JP2016522880A - 体液内の粒子及び可溶化学物質の体外での検出のためのシステムおよび方法 - Google Patents

体液内の粒子及び可溶化学物質の体外での検出のためのシステムおよび方法 Download PDF

Info

Publication number
JP2016522880A
JP2016522880A JP2015562467A JP2015562467A JP2016522880A JP 2016522880 A JP2016522880 A JP 2016522880A JP 2015562467 A JP2015562467 A JP 2015562467A JP 2015562467 A JP2015562467 A JP 2015562467A JP 2016522880 A JP2016522880 A JP 2016522880A
Authority
JP
Japan
Prior art keywords
electromagnetic radiation
microscope
image
light
measurement device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015562467A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016522880A5 (enExample
Inventor
リチャード・ハリー・ターナー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2016522880A publication Critical patent/JP2016522880A/ja
Publication of JP2016522880A5 publication Critical patent/JP2016522880A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/088—Condensers for both incident illumination and transillumination
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/70—Determining position or orientation of objects or cameras
    • G06T7/73—Determining position or orientation of objects or cameras using feature-based methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10141—Special mode during image acquisition
    • G06T2207/10152—Varying illumination
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Image Processing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Microscoopes, Condenser (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
JP2015562467A 2013-03-15 2014-03-10 体液内の粒子及び可溶化学物質の体外での検出のためのシステムおよび方法 Pending JP2016522880A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790764P 2013-03-15 2013-03-15
US61/790,764 2013-03-15
PCT/IB2014/059581 WO2014141034A2 (en) 2013-03-15 2014-03-10 A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids

Publications (2)

Publication Number Publication Date
JP2016522880A true JP2016522880A (ja) 2016-08-04
JP2016522880A5 JP2016522880A5 (enExample) 2017-04-13

Family

ID=51538221

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015562467A Pending JP2016522880A (ja) 2013-03-15 2014-03-10 体液内の粒子及び可溶化学物質の体外での検出のためのシステムおよび方法

Country Status (10)

Country Link
US (1) US10032270B2 (enExample)
EP (1) EP2973408A4 (enExample)
JP (1) JP2016522880A (enExample)
CN (1) CN105492887A (enExample)
AU (1) AU2014229420A1 (enExample)
BR (1) BR112015023081A2 (enExample)
CA (1) CA2905564A1 (enExample)
EA (1) EA201591800A1 (enExample)
SG (2) SG11201506786VA (enExample)
WO (1) WO2014141034A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019012765A1 (ja) * 2017-07-11 2019-01-17 浜松ホトニクス株式会社 試料観察装置及び試料観察方法
WO2024080385A1 (ja) 2022-10-14 2024-04-18 アークレイ株式会社 情報処理装置、情報処理方法、及び情報処理プログラム

