JP2016520598A5 - - Google Patents
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- JP2016520598A5 JP2016520598A5 JP2016515582A JP2016515582A JP2016520598A5 JP 2016520598 A5 JP2016520598 A5 JP 2016520598A5 JP 2016515582 A JP2016515582 A JP 2016515582A JP 2016515582 A JP2016515582 A JP 2016515582A JP 2016520598 A5 JP2016520598 A5 JP 2016520598A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- polypeptide
- acid modification
- heteromultimer
- hinge region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829973P | 2013-05-31 | 2013-05-31 | |
| US61/829,973 | 2013-05-31 | ||
| PCT/CA2014/050507 WO2014190441A1 (en) | 2013-05-31 | 2014-05-30 | Heteromultimers with reduced or silenced effector function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520598A JP2016520598A (ja) | 2016-07-14 |
| JP2016520598A5 true JP2016520598A5 (enExample) | 2017-06-22 |
| JP6567506B2 JP6567506B2 (ja) | 2019-08-28 |
Family
ID=51987817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515582A Active JP6567506B2 (ja) | 2013-05-31 | 2014-05-30 | 低下した又はサイレント化したエフェクター機能を持つヘテロ多量体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11098105B2 (enExample) |
| EP (1) | EP3004174B1 (enExample) |
| JP (1) | JP6567506B2 (enExample) |
| KR (1) | KR102332303B1 (enExample) |
| CN (1) | CN105849129A (enExample) |
| AU (1) | AU2014273817B2 (enExample) |
| BR (1) | BR112015029788B1 (enExample) |
| CA (1) | CA2913370C (enExample) |
| DK (1) | DK3004174T3 (enExample) |
| ES (1) | ES2736326T3 (enExample) |
| RU (1) | RU2655439C2 (enExample) |
| WO (1) | WO2014190441A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| EP2275443B1 (en) | 2008-04-11 | 2015-12-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| TWI654204B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| WO2013125667A1 (ja) | 2012-02-24 | 2013-08-29 | 中外製薬株式会社 | FcγRIIBを介して抗原の消失を促進する抗原結合分子 |
| US20140154253A1 (en) * | 2012-07-13 | 2014-06-05 | Zymeworks Inc. | Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs |
| SG11201500873XA (en) | 2012-08-24 | 2015-04-29 | Chugai Pharmaceutical Co Ltd | Fcgriib-specific fc region variant |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| TWI636062B (zh) | 2013-04-02 | 2018-09-21 | 中外製藥股份有限公司 | Fc region variant |
| EP4570318A3 (en) | 2013-11-27 | 2025-10-15 | Zymeworks BC Inc. | Bispecific antigen-binding constructs targeting her2 |
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| NZ730607A (en) | 2014-12-19 | 2022-07-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| JP7082604B2 (ja) | 2016-03-21 | 2022-06-08 | マレンゴ・セラピューティクス，インコーポレーテッド | 多重特異性および多機能性分子ならびにその使用 |
| KR102775461B1 (ko) | 2016-04-01 | 2025-02-28 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩타이드 조성물 및 이의 용도 |
| AU2017290389B2 (en) | 2016-07-01 | 2024-09-26 | Resolve Therapeutics, Llc | Optimized binuclease fusions and methods |
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| SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
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| RU2019128134A (ru) | 2017-02-07 | 2021-03-09 | Дайити Санкио Компани, Лимитед | Антитело против gprc5d и молекула, содержащая антитело |
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| CN111094330A (zh) | 2017-07-03 | 2020-05-01 | 转矩医疗股份有限公司 | 编码免疫刺激融合分子的多核苷酸及其用途 |
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| CN118638788A (zh) | 2017-12-06 | 2024-09-13 | 艾维迪提生物科学公司 | 治疗肌萎缩和强直性肌营养不良的组合物和方法 |
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| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| CA3093729A1 (en) | 2018-03-15 | 2019-09-19 | Chugai Seiyaku Kabushiki Kaisha | Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use |
