JP2016522833A5 - - Google Patents
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- JP2016522833A5 JP2016522833A5 JP2016516193A JP2016516193A JP2016522833A5 JP 2016522833 A5 JP2016522833 A5 JP 2016522833A5 JP 2016516193 A JP2016516193 A JP 2016516193A JP 2016516193 A JP2016516193 A JP 2016516193A JP 2016522833 A5 JP2016522833 A5 JP 2016522833A5
- Authority
- JP
- Japan
- Prior art keywords
- nanoparticles
- compound
- pharmaceutical composition
- composition according
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000002105 nanoparticle Substances 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 230000001225 therapeutic effect Effects 0.000 claims 8
- 230000001988 toxicity Effects 0.000 claims 5
- 231100000419 toxicity Toxicity 0.000 claims 5
- 229910010272 inorganic material Inorganic materials 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 2
- 239000011147 inorganic material Substances 0.000 claims 2
- 239000011777 magnesium Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229910002706 AlOOH Inorganic materials 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910002588 FeOOH Inorganic materials 0.000 claims 1
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229910004298 SiO 2 Inorganic materials 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- CUPCBVUMRUSXIU-UHFFFAOYSA-N [Fe].OOO Chemical compound [Fe].OOO CUPCBVUMRUSXIU-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 229910052788 barium Inorganic materials 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- FAHBNUUHRFUEAI-UHFFFAOYSA-M hydroxidooxidoaluminium Chemical compound O[Al]=O FAHBNUUHRFUEAI-UHFFFAOYSA-M 0.000 claims 1
- 150000002484 inorganic compounds Chemical class 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 229910021519 iron(III) oxide-hydroxide Inorganic materials 0.000 claims 1
- HDMKAUUMGFGBRJ-UHFFFAOYSA-N iron;dihydrate Chemical compound O.O.[Fe] HDMKAUUMGFGBRJ-UHFFFAOYSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims 1
- 239000000347 magnesium hydroxide Substances 0.000 claims 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000002082 metal nanoparticle Substances 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 229910052976 metal sulfide Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229910052814 silicon oxide Inorganic materials 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 229910052712 strontium Inorganic materials 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361828794P | 2013-05-30 | 2013-05-30 | |
| EP13305712 | 2013-05-30 | ||
| EP13305712.5 | 2013-05-30 | ||
| US61/828,794 | 2013-05-30 | ||
| PCT/EP2014/061296 WO2014191569A1 (en) | 2013-05-30 | 2014-05-30 | Pharmaceutical composition, preparation and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016522833A JP2016522833A (ja) | 2016-08-04 |
| JP2016522833A5 true JP2016522833A5 (enExample) | 2017-05-25 |
| JP6387400B2 JP6387400B2 (ja) | 2018-09-05 |
Family
ID=48656009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516193A Active JP6387400B2 (ja) | 2013-05-30 | 2014-05-30 | 医薬組成物、その製造および使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10413509B2 (enExample) |
| EP (1) | EP3003288A1 (enExample) |
| JP (1) | JP6387400B2 (enExample) |
| KR (1) | KR102245421B1 (enExample) |
| CN (2) | CN112107558A (enExample) |
| AU (1) | AU2014273043B2 (enExample) |
| BR (1) | BR112015029853A2 (enExample) |
| CA (1) | CA2913023C (enExample) |
| EA (1) | EA038671B1 (enExample) |
| HK (1) | HK1222563A1 (enExample) |
| MA (1) | MA38687A1 (enExample) |
| MX (1) | MX376269B (enExample) |
| NZ (1) | NZ714273A (enExample) |
| SG (1) | SG11201509436TA (enExample) |
| UA (1) | UA116380C2 (enExample) |
