BR9812131A - Composições contendo bergamotina para aumentar a biodisponibilidade oral de agentes farmacêuticos - Google Patents

Composições contendo bergamotina para aumentar a biodisponibilidade oral de agentes farmacêuticos

Info

Publication number
BR9812131A
BR9812131A BR9812131-6A BR9812131A BR9812131A BR 9812131 A BR9812131 A BR 9812131A BR 9812131 A BR9812131 A BR 9812131A BR 9812131 A BR9812131 A BR 9812131A
Authority
BR
Brazil
Prior art keywords
bergamotine
increase
oral bioavailability
compositions containing
pharmaceutical agents
Prior art date
Application number
BR9812131-6A
Other languages
English (en)
Inventor
Kan He
Paul Hollenberg
Thomas F Woolf
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR9812131A publication Critical patent/BR9812131A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçõES CONTENDO BERGAMOTINA PARA AUMENTAR A BIODISPONIBILIDADE ORAL DE AGENTES FARMACêUTICOS"<D>. A bergamotina, um composto principal no suco de toranja responsável pela inibição do P450 3A4, a enzima P450 predominante no intestino, é co-administrado com um composto tendo baixa biodisponibilidade a um paciente para aumentar a biodisponibilidade oral do composto e suas composições farmacêuticas, bem como um método de isolamento do BG do suco de toranja.
BR9812131-6A 1997-08-19 1998-08-11 Composições contendo bergamotina para aumentar a biodisponibilidade oral de agentes farmacêuticos BR9812131A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5612997P 1997-08-19 1997-08-19
PCT/US1998/016579 WO1999008676A1 (en) 1997-08-19 1998-08-11 Compositions containing bergamottin for increasing the oral bioavailability of pharmaceutical agents

Publications (1)

Publication Number Publication Date
BR9812131A true BR9812131A (pt) 2000-07-18

Family

ID=22002350

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812131-6A BR9812131A (pt) 1997-08-19 1998-08-11 Composições contendo bergamotina para aumentar a biodisponibilidade oral de agentes farmacêuticos

Country Status (15)

Country Link
US (1) US6509371B1 (pt)
EP (1) EP1007034B1 (pt)
JP (1) JP2001515035A (pt)
KR (1) KR100510809B1 (pt)
AT (1) ATE253357T1 (pt)
AU (1) AU747051B2 (pt)
BR (1) BR9812131A (pt)
CA (1) CA2291233C (pt)
DE (1) DE69819519T2 (pt)
DK (1) DK1007034T3 (pt)
ES (1) ES2209184T3 (pt)
NZ (1) NZ502668A (pt)
PT (1) PT1007034E (pt)
WO (1) WO1999008676A1 (pt)
ZA (1) ZA987436B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1014575A3 (fr) * 2002-01-16 2004-01-13 Chapelle Andre Composition a base de 5,7 dmc et/ou de bergamottine.
US7169763B2 (en) * 2002-02-22 2007-01-30 Oliver Yoa-Pu Hu Cytochrome P450 3A inhibitors and enhancers
WO2006077975A1 (ja) 2005-01-21 2006-07-27 Arkray, Inc. メタボリックシンドローム改善剤、ならびにそれを含む医薬、サプリメント、機能性食品および食品添加物
JP4902964B2 (ja) * 2005-03-30 2012-03-21 株式会社ファンケル 薬物の代謝阻害剤とその使用
UA116380C2 (uk) 2013-05-30 2018-03-12 Нанобіотікс Посилення терапевтичної або профілактичної ефективності фармацевтичної сполуки
HUE062561T2 (hu) 2014-11-25 2023-11-28 Curadigm Sas Legalább két eltérõ nanorészecskéket és egy gyógyászati vegyületet kombináló gyógyászati készítmény, annak elõállítása és alkalmazásai
ES2890662T3 (es) * 2014-11-25 2022-01-21 Curadigm Sas Composiciones farmacéuticas, preparación y usos de las mismas
KR101729494B1 (ko) 2015-06-29 2017-04-25 제주대학교 산학협력단 6,7-디하이드록시 베르가모틴을 함유한 화장료 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2996838B2 (ja) * 1993-07-12 2000-01-11 株式会社ポッカコーポレーション 抗菌剤
US5567592A (en) 1994-02-02 1996-10-22 Regents Of The University Of California Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
US5716928A (en) 1995-06-07 1998-02-10 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
US5665386A (en) 1995-06-07 1997-09-09 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
WO1996040192A1 (en) * 1995-06-07 1996-12-19 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
US6160006A (en) * 1996-10-18 2000-12-12 Wayne State University 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in grapefruit

Also Published As

Publication number Publication date
DK1007034T3 (da) 2004-03-22
NZ502668A (en) 2001-10-26
AU8777098A (en) 1999-03-08
AU747051B2 (en) 2002-05-09
DE69819519T2 (de) 2004-09-23
EP1007034A1 (en) 2000-06-14
ATE253357T1 (de) 2003-11-15
DE69819519D1 (de) 2003-12-11
KR100510809B1 (ko) 2005-08-31
ES2209184T3 (es) 2004-06-16
KR20010023034A (ko) 2001-03-26
WO1999008676A1 (en) 1999-02-25
ZA987436B (en) 1999-02-22
CA2291233C (en) 2006-10-10
EP1007034B1 (en) 2003-11-05
JP2001515035A (ja) 2001-09-18
US6509371B1 (en) 2003-01-21
PT1007034E (pt) 2004-03-31
CA2291233A1 (en) 1999-02-25

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.