JP2016520598A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016520598A5 JP2016520598A5 JP2016515582A JP2016515582A JP2016520598A5 JP 2016520598 A5 JP2016520598 A5 JP 2016520598A5 JP 2016515582 A JP2016515582 A JP 2016515582A JP 2016515582 A JP2016515582 A JP 2016515582A JP 2016520598 A5 JP2016520598 A5 JP 2016520598A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- polypeptide
- acid modification
- heteromultimer
- hinge region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829973P | 2013-05-31 | 2013-05-31 | |
| US61/829,973 | 2013-05-31 | ||
| PCT/CA2014/050507 WO2014190441A1 (en) | 2013-05-31 | 2014-05-30 | Heteromultimers with reduced or silenced effector function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520598A JP2016520598A (ja) | 2016-07-14 |
| JP2016520598A5 true JP2016520598A5 (enExample) | 2017-06-22 |
| JP6567506B2 JP6567506B2 (ja) | 2019-08-28 |
Family
ID=51987817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515582A Active JP6567506B2 (ja) | 2013-05-31 | 2014-05-30 | 低下した又はサイレント化したエフェクター機能を持つヘテロ多量体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11098105B2 (enExample) |
| EP (1) | EP3004174B1 (enExample) |
| JP (1) | JP6567506B2 (enExample) |
| KR (1) | KR102332303B1 (enExample) |
| CN (1) | CN105849129A (enExample) |
| AU (1) | AU2014273817B2 (enExample) |
| BR (1) | BR112015029788B1 (enExample) |
| CA (1) | CA2913370C (enExample) |
| DK (1) | DK3004174T3 (enExample) |
| ES (1) | ES2736326T3 (enExample) |
| RU (1) | RU2655439C2 (enExample) |
| WO (1) | WO2014190441A1 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| TWI700293B (zh) | 2008-04-11 | 2020-08-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗體 |
| KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| US20140154253A1 (en) * | 2012-07-13 | 2014-06-05 | Zymeworks Inc. | Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| PT3074424T (pt) | 2013-11-27 | 2025-05-29 | Zymeworks Bc Inc | Construções de ligação a antigénio biespecíficas direcionadas a her2 |
| DK3223848T3 (da) | 2014-11-27 | 2025-03-03 | Zymeworks Bc Inc | Fremgangsmåder til anvendelse af bispecifikke antigenbindingskonstrukter målrettet her2 |
| TWI656133B (zh) | 2014-12-19 | 2019-04-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Ｆｃ區域之多胜肽及使用方法 |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CA3016563A1 (en) | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| KR102775461B1 (ko) | 2016-04-01 | 2025-02-28 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩타이드 조성물 및 이의 용도 |
| JP7308034B2 (ja) | 2016-07-01 | 2023-07-13 | リゾルブ セラピューティクス， エルエルシー | 最適化二重ヌクレアーゼ融合物および方法 |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
| SG10202107429WA (en) | 2017-01-06 | 2021-08-30 | Avidity Biosciences Inc | Nucleic acid-polypeptide compositions and methods of inducing exon skipping |
| WO2018147245A1 (ja) | 2017-02-07 | 2018-08-16 | 第一三共株式会社 | 抗ｇｐｒｃ５ｄ抗体及び該抗体を含む分子 |
| US20200291089A1 (en) | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| ES2932759T3 (es) | 2017-02-17 | 2023-01-25 | Denali Therapeutics Inc | Polipéptidos de unión al receptor de transferrina diseñados |
| MX2019013132A (es) * | 2017-05-25 | 2020-01-27 | Bristol Myers Squibb Co | Anticuerpos que comprenden regiones constantes pesadas modificadas. |
