JP2016533738A - 癌幹細胞を含む癌の診断および治療法 - Google Patents

癌幹細胞を含む癌の診断および治療法 Download PDF

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Publication number
JP2016533738A
JP2016533738A JP2016530504A JP2016530504A JP2016533738A JP 2016533738 A JP2016533738 A JP 2016533738A JP 2016530504 A JP2016530504 A JP 2016530504A JP 2016530504 A JP2016530504 A JP 2016530504A JP 2016533738 A JP2016533738 A JP 2016533738A
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cancer
cldn6
antibody
cells
stem cells
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Japanese (ja)
Inventor
ウグル サヒン，
ウグル サヒン，
エズレム テューレヒ，
エズレム テューレヒ，
コルデン ウォルター，
コルデン ウォルター，
マイケ ワグナー，
マイケ ワグナー，
マリア クロイツベルク，
マリア クロイツベルク，
サビーネ ヘッカー，
サビーネ ヘッカー，
シュテファン ヤコブス，
シュテファン ヤコブス，
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TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH
Biontech SE
Original Assignee
TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH
Biontech SE
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Publication of JP2016533738A publication Critical patent/JP2016533738A/ja
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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JP2016530504A 2013-07-31 2014-07-30 癌幹細胞を含む癌の診断および治療法 Pending JP2016533738A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2013/002272 2013-07-31
PCT/EP2013/002272 WO2015014376A1 (en) 2013-07-31 2013-07-31 Diagnosis and therapy of cancer involving cancer stem cells
PCT/EP2014/066330 WO2015014870A1 (en) 2013-07-31 2014-07-30 Diagnosis and therapy of cancer involving cancer stem cells

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JP2016530504A Pending JP2016533738A (ja) 2013-07-31 2014-07-30 癌幹細胞を含む癌の診断および治療法
JP2019020349A Active JP6865778B2 (ja) 2013-07-31 2019-02-07 癌幹細胞を含む癌の診断および治療法
JP2020024949A Active JP7136822B2 (ja) 2013-07-31 2020-02-18 癌幹細胞を含む癌の診断および治療法
JP2022139001A Active JP7611196B2 (ja) 2013-07-31 2022-09-01 癌幹細胞を含む癌の診断および治療法
JP2024174919A Pending JP2025011178A (ja) 2013-07-31 2024-10-04 癌幹細胞を含む癌の診断および治療法

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JP2020024949A Active JP7136822B2 (ja) 2013-07-31 2020-02-18 癌幹細胞を含む癌の診断および治療法
JP2022139001A Active JP7611196B2 (ja) 2013-07-31 2022-09-01 癌幹細胞を含む癌の診断および治療法
JP2024174919A Pending JP2025011178A (ja) 2013-07-31 2024-10-04 癌幹細胞を含む癌の診断および治療法

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US (3) US10604568B2 (https=)
JP (5) JP2016533738A (https=)
KR (4) KR102483410B1 (https=)
CN (3) CN113406327B (https=)
AR (1) AR097178A1 (https=)
AU (3) AU2014298505B2 (https=)
BR (1) BR112016002000A2 (https=)
CA (1) CA2919570A1 (https=)
DK (1) DK3027208T3 (https=)
ES (2) ES2807181T3 (https=)
HU (1) HUE050622T2 (https=)
IL (4) IL308523B2 (https=)
MX (2) MX385872B (https=)
NZ (1) NZ716473A (https=)
PT (1) PT3027208T (https=)
RU (2) RU2749867C2 (https=)
SG (2) SG11201600722PA (https=)
UA (1) UA123428C2 (https=)
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JP2020524669A (ja) * 2017-06-15 2020-08-20 ディベロップメント センター フォー バイオテクノロジーＤｅｖｅｌｏｐｍｅｎｔ Ｃｅｎｔｅｒ Ｆｏｒ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ 抗ｇｌｏｂｏ ｈ抗体を含有する抗体−薬物コンジュゲートおよびその使用
JP2020536507A (ja) * 2017-09-18 2020-12-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア クローディン６抗体及びがんを治療するための方法
JP2022527151A (ja) * 2019-03-20 2022-05-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア クローディン６抗体及び薬物複合体

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EP2404936A1 (en) 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
ES2989943T3 (es) 2011-05-13 2024-11-28 Astellas Pharma Inc Anticuerpos para el tratamiento de un cáncer que expresa la Claudina 6
ES2702315T3 (es) 2012-08-24 2019-02-28 Univ California Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis
WO2015014376A1 (en) * 2013-07-31 2015-02-05 Biontech Ag Diagnosis and therapy of cancer involving cancer stem cells
RU2016122041A (ru) 2013-11-06 2017-12-11 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Новые анти-клаудин антитела и способы их применения
JP6408134B2 (ja) * 2015-03-31 2018-10-17 三菱日立パワーシステムズ株式会社 燃焼バーナ及びボイラ
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
US20180371550A1 (en) * 2015-07-08 2018-12-27 Children's Hospital Medical Center Loss of transcriptional fidelity leads to immunotherapy resistance in cancers
TWI767915B (zh) 2016-06-27 2022-06-21 加州大學董事會 Ror-1與btk拮抗劑的組合
CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
WO2019048040A1 (en) * 2017-09-06 2019-03-14 Ganymed Pharmaceuticals Gmbh ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER
EP3681993B1 (en) 2017-09-13 2026-04-01 BioNTech SE Rna replicon for reprogramming somatic cells
NZ762505A (en) 2017-09-29 2026-03-27 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
EP3838291A4 (en) * 2018-08-13 2022-05-11 Cancerstem Tech Inc. CANCER STEM CELL MARKERS AND ANTI-CANCER STEM CELL PHARMACEUTICALS
MA54955A (fr) 2019-02-15 2021-12-22 Integral Molecular Inc Anticorps anti-claudine 6 et leurs utilisations
WO2020190725A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
MX2022000111A (es) 2019-07-10 2022-02-10 Chugai Pharmaceutical Co Ltd Moleculas de union a claudina-6 y usos de las mismas.
CN111087465B (zh) * 2019-12-24 2020-12-08 广州医科大学 一种针对密蛋白6的抗体偶联药物及应用
CN113832226B (zh) * 2020-06-24 2023-06-30 广州医科大学附属第五医院 研究gnl3与肝癌发展的相关性的方法及gnl3作为肝肿瘤干细胞、肝癌标志物的用途
JP2024511277A (ja) 2021-02-19 2024-03-13 メビオン・メディカル・システムズ・インコーポレーテッド 粒子線治療システムのためのガントリー
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