JP2016529916A5 - - Google Patents
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- Publication number
- JP2016529916A5 JP2016529916A5 JP2016542829A JP2016542829A JP2016529916A5 JP 2016529916 A5 JP2016529916 A5 JP 2016529916A5 JP 2016542829 A JP2016542829 A JP 2016542829A JP 2016542829 A JP2016542829 A JP 2016542829A JP 2016529916 A5 JP2016529916 A5 JP 2016529916A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- seq
- fluorescent protein
- human mammal
- transgenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091006047 fluorescent proteins Proteins 0.000 claims description 38
- 102000034287 fluorescent proteins Human genes 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 37
- 230000009261 transgenic effect Effects 0.000 claims description 36
- 102000040430 polynucleotide Human genes 0.000 claims description 32
- 108091033319 polynucleotide Proteins 0.000 claims description 32
- 239000002157 polynucleotide Substances 0.000 claims description 32
- 108091008874 T cell receptors Proteins 0.000 claims description 25
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 25
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 20
- 210000001161 mammalian embryo Anatomy 0.000 claims description 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims description 12
- 241000283984 Rodentia Species 0.000 claims description 12
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims description 12
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims description 7
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims description 7
- 239000005090 green fluorescent protein Substances 0.000 claims description 7
- 108091005957 yellow fluorescent proteins Proteins 0.000 claims description 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 210000000130 stem cell Anatomy 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 4
- 230000005867 T cell response Effects 0.000 claims description 4
- 210000003855 cell nucleus Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 210000001082 somatic cell Anatomy 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 230000000779 depleting effect Effects 0.000 claims description 3
- 244000052769 pathogen Species 0.000 claims description 3
- 241001529936 Murinae Species 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 206010038997 Retroviral infections Diseases 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 2
- 210000003754 fetus Anatomy 0.000 claims description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 238000000520 microinjection Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 210000000287 oocyte Anatomy 0.000 claims description 2
- 230000001717 pathogenic effect Effects 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 241000699660 Mus musculus Species 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361877120P | 2013-09-12 | 2013-09-12 | |
| US61/877,120 | 2013-09-12 | ||
| PCT/US2014/055492 WO2015038959A2 (en) | 2013-09-12 | 2014-09-12 | T cell receptors that are specific to a fluorescent protein, transgenic animals and methods of their making, isolated t cells, and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019211002A Division JP2020039353A (ja) | 2013-09-12 | 2019-11-22 | 蛍光タンパク質に特異的なｔ細胞受容体を有する遺伝子導入動物の作製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016529916A JP2016529916A (ja) | 2016-09-29 |
| JP2016529916A5 true JP2016529916A5 (https=) | 2017-10-19 |
| JP6876434B2 JP6876434B2 (ja) | 2021-05-26 |
Family
ID=52666523
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542829A Active JP6876434B2 (ja) | 2013-09-12 | 2014-09-12 | 蛍光タンパク質に特異的なｔ細胞受容体を有する遺伝子導入動物の作製方法 |
| JP2019211002A Withdrawn JP2020039353A (ja) | 2013-09-12 | 2019-11-22 | 蛍光タンパク質に特異的なｔ細胞受容体を有する遺伝子導入動物の作製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019211002A Withdrawn JP2020039353A (ja) | 2013-09-12 | 2019-11-22 | 蛍光タンパク質に特異的なｔ細胞受容体を有する遺伝子導入動物の作製方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11044896B2 (https=) |
| EP (2) | EP3610724A1 (https=) |
| JP (2) | JP6876434B2 (https=) |
| AU (1) | AU2014318520B2 (https=) |
| CA (1) | CA2922561C (https=) |
| ES (1) | ES2761280T3 (https=) |
| WO (1) | WO2015038959A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014318520B2 (en) * | 2013-09-12 | 2020-09-03 | Icahn School Of Medicine At Mount Sinai | Methods of making transgenic animals with T cell receptors that are specific to a flourescent protein |
| WO2018208553A1 (en) * | 2017-05-12 | 2018-11-15 | Augusta University Research Institute, Inc. | Human alpha fetoprotein-specific t cell receptors and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237224A (en) | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
| US6416971B1 (en) | 1990-05-15 | 2002-07-09 | E.R. Squibb & Sons, Inc. | Soluble single chain T cell receptors |
| US5602307A (en) | 1992-08-12 | 1997-02-11 | Baylor College Of Medicine | Non-human animal having predefined allele of a cellular adhesion gene |
| US5602299A (en) | 1992-09-23 | 1997-02-11 | Mount Sinai School Of Medicine Of The City University Of New York | Transgenic animal models for neurodegenerative disease |
| US5489743A (en) | 1993-01-19 | 1996-02-06 | Amgen Inc. | Transgenic animal models for thrombocytopenia |
| JPH07132033A (ja) | 1993-11-12 | 1995-05-23 | Hoechst Japan Ltd | アルツハイマー病モデルトランスジェニック動物 |
| US6066778A (en) | 1996-11-06 | 2000-05-23 | The Regents Of The University Of Michigan | Transgenic mice expressing APC resistant factor V |
| GB9930616D0 (en) * | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| WO2006132524A1 (en) | 2005-06-06 | 2006-12-14 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for generating a t cell against an antigen of interest. |
| AU2014318520B2 (en) * | 2013-09-12 | 2020-09-03 | Icahn School Of Medicine At Mount Sinai | Methods of making transgenic animals with T cell receptors that are specific to a flourescent protein |
-
2014
- 2014-09-12 AU AU2014318520A patent/AU2014318520B2/en active Active
- 2014-09-12 CA CA2922561A patent/CA2922561C/en active Active
- 2014-09-12 EP EP19188330.5A patent/EP3610724A1/en not_active Withdrawn
- 2014-09-12 WO PCT/US2014/055492 patent/WO2015038959A2/en not_active Ceased
- 2014-09-12 JP JP2016542829A patent/JP6876434B2/ja active Active
- 2014-09-12 ES ES14843371T patent/ES2761280T3/es active Active
- 2014-09-12 EP EP14843371.7A patent/EP3043641B1/en active Active
- 2014-09-12 US US15/021,026 patent/US11044896B2/en active Active
-
2019
- 2019-11-22 JP JP2019211002A patent/JP2020039353A/ja not_active Withdrawn
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