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10831013B2 (en) 2013-08-26 2020-11-10 S.D. Sight Diagnostics Ltd. Digital microscopy systems, methods and computer program products
JP6537332B2 (ja) * 2014-04-28 2019-07-03 キヤノン株式会社 画像処理方法および撮影装置
US10783439B2 (en) * 2015-05-08 2020-09-22 FlowJo, LLC Plugin interface and framework for integrating a remote server with sample data analysis software
EP3859425B1 (en) 2015-09-17 2024-04-17 S.D. Sight Diagnostics Ltd. Methods and apparatus for detecting an entity in a bodily sample
JP6887599B2 (ja) * 2015-10-14 2021-06-16 ホリバ インスツルメンツ インコーポレイテッドHoriba Instruments Incorporated コロイド粒子の成長キネティクスまたは分解キネティクスの測定のための装置および方法
JP2017142118A (ja) * 2016-02-09 2017-08-17 株式会社イシダ 光検査装置
US11733150B2 (en) 2016-03-30 2023-08-22 S.D. Sight Diagnostics Ltd. Distinguishing between blood sample components
KR102497849B1 (ko) * 2016-05-09 2023-02-07 삼성전자주식회사 분석물질 농도 예측 방법 및 장치
AU2017263807B2 (en) 2016-05-11 2023-02-02 S.D. Sight Diagnostics Ltd Performing optical measurements on a sample
US11307196B2 (en) 2016-05-11 2022-04-19 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
EP3279635B1 (en) * 2016-08-04 2022-06-01 Malvern Panalytical Limited Method, processor and machine-readable, non-transient storage medium for characterising particles suspended in a fluid dispersant
CN117806119B (zh) * 2016-12-02 2025-05-27 分子印记公司 在压印光刻工艺中配置光学层
WO2018187790A2 (en) * 2017-04-07 2018-10-11 Toi Labs, Inc. Biomonitoring devices, methods, and systems for use in a bathroom setting
US12440193B2 (en) 2017-04-07 2025-10-14 Toi Labs, Inc. System, method and apparatus for forming machine learning sessions
JP6959755B2 (ja) * 2017-04-14 2021-11-05 シスメックス株式会社 蛍光画像分析装置、蛍光画像の分析方法及びコンピュータプログラム
CN107290291A (zh) * 2017-07-02 2017-10-24 广东技术师范学院 双光程调制透射和荧光激发光源测量复杂溶液成分的方法
CN111970970A (zh) * 2017-10-26 2020-11-20 Essenlix公司 血小板的快速测量
FR3073047B1 (fr) * 2017-11-02 2021-01-29 Commissariat Energie Atomique Procede optique d'estimation d'un volume representatif de particules presentes dans un echantillon
EP3710810B1 (en) 2017-11-14 2023-09-06 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
CN119818065A (zh) 2017-12-15 2025-04-15 葛思特克朗兹公司 用于基于留置导管的治疗的传感器监测系统
CN109001191A (zh) * 2018-06-06 2018-12-14 西安纸贵互联网科技有限公司 一种体外诊断试剂的半定量识别方法及装置
CN109235585A (zh) * 2018-09-19 2019-01-18 浙江瑞宝生物科技有限公司 马桶内藏排泄物潜血检测装置及其方法
WO2020076872A1 (en) * 2018-10-08 2020-04-16 Bioelectronica Corporation Systems and methods for optically processing samples
CN111077073A (zh) * 2018-10-19 2020-04-28 深圳迈瑞生物医疗电子股份有限公司 一种样本分析仪
JP2022508961A (ja) * 2018-10-22 2022-01-19 バイオエレクトロニカ コーポレイション 多重化アッセイシステムおよび方法
JP7376245B2 (ja) 2019-03-29 2023-11-08 シスメックス株式会社 蛍光画像分析装置及び蛍光画像分析方法
USD984637S1 (en) 2019-06-26 2023-04-25 Gastroklenz Inc. Measurement vessel
USD903126S1 (en) 2019-06-26 2020-11-24 Gastroklenz Inc. Monitoring device
BR112021025986A2 (pt) 2019-06-26 2022-02-08 Gastroklenz Inc Sistemas, dispositivos e métodos para monitoramento de fluido
CN110426335B (zh) * 2019-09-05 2022-03-22 苏州大学 一种基于原子力显微镜的纳米颗粒浓度测量方法
KR102931515B1 (ko) 2019-10-22 2026-02-27 에스.디. 사이트 다이그노틱스 엘티디 광학 측정들에서의 오류들의 고려
BR112022011233A2 (pt) 2019-12-12 2022-08-30 S D Sight Diagnostics Ltd Detecção de plaquetas em uma amostra sanguínea
BR112022011312A2 (pt) 2019-12-12 2022-08-23 S D Sight Diagnostics Ltd Análise de um analito disposto dentro de um meio
BR112022011354A2 (pt) 2019-12-12 2022-08-23 S D Sight Diagnostics Ltd Geração artificial de uma imagem colorida de esfregaço sanguíneo
CN110940621B (zh) * 2019-12-19 2020-09-15 西安交通大学 一种基于红外技术的凝结液珠形态的识别方法
US10823662B1 (en) * 2020-02-18 2020-11-03 Horiba Instruments, Incorporated Special purpose cuvette assembly and method for optical microscopy of nanoparticle colloids
EP3933479A1 (en) * 2020-07-03 2022-01-05 Leica Microsystems CMS GmbH Microscope for microscopic examination of a sample
CN113340894B (zh) * 2021-05-28 2023-04-07 上海睿钰生物科技有限公司 一种非透明微粒的检测方法
JP2026017219A (ja) * 2024-07-23 2026-02-04 富士フイルム株式会社 観察装置及び観察方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05501151A (ja) * 1989-02-24 1993-03-04 セル・アナラシス・システムズ・インコーポレーテッド 細胞の染色および分析を行なうためのデュアルカメラ顕微鏡およびその方法
JP2006098227A (ja) * 2004-09-29 2006-04-13 Fuji Photo Film Co Ltd 反射光測定装置及び生化学分析装置
JP2006238802A (ja) * 2005-03-03 2006-09-14 Olympus Corp 細胞観察装置、細胞観察方法、顕微鏡システム、及び細胞観察プログラム
JP2010517046A (ja) * 2007-01-26 2010-05-20 ベクトン・ディキンソン・アンド・カンパニー 細胞計数及び分析のための方法、システム及び組成
WO2011144212A1 (en) * 2010-05-21 2011-11-24 Chemometec A/S A compact dark field light source and dark field image analysis at low magnification
JP2012014078A (ja) * 2010-07-02 2012-01-19 Sony Corp 顕微鏡及び領域判定方法
JP2013027392A (ja) * 2000-06-08 2013-02-07 Regents Of The Univ Of California 視覚的サーボ制御光学顕微鏡

