JP2016524016A5 - - Google Patents

Info

Publication number

JP2016524016A5

JP2016524016A5 JP2016522286A JP2016522286A JP2016524016A5 JP 2016524016 A5 JP2016524016 A5 JP 2016524016A5 JP 2016522286 A JP2016522286 A JP 2016522286A JP 2016522286 A JP2016522286 A JP 2016522286A JP 2016524016 A5 JP2016524016 A5 JP 2016524016A5

Authority

JP

Japan

Prior art keywords

hyaluronic acid

acid product

shaped

crosslinked hyaluronic

liquid medium

Prior art date

2013-06-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 69
• 229920002674 hyaluronan Polymers 0.000 claims description 69
• 229960003160 hyaluronic acid Drugs 0.000 claims description 69
• 238000000034 method Methods 0.000 claims description 43
• SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims description 16
• 239000003431 cross linking reagent Substances 0.000 claims description 16
• 239000007788 liquid Substances 0.000 claims description 16
• 239000003960 organic solvent Substances 0.000 claims description 14
• 239000000835 fiber Substances 0.000 claims description 12
• 239000000758 substrate Substances 0.000 claims description 11
• 239000000203 mixture Substances 0.000 claims description 10
• 238000001556 precipitation Methods 0.000 claims description 10
• 239000004971 Cross linker Substances 0.000 claims description 8
• 238000004132 cross linking Methods 0.000 claims description 8
• -1 polypropylene Polymers 0.000 claims description 8
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
• 125000005233 alkylalcohol group Chemical group 0.000 claims description 6
• 238000012986 modification Methods 0.000 claims description 6
• 230000004048 modification Effects 0.000 claims description 6
• 239000000463 material Substances 0.000 claims description 5
• 239000002245 particle Substances 0.000 claims description 5
• AOBIOSPNXBMOAT-UHFFFAOYSA-N 2-[2-(oxiran-2-ylmethoxy)ethoxymethyl]oxirane Chemical compound C1OC1COCCOCC1CO1 AOBIOSPNXBMOAT-UHFFFAOYSA-N 0.000 claims description 4
• HEGWNIMGIDYRAU-UHFFFAOYSA-N 3-hexyl-2,4-dioxabicyclo[1.1.0]butane Chemical compound O1C2OC21CCCCCC HEGWNIMGIDYRAU-UHFFFAOYSA-N 0.000 claims description 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
• 239000004698 Polyethylene Substances 0.000 claims description 4
• 239000004743 Polypropylene Substances 0.000 claims description 4
• 239000007864 aqueous solution Substances 0.000 claims description 4
• 239000011324 bead Substances 0.000 claims description 4
• AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims description 4
• 230000005661 hydrophobic surface Effects 0.000 claims description 4
• 229920000573 polyethylene Polymers 0.000 claims description 4
• 229920001155 polypropylene Polymers 0.000 claims description 4
• 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 4
• 239000004810 polytetrafluoroethylene Substances 0.000 claims description 4
• 230000008961 swelling Effects 0.000 claims description 4
• 238000003916 acid precipitation Methods 0.000 claims description 2
• 238000006243 chemical reaction Methods 0.000 claims description 2
• 125000000600 disaccharide group Chemical group 0.000 claims description 2
• NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical group FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims description 2
• 230000002209 hydrophobic effect Effects 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 229920000139 polyethylene terephthalate Polymers 0.000 claims description 2
• 239000005020 polyethylene terephthalate Substances 0.000 claims description 2
• 229920005644 polyethylene terephthalate glycol copolymer Polymers 0.000 claims description 2
• 239000000243 solution Substances 0.000 claims description 2
• 230000001954 sterilising effect Effects 0.000 claims description 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
• 238000002316 cosmetic surgery Methods 0.000 description 3
• 238000001356 surgical procedure Methods 0.000 description 3
• 239000002537 cosmetic Substances 0.000 description 2
• 206010021639 Incontinence Diseases 0.000 description 1
• 208000031737 Tissue Adhesions Diseases 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 230000037237 body shape Effects 0.000 description 1
• 238000012377 drug delivery Methods 0.000 description 1
• 230000000399 orthopedic effect Effects 0.000 description 1
• 229940071643 prefilled syringe Drugs 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1