JP2016535015A5 - - Google Patents
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- Publication number
- JP2016535015A5 JP2016535015A5 JP2016525032A JP2016525032A JP2016535015A5 JP 2016535015 A5 JP2016535015 A5 JP 2016535015A5 JP 2016525032 A JP2016525032 A JP 2016525032A JP 2016525032 A JP2016525032 A JP 2016525032A JP 2016535015 A5 JP2016535015 A5 JP 2016535015A5
- Authority
- JP
- Japan
- Prior art keywords
- ctp
- growth hormone
- seq
- added
- pharmaceutical preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101800005309 Carboxy-terminal peptide Proteins 0.000 claims 43
- 102000018997 Growth Hormone Human genes 0.000 claims 35
- 108010051696 Growth Hormone Proteins 0.000 claims 35
- 239000000122 growth hormone Substances 0.000 claims 35
- 229920001184 polypeptide Polymers 0.000 claims 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 239000000825 pharmaceutical preparation Substances 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 14
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 14
- 229940015047 chorionic gonadotropin Drugs 0.000 claims 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 10
- 210000004899 c-terminal region Anatomy 0.000 claims 9
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 8
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 8
- 102000002265 Human Growth Hormone Human genes 0.000 claims 6
- 108010000521 Human Growth Hormone Proteins 0.000 claims 6
- 239000000854 Human Growth Hormone Substances 0.000 claims 6
- 102000006771 Gonadotropins Human genes 0.000 claims 4
- 108010086677 Gonadotropins Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000002622 gonadotropin Substances 0.000 claims 4
- 229940094892 gonadotropins Drugs 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 206010056438 Growth hormone deficiency Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229960004407 chorionic gonadotrophin Drugs 0.000 claims 2
- 238000009578 growth hormone therapy Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 239000012929 tonicity agent Substances 0.000 claims 2
- 230000003442 weekly effect Effects 0.000 claims 2
- 108010038988 Peptide Hormones Proteins 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000007951 isotonicity adjuster Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000813 peptide hormone Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/059,134 | 2013-10-21 | ||
| US14/059,134 US20140113860A1 (en) | 2006-02-03 | 2013-10-21 | Long-acting polypeptides and methods of producing and administering same |
| US14/309,496 US20150038413A1 (en) | 2006-02-03 | 2014-06-19 | Long-acting polypeptides and methods of producing and administering same |
| US14/309,496 | 2014-06-19 | ||
| PCT/IL2014/050910 WO2015059695A1 (en) | 2013-10-21 | 2014-10-21 | Long-acting polypeptides and methods of producing and administering same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019236267A Division JP7051797B2 (ja) | 2013-10-21 | 2019-12-26 | 長期活性型ポリペプチドならびに当該ポリペプチドの製造方法および投与方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535015A JP2016535015A (ja) | 2016-11-10 |
| JP2016535015A5 true JP2016535015A5 (enExample) | 2017-11-30 |
| JP6640720B2 JP6640720B2 (ja) | 2020-02-05 |
Family
ID=52992360
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525032A Active JP6640720B2 (ja) | 2013-10-21 | 2014-10-21 | 長期活性型ポリペプチドならびに当該ポリペプチドの製造方法および投与方法 |
| JP2019236267A Active JP7051797B2 (ja) | 2013-10-21 | 2019-12-26 | 長期活性型ポリペプチドならびに当該ポリペプチドの製造方法および投与方法 |
| JP2022052919A Active JP7445695B2 (ja) | 2013-10-21 | 2022-03-29 | 長期活性型ポリペプチドならびに当該ポリペプチドの製造方法および投与方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019236267A Active JP7051797B2 (ja) | 2013-10-21 | 2019-12-26 | 長期活性型ポリペプチドならびに当該ポリペプチドの製造方法および投与方法 |
| JP2022052919A Active JP7445695B2 (ja) | 2013-10-21 | 2022-03-29 | 長期活性型ポリペプチドならびに当該ポリペプチドの製造方法および投与方法 |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP3763733A1 (enExample) |
| JP (3) | JP6640720B2 (enExample) |
| KR (4) | KR20160068969A (enExample) |
| CN (1) | CN106163543A (enExample) |
| AU (3) | AU2014338575B2 (enExample) |
| CA (1) | CA2928269C (enExample) |
| DK (1) | DK3060239T3 (enExample) |
| ES (1) | ES2811068T3 (enExample) |
| FR (1) | FR22C1035I2 (enExample) |
| HR (1) | HRP20201114T1 (enExample) |
| HU (2) | HUE050002T2 (enExample) |
| IL (1) | IL297219B2 (enExample) |
| LU (1) | LUC00259I2 (enExample) |
| MX (2) | MX381148B (enExample) |
| NL (1) | NL301170I2 (enExample) |
| PL (1) | PL3060239T3 (enExample) |
| PT (1) | PT3060239T (enExample) |
| RU (1) | RU2746943C2 (enExample) |