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4592089A (en) * 1983-08-15 1986-05-27 Bio Image Corporation Electrophoretogram analytical image processing system
US5134662A (en) 1985-11-04 1992-07-28 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
US4965725B1 (en) * 1988-04-08 1996-05-07 Neuromedical Systems Inc Neural network based automated cytological specimen classification system and method
ATE140880T1 (de) 1992-05-01 1996-08-15 Univ Pennsylvania Fluessigkeitsbehandlung in mikrofabrizierten analytischen vorrichtungen
US5889881A (en) * 1992-10-14 1999-03-30 Oncometrics Imaging Corp. Method and apparatus for automatically detecting malignancy-associated changes
WO2002007587A2 (en) * 2000-07-14 2002-01-31 Xillix Technologies Corporation Compact fluorescent endoscopy video system
US6993169B2 (en) * 2001-01-11 2006-01-31 Trestle Corporation System and method for finding regions of interest for microscopic digital montage imaging
JP2003075725A (ja) * 2001-09-04 2003-03-12 Olympus Optical Co Ltd 透過照明装置
JP2006516920A (ja) * 2003-02-06 2006-07-13 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 血液分析のための装置及び方法
DK2308419T3 (da) * 2003-03-28 2016-06-06 Inguran Llc Fremgangsmåde til bedømmelse af farvningstilstandene for dyresperm, som skal sorteres.
DE102005052752A1 (de) * 2005-11-04 2007-05-10 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
WO2005121864A2 (en) * 2004-06-07 2005-12-22 Fluidigm Corporation Optical lens system and method for microfluidic devices
US20060066850A1 (en) 2004-09-29 2006-03-30 Fuji Photo Film Co., Ltd. Light measuring device, biochemical analyzer, biochemical analysis method, and spectrophotometer
AU2006247747A1 (en) * 2005-05-11 2006-11-23 Embrex, Inc. Competitive particle immunoassay methods utilizing fluorescence microscopy
TWI330380B (en) * 2006-12-07 2010-09-11 Nat Univ Tsing Hua A specimen kit for electron microscope and its fabrication process
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
TWI320856B (en) * 2007-03-26 2010-02-21 Asia Optical Co Inc Optical apparatus with dual illuminating devices
EP2610007B1 (en) * 2007-07-23 2018-12-05 CLONDIAG GmbH Assays
AT508102A1 (de) * 2009-04-08 2010-10-15 Photonic Optische Geraete Gmbh Beleuchtungseinrichtung
US8570370B2 (en) * 2009-08-31 2013-10-29 Bio-Rad Laboratories, Inc. Compact automated cell counter
FR2951542B1 (fr) * 2009-10-16 2011-12-02 Commissariat Energie Atomique Procede de detection optique d'objets micrometriques en solution
EP2524261A4 (en) 2010-01-15 2015-06-03 Qbc Diagnostics Inc FLUORESCENT MICROSCOPE PUSHER
EP2550522B1 (en) * 2010-03-23 2016-11-02 California Institute of Technology Super resolution optofluidic microscopes for 2d and 3d imaging
WO2012058233A2 (en) * 2010-10-26 2012-05-03 California Institute Of Technology Scanning projective lensless microscope system
JP2016501428A (ja) * 2012-11-16 2016-01-18 プロトチップス,インコーポレイテッド 電子顕微鏡ホルダにおいて試料支持体への電気的接続を形成する方法
CA2900842C (en) * 2013-03-12 2020-01-21 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05501151A (ja) * 1989-02-24 1993-03-04 セル・アナラシス・システムズ・インコーポレーテッド 細胞の染色および分析を行なうためのデュアルカメラ顕微鏡およびその方法
JP2013027392A (ja) * 2000-06-08 2013-02-07 Regents Of The Univ Of California 視覚的サーボ制御光学顕微鏡
JP2006098227A (ja) * 2004-09-29 2006-04-13 Fuji Photo Film Co Ltd 反射光測定装置及び生化学分析装置
JP2006238802A (ja) * 2005-03-03 2006-09-14 Olympus Corp 細胞観察装置、細胞観察方法、顕微鏡システム、及び細胞観察プログラム
JP2010517046A (ja) * 2007-01-26 2010-05-20 ベクトン・ディキンソン・アンド・カンパニー 細胞計数及び分析のための方法、システム及び組成
WO2011144212A1 (en) * 2010-05-21 2011-11-24 Chemometec A/S A compact dark field light source and dark field image analysis at low magnification
JP2012014078A (ja) * 2010-07-02 2012-01-19 Sony Corp 顕微鏡及び領域判定方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019012765A1 (ja) * 2017-07-11 2019-01-17 浜松ホトニクス株式会社 試料観察装置及び試料観察方法
JP7007122B2 (ja) 2017-07-11 2022-01-24 浜松ホトニクス株式会社 試料観察装置及び試料観察方法
US11340165B2 (en) 2017-07-11 2022-05-24 Hamamatsu Photonics K.K. Sample observation device and sample observation method
WO2024080385A1 (ja) 2022-10-14 2024-04-18 アークレイ株式会社 情報処理装置、情報処理方法、及び情報処理プログラム

