JP2016525498A5 - - Google Patents

Info

Publication number

JP2016525498A5

JP2016525498A5 JP2015557262A JP2015557262A JP2016525498A5 JP 2016525498 A5 JP2016525498 A5 JP 2016525498A5 JP 2015557262 A JP2015557262 A JP 2015557262A JP 2015557262 A JP2015557262 A JP 2015557262A JP 2016525498 A5 JP2016525498 A5 JP 2016525498A5

Authority

JP

Japan

Prior art keywords

peptide

amino acid

cells

apc

group

Prior art date

2014-05-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims 24
• 210000000612 antigen-presenting cell Anatomy 0.000 claims 11
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 239000012634 fragment Substances 0.000 claims 9
• 210000000447 Th1 cell Anatomy 0.000 claims 7
• 230000001939 inductive effect Effects 0.000 claims 6
• 102000040430 polynucleotide Human genes 0.000 claims 6
• 108091033319 polynucleotide Proteins 0.000 claims 6
• 239000002157 polynucleotide Substances 0.000 claims 6
• 210000001744 T-lymphocyte Anatomy 0.000 claims 5
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 108010027412 Histocompatibility Antigens Class II Proteins 0.000 claims 4
• 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 4
• 108091008874 T cell receptors Proteins 0.000 claims 4
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 102000043131 MHC class II family Human genes 0.000 claims 3
• 108091054438 MHC class II family Proteins 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• 238000012258 culturing Methods 0.000 claims 3
• 238000000338 in vitro Methods 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108010055807 HLA-DR14 Proteins 0.000 claims 2
• 108010055966 HLA-DR53 Proteins 0.000 claims 2
• 108010086066 HLA-DR8 antigen Proteins 0.000 claims 2
• 108010029172 HLA-DR9 antigen Proteins 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 102100030403 Signal peptide peptidase-like 2A Human genes 0.000 claims 1
• 108050005900 Signal peptide peptidase-like 2a Proteins 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 230000002980 postoperative effect Effects 0.000 claims 1