| SI (1) | SI3060239T1 (enExample) |
| TW (5) | TWI720940B (enExample) |
| WO (1) | WO2015059695A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20201114T1 (hr) | 2013-10-21 | 2020-10-30 | Opko Biologics Ltd. | Dugodjelujući polipeptidi i postupci njihove proizvodnje i primjene |
| JOP20190019A1 (ar) * | 2016-08-30 | 2019-02-12 | Genexine Inc | تركيبة صيدلانية لعلاج نقص في هرمون نمو يحتوي على بروتين اندماجي لهرمون نمو بشري (hGH) |
| CN109942717A (zh) * | 2019-04-24 | 2019-06-28 | 上海延立药业有限公司 | 一种长效重组人促卵泡激素及其制备方法和应用 |
| KR20230171936A (ko) * | 2021-03-19 | 2023-12-21 | 화이자 인코포레이티드 | 지속 작용성 성장 호르몬 폴리펩타이드를 투여하는 방법 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| DE3421468A1 (de) | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| JP2874751B2 (ja) | 1986-04-09 | 1999-03-24 | ジェンザイム・コーポレーション | 希望する蛋白質をミルク中へ分泌する遺伝子移植動物 |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| EP0374257B1 (en) | 1988-05-06 | 1994-08-31 | Toray Industries, Inc. | STABLE INTERFERON $g(b) COMPOSITION |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| ATE148171T1 (de) | 1989-02-21 | 1997-02-15 | Univ Washington | Modifizierte formen von fortpflanzungshormonen |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US5541110A (en) | 1994-05-17 | 1996-07-30 | Bristol-Myers Squibb | Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica |
| US8946155B2 (en) * | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8304386B2 (en) * | 2006-02-03 | 2012-11-06 | Prolor Biotech, Inc. | Long-acting growth hormone and methods of producing same |
| US8476234B2 (en) * | 2006-02-03 | 2013-07-02 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| WO2007092252A2 (en) * | 2006-02-03 | 2007-08-16 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US8048849B2 (en) * | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US8450269B2 (en) * | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| DE102007006189B4 (de) * | 2007-02-07 | 2009-07-30 | Isotopen Technologien München AG | Vorrichtung zum Befüllen eines medizinischen Instruments mit einer radioaktiven Substanz und Verfahren |
| HRP20201114T1 (hr) | 2013-10-21 | 2020-10-30 | Opko Biologics Ltd. | Dugodjelujući polipeptidi i postupci njihove proizvodnje i primjene |
-
2014
- 2014-10-21 HR HRP20201114TT patent/HRP20201114T1/hr unknown
- 2014-10-21 TW TW103143380A patent/TWI720940B/zh active
- 2014-10-21 PT PT148566664T patent/PT3060239T/pt unknown
- 2014-10-21 TW TW103143381A patent/TW201536312A/zh unknown
- 2014-10-21 WO PCT/IL2014/050910 patent/WO2015059695A1/en not_active Ceased
- 2014-10-21 IL IL297219A patent/IL297219B2/en unknown
- 2014-10-21 KR KR1020167013555A patent/KR20160068969A/ko not_active Ceased
- 2014-10-21 SI SI201431630T patent/SI3060239T1/sl unknown
- 2014-10-21 KR KR1020217030424A patent/KR102444140B1/ko active Active
- 2014-10-21 MX MX2016005227A patent/MX381148B/es unknown
- 2014-10-21 PL PL14856666T patent/PL3060239T3/pl unknown
- 2014-10-21 TW TW110104795A patent/TWI777407B/zh active
- 2014-10-21 KR KR1020227031563A patent/KR20220130254A/ko not_active Ceased
- 2014-10-21 HU HUE14856666A patent/HUE050002T2/hu unknown
- 2014-10-21 ES ES14856666T patent/ES2811068T3/es active Active
- 2014-10-21 DK DK14856666.4T patent/DK3060239T3/da active
- 2014-10-21 TW TW111132309A patent/TWI893324B/zh active
- 2014-10-21 RU RU2016119565A patent/RU2746943C2/ru active
- 2014-10-21 AU AU2014338575A patent/AU2014338575B2/en active Active
- 2014-10-21 EP EP20172836.7A patent/EP3763733A1/en active Pending
- 2014-10-21 CN CN201480070117.5A patent/CN106163543A/zh active Pending
- 2014-10-21 CA CA2928269A patent/CA2928269C/en active Active
- 2014-10-21 TW TW103136384A patent/TWI720939B/zh active
- 2014-10-21 JP JP2016525032A patent/JP6640720B2/ja active Active
- 2014-10-21 EP EP14856666.4A patent/EP3060239B1/en active Active
- 2014-10-21 KR KR1020247021540A patent/KR20240110069A/ko not_active Ceased
-
2016
- 2016-04-21 MX MX2021003908A patent/MX2021003908A/es unknown
-
2019
- 2019-12-26 JP JP2019236267A patent/JP7051797B2/ja active Active
-
2020
- 2020-02-06 AU AU2020200874A patent/AU2020200874A1/en not_active Abandoned
-
2022
- 2022-03-29 JP JP2022052919A patent/JP7445695B2/ja active Active
- 2022-04-19 NL NL301170C patent/NL301170I2/nl unknown
- 2022-05-02 HU HUS2200014C patent/HUS2200014I1/hu unknown
- 2022-05-06 LU LU00259C patent/LUC00259I2/fr unknown
- 2022-07-13 FR FR22C1035C patent/FR22C1035I2/fr active Active
- 2022-10-07 AU AU2022246472A patent/AU2022246472B2/en active Active
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