| WO2018222901A1 (en) | 2017-05-31 | 2018-12-06 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| EP3648786A4 (en) | 2017-07-03 | 2021-12-15 | Torque Therapeutics, Inc. | FUSION MOLECULES TARGETING IMMUNE REGULATORY CELLS AND THEIR USES |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| WO2019040674A1 (en) | 2017-08-22 | 2019-02-28 | Sanabio, Llc | SOLUBLE INTERFERON RECEPTORS AND USES THEREOF |
| CN118638787A (zh) | 2017-12-06 | 2024-09-13 | 艾维迪提生物科学公司 | 治疗肌萎缩和强直性肌营养不良的组合物和方法 |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| IL277049B2 (en) | 2018-03-13 | 2024-02-01 | Zymeworks Bc Inc | Conjugates of biparatopic anti-HER2 antibody and drug and methods of use |
| WO2019178364A2 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| IL277375B2 (en) | 2018-03-15 | 2025-08-01 | Chugai Pharmaceutical Co Ltd | Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use |
| CA3103265A1 (en) * | 2018-06-12 | 2019-12-19 | Angiex, Inc. | Antibody-oligonucleotide conjugates |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| EP3873930A4 (en) * | 2018-10-23 | 2022-12-07 | Magenta Therapeutics, Inc. | FC-ALIMINATED ANTIBODY DRUG CONJUGATES (ADCS) AND THEIR USES |
| EP3927744A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
| EP3927746A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| EP3927431A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| CN114127112A (zh) | 2019-02-21 | 2022-03-01 | 马伦戈治疗公司 | 与t细胞结合的多功能分子及其治疗自身免疫性病症的用途 |
| JP2022522007A (ja) * | 2019-02-27 | 2022-04-13 | アンジーエックス・インコーポレーテッド | 抗ｔｍ４ｓｆ１抗体を含む抗体薬物コンジュゲートおよびそれを使用する方法 |
| EP3959319A4 (en) | 2019-04-25 | 2023-06-07 | Avidity Biosciences, Inc. | NUCLEIC ACID COMPOSITIONS AND METHODS FOR MULTI-EXON SKIPPING |
| WO2020243477A2 (en) * | 2019-05-30 | 2020-12-03 | Amgen Inc. | Engineering the hinge region to drive antibody dimerization |
| EP4084823A4 (en) | 2020-01-03 | 2024-05-15 | Marengo Therapeutics, Inc. | ANTI-TCR ANTIBODY MOLECULES AND THEIR USES |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| US20230090552A1 (en) | 2020-01-08 | 2023-03-23 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| AU2021237465A1 (en) | 2020-03-19 | 2022-10-13 | Avidity Biosciences, Inc. | Compositions and methods of treating Facioscapulohumeral muscular dystrophy |
| IL296514A (en) * | 2020-03-30 | 2022-11-01 | Univ Mie | Bispecific antibody |
| CA3180321A1 (en) | 2020-04-24 | 2021-10-28 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| GB2616128A (en) | 2020-08-26 | 2023-08-30 | Marengo Therapeutics Inc | Antibody molecules that bind to NKp30 and uses thereof |
| JP2023540248A (ja) | 2020-08-26 | 2023-09-22 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔｒｂｃ１またはｔｒｂｃ２を検出する方法 |
| WO2022046920A2 (en) | 2020-08-26 | 2022-03-03 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| MX2023008302A (es) | 2021-01-13 | 2023-09-25 | Visterra Inc | Anticuerpos humanizados contra el receptor 1 del componente 5a del complemento y métodos de uso de estos. |
| KR20240004462A (ko) | 2021-04-08 | 2024-01-11 | 마렝고 테라퓨틱스, 인크. | Tcr에 결합하는 다기능성 분자 및 이의 용도 |
| EP4328243A4 (en) * | 2021-04-20 | 2025-05-21 | Korea University Research and Business Foundation | Asymmetric antibody with improved cytotoxicity against cancer cell |
| US12071621B2 (en) | 2022-04-05 | 2024-08-27 | Avidity Biosciences, Inc. | Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping |
