JP2016527230A5 - - Google Patents
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- JP2016527230A5 JP2016527230A5 JP2016527006A JP2016527006A JP2016527230A5 JP 2016527230 A5 JP2016527230 A5 JP 2016527230A5 JP 2016527006 A JP2016527006 A JP 2016527006A JP 2016527006 A JP2016527006 A JP 2016527006A JP 2016527230 A5 JP2016527230 A5 JP 2016527230A5
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- Prior art keywords
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- 229920001184 polypeptide Polymers 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 108091008874 T cell receptors Proteins 0.000 claims 21
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 102000004169 proteins and genes Human genes 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 241000701806 Human papillomavirus Species 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 6
- 238000003259 recombinant expression Methods 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000006994 Precancerous Conditions Diseases 0.000 claims 2
- 210000002255 anal canal Anatomy 0.000 claims 2
- 210000000436 anus Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 210000003300 oropharynx Anatomy 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 210000003899 penis Anatomy 0.000 claims 2
- 210000003905 vulva Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019219105A JP6959970B2 (ja) | 2013-07-15 | 2019-12-03 | 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体 |
| JP2021166407A JP7223822B2 (ja) | 2013-07-15 | 2021-10-08 | 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361846167P | 2013-07-15 | 2013-07-15 | |
| US61/846,167 | 2013-07-15 | ||
| PCT/US2014/046480 WO2015009606A1 (en) | 2013-07-15 | 2014-07-14 | Anti-human papillomavirus 16 e6 t cell receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019219105A Division JP6959970B2 (ja) | 2013-07-15 | 2019-12-03 | 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016527230A JP2016527230A (ja) | 2016-09-08 |
| JP2016527230A5 true JP2016527230A5 (enExample) | 2017-08-17 |
| JP6628719B2 JP6628719B2 (ja) | 2020-01-15 |
Family
ID=51298958
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527006A Active JP6628719B2 (ja) | 2013-07-15 | 2014-07-14 | 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体 |
| JP2019219105A Active JP6959970B2 (ja) | 2013-07-15 | 2019-12-03 | 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体 |
| JP2021166407A Active JP7223822B2 (ja) | 2013-07-15 | 2021-10-08 | 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019219105A Active JP6959970B2 (ja) | 2013-07-15 | 2019-12-03 | 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体 |
| JP2021166407A Active JP7223822B2 (ja) | 2013-07-15 | 2021-10-08 | 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US9822162B2 (enExample) |
| EP (2) | EP3022223B1 (enExample) |
| JP (3) | JP6628719B2 (enExample) |
| CN (2) | CN110511960B (enExample) |
| AU (1) | AU2014290288B2 (enExample) |
| CA (1) | CA2918216C (enExample) |
| ES (2) | ES2745472T3 (enExample) |
| WO (1) | WO2015009606A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DK3149031T3 (da) | 2014-05-29 | 2020-03-16 | Us Health | Anti-human papillomavirus 16 e7 t-cellereceptorer |
| US9422547B1 (en) | 2015-06-09 | 2016-08-23 | Gigagen, Inc. | Recombinant fusion proteins and libraries from immune cell repertoires |
| EP3356396A1 (en) * | 2015-10-01 | 2018-08-08 | Ospedale San Raffaele S.r.l. | Tcr and uses thereof |
| CN114195882A (zh) | 2015-10-01 | 2022-03-18 | 圣拉斐尔医院有限公司 | Tcr及其用途 |
| EP3156067A1 (en) | 2015-10-16 | 2017-04-19 | Max-Delbrück-Centrum Für Molekulare Medizin | High avidity hpv t-cell receptors |
| WO2017139199A1 (en) | 2016-02-10 | 2017-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible arginase |
| PL3430037T3 (pl) * | 2016-03-16 | 2022-12-19 | Immatics Biotechnologies Gmbh | Transfekowane komórki t oraz receptory komórek t do stosowania w immunoterapii przeciwnowotworowej |
| US11352410B2 (en) | 2016-04-26 | 2022-06-07 | The United States of American, as represented by the Secretary, Department of Health and Human Service | Anti-KK-LC-1 T cell receptors |
