JP2016522159A5 - - Google Patents
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- JP2016522159A5 JP2016522159A5 JP2016503339A JP2016503339A JP2016522159A5 JP 2016522159 A5 JP2016522159 A5 JP 2016522159A5 JP 2016503339 A JP2016503339 A JP 2016503339A JP 2016503339 A JP2016503339 A JP 2016503339A JP 2016522159 A5 JP2016522159 A5 JP 2016522159A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 61
- 239000000203 mixture Substances 0.000 claims description 31
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 150000001413 amino acids Chemical group 0.000 claims description 8
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 230000002685 pulmonary effect Effects 0.000 claims description 2
- 206010016654 Fibrosis Diseases 0.000 claims 3
- 230000004761 fibrosis Effects 0.000 claims 3
- 150000008574 D-amino acids Chemical class 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 150000008575 L-amino acids Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 18
- 238000000034 method Methods 0.000 description 15
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 10
- 210000002950 fibroblast Anatomy 0.000 description 7
- 238000000099 in vitro assay Methods 0.000 description 7
- 238000005462 in vivo assay Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 6
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
- 230000003510 anti-fibrotic effect Effects 0.000 description 5
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 description 4
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 description 4
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 4
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 230000001404 mediated effect Effects 0.000 description 4
- 108010043655 penetratin Proteins 0.000 description 4
- MCYTYTUNNNZWOK-LCLOTLQISA-N penetratin Chemical compound C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=CC=C1 MCYTYTUNNNZWOK-LCLOTLQISA-N 0.000 description 4
- 102000004504 Urokinase Plasminogen Activator Receptors Human genes 0.000 description 3
- 108010042352 Urokinase Plasminogen Activator Receptors Proteins 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 125000006726 (C1-C5) alkenyl group Chemical group 0.000 description 1
- 101100222094 Arabidopsis thaliana CSP4 gene Proteins 0.000 description 1
- 101150104494 CAV1 gene Proteins 0.000 description 1
- 102000003727 Caveolin 1 Human genes 0.000 description 1
- 108090000026 Caveolin 1 Proteins 0.000 description 1
- 101000760337 Homo sapiens Urokinase plasminogen activator surface receptor Proteins 0.000 description 1
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 108010088535 Pep-1 peptide Proteins 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 101710089934 Protein UL49 Proteins 0.000 description 1
- 102220582112 Putative uncharacterized protein FER1L6-AS1_W48F_mutation Human genes 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 101710192266 Tegument protein VP22 Proteins 0.000 description 1
- 102100024689 Urokinase plasminogen activator surface receptor Human genes 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- PBKWZFANFUTEPS-CWUSWOHSSA-N transportan Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1 PBKWZFANFUTEPS-CWUSWOHSSA-N 0.000 description 1
- 108010062760 transportan Proteins 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018134098A JP6975690B2 (ja) | 2013-03-15 | 2018-07-17 | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361800117P | 2013-03-15 | 2013-03-15 | |
| US61/800,117 | 2013-03-15 | ||
| PCT/US2014/030147 WO2014145389A1 (en) | 2013-03-15 | 2014-03-17 | Inhibition of pulmonary fibrosis with nutlin-3a and peptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018134098A Division JP6975690B2 (ja) | 2013-03-15 | 2018-07-17 | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016522159A JP2016522159A (ja) | 2016-07-28 |
| JP2016522159A5 true JP2016522159A5 (enExample) | 2017-04-20 |
| JP6603207B2 JP6603207B2 (ja) | 2019-11-06 |
Family
ID=51537978
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503339A Active JP6603207B2 (ja) | 2013-03-15 | 2014-03-17 | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
| JP2018134098A Active JP6975690B2 (ja) | 2013-03-15 | 2018-07-17 | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
| JP2021128989A Active JP7378833B2 (ja) | 2013-03-15 | 2021-08-05 | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
| JP2023183297A Pending JP2023178440A (ja) | 2013-03-15 | 2023-10-25 | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018134098A Active JP6975690B2 (ja) | 2013-03-15 | 2018-07-17 | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
| JP2021128989A Active JP7378833B2 (ja) | 2013-03-15 | 2021-08-05 | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
