | Heterocyclic compounds and their use |
| PL2139882T3 (pl) | 2007-03-23 | 2014-05-30 | Amgen Inc | 3-podstawione pochodne chinoliny lub chinoksaliny i ich zastosowanie jako inhibitorów 3-kinazy fosfatydyloinozytolu (pi3k) |
| PT2137186E (pt) | 2007-03-23 | 2016-03-30 | Amgen Inc | Compostos heterocíclicos e suas utilizações |
| US7625895B2 (en) | 2007-04-12 | 2009-12-01 | Hoffmann-Le Roche Inc. | Diphenyl-dihydro-imidazopyridinones |
| EP2170887A2 (en) | 2007-06-07 | 2010-04-07 | Amgen Inc. | Heterocyclic compounds as raf kinase modulators |
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| EP2231656A1 (en) | 2007-12-19 | 2010-09-29 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
| ATE531372T1 (de) | 2008-04-07 | 2011-11-15 | Amgen Inc | Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren |
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| WO2010083246A1 (en) | 2009-01-15 | 2010-07-22 | Amgen Inc. | Fluoroisoquinoline substituted thiazole compounds and methods of use |
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| AU2010226490A1 (en) | 2009-03-20 | 2011-10-06 | Amgen Inc. | Inhibitors of PI3 kinase |
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| JP2012531436A (ja) | 2009-06-25 | 2012-12-10 | アムジエン・インコーポレーテツド | 複素環式化合物およびそれらのｐｉ３ｋ活性阻害剤としての使用 |
| AR077267A1 (es) | 2009-06-25 | 2011-08-17 | Amgen Inc | Derivados nitrogenados heterociclicos inhibidores selectivos de pi3k, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y/o autoinmunes. |
| ES2528485T3 (es) | 2009-09-11 | 2015-02-10 | Amgen, Inc | N-(4-((3-(2-amino-4-pirimidinil)-2-piridinil)oxi)fenil)-4-(4-metil-2-tienil)-1-ftalazinamina para su uso en el tratamiento del cáncer resistente a agentes antimitóticos |
| JO2998B1 (ar) * | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| KR20120031734A (ko) * | 2010-09-27 | 2012-04-04 | 삼성전자주식회사 | 급성 골수성 백혈병 환자의 시타라빈 민감성을 예측하기 위한 키트 및 방법 |
| EP2670396A1 (en) * | 2011-01-31 | 2013-12-11 | Celgene Corporation | Pharmaceutical compositions of cytidine analogs and methods of use thereof |
| WO2013049250A1 (en) | 2011-09-27 | 2013-04-04 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
| US9216170B2 (en) * | 2012-03-19 | 2015-12-22 | Hoffmann-La Roche Inc. | Combination therapy for proliferative disorders |
| JP2015511632A (ja) | 2012-03-30 | 2015-04-20 | 武田薬品工業株式会社 | メラノーマの治療におけるｒａｆ阻害剤およびｍｅｋ阻害剤の投与 |
| AU2014219075C1 (en) | 2013-02-19 | 2018-09-06 | Amgen Inc. | Cis-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| EP2961735B1 (en) | 2013-02-28 | 2017-09-27 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
| JP6377123B2 (ja) | 2013-03-14 | 2018-08-22 | アムジエン・インコーポレーテツド | 癌の治療のためのｍｄｍ２阻害剤としてのヘテロアリール酸モルホリノン化合物 |
| JOP20200296A1 (ar) * | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| CA2919294A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Volasertib in combination with decitabine for the treatment of acute myeloid leukemia and myelodysplastic syndrome ii |
| DK3068393T5 (da) * | 2013-11-11 | 2022-08-22 | Amgen Inc | Kombinationsterapi som inkluderer en mdm2-inhibitor og et eller flere yderligere farmaceutisk aktive midler til behandlingen af kræftformer |
-
2014
- 2014-11-11 DK DK14805743.3T patent/DK3068393T5/da active
- 2014-11-11 MX MX2020001550A patent/MX391859B/es unknown
- 2014-11-11 HR HRP20220718TT patent/HRP20220718T1/hr unknown
- 2014-11-11 AU AU2014346354A patent/AU2014346354A1/en not_active Abandoned
