JP2016520598A5 - - Google Patents
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- JP2016520598A5 JP2016520598A5 JP2016515582A JP2016515582A JP2016520598A5 JP 2016520598 A5 JP2016520598 A5 JP 2016520598A5 JP 2016515582 A JP2016515582 A JP 2016515582A JP 2016515582 A JP2016515582 A JP 2016515582A JP 2016520598 A5 JP2016520598 A5 JP 2016520598A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- polypeptide
- acid modification
- heteromultimer
- hinge region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829973P | 2013-05-31 | 2013-05-31 | |
| US61/829,973 | 2013-05-31 | ||
| PCT/CA2014/050507 WO2014190441A1 (en) | 2013-05-31 | 2014-05-30 | Heteromultimers with reduced or silenced effector function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520598A JP2016520598A (ja) | 2016-07-14 |
| JP2016520598A5 true JP2016520598A5 (https=) | 2017-06-22 |
| JP6567506B2 JP6567506B2 (ja) | 2019-08-28 |
Family
ID=51987817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515582A Active JP6567506B2 (ja) | 2013-05-31 | 2014-05-30 | 低下した又はサイレント化したエフェクター機能を持つヘテロ多量体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11098105B2 (https=) |
| EP (1) | EP3004174B1 (https=) |
| JP (1) | JP6567506B2 (https=) |
| KR (1) | KR102332303B1 (https=) |
| CN (1) | CN105849129A (https=) |
| AU (1) | AU2014273817B2 (https=) |
| BR (1) | BR112015029788B1 (https=) |
| CA (1) | CA2913370C (https=) |
| DK (1) | DK3004174T3 (https=) |
| ES (1) | ES2736326T3 (https=) |
| RU (1) | RU2655439C2 (https=) |
| WO (1) | WO2014190441A1 (https=) |
Families Citing this family (66)
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| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| ES2595638T3 (es) | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| EP2647706B1 (en) | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
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| CN105246914B (zh) | 2013-04-02 | 2021-08-27 | 中外制药株式会社 | Fc区变体 |
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| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
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| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
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| EP3927746A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| MX2021010254A (es) | 2019-02-27 | 2021-09-21 | Angiex Inc | Conjugados de anticuerpo-farmaco que comprenden anticuerpos anti-tm4sf1 y metodos de uso de los mismos. |
| WO2020219820A1 (en) | 2019-04-25 | 2020-10-29 | Avidity Biosciences, Inc. | Nucleic acid compositions and methods of multi-exon skipping |
| JP7500619B2 (ja) * | 2019-05-30 | 2024-06-17 | アムジエン・インコーポレーテツド | 抗体の二量体化を促進するためのヒンジ領域の操作 |
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| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
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| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| WO2021188390A1 (en) | 2020-03-19 | 2021-09-23 | Avidity Biosciences, Inc. | Compositions and methods of treating facioscapulohumeral muscular dystrophy |
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| GB2616354A (en) | 2020-08-26 | 2023-09-06 | Marengo Therapeutics Inc | Methods of detecting TRBC1 or TRBC2 |
| JP7769007B2 (ja) * | 2020-12-23 | 2025-11-12 | イミュノウェイク インコーポレイテッド | イムノサイトカイン及びその使用 |
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| WO2022216993A2 (en) | 2021-04-08 | 2022-10-13 | Marengo Therapeutics, Inc. | Multifuntional molecules binding to tcr and uses thereof |
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| CN121712526A (zh) | 2023-06-13 | 2026-03-20 | 辛瑟斯治疗股份有限公司 | 抗cd5抗体及其用途 |
| AU2024346987A1 (en) * | 2023-09-19 | 2026-04-02 | Telix Targeting Technologies, Inc. | Antigen binding constructs |
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| WO2026050572A2 (en) | 2024-08-29 | 2026-03-05 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
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-
2014
- 2014-05-30 KR KR1020157036704A patent/KR102332303B1/ko active Active
- 2014-05-30 JP JP2016515582A patent/JP6567506B2/ja active Active
- 2014-05-30 ES ES14803370T patent/ES2736326T3/es active Active
- 2014-05-30 RU RU2015152084A patent/RU2655439C2/ru active
- 2014-05-30 EP EP14803370.7A patent/EP3004174B1/en active Active
- 2014-05-30 US US14/893,503 patent/US11098105B2/en active Active
- 2014-05-30 CA CA2913370A patent/CA2913370C/en active Active
- 2014-05-30 WO PCT/CA2014/050507 patent/WO2014190441A1/en not_active Ceased
- 2014-05-30 DK DK14803370.7T patent/DK3004174T3/da active
- 2014-05-30 CN CN201480039387.XA patent/CN105849129A/zh active Pending
- 2014-05-30 AU AU2014273817A patent/AU2014273817B2/en not_active Ceased
- 2014-05-30 BR BR112015029788-9A patent/BR112015029788B1/pt not_active IP Right Cessation
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