JP2016522819A5 - - Google Patents
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- JP2016522819A5 JP2016522819A5 JP2016512111A JP2016512111A JP2016522819A5 JP 2016522819 A5 JP2016522819 A5 JP 2016522819A5 JP 2016512111 A JP2016512111 A JP 2016512111A JP 2016512111 A JP2016512111 A JP 2016512111A JP 2016522819 A5 JP2016522819 A5 JP 2016522819A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- subject
- administration
- ear canal
- nerve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 44
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims 12
- 210000000613 ear canal Anatomy 0.000 claims 10
- 210000001186 vagus nerve Anatomy 0.000 claims 9
- 238000007483 tonsillectomy Methods 0.000 claims 8
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 claims 7
- VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 claims 6
- 208000006673 asthma Diseases 0.000 claims 6
- 229960005274 benzocaine Drugs 0.000 claims 6
- 229960005222 phenazone Drugs 0.000 claims 6
- VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 claims 4
- 230000003444 anaesthetic effect Effects 0.000 claims 4
- 229960003976 etidocaine Drugs 0.000 claims 4
- 230000008035 nerve activity Effects 0.000 claims 4
- 230000001766 physiological effect Effects 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 230000000202 analgesic effect Effects 0.000 claims 3
- 210000003792 cranial nerve Anatomy 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010013952 Dysphonia Diseases 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 2
- 206010068319 Oropharyngeal pain Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 201000007100 Pharyngitis Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 206010006451 bronchitis Diseases 0.000 claims 2
- 229960001747 cinchocaine Drugs 0.000 claims 2
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 230000002920 convulsive effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229960004194 lidocaine Drugs 0.000 claims 2
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 2
- 206010039083 rhinitis Diseases 0.000 claims 2
- 229960002372 tetracaine Drugs 0.000 claims 2
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 claims 1
- 206010003062 Apraxia Diseases 0.000 claims 1
- QTGIAADRBBLJGA-UHFFFAOYSA-N Articaine Chemical compound CCCNC(C)C(=O)NC=1C(C)=CSC=1C(=O)OC QTGIAADRBBLJGA-UHFFFAOYSA-N 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 206010048994 Bladder spasm Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 208000019505 Deglutition disease Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 208000008967 Enuresis Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000031361 Hiccup Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- 208000004356 Hysteria Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims 1
- 206010028735 Nasal congestion Diseases 0.000 claims 1
- 206010028836 Neck pain Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000005141 Otitis Diseases 0.000 claims 1
- 208000000450 Pelvic Pain Diseases 0.000 claims 1
- YQKAVWCGQQXBGW-UHFFFAOYSA-N Piperocaine Chemical compound CC1CCCCN1CCCOC(=O)C1=CC=CC=C1 YQKAVWCGQQXBGW-UHFFFAOYSA-N 0.000 claims 1
- CAJIGINSTLKQMM-UHFFFAOYSA-N Propoxycaine Chemical compound CCCOC1=CC(N)=CC=C1C(=O)OCCN(CC)CC CAJIGINSTLKQMM-UHFFFAOYSA-N 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000007613 Shoulder Pain Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 206010041235 Snoring Diseases 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 229960000212 aminophenazone Drugs 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 229960003831 articaine Drugs 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 229960002023 chloroprocaine Drugs 0.000 claims 1
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 208000012839 conversion disease Diseases 0.000 claims 1
- 201000003146 cystitis Diseases 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229950010160 dimethocaine Drugs 0.000 claims 1
- OWQIUQKMMPDHQQ-UHFFFAOYSA-N dimethocaine Chemical compound CCN(CC)CC(C)(C)COC(=O)C1=CC=C(N)C=C1 OWQIUQKMMPDHQQ-UHFFFAOYSA-N 0.000 claims 1
- 229940120889 dipyrone Drugs 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 206010013990 dysuria Diseases 0.000 claims 1
