JP2017507959A - 選択された抗コリン作動性両性イオンの使用 - Google Patents

選択された抗コリン作動性両性イオンの使用 Download PDF

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Publication number
JP2017507959A
JP2017507959A JP2016556253A JP2016556253A JP2017507959A JP 2017507959 A JP2017507959 A JP 2017507959A JP 2016556253 A JP2016556253 A JP 2016556253A JP 2016556253 A JP2016556253 A JP 2016556253A JP 2017507959 A JP2017507959 A JP 2017507959A
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JP
Japan
Prior art keywords
compound
hydroxyacetoxy
cyclopentyl
carboxymethyl
phenyl
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JP2016556253A
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English (en)
Japanese (ja)
Inventor
ニコラス エス． ボドール，
ニコラス エス． ボドール，
Original Assignee
ボドール ラボラトリーズ， インコーポレイテッド
ボドール ラボラトリーズ， インコーポレイテッド
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Application filed by ボドール ラボラトリーズ， インコーポレイテッド, ボドール ラボラトリーズ， インコーポレイテッド filed Critical ボドール ラボラトリーズ， インコーポレイテッド
Publication of JP2017507959A publication Critical patent/JP2017507959A/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2016556253A 2014-03-13 2015-03-12 選択された抗コリン作動性両性イオンの使用 Withdrawn JP2017507959A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461952342P 2014-03-13 2014-03-13
US61/952,342 2014-03-13
PCT/US2015/020137 WO2015138700A1 (en) 2014-03-13 2015-03-12 Use of selected anticholinergic zwitterions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020050858A Division JP6732356B2 (ja) 2014-03-13 2020-03-23 選択された抗コリン作動性両性イオンの使用

Publications (1)

Publication Number Publication Date
JP2017507959A true JP2017507959A (ja) 2017-03-23

Family

ID=54072392

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2016556253A Withdrawn JP2017507959A (ja) 2014-03-13 2015-03-12 選択された抗コリン作動性両性イオンの使用
JP2018511381A Active JP6750900B2 (ja) 2014-03-13 2016-08-26 選択された抗コリン作用性双性イオンの使用
JP2020050858A Active JP6732356B2 (ja) 2014-03-13 2020-03-23 選択された抗コリン作動性両性イオンの使用
JP2020115416A Active JP6968457B2 (ja) 2014-03-13 2020-07-03 選択された抗コリン作動性両性イオンの使用
JP2020134413A Active JP6981694B2 (ja) 2014-03-13 2020-08-07 選択された抗コリン作用性双性イオンの使用

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2018511381A Active JP6750900B2 (ja) 2014-03-13 2016-08-26 選択された抗コリン作用性双性イオンの使用
JP2020050858A Active JP6732356B2 (ja) 2014-03-13 2020-03-23 選択された抗コリン作動性両性イオンの使用
JP2020115416A Active JP6968457B2 (ja) 2014-03-13 2020-07-03 選択された抗コリン作動性両性イオンの使用
JP2020134413A Active JP6981694B2 (ja) 2014-03-13 2020-08-07 選択された抗コリン作用性双性イオンの使用

Country Status (3)

Country Link
US (2) US10632067B2 (cg-RX-API-DMAC7.html)
JP (5) JP2017507959A (cg-RX-API-DMAC7.html)
WO (2) WO2015138700A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150259283A1 (en) 2014-03-13 2015-09-17 Brickell Biotech, Inc. Formulation for soft anticholinergic analogs
WO2015138700A1 (en) 2014-03-13 2015-09-17 Bodor Laboratories, Inc. Use of selected anticholinergic zwitterions
CN119033772A (zh) 2015-07-21 2024-11-29 博多尔实验仪器公司 软性抗胆碱能药类似物的制剂
EP3478365A4 (en) * 2016-07-01 2020-03-04 Bodor Laboratories, Inc. COMPOSITIONS AND METHODS FOR TREATING COPD
TWI767507B (zh) 2016-07-21 2022-06-11 美商波德實驗股份有限公司 軟性抗膽鹼類似物之製劑
WO2021252628A1 (en) * 2020-06-11 2021-12-16 The Trustees Of Columbia University In The City Of New York Methods and compositions for preventing and treating myopia with trichostatin a, a histone deacetylase (hdac) inhibitor, and derivatives thereof
CA3182397A1 (en) * 2020-06-11 2021-12-16 Andrei V. Tkatchenko Methods and compositions for preventing and treating myopia with fenoterol hydrobromide, a .beta.2-adrenergic receptor agonist, and derivatives thereof
IL298996A (en) * 2020-06-11 2023-02-01 Univ Columbia Methods and preparations for the prevention and treatment of myopia (myopia) with pingolimod, a sphingosine-1-phosphate receptor modulator, and their derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007308398A (ja) * 2006-05-17 2007-11-29 Chang Gung Memorial Hospital 目薬、及びその製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU701127B2 (en) * 1994-10-27 1999-01-21 Merck & Co., Inc. Muscarine antagonists
US6433003B1 (en) 1999-04-23 2002-08-13 Arthur M. Bobrove Method for treating hyperhidrosis in mammals
EP1438001A4 (en) 2001-09-26 2006-03-15 Alison B Lukacsko COMPOSITIONS AND METHODS FOR INHIBITING ECCRINS PERSPIRATION IN HUMANS
WO2007059021A1 (en) * 2005-11-10 2007-05-24 Bodor Nicholas S Soft anticholinergic zwitterions
ATE529399T1 (de) 2005-11-10 2011-11-15 Nicholas S Bodor Sanfte anticholinerge ester
AU2007339929A1 (en) * 2006-12-26 2008-07-10 Qlt Inc. Drug delivery implants for inhibition of optical defects
ES2671874T3 (es) 2007-10-18 2018-06-11 Rose U, Llc Formulaciones tópicas de glicopirrolato
KR102153457B1 (ko) 2013-03-15 2020-09-08 보도르 라보래토리즈, 인크. 다한증 치료용 항콜린성 글리코피롤레이트 에스테르
WO2015138700A1 (en) 2014-03-13 2015-09-17 Bodor Laboratories, Inc. Use of selected anticholinergic zwitterions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007308398A (ja) * 2006-05-17 2007-11-29 Chang Gung Memorial Hospital 目薬、及びその製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PHARMAZIE,2008, VOL.63, NO.3, PP.200-209, JPN6018049103, ISSN: 0004158381 *

Also Published As

Publication number Publication date
JP6981694B2 (ja) 2021-12-17
US20180243209A1 (en) 2018-08-30
JP6732356B2 (ja) 2020-07-29
US10335367B2 (en) 2019-07-02
JP6968457B2 (ja) 2021-11-17
US20150374621A1 (en) 2015-12-31
US10632067B2 (en) 2020-04-28
WO2015138700A1 (en) 2015-09-17
JP2018529666A (ja) 2018-10-11
JP2020176154A (ja) 2020-10-29
JP2020105218A (ja) 2020-07-09
JP6750900B2 (ja) 2020-09-02
WO2017040307A1 (en) 2017-03-09
JP2020158545A (ja) 2020-10-01

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