| WO2024092031A1 (en) | 2022-10-25 | 2024-05-02 | Seismic Therapeutic, Inc. | VARIANT IgG FC POLYPEPTIDES AND USES THEREOF |
| CN121712526A (zh) | 2023-06-13 | 2026-03-20 | 辛瑟斯治疗股份有限公司 | 抗cd5抗体及其用途 |
| WO2025064435A1 (en) * | 2023-09-19 | 2025-03-27 | Imaginab, Inc. | Antigen binding constructs directed to integrin αvβ6 |
| WO2026011013A1 (en) | 2024-07-02 | 2026-01-08 | Epibiologics, Inc. | Binding agents and uses thereof |
| WO2026037839A2 (en) | 2024-08-12 | 2026-02-19 | ONA Therapeutics S.L. | Anti-fgfr4 molecules and uses thereof |
| WO2026050572A2 (en) | 2024-08-29 | 2026-03-05 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US7951917B1 (en) * | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| US20030157108A1 (en) | 2001-10-25 | 2003-08-21 | Genentech, Inc. | Glycoprotein compositions |
| US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US20040110226A1 (en) | 2002-03-01 | 2004-06-10 | Xencor | Antibody optimization |
| RU2325186C2 (ru) * | 2002-09-27 | 2008-05-27 | Ксенкор, Инк. | АНТИТЕЛО, СОДЕРЖАЩЕЕ Fc-ВАРИАНТНУЮ ЧАСТЬ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ АНТИТЕЛО, И СПОСОБ ЛЕЧЕНИЯ МЛЕКОПИТАЮЩЕГО |
| WO2004029207A2 (en) | 2002-09-27 | 2004-04-08 | Xencor Inc. | Optimized fc variants and methods for their generation |
| US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
| EP2368578A1 (en) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
| US8399618B2 (en) | 2004-10-21 | 2013-03-19 | Xencor, Inc. | Immunoglobulin insertions, deletions, and substitutions |
| KR100956913B1 (ko) | 2003-12-19 | 2010-05-11 | 제넨테크, 인크. | 치료제로서 유용한 일가 항체 단편 |
| US7632497B2 (en) | 2004-11-10 | 2009-12-15 | Macrogenics, Inc. | Engineering Fc Antibody regions to confer effector function |
| EP1871808A2 (en) | 2005-03-31 | 2008-01-02 | Xencor, Inc. | Fc VARIANTS WITH OPTIMIZED PROPERTIES |
| WO2007022520A2 (en) | 2005-08-19 | 2007-02-22 | Cerus Corporation | Antibody-mediated enhancement of immune response |
| DK2176298T3 (en) | 2007-05-30 | 2018-02-12 | Xencor Inc | Methods and compositions for inhibiting CD32B-expressing cells |
| EP2631297B1 (en) | 2008-05-15 | 2017-04-12 | National Research Council Of Canada | Process, vectors and engineered cell lines for enhanced large-scale transfection |
| EP2233500A1 (en) | 2009-03-20 | 2010-09-29 | LFB Biotechnologies | Optimized Fc variants |
| AU2010321720B2 (en) * | 2009-11-23 | 2017-03-02 | Amgen Inc. | Monomeric antibody Fc |
| PL2506871T3 (pl) | 2009-11-30 | 2017-03-31 | Janssen Biotech, Inc | Przeciwciała ze zmutowanymi regionami Fc i utraconymi funkcjami efektorowymi |
| MX341925B (es) | 2010-03-29 | 2016-09-07 | Zymeworks Inc | Anticuerpos con funcion efectora suprimida o mejorada. |
| PL2560993T3 (pl) * | 2010-04-20 | 2024-11-04 | Genmab A/S | Heterodimeryczne białka zawierające region FC przeciwciała i sposoby ich wytwarzania |
| CA2797981C (en) | 2010-05-14 | 2019-04-23 | Rinat Neuroscience Corporation | Heterodimeric proteins and methods for producing and purifying them |
| AU2011325833C1 (en) * | 2010-11-05 | 2017-07-13 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
| EP3604330A1 (en) * | 2011-02-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc antibody |
| ES2668895T3 (es) | 2011-03-16 | 2018-05-23 | Amgen Inc. | Variantes de Fc |
| BR112013024574B1 (pt) | 2011-03-29 | 2022-08-09 | Roche Glycart Ag | Anticorpo e uso do anticorpo |