| WO (1) | WO2014191569A1 (enExample) |
| ZA (1) | ZA201509307B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX362089B (es) | 2011-12-16 | 2019-01-07 | Nanobiotix | Nanopartículas que comprenden materiales metálicos y óxido de hafnio, preparación y usos de los mismos. |
| BR112015029853A2 (pt) | 2013-05-30 | 2017-07-25 | Nanobiotix | uso de uma composição farmacêutica |
| PT3229776T (pt) | 2014-11-25 | 2023-08-17 | Curadigm Sas | Composição farmacêutica combinando pelo menos duas nanopartícuas distintas e um composto farmacêutico, preparaçâo e suas utilizações |
| JP6789960B2 (ja) * | 2014-11-25 | 2020-11-25 | キュラディグム・エスアエスＣｕｒａｄｉｇｍ Ｓａｓ | 医薬組成物、その調製及び使用 |
| PL3229843T3 (pl) * | 2014-11-25 | 2020-06-29 | Curadigm Sas | Kompozycja farmaceutyczna, wytwarzanie i zastosowanie tej kompozycji |
| LT3223796T (lt) | 2014-11-25 | 2021-10-25 | Curadigm Sas | Farmacinės kompozicijos, jų gamyba ir panaudojimo būdai |
| US10792366B2 (en) * | 2015-02-19 | 2020-10-06 | Carnegie Mellon University | Methods to reduce toxicities and to improve bioavailabilities of nanodrugs |
| EA201792560A1 (ru) | 2015-05-28 | 2018-06-29 | Нанобиотикс | Наночастицы для применения в качестве терапевтической вакцины |
| CN105055447B (zh) * | 2015-06-23 | 2018-03-13 | 中南大学湘雅二医院 | 氧化铁纳米颗粒用于制备改善厄洛替尼耐药性药物的应用 |
| WO2020006493A1 (en) * | 2018-06-29 | 2020-01-02 | North Carolina State University | In situ sprayed bioresponsive immunotherapeutic gel for post-surgical treatment |
| CN108969757B (zh) * | 2018-07-11 | 2021-07-27 | 浙江大学 | 负载microRNA的氧化铈纳米复合水凝胶及制备方法和应用 |
| CN110498607B (zh) * | 2019-08-21 | 2022-03-08 | 中国科学院上海硅酸盐研究所 | 一种多功能钙硅基稀土掺杂的生物活性粉体及其制备方法和应用 |
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| JP6789960B2 (ja) | 2014-11-25 | 2020-11-25 | キュラディグム・エスアエスＣｕｒａｄｉｇｍ Ｓａｓ | 医薬組成物、その調製及び使用 |
| PT3229776T (pt) | 2014-11-25 | 2023-08-17 | Curadigm Sas | Composição farmacêutica combinando pelo menos duas nanopartícuas distintas e um composto farmacêutico, preparaçâo e suas utilizações |
| CA2968473A1 (en) | 2014-11-25 | 2016-06-02 | Nanobiotix | Pharmaceutical composition, preparation and uses thereof |
| LT3223796T (lt) | 2014-11-25 | 2021-10-25 | Curadigm Sas | Farmacinės kompozicijos, jų gamyba ir panaudojimo būdai |
| PL3229843T3 (pl) | 2014-11-25 | 2020-06-29 | Curadigm Sas | Kompozycja farmaceutyczna, wytwarzanie i zastosowanie tej kompozycji |
-
2014
- 2014-05-30 BR BR112015029853A patent/BR112015029853A2/pt not_active Application Discontinuation
- 2014-05-30 SG SG11201509436TA patent/SG11201509436TA/en unknown
- 2014-05-30 CN CN202010861645.XA patent/CN112107558A/zh active Pending
- 2014-05-30 CA CA2913023A patent/CA2913023C/en active Active
- 2014-05-30 CN CN201480031188.4A patent/CN105407878A/zh active Pending
- 2014-05-30 HK HK16110781.4A patent/HK1222563A1/zh unknown
- 2014-05-30 US US14/892,271 patent/US10413509B2/en active Active
- 2014-05-30 AU AU2014273043A patent/AU2014273043B2/en active Active
- 2014-05-30 JP JP2016516193A patent/JP6387400B2/ja active Active
- 2014-05-30 WO PCT/EP2014/061296 patent/WO2014191569A1/en not_active Ceased
- 2014-05-30 MA MA38687A patent/MA38687A1/fr unknown
- 2014-05-30 UA UAA201513039A patent/UA116380C2/uk unknown
- 2014-05-30 EP EP14727810.5A patent/EP3003288A1/en active Pending
- 2014-05-30 NZ NZ714273A patent/NZ714273A/en unknown
- 2014-05-30 EA EA201592279A patent/EA038671B1/ru unknown
- 2014-05-30 KR KR1020157036985A patent/KR102245421B1/ko active Active
- 2014-05-30 MX MX2015016456A patent/MX376269B/es active IP Right Grant
-
2015
- 2015-12-22 ZA ZA2015/09307A patent/ZA201509307B/en unknown
-
2019
- 2019-08-29 US US16/554,765 patent/US11357724B2/en active Active