JP2016520615A - アルツハイマー病を処置するためのｉｌ−１アンタゴニストを使用する方法 - Google Patents

アルツハイマー病を処置するためのｉｌ−１アンタゴニストを使用する方法 Download PDF

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JP2016520615A
JP2016520615A JP2016517030A JP2016517030A JP2016520615A JP 2016520615 A JP2016520615 A JP 2016520615A JP 2016517030 A JP2016517030 A JP 2016517030A JP 2016517030 A JP2016517030 A JP 2016517030A JP 2016520615 A JP2016520615 A JP 2016520615A
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disease
administration
trap
antagonist
amyloid
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JP2016520615A5 (OSRAM
Inventor
スーザン ディー． クロール，
スーザン ディー． クロール，
スタンリー ウィガン，
スタンリー ウィガン，
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2006—IL-1
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
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  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
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  • Toxicology (AREA)
  • Microbiology (AREA)
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  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2016517030A 2013-05-31 2014-05-30 アルツハイマー病を処置するためのｉｌ−１アンタゴニストを使用する方法 Pending JP2016520615A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361829713P 2013-05-31 2013-05-31
US61/829,713 2013-05-31
PCT/US2014/040160 WO2014194166A1 (en) 2013-05-31 2014-05-30 Methods of using il-1 antagonists to treat alzheimer's disease

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JP2018076729A Division JP2018111723A (ja) 2013-05-31 2018-04-12 アルツハイマー病を処置するためのｉｌ−１アンタゴニストを使用する方法

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JP2016520615A true JP2016520615A (ja) 2016-07-14
JP2016520615A5 JP2016520615A5 (OSRAM) 2017-05-18

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JP2016517030A Pending JP2016520615A (ja) 2013-05-31 2014-05-30 アルツハイマー病を処置するためのｉｌ−１アンタゴニストを使用する方法
JP2018076729A Pending JP2018111723A (ja) 2013-05-31 2018-04-12 アルツハイマー病を処置するためのｉｌ−１アンタゴニストを使用する方法

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US (1) US20160120941A1 (OSRAM)
EP (1) EP3003356B1 (OSRAM)
JP (2) JP2016520615A (OSRAM)
AU (1) AU2014274044B2 (OSRAM)
CA (1) CA2911547A1 (OSRAM)
WO (1) WO2014194166A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019526612A (ja) * 2016-09-12 2019-09-19 スティーブン・ホフマン 認知症を治療するための組成物

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JP2018516901A (ja) * 2015-05-18 2018-06-28 シナプテック・ディヴェロップメント・エルエルシーＳｙｎａｐｔｅｃ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｌｃ アミロイドβのガランタミンクリアランス
CN118994394A (zh) 2017-06-12 2024-11-22 蓝鳍生物医药公司 抗-il1rap抗体和抗体药物缀合物
JP7368856B2 (ja) 2017-07-25 2023-10-25 トゥルーバインディング，インコーポレイテッド Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療
JP7290872B2 (ja) * 2018-01-31 2023-06-14 オラテック セラピューティクス リミティド ライアビリティ カンパニー アルツハイマー病の予防又は治療方法
CN116063505B (zh) 2019-01-30 2024-05-03 真和制药有限公司 抗gal3抗体及其用途
US12281166B2 (en) 2020-05-26 2025-04-22 Truebinding, Inc. Methods of treating inflammatory diseases by blocking Galectin-3
CN111956933B (zh) * 2020-08-27 2022-05-03 北京理工大学 一种阿尔兹海默病神经反馈康复系统
WO2022167916A1 (en) * 2021-02-03 2022-08-11 Novartis Ag Use of il-1b binding antibodies for treating neuroinflammatory disorders
EP4464329A4 (en) * 2022-01-10 2025-06-11 GI Innovation, Inc. PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF DEGENERATIVE BRAIN DISEASES, CONTAINING A GLUCAGON-LIKE PEPTIDE-1 AND AN INTERLEUKIN-1 RECEPTOR ANTAGONIST

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JP2008501716A (ja) * 2004-06-04 2008-01-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 自己炎症性疾患を処置するためのｉｌ−１アンタゴニストを使用する方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019526612A (ja) * 2016-09-12 2019-09-19 スティーブン・ホフマン 認知症を治療するための組成物

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HK1220896A1 (en) 2017-05-19
EP3003356A1 (en) 2016-04-13
EP3003356B1 (en) 2019-07-03
CA2911547A1 (en) 2014-12-04
AU2014274044B2 (en) 2019-06-27
JP2018111723A (ja) 2018-07-19
AU2014274044A1 (en) 2016-01-21
US20160120941A1 (en) 2016-05-05
WO2014194166A1 (en) 2014-12-04

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