| EP2698431B1 (en) | 2011-03-30 | 2020-09-09 | Chugai Seiyaku Kabushiki Kaisha | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
| US9890218B2 (en) | 2011-06-30 | 2018-02-13 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
| AU2012332021B8 (en) | 2011-11-04 | 2017-10-12 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
| CN112079929A (zh) | 2012-11-21 | 2020-12-15 | 武汉友芝友生物制药有限公司 | 双特异性抗体 |
| DE112014002624B4 (de) | 2013-05-31 | 2024-10-31 | Micromass Uk Limited | Kompaktes Massenspektrometer |
| US20160355588A1 (en) | 2013-07-12 | 2016-12-08 | Zymeworks Inc. | Bispecific CD3 and CD19 Antigen Binding Constructs |
-
2014
- 2014-05-30 CA CA2913370A patent/CA2913370C/en active Active
- 2014-05-30 ES ES14803370T patent/ES2736326T3/es active Active
- 2014-05-30 US US14/893,503 patent/US11098105B2/en active Active
- 2014-05-30 AU AU2014273817A patent/AU2014273817B2/en not_active Ceased
- 2014-05-30 DK DK14803370.7T patent/DK3004174T3/da active
- 2014-05-30 RU RU2015152084A patent/RU2655439C2/ru active
- 2014-05-30 EP EP14803370.7A patent/EP3004174B1/en active Active
- 2014-05-30 CN CN201480039387.XA patent/CN105849129A/zh active Pending
- 2014-05-30 KR KR1020157036704A patent/KR102332303B1/ko active Active
- 2014-05-30 BR BR112015029788-9A patent/BR112015029788B1/pt active IP Right Grant
- 2014-05-30 WO PCT/CA2014/050507 patent/WO2014190441A1/en not_active Ceased
- 2014-05-30 JP JP2016515582A patent/JP6567506B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016520598A5 (enExample) | ||
| JP7178342B2 (ja) | アゴニズム及びエフェクター機能が増強した改変抗体、及び他のＦｃドメイン含有分子 | |
| US11739143B2 (en) | Humanized antibody for treating or preventing cognitive disorders, process for producing the same, and agent for treating or preventing cognitive disorders using the same | |
| CN114341186B (zh) | 双特异性抗LRRC15和CD3ε抗体 | |
| JP2021019598A (ja) | Ｆｃ含有ポリペプチドの安定化 | |
| RU2015152084A (ru) | Гетеромультимеры с уменьшенной или подавленной эффекторной функцией | |
| TW202227494A (zh) | 多特異性免疫靶向分子及其用途 | |
| JP2022033769A (ja) | 強化されたアゴニスト活性を有する、Ｆｃが遺伝子操作を受けた抗ＴＮＦＲスーパーファミリーメンバー抗体及びその使用方法 | |
| JP7597784B2 (ja) | 胸腺間質性リンパ球新生因子（ｔｓｌｐ）受容体シグナル伝達に干渉する薬剤 | |
| TW202108618A (zh) | 用於調節t細胞介導之免疫的材料及方法 | |
| TW202233674A (zh) | 用於調節δγ鏈介導之免疫的組成物及方法 | |
| IL300930A (en) | Methods and compositions for the treatment of autoimmune diseases and cancer | |
| WO2023051727A1 (zh) | 结合cd3的抗体及其用途 | |
| AU2019337394A1 (en) | Improved anti-FLT3 antigen binding proteins | |
| CN111465618A (zh) | 双特异性cd16-结合分子及其在疾病治疗中的用途 | |
| JP7822466B2 (ja) | 低減された凝集能及び低減された疎水性を有する、改善されたＦｃサイレンシングされた抗ｏｘＭＩＦ抗体 | |
| CN121057752A (zh) | 铰链经修饰的双特异性抗体 | |
| EP3623383A1 (en) | Improved bispecific flt3xcd3 antigen binding proteins | |
| TW202336035A (zh) | 治療自體免疫疾病及癌症之方法及組成物 | |
| WO2025201240A1 (en) | Antibodies targeting cd3, cd28, and pd-l1 and uses thereof | |
| WO2025133013A1 (en) | Anti-bacterial polypeptides | |
| WO2024188319A1 (zh) | 抗muc17、cd3和cd28三特异性抗体 | |
| HK40092434A (zh) | Btla抗体 | |
| EA040482B1 (ru) | Гуманизированное антитело для лечения или предотвращения когнитивных расстройств, способ его получения и агент для лечения или предотвращения когнитивных расстройств с его применением | |
| EA048178B1 (ru) | Гуманизированное антитело для лечения или предотвращения когнитивных расстройств, способ его получения и агент для лечения или предотвращения когнитивных расстройств с его применением |