JP2016520598A5 - - Google Patents
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- JP2016520598A5 JP2016520598A5 JP2016515582A JP2016515582A JP2016520598A5 JP 2016520598 A5 JP2016520598 A5 JP 2016520598A5 JP 2016515582 A JP2016515582 A JP 2016515582A JP 2016515582 A JP2016515582 A JP 2016515582A JP 2016520598 A5 JP2016520598 A5 JP 2016520598A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- polypeptide
- acid modification
- heteromultimer
- hinge region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 169
- 229920001184 polypeptide Polymers 0.000 claims description 166
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 166
- 230000004048 modification Effects 0.000 claims description 136
- 238000012986 modification Methods 0.000 claims description 136
- 150000001413 amino acids Chemical class 0.000 claims description 134
- 238000000034 method Methods 0.000 claims description 19
- -1 CH3 amino acid Chemical class 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 239000012636 effector Substances 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 239000004308 thiabendazole Substances 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 5
- 108020004707 nucleic acids Proteins 0.000 claims description 5
- 150000007523 nucleic acids Chemical class 0.000 claims description 5
- 238000000746 purification Methods 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 108091006020 Fc-tagged proteins Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 2
- 230000005888 antibody-dependent cellular phagocytosis Effects 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 238000004255 ion exchange chromatography Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 231100000331 toxic Toxicity 0.000 claims description 2
- 230000002588 toxic effect Effects 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 108700012359 toxins Proteins 0.000 claims description 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 5
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 4
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000006870 function Effects 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000002844 melting Methods 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- 102000009490 IgG Receptors Human genes 0.000 description 5
- 108010073807 IgG Receptors Proteins 0.000 description 5
- 102000009109 Fc receptors Human genes 0.000 description 2
- 108010087819 Fc receptors Proteins 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829973P | 2013-05-31 | 2013-05-31 | |
| US61/829,973 | 2013-05-31 | ||
| PCT/CA2014/050507 WO2014190441A1 (en) | 2013-05-31 | 2014-05-30 | Heteromultimers with reduced or silenced effector function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520598A JP2016520598A (ja) | 2016-07-14 |
| JP2016520598A5 true JP2016520598A5 (enExample) | 2017-06-22 |
| JP6567506B2 JP6567506B2 (ja) | 2019-08-28 |
Family
ID=51987817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515582A Active JP6567506B2 (ja) | 2013-05-31 | 2014-05-30 | 低下した又はサイレント化したエフェクター機能を持つヘテロ多量体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11098105B2 (enExample) |
| EP (1) | EP3004174B1 (enExample) |
| JP (1) | JP6567506B2 (enExample) |
| KR (1) | KR102332303B1 (enExample) |
| CN (1) | CN105849129A (enExample) |
| AU (1) | AU2014273817B2 (enExample) |
| BR (1) | BR112015029788B1 (enExample) |
| CA (1) | CA2913370C (enExample) |
| DK (1) | DK3004174T3 (enExample) |
| ES (1) | ES2736326T3 (enExample) |
| RU (1) | RU2655439C2 (enExample) |
| WO (1) | WO2014190441A1 (enExample) |
Families Citing this family (63)
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| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| HK1207575A1 (en) * | 2012-07-13 | 2016-02-05 | Zymeworks, Inc. | Bispecific asymmetric heterodimers comprising anti-cd3 constructs |
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| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスＦｃγＲＩＩ特異的Ｆｃ抗体 |
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-
2014
- 2014-05-30 KR KR1020157036704A patent/KR102332303B1/ko active Active
- 2014-05-30 DK DK14803370.7T patent/DK3004174T3/da active
- 2014-05-30 WO PCT/CA2014/050507 patent/WO2014190441A1/en not_active Ceased
- 2014-05-30 CA CA2913370A patent/CA2913370C/en active Active
- 2014-05-30 US US14/893,503 patent/US11098105B2/en active Active
- 2014-05-30 EP EP14803370.7A patent/EP3004174B1/en active Active
- 2014-05-30 ES ES14803370T patent/ES2736326T3/es active Active
- 2014-05-30 RU RU2015152084A patent/RU2655439C2/ru active
- 2014-05-30 AU AU2014273817A patent/AU2014273817B2/en not_active Ceased
- 2014-05-30 JP JP2016515582A patent/JP6567506B2/ja active Active
- 2014-05-30 CN CN201480039387.XA patent/CN105849129A/zh active Pending
- 2014-05-30 BR BR112015029788-9A patent/BR112015029788B1/pt active IP Right Grant
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