JP2016535741A5 - - Google Patents

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Publication number
JP2016535741A5
JP2016535741A5 JP2016526141A JP2016526141A JP2016535741A5 JP 2016535741 A5 JP2016535741 A5 JP 2016535741A5 JP 2016526141 A JP2016526141 A JP 2016526141A JP 2016526141 A JP2016526141 A JP 2016526141A JP 2016535741 A5 JP2016535741 A5 JP 2016535741A5
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
amino acids
seq
endoglin polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016526141A
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English (en)
Japanese (ja)
Other versions
JP6546587B2 (ja
JP2016535741A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/062147 external-priority patent/WO2015061666A1/en
Publication of JP2016535741A publication Critical patent/JP2016535741A/ja
Publication of JP2016535741A5 publication Critical patent/JP2016535741A5/ja
Application granted granted Critical
Publication of JP6546587B2 publication Critical patent/JP6546587B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016526141A 2013-10-25 2014-10-24 線維性疾患を処置するためのエンドグリンポリペプチド Expired - Fee Related JP6546587B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361896002P 2013-10-25 2013-10-25
US61/896,002 2013-10-25
PCT/US2014/062147 WO2015061666A1 (en) 2013-10-25 2014-10-24 Endoglin peptides to treat fibrotic diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019115063A Division JP6994481B2 (ja) 2013-10-25 2019-06-21 線維性疾患を処置するためのエンドグリンポリペプチド

Publications (3)

Publication Number Publication Date
JP2016535741A JP2016535741A (ja) 2016-11-17
JP2016535741A5 true JP2016535741A5 (https=) 2017-11-30
JP6546587B2 JP6546587B2 (ja) 2019-07-17

Family

ID=51894230

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016526141A Expired - Fee Related JP6546587B2 (ja) 2013-10-25 2014-10-24 線維性疾患を処置するためのエンドグリンポリペプチド
JP2019115063A Expired - Fee Related JP6994481B2 (ja) 2013-10-25 2019-06-21 線維性疾患を処置するためのエンドグリンポリペプチド
JP2021201819A Pending JP2022058352A (ja) 2013-10-25 2021-12-13 線維性疾患を処置するためのエンドグリンポリペプチド

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019115063A Expired - Fee Related JP6994481B2 (ja) 2013-10-25 2019-06-21 線維性疾患を処置するためのエンドグリンポリペプチド
JP2021201819A Pending JP2022058352A (ja) 2013-10-25 2021-12-13 線維性疾患を処置するためのエンドグリンポリペプチド

Country Status (9)

Country Link
US (2) US20150202260A1 (https=)
EP (2) EP3851118A1 (https=)
JP (3) JP6546587B2 (https=)
KR (2) KR102354787B1 (https=)
CN (1) CN105899225A (https=)
AU (2) AU2014339898B2 (https=)
CA (1) CA2928708A1 (https=)
EA (2) EA035481B1 (https=)
WO (1) WO2015061666A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642031B2 (en) 2006-11-02 2014-02-04 Acceleron Pharma, Inc. Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof
JP6250533B2 (ja) 2011-04-20 2017-12-20 アクセレロン ファーマ インコーポレイテッドAcceleron Pharma,Inc. エンドグリンポリペプチドおよびその使用
EP3851118A1 (en) 2013-10-25 2021-07-21 Acceleron Pharma Inc. Endoglin peptides to treat fibrotic diseases
EP3303387A2 (en) * 2015-06-05 2018-04-11 Novartis AG Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor
CA3029890A1 (en) * 2016-07-07 2018-01-11 Acceleron Pharma Inc. Tgf-beta superfamily heteromultimers and uses thereof
CN106994181A (zh) * 2017-03-10 2017-08-01 上海交通大学医学院附属第九人民医院 Bmp9在制备延缓肝纤维化药物中的应用
WO2020022438A1 (ja) * 2018-07-26 2020-01-30 参天製薬株式会社 網膜線維化を伴う眼疾患の処置剤
JP7411875B2 (ja) * 2020-10-08 2024-01-12 株式会社 キュロム・バイオサイエンス ベータ-ラパコンを有効成分として含む胆汁うっ滞性肝疾患予防又は治療用薬学組成物
WO2024237730A1 (ko) * 2023-05-18 2024-11-21 한국과학기술연구원 항-엔도글린 항체 및 이의 용도