- 2014-11-11 RS RS20220533A patent/RS63348B9/sr unknown
- 2014-11-11 MY MYPI2016000850A patent/MY192088A/en unknown
- 2014-11-11 JP JP2016553270A patent/JP2016535795A/ja not_active Ceased
- 2014-11-11 AP AP2016009243A patent/AP2016009243A0/en unknown
- 2014-11-11 PT PT148057433T patent/PT3068393T/pt unknown
- 2014-11-11 MX MX2020013670A patent/MX2020013670A/es unknown
- 2014-11-11 KR KR1020167015298A patent/KR102305351B1/ko not_active Expired - Fee Related
- 2014-11-11 MX MX2016006025A patent/MX378969B/es unknown
- 2014-11-11 UA UAA201606309A patent/UA120750C2/uk unknown
- 2014-11-11 BR BR112016010564A patent/BR112016010564A2/pt not_active IP Right Cessation
- 2014-11-11 WO PCT/US2014/065034 patent/WO2015070224A2/en not_active Ceased
- 2014-11-11 EP EP14805743.3A patent/EP3068393B9/en active Active
- 2014-11-11 SI SI201431961T patent/SI3068393T1/sl unknown
- 2014-11-11 SG SG10201902429PA patent/SG10201902429PA/en unknown
- 2014-11-11 CN CN201480072891.XA patent/CN105934255A/zh active Pending
- 2014-11-11 MX MX2019009853A patent/MX393610B/es unknown
- 2014-11-11 EA EA201690980A patent/EA036942B1/ru unknown
- 2014-11-11 SM SM20220241T patent/SMT202200241T1/it unknown
- 2014-11-11 LT LTEPPCT/US2014/065034T patent/LT3068393T/lt unknown
- 2014-11-11 NZ NZ720766A patent/NZ720766A/en not_active IP Right Cessation
- 2014-11-11 EA EA202092456A patent/EA202092456A3/ru unknown
- 2014-11-11 US US15/035,438 patent/US20160287569A1/en not_active Abandoned
- 2014-11-11 CA CA2930244A patent/CA2930244A1/en active Pending
- 2014-11-11 PL PL14805743.3T patent/PL3068393T3/pl unknown
- 2014-11-11 MA MA39094A patent/MA39094B1/fr unknown
- 2014-11-11 EP EP22154212.9A patent/EP4039256A1/en not_active Withdrawn
- 2014-11-11 HU HUE14805743A patent/HUE059351T2/hu unknown
- 2014-11-11 CN CN202011275297.4A patent/CN112933236A/zh active Pending
- 2014-11-11 ES ES14805743T patent/ES2916721T3/es active Active
- 2014-11-11 KR KR1020217029928A patent/KR102473485B1/ko active Active
- 2014-11-11 TN TN2016000176A patent/TN2016000176A1/en unknown
- 2014-11-11 NZ NZ758548A patent/NZ758548A/en not_active IP Right Cessation
- 2014-11-11 KR KR1020227041845A patent/KR20220167335A/ko not_active Ceased
-
2016
- 2016-05-06 MX MX2022012320A patent/MX2022012320A/es unknown
- 2016-05-06 MX MX2022008175A patent/MX2022008175A/es unknown
- 2016-05-10 IL IL245568A patent/IL245568B/en unknown
- 2016-05-11 CL CL2016001131A patent/CL2016001131A1/es unknown
- 2016-05-11 PH PH12016500871A patent/PH12016500871A1/en unknown
- 2016-05-17 ZA ZA2016/03342A patent/ZA201603342B/en unknown
-
2018
- 2018-12-21 US US16/229,150 patent/US10881648B2/en not_active Expired - Fee Related
-
2019
- 2019-04-17 JP JP2019078325A patent/JP2019142916A/ja active Pending
-
2020
- 2020-02-24 AU AU2020201321A patent/AU2020201321B2/en not_active Ceased
- 2020-10-13 JP JP2020172367A patent/JP6972274B2/ja not_active Expired - Fee Related
-
2021
- 2021-08-16 IL IL285646A patent/IL285646A/en unknown
- 2021-09-09 US US17/470,136 patent/US20220280495A1/en not_active Abandoned
- 2021-11-01 JP JP2021178554A patent/JP2022009805A/ja active Pending
-
2022
- 2022-03-03 AU AU2022201495A patent/AU2022201495A1/en not_active Abandoned
- 2022-06-08 CY CY20221100397T patent/CY1125358T1/el unknown
-
2023
- 2023-01-13 JP JP2023003579A patent/JP2023033414A/ja active Pending
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