| JP2023183297A Pending JP2023178440A (ja) | 2013-03-15 | 2023-10-25 | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
Country Status (11)
| Country | Link |
|---|---|
| US (8) | US9630990B2 (enExample) |
| EP (3) | EP4438044A3 (enExample) |
| JP (4) | JP6603207B2 (enExample) |
| KR (3) | KR102268883B1 (enExample) |
| CN (3) | CN110201144B (enExample) |
| AU (3) | AU2014233055B2 (enExample) |
| CA (1) | CA2904870C (enExample) |
| DK (2) | DK2970383T3 (enExample) |
| ES (2) | ES2993671T3 (enExample) |
| PT (2) | PT2970383T (enExample) |
| WO (1) | WO2014145389A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| SG173492A1 (en) | 2009-02-03 | 2011-09-29 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells. |
| JP6603207B2 (ja) | 2013-03-15 | 2019-11-06 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| US9993472B2 (en) | 2014-01-28 | 2018-06-12 | Unity Biotechnology, Inc. | Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2 |
| US20190269675A1 (en) | 2014-01-28 | 2019-09-05 | Buck Institute for Research and Aging | Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents |
| AU2015261380B2 (en) | 2014-05-16 | 2021-04-15 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
| GB201421092D0 (en) * | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| AU2016225111B2 (en) | 2015-02-27 | 2021-12-09 | Board Of Regents, The University Of Texas System | Polypeptide therapeutics and uses thereof |
| GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| WO2018190680A1 (ko) * | 2017-04-13 | 2018-10-18 | 충남대학교산학협력단 | 세포내 결핵균 제어를 위한 뉴트린-3α 및 피53 발현 조절 조성물 또는 방법 |
| KR102082285B1 (ko) * | 2017-04-13 | 2020-02-28 | 충남대학교산학협력단 | 세포내 결핵균 제어를 위한 Nutlin-3α (뉴트린-3α) 및 p53 발현 조절 조성물 또는 방법 |
| CN107987128B (zh) * | 2017-11-17 | 2019-06-11 | 广东医科大学 | 一种功能多肽及其在制备防治肺纤维化药物中的应用 |
| US12281180B2 (en) | 2018-07-13 | 2025-04-22 | New York University | Peptoid-peptide macrocycles, pharmaceutical compositions and methods of using the same |
| EP3849581A4 (en) * | 2018-09-10 | 2022-07-06 | Board of Regents, The University of Texas System | DRY POWDER FORMULATION OF CAVEOLIN-1 PEPTIDES AND METHODS OF USE THEREOF |
| AU2019339260B2 (en) * | 2018-09-10 | 2025-06-26 | Rein Therapeutics, Inc. | Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis |
| CN109010798A (zh) * | 2018-09-17 | 2018-12-18 | 中山大学中山眼科中心 | 一种多肽的新用途 |
| GB201819224D0 (en) | 2018-11-26 | 2019-01-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Hepatocyte expansion methods |
| KR20220121867A (ko) * | 2019-12-31 | 2022-09-01 | 시아먼 유니버시티 | 분자의 세포 내 전달을 위한 다량체화 전달 시스템 |
| WO2022182949A2 (en) | 2021-02-25 | 2022-09-01 | Lung Therapeutics, Inc. | Biomarkers for the treatment of interstitial lung disease |
| WO2022217037A1 (en) | 2021-04-09 | 2022-10-13 | Board Of Regents, The University Of Texas System | Compositions and methods for treatment of chronic lung diseases |
| WO2025007890A1 (zh) * | 2023-07-06 | 2025-01-09 | 厦门大学 | 新型疫苗递送体系 |
| CN116789751B (zh) * | 2023-08-22 | 2023-11-17 | 中国农业大学 | 预防和/或治疗纤维化疾病的多肽及其应用 |
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| US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US4021387A (en) | 1975-11-19 | 1977-05-03 | President And Fellows Of Harvard College | Eosinophilotactic tetrapeptides |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| US4816449A (en) | 1984-08-09 | 1989-03-28 | Immunetech Pharmaceuticals | Immunotherapeutic anti-inflammatory peptide agents |
| US4613676A (en) * | 1983-11-23 | 1986-09-23 | Ciba-Geigy Corporation | Substituted 5-amino-4-hydroxyvaleryl derivatives |
| ZA846192B (en) | 1984-08-09 | 1986-03-26 | Merck Patent Gmbh | Immunotherapeutic polypeptide agents |
| US5728680A (en) | 1987-12-30 | 1998-03-17 | Cytoven J.V. | Methods for normalizing numbers of lymphocytes |
| DK53291D0 (da) * | 1991-03-25 | 1991-03-25 | Carlbiotech Ltd As | Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser |
| CA2150371C (en) * | 1992-12-11 | 2002-09-17 | Dov Borovsky | Materials and methods for control of pests |
| US5559209A (en) * | 1993-02-18 | 1996-09-24 | The General Hospital Corporation | Regulator regions of G proteins |
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| US6017735A (en) | 1997-01-23 | 2000-01-25 | Marie Curie Cancer Care | Materials and methods for intracellular transport and their uses |
| US20030113271A1 (en) | 1997-01-29 | 2003-06-19 | University Technology Corporation | Formulations for pulmonary delivery |
| EP1076091A1 (en) | 1999-08-09 | 2001-02-14 | Universite Catholique De Louvain | Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds |
| US20020077283A1 (en) | 2000-09-08 | 2002-06-20 | Sessa William C. | Caveolin peptides and their use as therapeutics |
| WO2002053161A1 (en) | 2000-12-29 | 2002-07-11 | Alteon, Inc. | Method for treating fibrotic diseases or other indications |