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8529014D0 (en) 1985-11-25 1986-01-02 Biogen Nv Enhanced secretion of heterologous proteins
WO1987005330A1 (en) 1986-03-07 1987-09-11 Michel Louis Eugene Bergh Method for enhancing glycoprotein stability
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5198346A (en) 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5096815A (en) 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
US5462990A (en) 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US6582959B2 (en) 1991-03-29 2003-06-24 Genentech, Inc. Antibodies to vascular endothelial cell growth factor
US20030206899A1 (en) 1991-03-29 2003-11-06 Genentech, Inc. Vascular endothelial cell growth factor antagonists
AU687727B2 (en) 1992-10-28 1998-03-05 Genentech Inc. Vascular endothelial cell growth factor antagonists
WO1994010187A1 (en) 1992-10-30 1994-05-11 Hsc Research And Development Limited Partnership COMPOSITIONS AND METHODS FOR MODIFYING THE REGULATORY ACTIVITY OF TGF-$g(b)
US5830847A (en) * 1992-10-30 1998-11-03 Hsc Research & Development Limited Partnership Soluble TGF-β-binding endoglin polypeptides and homodimers
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5541087A (en) 1994-09-14 1996-07-30 Fuji Immunopharmaceuticals Corporation Expression and export technology of proteins as immunofusins
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
US6423501B2 (en) 1996-12-13 2002-07-23 Beth Israel Deaconess Medical Center Calcium-independent negative regulation by CD81 of receptor signaling
MX9701946A (es) 1997-03-14 1998-04-30 Arturo Jimenez Bayardo Solucion oftalmica transportadora.
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
PT971959E (pt) 1997-04-07 2006-05-31 Genentech Inc Anticorpos humanizados e metodos para formar anticorpos humanizados
KR100816621B1 (ko) 1997-04-07 2008-03-24 제넨테크, 인크. 항-vegf 항체
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
WO1998047531A2 (en) 1997-04-21 1998-10-29 Arch Development Corporation Fc receptor non-binding anti-cd3 monoclonal antibodies deliver a partial tcr signal and induce clonal anergy
ATE375365T1 (de) 1998-04-02 2007-10-15 Genentech Inc Antikörper varianten und fragmente davon
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
AU784231B2 (en) 2000-06-23 2006-02-23 Schering Aktiengesellschaft Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/tie receptor function and their use (II)
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
DK1638941T3 (da) 2003-05-22 2010-10-11 Abbott Lab Indazol-, benzisoxazol- og benzisothiazolkinaseinhibitorer
UA101945C2 (uk) 2003-05-30 2013-05-27 Дженентек, Инк. Лікування злоякісного новоутворення за допомогою бевацизумабу
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
WO2005044853A2 (en) 2003-11-01 2005-05-19 Genentech, Inc. Anti-vegf antibodies
US20090286271A1 (en) 2006-05-31 2009-11-19 Karumanchi Ananth S Methods of Diagnosing and Treating Complications of Pregnancy
WO2007143023A1 (en) 2006-05-31 2007-12-13 Beth Israel Deaconess Medical Center Soluble endoglin compounds and uses thereof for the treatment and prevention of cancer
CN111518218A (zh) 2006-11-02 2020-08-11 阿塞勒隆制药公司 Alk1受体和配体拮抗剂及其用途
MX2009012934A (es) 2007-06-01 2009-12-15 Wyeth Corp Metodos y composiciones para modular la actividad de bmp-10.
US20100210713A1 (en) * 2009-01-16 2010-08-19 The General Hospital Corporation Regeneration and survival of cardiac progenitors and cardiomyocytes with a stretch activated transcription factor
EP2209003A1 (en) * 2009-01-16 2010-07-21 F. Hoffmann-Roche AG Means and methods for differentiating between fibrosis and cirrhosis
JP5755635B2 (ja) * 2009-03-30 2015-07-29 アクセルロン ファーマ, インコーポレイテッド Bmp−alk3アンタゴニストおよび骨成長促進のためのその使用
WO2010128158A1 (en) 2009-05-08 2010-11-11 Novartis Ag Diagnostic biomarkers for fibrotic disorders
WO2011088047A1 (en) 2010-01-12 2011-07-21 Beth Israel Deaconess Medical Center Soluble endoglin and uses thereof
JP6250533B2 (ja) * 2011-04-20 2017-12-20 アクセレロン ファーマ インコーポレイテッドAcceleron Pharma,Inc. エンドグリンポリペプチドおよびその使用
EP2739645B1 (en) * 2011-08-01 2018-12-19 Tufts Medical Center, Inc. Endoglin-specific antibody for use in a method of treating heart failure and related conditions
US10214590B2 (en) 2013-09-20 2019-02-26 Tufts Medical Center, Inc. Inhibitors of endoglin activity for the treatment of fibrosis
EP3851118A1 (en) 2013-10-25 2021-07-21 Acceleron Pharma Inc. Endoglin peptides to treat fibrotic diseases
CA2966905A1 (en) * 2014-11-12 2016-05-19 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof

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