- 208000019258 ear infection Diseases 0.000 claims 1
- 210000000256 facial nerve Anatomy 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 210000001932 glossopharyngeal nerve Anatomy 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 230000002175 menstrual effect Effects 0.000 claims 1
- 229960002409 mepivacaine Drugs 0.000 claims 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims 1
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 claims 1
- 230000027939 micturition Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 230000003880 negative regulation of appetite Effects 0.000 claims 1
- 229940053973 novocaine Drugs 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000000196 olfactory nerve Anatomy 0.000 claims 1
- 229960001045 piperocaine Drugs 0.000 claims 1
- 229960001807 prilocaine Drugs 0.000 claims 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims 1
- 229960004919 procaine Drugs 0.000 claims 1
- -1 propalacaine Chemical compound 0.000 claims 1
- 229950003255 propoxycaine Drugs 0.000 claims 1
- 229960002189 propyphenazone Drugs 0.000 claims 1
- PXWLVJLKJGVOKE-UHFFFAOYSA-N propyphenazone Chemical compound O=C1C(C(C)C)=C(C)N(C)N1C1=CC=CC=C1 PXWLVJLKJGVOKE-UHFFFAOYSA-N 0.000 claims 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical class O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 claims 1
- 230000011514 reflex Effects 0.000 claims 1
- 229960001549 ropivacaine Drugs 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 206010041232 sneezing Diseases 0.000 claims 1
- 210000003901 trigeminal nerve Anatomy 0.000 claims 1
- 229950002569 trimecaine Drugs 0.000 claims 1
- GOZBHBFUQHMKQB-UHFFFAOYSA-N trimecaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=C(C)C=C1C GOZBHBFUQHMKQB-UHFFFAOYSA-N 0.000 claims 1
- 239000005526 vasoconstrictor agent Substances 0.000 claims 1
- 208000001319 vasomotor rhinitis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361819023P | 2013-05-03 | 2013-05-03 | |
| US61/819,023 | 2013-05-03 | ||
| PCT/US2014/036855 WO2014179814A1 (en) | 2013-05-03 | 2014-05-05 | Method of treating disease by auricular anesthesia of cranial nerves |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016522819A JP2016522819A (ja) | 2016-08-04 |
| JP2016522819A5 true JP2016522819A5 (enExample) | 2017-06-08 |
| JP6433985B2 JP6433985B2 (ja) | 2018-12-05 |
Family
ID=51844020
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512111A Active JP6433985B2 (ja) | 2013-05-03 | 2014-05-05 | 脳神経の耳麻酔により疾患を処置する方法 |
| JP2018543020A Pending JP2018536709A (ja) | 2013-05-03 | 2016-11-02 | 脳神経の耳麻酔による疾患の治療方法 |
| JP2022016897A Active JP7512317B2 (ja) | 2013-05-03 | 2022-02-07 | 脳神経の耳麻酔による疾患の治療方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543020A Pending JP2018536709A (ja) | 2013-05-03 | 2016-11-02 | 脳神経の耳麻酔による疾患の治療方法 |
| JP2022016897A Active JP7512317B2 (ja) | 2013-05-03 | 2022-02-07 | 脳神経の耳麻酔による疾患の治療方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20140357686A1 (enExample) |
| EP (2) | EP2991620B1 (enExample) |
| JP (3) | JP6433985B2 (enExample) |
| KR (2) | KR102086709B1 (enExample) |
| CN (2) | CN105163718B (enExample) |
| AU (2) | AU2014262148B2 (enExample) |
| CA (2) | CA2910422C (enExample) |
| DK (1) | DK2991620T3 (enExample) |
| ES (1) | ES2823624T3 (enExample) |
| HK (1) | HK1212230A1 (enExample) |
| IL (2) | IL242339B (enExample) |
| MX (2) | MX381106B (enExample) |
| MY (2) | MY180310A (enExample) |
| RU (2) | RU2687249C2 (enExample) |
| SG (1) | SG11201508509XA (enExample) |
| WO (2) | WO2014179814A1 (enExample) |
| ZA (2) | ZA201508782B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2991620B1 (en) * | 2013-05-03 | 2020-07-08 | Crews, Thomas, M. | Combinations of antipyrine and benzocaine for the treatment of diseases associated with a cranial nerve |
| WO2016137352A1 (ru) * | 2015-02-26 | 2016-09-01 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Фармацевтическая композиция для лечения воспалительных заболеваний уха, способ ее получения и способ лечения указанной композицией |
| EP3509585B1 (en) | 2016-09-07 | 2023-11-01 | Glia, LLC | Treatment of symptoms related to neurodegenerative disorders through pharmacological dermal activation of cranial nerves |