| GB0119852D0 (en) | 2001-08-15 | 2001-10-10 | Univ York | Baculovirus |
| RU2305095C2 (ru) | 2001-12-18 | 2007-08-27 | Ф.Хоффманн-Ля Рош Аг | Цис-2,4,5-трифенилимидазолины и фармацевтическая композиция на их основе |
| US7625865B2 (en) | 2004-03-26 | 2009-12-01 | Universita Degli Studi Di Parma | Insulin highly respirable microparticles |
| US8101726B2 (en) * | 2004-05-25 | 2012-01-24 | Tactic Pharma, Llc | Ligands binding the complex of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) that inhibit downstream uPAR interactions: identification and use in diagnosis or therapy |
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| US8969077B2 (en) | 2010-11-05 | 2015-03-03 | The Regents Of The University Of California | Neuronal specific targeting of caveolin expression to restore synaptic signaling and improve cognitive function in the neurodegenerative brain and motor function in spinal cord |
| US20150141340A1 (en) * | 2012-06-04 | 2015-05-21 | Yale University | Method of treating and preventing ocular angiogenesis |
| MX2015012931A (es) | 2013-03-13 | 2016-07-20 | Forest Lab Holdings Ltd | Composiciones farmaceuticas micronizadas. |
| JP6603207B2 (ja) * | 2013-03-15 | 2019-11-06 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | ヌトリン３ａおよびペプチドを用いた肺線維症の阻害 |
| CA2928759A1 (en) | 2013-11-04 | 2015-05-07 | Board Of Regents, The University Of Texas System | Compositions and methods for administration of an enzyme to a subject's airway |
| ES2806027T3 (es) | 2013-11-26 | 2021-02-16 | Univ Yale | Nuevas composiciones penetrantes de células y métodos de uso de las mismas |
| ES2743622T3 (es) | 2013-11-26 | 2020-02-20 | E & B Tech Llc | Tratamiento de la enfermedad autoinmune y/o inflamatoria usando moduladores de la caveolina novedosos |
| AU2019339260B2 (en) | 2018-09-10 | 2025-06-26 | Rein Therapeutics, Inc. | Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis |
| EP3849581A4 (en) | 2018-09-10 | 2022-07-06 | Board of Regents, The University of Texas System | DRY POWDER FORMULATION OF CAVEOLIN-1 PEPTIDES AND METHODS OF USE THEREOF |
-
2014
- 2014-03-17 JP JP2016503339A patent/JP6603207B2/ja active Active
- 2014-03-17 CN CN201910393777.1A patent/CN110201144B/zh active Active
- 2014-03-17 ES ES21168926T patent/ES2993671T3/es active Active
- 2014-03-17 CN CN202311699535.8A patent/CN117679487A/zh active Pending
- 2014-03-17 DK DK14762435.7T patent/DK2970383T3/da active
- 2014-03-17 EP EP24188856.9A patent/EP4438044A3/en active Pending
- 2014-03-17 AU AU2014233055A patent/AU2014233055B2/en active Active
- 2014-03-17 PT PT147624357T patent/PT2970383T/pt unknown
- 2014-03-17 WO PCT/US2014/030147 patent/WO2014145389A1/en not_active Ceased
- 2014-03-17 KR KR1020157025554A patent/KR102268883B1/ko active Active
- 2014-03-17 PT PT211689260T patent/PT3929207T/pt unknown
- 2014-03-17 CA CA2904870A patent/CA2904870C/en active Active
- 2014-03-17 US US14/775,895 patent/US9630990B2/en active Active
- 2014-03-17 ES ES14762435T patent/ES2875853T3/es active Active
- 2014-03-17 CN CN201480016012.1A patent/CN105263948B/zh active Active
- 2014-03-17 KR KR1020217018508A patent/KR102588702B1/ko active Active
- 2014-03-17 EP EP21168926.0A patent/EP3929207B1/en active Active
- 2014-03-17 DK DK21168926.0T patent/DK3929207T3/da active
- 2014-03-17 EP EP14762435.7A patent/EP2970383B1/en active Active
- 2014-03-17 KR KR1020237034239A patent/KR20230148263A/ko not_active Withdrawn
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2017
- 2017-03-10 US US15/455,670 patent/US10377796B2/en active Active
- 2017-10-09 US US15/727,828 patent/US20180086791A1/en not_active Abandoned
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2018
- 2018-07-12 AU AU2018205157A patent/AU2018205157A1/en not_active Abandoned
- 2018-07-17 JP JP2018134098A patent/JP6975690B2/ja active Active
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2019
- 2019-12-03 US US16/702,101 patent/US11161875B2/en active Active
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2020
- 2020-05-15 AU AU2020203192A patent/AU2020203192A1/en not_active Abandoned
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2021
- 2021-08-05 JP JP2021128989A patent/JP7378833B2/ja active Active
- 2021-10-12 US US17/499,859 patent/US11780879B2/en active Active
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2022
- 2022-12-02 US US18/061,084 patent/US20230100467A1/en not_active Abandoned
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2023
- 2023-08-15 US US18/450,056 patent/US12173089B2/en active Active
- 2023-10-25 JP JP2023183297A patent/JP2023178440A/ja active Pending
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2024
- 2024-11-08 US US18/941,370 patent/US20250304619A1/en active Pending
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