| US12458705B2 (en) * | 2018-06-12 | 2025-11-04 | Angiex, Inc. | Antibody-oligonucleotide conjugates |
| WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| EP3873930A4 (en) * | 2018-10-23 | 2022-12-07 | Magenta Therapeutics, Inc. | FC-ALIMINATED ANTIBODY DRUG CONJUGATES (ADCS) AND THEIR USES |
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| JP7706373B2 (ja) | 2019-02-21 | 2025-07-11 | マレンゴ・セラピューティクス，インコーポレーテッド | カルレティキュリンに結合する多機能性分子およびその使用 |
| CA3131391A1 (en) * | 2019-02-27 | 2020-09-03 | Angiex, Inc. | Antibody-drug conjugates comprising anti-tm4sf1 antibodies and methods of using the same |
| CA3137715A1 (en) | 2019-04-25 | 2020-10-29 | Avidity Biosciences, Inc. | Nucleic acid compositions and methods of multi-exon skipping |
| SG11202112926YA (en) * | 2019-05-30 | 2021-12-30 | Amgen Inc | Engineering the hinge region to drive antibody dimerization |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| EP4087657A1 (en) | 2020-01-08 | 2022-11-16 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| WO2021188390A1 (en) | 2020-03-19 | 2021-09-23 | Avidity Biosciences, Inc. | Compositions and methods of treating facioscapulohumeral muscular dystrophy |
| KR20220160598A (ko) * | 2020-03-30 | 2022-12-06 | 고쿠리츠다이가쿠호진 미에다이가쿠 | 이중 특이적 항체 |
| KR20230028242A (ko) | 2020-04-24 | 2023-02-28 | 마렝고 테라퓨틱스, 인크. | T 세포 관련 암 세포에 결합하는 다중기능성 분자 및 그것의 용도 |
| CN116249718A (zh) | 2020-08-26 | 2023-06-09 | 马伦戈治疗公司 | 结合至钙网蛋白的多功能性分子及其用途 |
| GB2616354A (en) | 2020-08-26 | 2023-09-06 | Marengo Therapeutics Inc | Methods of detecting TRBC1 or TRBC2 |
| KR20230074144A (ko) | 2020-08-26 | 2023-05-26 | 마렝고 테라퓨틱스, 인크. | NKp30에 결합하는 항체 분자 및 이의 용도 |
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| CN120309734A (zh) | 2021-01-13 | 2025-07-15 | 威特拉公司 | 人源化补体5a受体1抗体和其使用方法 |
| JP2024515591A (ja) | 2021-04-08 | 2024-04-10 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔｃｒに結合する多機能性分子およびその使用 |
| JP7651145B2 (ja) * | 2021-04-20 | 2025-03-26 | コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーション | 向上した癌細胞死滅効能を有する非対称抗体 |
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| EP4727586A1 (en) | 2023-06-13 | 2026-04-22 | Synthis Therapeutics, Inc. | Anti-cd5 antibodies and their uses |
| AU2024346490A1 (en) * | 2023-09-19 | 2026-04-02 | Telix Targeting Technologies, Inc. | ANTIGEN BINDING CONSTRUCTS DIRECTED TO INTEGRIN αVβ6 |
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| WO2026037841A1 (en) | 2024-08-12 | 2026-02-19 | ONA Therapeutics S.L. | Anti-fgfr4 molecules and uses thereof |
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| WO2026090160A2 (en) | 2024-10-22 | 2026-04-30 | Gilead Sciences, Inc. | Cd4-targeted il-15 molecules and methods of use |
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-
2014
- 2014-05-30 RU RU2015152084A patent/RU2655439C2/ru active
- 2014-05-30 BR BR112015029788-9A patent/BR112015029788B1/pt not_active IP Right Cessation
- 2014-05-30 WO PCT/CA2014/050507 patent/WO2014190441A1/en not_active Ceased
- 2014-05-30 CN CN201480039387.XA patent/CN105849129A/zh active Pending
- 2014-05-30 DK DK14803370.7T patent/DK3004174T3/da active
- 2014-05-30 ES ES14803370T patent/ES2736326T3/es active Active
- 2014-05-30 CA CA2913370A patent/CA2913370C/en active Active
- 2014-05-30 AU AU2014273817A patent/AU2014273817B2/en not_active Ceased
- 2014-05-30 KR KR1020157036704A patent/KR102332303B1/ko active Active
- 2014-05-30 EP EP14803370.7A patent/EP3004174B1/en active Active
- 2014-05-30 US US14/893,503 patent/US11098105B2/en active Active
- 2014-05-30 JP JP2016515582A patent/JP6567506B2/ja active Active
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