| US20220105052A1 (en) * | 2016-12-26 | 2022-04-07 | Cellix Bio Private Limited | Compositions and methods for the treatment of chronic pain |
| CN107789621A (zh) * | 2017-12-15 | 2018-03-13 | 阜阳市平衡医疗保健器械有限公司 | 一种治疗头痛的药物及其配制方法 |
| US11607275B2 (en) * | 2019-05-20 | 2023-03-21 | Medtronic Ireland Manufacturing Unlimited Company | Selection of hypertensive patients for treatment with renal denervation |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19524691A1 (de) * | 1995-07-06 | 1997-01-09 | Liedtke Pharmed Gmbh | Methode und Zusammensetzung einer topischen Therapie von Innenohr und Labyrinth-Symptomen |
| RU2104056C1 (ru) * | 1995-07-10 | 1998-02-10 | Александр Александрович Ланцов | Способ лечения периферических поражений лицевого нерва |
| JPH1094613A (ja) * | 1996-08-02 | 1998-04-14 | Mieko Sato | 食欲調整用具 |
| US6093417A (en) * | 1999-01-11 | 2000-07-25 | Advanced Medical Instruments | Composition to treat ear disorders |
| ATE541565T1 (de) * | 1999-05-27 | 2012-02-15 | Khoury George F El | Topische verwendung von muskarinischen und opioiden mitteln zur behandlung von tinnitus |
| DE10322497A1 (de) * | 2003-05-19 | 2004-12-09 | Liedtke, Rainer K., Dr. | Topisch pharmakologische Vorbeugung und Therapie der Hyperakusis |
| US8940321B2 (en) * | 2003-12-12 | 2015-01-27 | Otic Pharma Ltd. | Compositions for treatment of ear disorders and methods of use thereof |
| US8755892B2 (en) * | 2007-05-16 | 2014-06-17 | Cardiac Pacemakers, Inc. | Systems for stimulating neural targets |
| US20110208161A1 (en) * | 2009-08-13 | 2011-08-25 | Yehuda Ivri | Intracochlear drug delivery to the central nervous system |
| US20120252730A1 (en) * | 2009-09-03 | 2012-10-04 | University Of Chicago | Platelet aggregation inhibitors |
| CA2848730A1 (en) * | 2011-09-15 | 2013-03-21 | Yoseph Yaacobi | Systems and methods for treating ear disorders |
| EP2991620B1 (en) * | 2013-05-03 | 2020-07-08 | Crews, Thomas, M. | Combinations of antipyrine and benzocaine for the treatment of diseases associated with a cranial nerve |
-
2014
- 2014-05-05 EP EP14791131.7A patent/EP2991620B1/en active Active
- 2014-05-05 HK HK16100269.6A patent/HK1212230A1/xx unknown
- 2014-05-05 US US14/270,238 patent/US20140357686A1/en not_active Abandoned
- 2014-05-05 CA CA2910422A patent/CA2910422C/en active Active
- 2014-05-05 AU AU2014262148A patent/AU2014262148B2/en active Active
- 2014-05-05 MX MX2015015194A patent/MX381106B/es unknown
- 2014-05-05 ES ES14791131T patent/ES2823624T3/es active Active
- 2014-05-05 CN CN201480024269.1A patent/CN105163718B/zh active Active
- 2014-05-05 DK DK14791131.7T patent/DK2991620T3/da active
- 2014-05-05 WO PCT/US2014/036855 patent/WO2014179814A1/en not_active Ceased
- 2014-05-05 MY MYPI2015002669A patent/MY180310A/en unknown
- 2014-05-05 RU RU2015148757A patent/RU2687249C2/ru active
- 2014-05-05 KR KR1020157033239A patent/KR102086709B1/ko active Active
- 2014-05-05 JP JP2016512111A patent/JP6433985B2/ja active Active
- 2014-05-05 SG SG11201508509XA patent/SG11201508509XA/en unknown
-
2015
- 2015-10-29 IL IL242339A patent/IL242339B/en active IP Right Grant
- 2015-11-03 US US14/931,581 patent/US9968589B2/en active Active
- 2015-12-01 ZA ZA2015/08782A patent/ZA201508782B/en unknown
-
2016
- 2016-11-02 CA CA3004160A patent/CA3004160C/en active Active
- 2016-11-02 AU AU2016349784A patent/AU2016349784B2/en active Active
- 2016-11-02 MY MYPI2018701738A patent/MY196979A/en unknown
- 2016-11-02 KR KR1020187015606A patent/KR102796310B1/ko active Active
- 2016-11-02 JP JP2018543020A patent/JP2018536709A/ja active Pending
- 2016-11-02 CN CN201680077107.3A patent/CN108430470A/zh active Pending
- 2016-11-02 RU RU2018118068A patent/RU2701548C1/ru active
- 2016-11-02 WO PCT/US2016/060085 patent/WO2017079270A1/en not_active Ceased
- 2016-11-02 EP EP16862858.4A patent/EP3370716A4/en active Pending
- 2016-11-02 MX MX2018005625A patent/MX390998B/es unknown
-
2018
- 2018-04-29 IL IL259019A patent/IL259019B/en active IP Right Grant
- 2018-05-14 US US15/978,742 patent/US11123284B2/en active Active
- 2018-05-25 ZA ZA2018/03483A patent/ZA201803483B/en unknown
-
2021
- 2021-09-20 US US17/479,780 patent/US20220387307A1/en not_active Abandoned
-
2022
- 2022-02-07 JP JP2022016897A patent/JP7512317B2/ja active Active
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