JP2010535508A5 - - Google Patents
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- JP2010535508A5 JP2010535508A5 JP2010520314A JP2010520314A JP2010535508A5 JP 2010535508 A5 JP2010535508 A5 JP 2010535508A5 JP 2010520314 A JP2010520314 A JP 2010520314A JP 2010520314 A JP2010520314 A JP 2010520314A JP 2010535508 A5 JP2010535508 A5 JP 2010535508A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- composition
- seq
- kinase
- cancer cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 3
- 238000001802 infusion Methods 0.000 claims description 2
- 238000007913 intrathecal administration Methods 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108091000080 Phosphotransferase Proteins 0.000 claims 8
- 102000020233 phosphotransferase Human genes 0.000 claims 8
- 229940043355 kinase inhibitor Drugs 0.000 claims 6
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 6
- 230000037396 body weight Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 150000008574 D-amino acids Chemical class 0.000 claims 1
- 150000008575 L-amino acids Chemical class 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000006201 parenteral dosage form Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008196 pharmacological composition Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000002513 implantation Methods 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000002330 subarachnoid space Anatomy 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96394107P | 2007-08-07 | 2007-08-07 | |
| US60/963,941 | 2007-08-07 | ||
| US99497007P | 2007-09-24 | 2007-09-24 | |
| US60/994,970 | 2007-09-24 | ||
| PCT/US2008/072525 WO2009021137A2 (en) | 2007-08-07 | 2008-08-07 | Kinase inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535508A JP2010535508A (ja) | 2010-11-25 |
| JP2010535508A5 true JP2010535508A5 (enExample) | 2014-05-15 |
| JP5703466B2 JP5703466B2 (ja) | 2015-04-22 |
Family
ID=40342047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520314A Expired - Fee Related JP5703466B2 (ja) | 2007-08-07 | 2008-08-07 | キナーゼ阻害薬およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8741849B2 (enExample) |
| EP (1) | EP2185698B1 (enExample) |
| JP (1) | JP5703466B2 (enExample) |
| DK (1) | DK2185698T3 (enExample) |
| ES (1) | ES2547229T3 (enExample) |
| WO (1) | WO2009021137A2 (enExample) |
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| US20080293640A1 (en) * | 2007-01-10 | 2008-11-27 | Arizona Board of Regents, A body Corporate, of the State of Arizona, acting for and on behalf of | Polypeptide inhibitors of HSP27 kinase and uses therefor |
| EP2617431B1 (en) | 2007-01-10 | 2017-04-12 | Purdue Research Foundation | Polypeptide inhibitors of HSP27 kinase and uses therefor |
| JP5703466B2 (ja) | 2007-08-07 | 2015-04-22 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | キナーゼ阻害薬およびその使用 |
| DK2349310T3 (da) * | 2008-10-20 | 2014-08-11 | Moerae Matrix Inc | Polypeptid til behandling eller forebyggelse af adhæsioner |
| AU2013202108B2 (en) * | 2008-12-10 | 2015-12-24 | Purdue Research Foundation | Cell-permeant peptide-based inhibitor of kinases |
| BRPI0922448A2 (pt) * | 2008-12-10 | 2021-02-17 | Purdue Research Foundation | inibidor com base em peptídeo penetrante celular de quinases |
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| TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
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| CA3087354C (en) | 2018-01-18 | 2023-01-03 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| KR20210021984A (ko) | 2018-05-15 | 2021-03-02 | 인터크 펩타이드 테라퓨틱스 리미티드 | 펩타이드 활성화 제제 |
| AU2019268411B2 (en) * | 2018-05-15 | 2024-03-14 | Interk Peptide Therapeutics Limited | Activating agents |
| CN112996794A (zh) | 2018-09-10 | 2021-06-18 | 阿雷生物药品公司 | 作为ret激酶抑制剂的稠合杂环化合物 |
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| BRPI0922448A2 (pt) | 2008-12-10 | 2021-02-17 | Purdue Research Foundation | inibidor com base em peptídeo penetrante celular de quinases |
| WO2011017132A2 (en) | 2009-07-27 | 2011-02-10 | Purdue Research, Foundation | Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration |
| US20110288036A1 (en) | 2010-05-24 | 2011-11-24 | Cynthia Lander | Methods for Treating or Preventing Vascular Graft Failure |
| ES2711670T3 (es) | 2011-04-12 | 2019-05-06 | Moerae Matrix Inc | Composiciones y métodos para la prevención o tratamiento de la fibrosis pulmonar |
-
2008
- 2008-08-07 JP JP2010520314A patent/JP5703466B2/ja not_active Expired - Fee Related
- 2008-08-07 ES ES08797416.8T patent/ES2547229T3/es active Active
- 2008-08-07 DK DK08797416.8T patent/DK2185698T3/en active
- 2008-08-07 EP EP20080797416 patent/EP2185698B1/en not_active Not-in-force
- 2008-08-07 US US12/188,109 patent/US8741849B2/en not_active Expired - Fee Related
- 2008-08-07 WO PCT/US2008/072525 patent/WO2009021137A2/en not_active Ceased
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2014
- 2014-04-22 US US14/258,418 patent/US9447158B2/en active Active
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