Also Published As

Publication number Publication date
US20160042507A1 (en) 2016-02-11
CN105492887A (zh) 2016-04-13
US10032270B2 (en) 2018-07-24
EP2973408A4 (en) 2017-06-14
WO2014141034A2 (en) 2014-09-18
EP2973408A2 (en) 2016-01-20
SG11201506786VA (en) 2015-09-29
SG10201707599WA (en) 2017-10-30
WO2014141034A3 (en) 2015-12-17
BR112015023081A2 (pt) 2017-07-18
CA2905564A1 (en) 2014-09-18
AU2014229420A1 (en) 2015-09-24
EA201591800A1 (ru) 2016-04-29

Similar Documents

Publication Publication Date Title
US10032270B2 (en) System and methods for the in vitro detection of particles and soluble chemical entities in body fluids
JP7672399B2 (ja) 光学測定におけるエラーの原因の説明
US11499908B2 (en) Urine analysis system, image capturing apparatus, urine analysis method
JP2022078344A (ja) 生物学的サンプルの画像分析および測定
JP6273276B2 (ja) 生物学的サンプルの画像分析および測定
CN1166950C (zh) 用于分析基本未稀释的生物液体样品的设备
JP5184697B2 (ja) 血小板を個々に、及び凝集塊として検出及び計数するための方法及び装置
CN101852715B (zh) 尿样分析仪
CN101672779B (zh) 用于在生物样品中进行稀有事件分析的高灵敏度多参数方法
JP2012529048A (ja) 濁り度光散乱技法を使用した試料の妥当性の確保
CN101151517A (zh) 鉴别癌症/异型细胞和粒子团的方法及细胞分析仪
US20130273524A1 (en) Device for performing a blood, cell, and/or pathogen count and methods for use thereof
EP4073491A1 (en) Off-focus microscopic images of a sample
US20210356460A1 (en) Method for Analyzing Immunoglobulins and Other Analytes in an Immunoassay
KR20180077820A (ko) 혈구 분석 장치 및 그의 검체 및 검체용기 감지방법
RU2803847C1 (ru) Учет ошибок при оптических измерениях
RU2797528C1 (ru) Учет ошибок при оптических измерениях

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170307

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170307

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171218

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20171215

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180709