| ZA201900664B (en) | 2016-08-17 | 2021-09-29 | Paul Ehrlich Strasse 15 Tuebingen 72076 Germany | T cell receptors and immune therapy using the same |
| DE102016115246C5 (de) * | 2016-08-17 | 2018-12-20 | Immatics Biotechnologies Gmbh | Neue t-zellrezeptoren und deren verwendung in immuntherapie |
| EP3519433A1 (en) * | 2016-10-03 | 2019-08-07 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
| CN110914295B (zh) | 2017-06-28 | 2024-08-09 | 里珍纳龙药品有限公司 | 抗人乳头瘤病毒(hpv)抗原结合蛋白及其使用方法 |
| DE102017114737A1 (de) * | 2017-06-30 | 2019-01-03 | Immatics Biotechnologies Gmbh | Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie |
| CN111655280B (zh) | 2017-09-01 | 2025-01-14 | 达纳-法伯癌症研究所股份有限公司 | 用于治疗癌症的bcma和taci抗原特异的免疫原性肽 |
| EP3692063A1 (en) | 2017-10-03 | 2020-08-12 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
| CA3077595A1 (en) * | 2017-10-05 | 2019-04-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for diagnosing, monitoring and treating neurological diseases and disorders |
| KR20200063215A (ko) | 2017-10-06 | 2020-06-04 | 오슬로 유니버시테시케후스 에이치에프 | 키메라 항원 수용체 |
| JP7282760B2 (ja) | 2017-10-18 | 2023-05-29 | アルパイン イミューン サイエンシズ インコーポレイテッド | バリアントｉｃｏｓリガンド免疫調節タンパク質ならびに関連する組成物および方法 |
| CN118374524A (zh) | 2018-02-09 | 2024-07-23 | 美国卫生和人力服务部 | 拴系白细胞介素-15和白细胞介素-21 |
| MA52003A (fr) * | 2018-03-12 | 2021-01-20 | Sqz Biotechnologies Co | Procédés de traitement de maladies associées au hpv |
| CN112566698A (zh) | 2018-04-05 | 2021-03-26 | 朱诺治疗学股份有限公司 | T细胞受体和表达该t细胞受体的工程化细胞 |
| EP3775238A1 (en) | 2018-04-05 | 2021-02-17 | Juno Therapeutics, Inc. | Methods of producing cells expressing a recombinant receptor and related compositions |
| AU2019247199A1 (en) | 2018-04-05 | 2020-10-15 | Editas Medicine, Inc. | T cells expressing a recombinant receptor, related polynucleotides and methods |
| WO2019196088A1 (en) * | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
| CN112262212B (zh) | 2018-04-24 | 2024-07-12 | 美国卫生和人力服务部 | 使用羟基柠檬酸和/或其盐产生t细胞群体的方法 |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| US12065476B2 (en) | 2018-06-15 | 2024-08-20 | Alpine Immune Sciences, Inc. | PD-1 variant immunomodulatory proteins and uses thereof |
| SG11202101204TA (en) | 2018-08-09 | 2021-03-30 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| CN113272435B (zh) * | 2018-09-05 | 2025-11-14 | 加利福尼亚大学董事会 | 在多个主要组织相容性复合体分子上受限的ny-eso-1特异性t细胞受体的组合物 |
| MX2021002574A (es) | 2018-09-11 | 2021-06-08 | Juno Therapeutics Inc | Metodos para el analisis por espectrometria de masas de composiciones de celulas modificadas. |
| JP7713886B2 (ja) | 2018-11-30 | 2025-07-28 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ｃｄ８６バリアント免疫調節タンパク質およびその使用 |
| US12448429B2 (en) | 2019-03-06 | 2025-10-21 | Dana-Farber Cancer Institute, Inc. | T cell receptors specific to b-cell maturation antigen for treatment of cancer |
| WO2020191365A1 (en) | 2019-03-21 | 2020-09-24 | Gigamune, Inc. | Engineered cells expressing anti-viral t cell receptors and methods of use thereof |
| US12404331B2 (en) | 2019-04-19 | 2025-09-02 | Tcrcure Biopharma Corp. | Anti-PD-1 antibodies and uses thereof |
| AU2020265741A1 (en) | 2019-05-01 | 2021-11-25 | Editas Medicine, Inc. | Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods |
| WO2020227091A1 (en) * | 2019-05-03 | 2020-11-12 | Gigamune, Inc. | Engineered cells expressing anti-tumor t cell receptors and methods of use thereof |
| WO2021155518A1 (en) * | 2020-02-05 | 2021-08-12 | Tcrcure Biopharma Corp | Anti-hpv t cell receptors and engineered cells |
| EP4125949A4 (en) * | 2020-03-23 | 2024-05-22 | The Council of the Queensland Institute of Medical Research | COMPOSITIONS AND METHODS FOR TARGETING HPV-INFECTED CELLS |
| WO2021260186A1 (en) | 2020-06-26 | 2021-12-30 | Juno Therapeutics Gmbh | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
| WO2022104035A2 (en) | 2020-11-13 | 2022-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Enhanced antigen reactivity of immune cells expressing a mutant non-signaling cd3 zeta chain |
| CN114539385A (zh) * | 2020-11-26 | 2022-05-27 | 香雪生命科学技术（广东）有限公司 | 一种识别hpv抗原的tcr |
| CN112480239B (zh) * | 2020-12-02 | 2022-06-07 | 中国科学院微生物研究所 | 人乳头瘤病毒特异性t细胞受体及其抗肿瘤用途 |
