RU2749867C2 - Диагностика и лечение рака, связанного с раковыми стволовыми клетками - Google Patents

Диагностика и лечение рака, связанного с раковыми стволовыми клетками Download PDF

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RU2749867C2
RU2749867C2 RU2016107005A RU2016107005A RU2749867C2 RU 2749867 C2 RU2749867 C2 RU 2749867C2 RU 2016107005 A RU2016107005 A RU 2016107005A RU 2016107005 A RU2016107005 A RU 2016107005A RU 2749867 C2 RU2749867 C2 RU 2749867C2
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cldn6
cancer
cells
antibody
cell
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RU2016107005A
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RU2016107005A (ru
RU2016107005A3 (https=
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Угур САХИН
Озлем ТЮРЕЧИ
Корден ВАЛЬТЕР
Майке ВАГНЕР
Мария КРОЙЦБЕРГ
Сабине ХЭКЕР
Штефан ЯКОБС
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Бионтех Аг
Астеллас Фарма Инк.
Трон - Транслационале Онкологи Ан Дер Универзитетсмедицин Дер Йоханнес Гутенберг-Универзитет Майнц Гемайннютциге Гмбх
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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RU2016107005A 2013-07-31 2014-07-30 Диагностика и лечение рака, связанного с раковыми стволовыми клетками RU2749867C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2013/002272 2013-07-31
PCT/EP2013/002272 WO2015014376A1 (en) 2013-07-31 2013-07-31 Diagnosis and therapy of cancer involving cancer stem cells
PCT/EP2014/066330 WO2015014870A1 (en) 2013-07-31 2014-07-30 Diagnosis and therapy of cancer involving cancer stem cells

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RU2016107005A RU2016107005A (ru) 2017-09-04
RU2016107005A3 RU2016107005A3 (https=) 2018-03-30
RU2749867C2 true RU2749867C2 (ru) 2021-06-17

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RU2020123616A RU2020123616A (ru) 2013-07-31 2014-07-30 Диагностика и лечение рака, связанного с раковыми стволовыми клетками

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US (3) US10604568B2 (https=)
JP (5) JP2016533738A (https=)
KR (4) KR102483410B1 (https=)
CN (3) CN113406327B (https=)
AR (1) AR097178A1 (https=)
AU (3) AU2014298505B2 (https=)
BR (1) BR112016002000A2 (https=)
CA (1) CA2919570A1 (https=)
DK (1) DK3027208T3 (https=)
ES (2) ES2807181T3 (https=)
HU (1) HUE050622T2 (https=)
IL (4) IL308523B2 (https=)
MX (2) MX385872B (https=)
NZ (1) NZ716473A (https=)
PT (1) PT3027208T (https=)
RU (2) RU2749867C2 (https=)
SG (2) SG11201600722PA (https=)
UA (1) UA123428C2 (https=)
WO (2) WO2015014376A1 (https=)

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WO2015014376A1 (en) * 2013-07-31 2015-02-05 Biontech Ag Diagnosis and therapy of cancer involving cancer stem cells
RU2016122041A (ru) 2013-11-06 2017-12-11 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Новые анти-клаудин антитела и способы их применения
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TWI767915B (zh) 2016-06-27 2022-06-21 加州大學董事會 Ror-1與btk拮抗劑的組合
CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
US10947316B2 (en) * 2017-06-15 2021-03-16 Development Center For Biotechnology Antibody-drug conjugates containing anti-Globo H antibodies and uses thereof
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NZ762505A (en) 2017-09-29 2026-03-27 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
EP3838291A4 (en) * 2018-08-13 2022-05-11 Cancerstem Tech Inc. CANCER STEM CELL MARKERS AND ANTI-CANCER STEM CELL PHARMACEUTICALS
MA54955A (fr) 2019-02-15 2021-12-22 Integral Molecular Inc Anticorps anti-claudine 6 et leurs utilisations
WO2020190725A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
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MX2022000111A (es) 2019-07-10 2022-02-10 Chugai Pharmaceutical Co Ltd Moleculas de union a claudina-6 y usos de las mismas.
CN111087465B (zh) * 2019-12-24 2020-12-08 广州医科大学 一种针对密蛋白6的抗体偶联药物及应用
CN113832226B (zh) * 2020-06-24 2023-06-30 广州医科大学附属第五医院 研究gnl3与肝癌发展的相关性的方法及gnl3作为肝肿瘤干细胞、肝癌标志物的用途
JP2024511277A (ja) 2021-02-19 2024-03-13 メビオン・メディカル・システムズ・インコーポレーテッド 粒子線治療システムのためのガントリー
TW202430574A (zh) 2022-11-30 2024-08-01 美商積分分子股份有限公司 針對密連蛋白６之抗體，包括其雙特異性格式
WO2024165057A1 (en) * 2023-02-07 2024-08-15 LaNova Medicines Limited Antibodies and antibody-drug conjugates targeting claudin 6
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