JP2018529666A5 - - Google Patents
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- Publication number
- JP2018529666A5 JP2018529666A5 JP2018511381A JP2018511381A JP2018529666A5 JP 2018529666 A5 JP2018529666 A5 JP 2018529666A5 JP 2018511381 A JP2018511381 A JP 2018511381A JP 2018511381 A JP2018511381 A JP 2018511381A JP 2018529666 A5 JP2018529666 A5 JP 2018529666A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hydroxyacetoxy
- cyclopentyl
- carboxymethyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 53
- KTCKPDPJTAUEPP-UHFFFAOYSA-N 2-[3-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy-1-methylpyrrolidin-1-ium-1-yl]acetate Chemical compound C1[N+](C)(CC([O-])=O)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 KTCKPDPJTAUEPP-UHFFFAOYSA-N 0.000 claims description 50
- 150000003839 salts Chemical class 0.000 claims description 50
- 150000001875 compounds Chemical class 0.000 claims description 42
- 230000004379 myopia Effects 0.000 claims description 18
- 208000001491 myopia Diseases 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 231100000252 nontoxic Toxicity 0.000 claims description 6
- 230000003000 nontoxic effect Effects 0.000 claims description 6
- 230000004515 progressive myopia Effects 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 2
- 230000003442 weekly effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 description 12
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020134413A JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952342P | 2014-03-13 | 2014-03-13 | |
| US14/845,645 US10632067B2 (en) | 2014-03-13 | 2015-09-04 | Use of selected anticholinergic zwitterions |
| US14/845,645 | 2015-09-04 | ||
| PCT/US2016/049047 WO2017040307A1 (en) | 2014-03-13 | 2016-08-26 | Use of selected anticholinergic zwitterions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020134413A Division JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529666A JP2018529666A (ja) | 2018-10-11 |
| JP2018529666A5 true JP2018529666A5 (cg-RX-API-DMAC7.html) | 2019-10-03 |
| JP6750900B2 JP6750900B2 (ja) | 2020-09-02 |
Family
ID=54072392
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556253A Withdrawn JP2017507959A (ja) | 2014-03-13 | 2015-03-12 | 選択された抗コリン作動性両性イオンの使用 |
| JP2018511381A Active JP6750900B2 (ja) | 2014-03-13 | 2016-08-26 | 選択された抗コリン作用性双性イオンの使用 |
| JP2020050858A Active JP6732356B2 (ja) | 2014-03-13 | 2020-03-23 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020115416A Active JP6968457B2 (ja) | 2014-03-13 | 2020-07-03 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020134413A Active JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556253A Withdrawn JP2017507959A (ja) | 2014-03-13 | 2015-03-12 | 選択された抗コリン作動性両性イオンの使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020050858A Active JP6732356B2 (ja) | 2014-03-13 | 2020-03-23 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020115416A Active JP6968457B2 (ja) | 2014-03-13 | 2020-07-03 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020134413A Active JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US10632067B2 (cg-RX-API-DMAC7.html) |
| JP (5) | JP2017507959A (cg-RX-API-DMAC7.html) |
| WO (2) | WO2015138700A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150259283A1 (en) | 2014-03-13 | 2015-09-17 | Brickell Biotech, Inc. | Formulation for soft anticholinergic analogs |
| WO2015138700A1 (en) | 2014-03-13 | 2015-09-17 | Bodor Laboratories, Inc. | Use of selected anticholinergic zwitterions |
| CN119033772A (zh) | 2015-07-21 | 2024-11-29 | 博多尔实验仪器公司 | 软性抗胆碱能药类似物的制剂 |
| EP3478365A4 (en) * | 2016-07-01 | 2020-03-04 | Bodor Laboratories, Inc. | COMPOSITIONS AND METHODS FOR TREATING COPD |
| TWI767507B (zh) | 2016-07-21 | 2022-06-11 | 美商波德實驗股份有限公司 | 軟性抗膽鹼類似物之製劑 |
| WO2021252628A1 (en) * | 2020-06-11 | 2021-12-16 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for preventing and treating myopia with trichostatin a, a histone deacetylase (hdac) inhibitor, and derivatives thereof |
| CA3182397A1 (en) * | 2020-06-11 | 2021-12-16 | Andrei V. Tkatchenko | Methods and compositions for preventing and treating myopia with fenoterol hydrobromide, a .beta.2-adrenergic receptor agonist, and derivatives thereof |
| IL298996A (en) * | 2020-06-11 | 2023-02-01 | Univ Columbia | Methods and preparations for the prevention and treatment of myopia (myopia) with pingolimod, a sphingosine-1-phosphate receptor modulator, and their derivatives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU701127B2 (en) * | 1994-10-27 | 1999-01-21 | Merck & Co., Inc. | Muscarine antagonists |
| US6433003B1 (en) | 1999-04-23 | 2002-08-13 | Arthur M. Bobrove | Method for treating hyperhidrosis in mammals |
| EP1438001A4 (en) | 2001-09-26 | 2006-03-15 | Alison B Lukacsko | COMPOSITIONS AND METHODS FOR INHIBITING ECCRINS PERSPIRATION IN HUMANS |
| WO2007059021A1 (en) * | 2005-11-10 | 2007-05-24 | Bodor Nicholas S | Soft anticholinergic zwitterions |
| ATE529399T1 (de) | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Sanfte anticholinerge ester |
| JP2007308398A (ja) * | 2006-05-17 | 2007-11-29 | Chang Gung Memorial Hospital | 目薬、及びその製造方法 |
| AU2007339929A1 (en) * | 2006-12-26 | 2008-07-10 | Qlt Inc. | Drug delivery implants for inhibition of optical defects |
| ES2671874T3 (es) | 2007-10-18 | 2018-06-11 | Rose U, Llc | Formulaciones tópicas de glicopirrolato |
| KR102153457B1 (ko) | 2013-03-15 | 2020-09-08 | 보도르 라보래토리즈, 인크. | 다한증 치료용 항콜린성 글리코피롤레이트 에스테르 |
| WO2015138700A1 (en) | 2014-03-13 | 2015-09-17 | Bodor Laboratories, Inc. | Use of selected anticholinergic zwitterions |
-
2015
- 2015-03-12 WO PCT/US2015/020137 patent/WO2015138700A1/en not_active Ceased
- 2015-03-12 JP JP2016556253A patent/JP2017507959A/ja not_active Withdrawn
- 2015-09-04 US US14/845,645 patent/US10632067B2/en active Active
-
2016
- 2016-08-26 WO PCT/US2016/049047 patent/WO2017040307A1/en not_active Ceased
- 2016-08-26 US US15/757,534 patent/US10335367B2/en active Active
- 2016-08-26 JP JP2018511381A patent/JP6750900B2/ja active Active
-
2020
- 2020-03-23 JP JP2020050858A patent/JP6732356B2/ja active Active
- 2020-07-03 JP JP2020115416A patent/JP6968457B2/ja active Active
- 2020-08-07 JP JP2020134413A patent/JP6981694B2/ja active Active