| CN114853878A (zh) * | 2021-02-03 | 2022-08-05 | 香雪生命科学技术（广东）有限公司 | 一种针对hpv的高亲和力tcr |
| AU2022310862A1 (en) | 2021-07-14 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Engineered t cell receptors fused to binding domains from antibodies |
| EP4384543A4 (en) * | 2021-09-07 | 2025-06-11 | Corregene Biotechnology Co., Ltd. | ANTIGEN-BINDING PROTEINS AND USES THEREOF |
| WO2023050063A1 (zh) * | 2021-09-28 | 2023-04-06 | 溧阳瑅赛生物医药有限公司 | 一种识别hla-a*02:01/e629-38的tcr及其应用 |
| US20250243260A1 (en) | 2022-03-07 | 2025-07-31 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins of variant cd80 polypeptides, cell therapies and related methods and uses |
| WO2023196884A1 (en) | 2022-04-06 | 2023-10-12 | Juno Therapeutics, Inc. | Detection assay for human papillomavirus (hpv) type 16 (hpv-16) |
| IL316032A (en) | 2022-04-08 | 2024-11-01 | Regeneron Pharma | Multicomponent receptor and signaling complexes |
| CN115286690B (zh) * | 2022-05-10 | 2023-06-20 | 广州医科大学 | 抗原短肽用于筛选治疗与hpv相关的疾病的药物中的用途及其筛选的tcr |
| WO2025160480A1 (en) | 2024-01-26 | 2025-07-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Enhanced tumor reactivity of t cells lacking sit1, lax1, or trat1 |
| CN118108854B (zh) * | 2024-03-26 | 2024-07-19 | 广西福莱明生物制药有限公司 | 一种含有双特异性抗体的抗病毒组合物及其应用 |
| WO2025250587A1 (en) | 2024-05-29 | 2025-12-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Drug-regulatable, inducible cytokine expression |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| IN165717B (enExample) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤 |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| CA2205138A1 (en) | 1994-11-16 | 1996-05-23 | Baxter International Inc. | Human antibodies to t-cell receptor peptides and methods for their preparation |
| US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| EP1257289A1 (en) | 2000-02-08 | 2002-11-20 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| US8034334B2 (en) | 2002-09-06 | 2011-10-11 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy |
| WO2007013092A1 (en) * | 2005-07-25 | 2007-02-01 | Trinity Future-In Pvt. Ltd | An electro-mechanical system for non-duplication of video files |
| AU2007248019B2 (en) * | 2006-05-03 | 2012-10-11 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Chimeric T cell receptors and related materials and methods of use |
| AU2008206442B2 (en) * | 2007-01-12 | 2012-10-18 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | gp100-specific T cell receptors and related materials and methods of use |
| JP6035503B2 (ja) | 2007-05-31 | 2016-11-30 | アカデミシュ ジーケンハウス ライデン ハー．オー．デー．エン． ルムク | ワクチンで使用するための、子宮頸部悪性腫瘍に浸潤するｔ細胞によって標的とされるｈｐｖエピトープ |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| GB0917090D0 (en) | 2009-09-29 | 2009-11-11 | Ucl Biomedica Plc | T-cell receptor |
| CN103124740B (zh) * | 2010-09-21 | 2015-09-02 | 美国卫生和人力服务部 | 抗-ssx-2t细胞受体和相关材料及使用方法 |
| US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
-
2014
- 2014-07-14 CN CN201910649441.7A patent/CN110511960B/zh active Active
- 2014-07-14 ES ES14748353T patent/ES2745472T3/es active Active
- 2014-07-14 AU AU2014290288A patent/AU2014290288B2/en active Active
- 2014-07-14 EP EP14748353.1A patent/EP3022223B1/en active Active
- 2014-07-14 EP EP19180239.6A patent/EP3572423B1/en active Active
- 2014-07-14 JP JP2016527006A patent/JP6628719B2/ja active Active
- 2014-07-14 ES ES19180239T patent/ES2973064T3/es active Active
- 2014-07-14 CA CA2918216A patent/CA2918216C/en active Active
- 2014-07-14 US US14/905,108 patent/US9822162B2/en active Active
- 2014-07-14 WO PCT/US2014/046480 patent/WO2015009606A1/en not_active Ceased
- 2014-07-14 CN CN201480044286.1A patent/CN105452288B/zh active Active
-
2017
- 2017-10-18 US US15/786,966 patent/US10329339B2/en active Active
-
2019
- 2019-05-10 US US16/408,939 patent/US10913785B2/en active Active
- 2019-12-03 JP JP2019219105A patent/JP6959970B2/ja active Active
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2021
- 2021-01-06 US US17/142,486 patent/US11697676B2/en active Active
- 2021-10-08 JP JP2021166407A patent/JP7223822B2/ja active Active
-
2023
- 2023-05-25 US US18/323,493 patent/US12187779B2/en active Active
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